After mpox outbreak, Africa is under the threat of yet another virus outbreak, this is the Marburg virus outbreak in Rwanda. So far, six people have died from the outbreak, confirmed the health minister. Most victims were the healthcare workers in the hospital's intensive care unit. As per reports, 20 cases have been identified since the outbreak was confirmed on Friday.

What Is Marbug Virus?

With the fatality rate of 8% it is the same virus family as Ebola. The main carrier is from fruit bats which spreads to humans then through the contact of bodily fluids of infected individuals, it spreads to others.

Common Signs And Symptoms

The common signs and symptoms of the Marburg virus include fever, pain, diarrhoea, vomiting and in the case of extreme blood loss, death too can happen.

So far, there is no specific treatment or vaccine for the virus. However, treatments like drugs and immune therapy are being developed as per the World Health Organisation (WHO).

Call Of Action

Rwanda says that it has intensified its contact tracing, surveillance and testing to contain the spread. It has also tracked about 300 people who had come into contact with individuals affected by the Marburg virus.

The health minister has urged people to stay vigilant and avoid any physical contact and to wash their hands with clean water, soap or sanitiser and report any suspected case.

As of now, most of the cases have spread to the capital in Kigali. In light of this, the US Embassy in the city has advised its employees to work remotely for the next week.

This is the first time Rwanda has confirmed for Marburg cases, before this, in 2023, Tanzania confirmed the outbreak, whereas three people had died of this in Uganda in 2017.

History Of Marburg

As per WHO, this virus kills half of the people it infects. In the previous outbreaks, it has killed between 24% to 88% of the patients.

The virus was first detected in 1976 after 31 people were infected, out of which 7 died in simultaneous outbreak in Marburg and Frankfurt in Germany, and Belgrade in Serbia.

The source was traced to African green monkeys who were imported from Uganda. However, other animals too are linked to the virus spread, including bats.

In the past, the virus outbreaks have happened in countries like Equatorial Guinea, Ghana, the Democratic Republic of the Congo, Kenya, South Africa, Uganda, and Zimbabwe. In 2005, this virus killed 300 people in Angola.

However, for the rest of the world, only two people have died from the virus in the rest of the world, with one of them being in Europe, and the other in the US. These both have been on expeditions to caves in Uganda.

The situation regarding the outbreak of Ebola is nowhere near slowing down, and the World Health Organization (WHO) said that this outbreak of Ebola is far from under control. The outbreak of the disease in eastern Democratic Republic of the Congo (DRC) and neighboring Uganda has already reached the 500 mark.

On Saturday, the Democratic Republic of the Congo (DRC) reported that its total number of Ebola cases had increased to 488 from 452 cases and caused 86 deaths. Its neighbor, Uganda, also has reported 19 cases.

This time the Ebola outbreak has caused most harm to the Democratic Republic of the Congo (DRC) and during this mayhem its neighboring nation Uganda which is also fighting to contain the disease as it is also seeing surge in cases thus it has completely closed off its western border with DRC.

The worsening condition of the situation is clear, as the global health monitoring organization, the World Health Organization (WHO), has already declared the outbreak an international public health emergency.

And it's not only the case with WHO, another big name in public health, but the United States' Centers for Disease Control and Prevention (CDC) warned that the Ebola outbreak of this time could swell to become the largest Ebola epidemic to date, and is likely to rival the 2014-2016 epidemic in West Africa.

The patient number is still growing as the disease is spreading, and this spread is very hard to contain without an approved vaccine. Though work on the vaccine is in full swing, research on three different vaccines for the Bundibugyo strain of Ebola still needs time, even after being set to be fast-tracked for trials.

What Is Ebola?

Ebola is a severe and deadly disease caused by a virus mostly found in Africa. The spread of the disease happens through contact with infected body fluids.

Some symptoms can indicate a possible infection. This includes fever, headache, weakness, vomiting, diarrhea, muscle pain, sore throat, and unexplained bleeding. This eventually leads to severe complications like bleeding, organ failure, and death.

Ebola is a highly lethal viral hemorrhagic fever first identified in 1976. Over the past five decades, it has caused over 30 outbreaks, primarily in Central and West Africa. The virus takes its name from the Ebola River in the Democratic Republic of the Congo (DRC).

Three strains of the virus — Ebola virus, Sudan virus, and Bundibugyo virus — have caused the largest outbreaks in Africa. Among them, the Ebola virus is considered the deadliest, with fatality rates reaching up to 90% without treatment.

These viruses have repeatedly emerged from animal reservoirs and infected humans in African countries. In the Democratic Republic of the Congo alone, this marks the 17th Ebola outbreak and the third linked to the Bundibugyo strain.

After Rajasthan and Hyderabad, Chhattisgarh today reported three suspected cases of Ebola involving foreign nationals.

According to media reports, the three have been isolated in Durg and placed under a 21-day quarantine as a precaution.

Chhattisgarh Health Minister Shyam Bihari Jaiswal announced that the state is fully prepared to handle any potential Ebola virus infection, stressing that hospitals and quarantine facilities have been put on alert and necessary arrangements are in place to ensure public safety.

Speaking to reporters, Jaiswal said the three individuals under observation were nationals from African countries and were being monitored in line with health protocols.

He added that no Ebola infection had been confirmed so far and that none of the individuals were showing symptoms of the disease.

"We have been fully prepared across the state at every level for a month now. The three individuals placed in isolation in Durg are nationals from African countries and have been quarantined for 21 days as a precautionary measure. So far, tests have not confirmed the presence of the virus, nor are they exhibiting any symptoms," he said.

Two Suspected Cases In Hyderabad

Earlier, two people in Hyderabad who returned from Sudan were isolated.

A Sudanese national, a student in his 20s, with a fever, was admitted to the state-run Gandhi Hospital. The student's condition improved, and he had no fever on Friday morning. His attendant was advised to stay in isolation at home, according to media reports.

Also read: WHO Says Ebola Fight Is Catching Up; Expert Explains Science Behind Patient Recoveries

Another Sudanese national, who arrived at Rajiv Gandhi International Airport a day earlier, was also shifted to the isolation ward of Gandhi Hospital for further tests after he was found to have a fever during thermal screening at the airport. The 35-year-old, who had come to Hyderabad for knee surgery, had no fever as of Friday morning and was asymptomatic, officials said.

Samples containing oral and nasal swabs have been collected and will be sent to the Centre for Cellular and Molecular Biology (CCMB) for testing. Though two patients have now tested negative.

Rajasthan Woman Isolated

Meanwhile, Rajasthan has also isolated one woman who returned from Uganda following symptoms.

During routine health screening at the airport, she exhibited symptoms associated with Ebola infection. The health department was immediately informed, and she was placed under special observation.

While she has displayed symptoms similar to Ebola infection, confirmation can only be made after laboratory testing. The results are awaited.

No Ebola Case Reported In India

Read More: Bundibugyo Ebola Outbreak: WHO Identifies Experimental Treatments, Vaccines

All suspected cases have been linked to travel to Ebola-affected countries such as Uganda, the Democratic Republic of Congo, and Sudan.

"No Ebola disease cases have been reported in India," the Health Ministry said in its latest update on June 3. The Health Ministry has also advised travelers arriving from Ebola-affected countries, including Uganda and the Democratic Republic of Congo, to remain alert for symptoms and seek medical guidance if they feel unwell.

"For information, guidance, and assistance, call MoHFW's 24x7 Health Helpline: 1075," the ministry said on X.

Ebola: A Global Health Emergency

On May 17, the World Health Organization classified the Ebola outbreaks in Uganda and the Democratic Republic of Congo as a Public Health Emergency of International Concern (PHEIC).

A total of 452 Ebola cases have been confirmed in the Democratic Republic of Congo, including 82 deaths. Uganda has reported 16 confirmed cases.

Meanwhile, the number of suspected cases has fallen from more than 1,000 last week to 116 as health teams work through the backlog. Six people in the DRC and two in Uganda have recovered to date.

After previously warning that Ebola was "outpacing us," WHO Director-General Tedros Adhanom Ghebreyesus said on Thursday that "we are catching up" as efforts to contain the outbreak in the Democratic Republic of Congo show progress.

A total of 452 Ebola cases have been confirmed in the Democratic Republic of Congo, including 82 deaths. Uganda has reported 16 confirmed cases. Meanwhile, the number of suspected cases has fallen from more than 1,000 last week to 116 as health teams work through the backlog.

WHO Sees Signs of Progress

“What I saw gave me hope,” Ghebreyesus said at a press conference.

“The outbreak had a big head start, and we're still behind, but under the leadership of the Government of DRC, we are catching up,” he added.

Importantly, he noted that six people in the DRC and two in Uganda have recovered to date, “showing that people can survive Ebola if they have access to care and go to health facilities as soon as they show symptoms.”

Why Are Patients Recovering?

The latest outbreak is caused by the Bundibugyo strain of the Ebola virus, for which there is currently neither a vaccine nor an antiviral treatment. So how are patients recovering?

Dr. Rajeev Jayadevan, Co-Chairman of the National IMA COVID Task Force and Past President of the Indian Medical Association, Cochin, told HealthandMe that a combination of factors—including the virus strain, access to medical care, and individual immune responses—can significantly influence whether a patient survives the disease.

Ebola virus disease is a severe illness caused by different strains of the Ebola virus. The current outbreak is linked to the Bundibugyo strain, which has a lower mortality rate than the more lethal Zaire strain responsible for several previous outbreaks, he said.

“The mortality of Ebola virus disease is tied to several components,” Dr. Rajeev explained.

Early Medical Care Improves Survival

One of the most important factors is access to early medical attention and supportive care. Patients who receive prompt treatment at well-equipped healthcare facilities staffed by experienced healthcare workers have a much greater chance of survival.

However, such healthcare access is often limited in outbreak-affected regions of Africa due to ongoing conflicts and socioeconomic challenges.

“The chance of survival is much higher if a person receives good medical attention and early supportive care,” he said.

Bundibugyo Strain vs Zaire Strain

Also read: Ebola Bundibugyo Strain: All You Should Know About The Rare Virus

The strain of the virus also plays a critical role. Dr. Rajeev said that because the Bundibugyo strain is less lethal than the Zaire strain, more infected individuals are expected to survive under similar conditions.

“If a hundred people get infected with the Zaire strain and another hundred with the Bundibugyo strain, more people in the Bundibugyo group will survive, all other conditions remaining the same,” he said.

Difference In Immune Response

Another important factor is the body's immune response, which varies from person to person. Dr. Rajeev highlighted the role of human leukocyte antigens (HLA), proteins that help the immune system recognize and respond to invading pathogens. Because each individual's HLA profile is unique, people infected with the same virus can generate different immune responses.

“HLA works closely with the immune system by presenting pieces of the virus to immune cells, helping the body build a targeted response,” he said.

Also read: Ebola Alert In India: Rajasthan, Hyderabad Report Suspected Cases of Deadly Virus

This biological diversity is one reason why the same infection can affect individuals differently. It is also considered an evolutionary safeguard that helps prevent a single pathogen from devastating the entire human population.

The Role of Probability

Dr. Rajeev also pointed to a simple statistical reality. “If the mortality rate in the current outbreak is around 30 per cent, that means about 70 per cent of infected individuals are expected to survive,” he said.

According to the expert, survival often results from a combination of favorable factors, including infection with a less lethal strain, timely medical care, a strong immune response, and the overall probability of recovery within a given outbreak.