Japan could become one of the first countries in the world to end the HIV epidemic, says the president of Gilead Sciences Japan, Kennet Brysting. The idea for now could seem a little too ambitious, but it is not entirely unrealistic, given that the availability of medicines that can prevent transmission of HIV. Drugs are not the cure, but control over the spread of virus to the point where the disease is no longer a major public health threat.

What Is The Role Of Preventative HIV Medicines?

Gilead's have two key drugs, Truvada and lenacapavir. These two are playing a crucial role in prevention. Truvada is taken as a daily pill, while lenacapavir requires two injections per year. It can make the virus undetectable in infected individuals and prevent transmission to those who are not infected yet. In trials, lenacapavir showed 100% efficacy in preventing HIV infections. This is why it is describe as "almost a vaccine".

In 2024, Japan also approved Truvada for HIV prevention, but the country has yet to approve lenacapavir for the same. Until now, people in Japan had been importing generic versions of Truvada or purchasing it from clinics that source it from overseas.

HIV In Japan

Up until now, Japan reported around 25,000 HIV infections, whereas 669 new cases were reported in 2023. For seven consecutive years, the number of new infections remained under 1,000. The downward trend thus shows that the virus has been controlled, however, getting to zero new infections remains the ultimate goal.

Brysting too acknowledged that simply having effective drug is not enough. What is important is to have a proper implementation, access and healthcare support to make sure that these treatments are widely available and effective.

What Are The Challenges In Implementation?

The biggest challenges is testing rates. There is a need to increase testing rates. At this very moment, around 86% people infective with Japan have been tested, but the goal is to increase it up to 95%, with an ideal goal of 100%. Without widespread testing, many infected people may not even know that they are infected and it could transmit the virus.

Another measure issue is the cost of preventative medication. While Japan's health insurance covers treatments for diseases, it does not cover preventative drugs. Those who purchase Truvada for prevention, pay around $470 per month. Some clinics in Tokyo offer generic alternatives too, which is cheaper, but they are not ideal.

Better Healthcare Support

Brysting expressed concern that individuals importing medications might not be consulting doctors regularly, which is essential for monitoring HIV status and overall health. Truvada users need to be tested for HIV initially and every three months, along with screenings for other infections and kidney function checks. Without proper medical supervision, there is a risk of misuse and inadequate protection.

Gilead is in discussions with Japanese authorities to improve access and insurance coverage for Truvada, and progress is being made. Japan has shown efficiency in approving critical medicines, as seen during the COVID-19 pandemic when Gilead’s remdesivir was approved in just three days.

What Is The Way Ahead?

Gilead at this moment is not only focused on HIV and hepatitis C, but also expanding into oncology with innovative treatments like CAR-T cell therapy, which strengthens a patient's immune system to fight cancer.

However, Japan’s strict approval processes can slow down drug availability. Phase 3 clinical trials often need to be conducted within the country, and Japan tends to approve medicines much later than other regions. For instance, Truvada was approved for prevention in Japan 12 years after the U.S. and nearly 20 years after its approval for treatment. inancial factors also play a role. The Japanese government adjusts drug prices annually, often reducing them, which can make long-term investment challenging for pharmaceutical companies.

A patient has received a pioneering stem cell treatment for Parkinson's disease in Japan, marking a world first following the therapy's conditional approval in the country.

Developed by Japanese drugmaker Sumitomo Pharma in collaboration with Dr Jun Takahashi at Kyoto University, the therapy, Amchepry (also known as raguneprocel), is the world's first induced pluripotent stem cell (iPSC)-based treatment for Parkinson's disease. It received conditional approval in March 2026 following successful clinical trial results.

The first transplant was performed at Kyoto University Hospital in October, the company said on Friday in an earnings press release, without providing further details, AFP reported.

How Does the Parkinson's Stem Cell Treatment Work?

Also read: Parkinson’s at 40: Why Younger Adults Are Being Diagnosed Earlier Than Before

The treatment uses iPSCs obtained from healthy donors, which are developed into precursors of dopamine-producing neurons and transplanted into the brain to replace cells lost due to Parkinson's disease.

iPSCs are created by reprogramming mature, specialised cells to return to an earlier state, allowing them to develop into different cell types.

Stem cell therapy, also known as regenerative medicine, uses stem cells or their derivatives to repair or replace damaged tissues.

What Did the Clinical Trial Find?

During the clinical trial, seven patients aged between 50 and 69 received implants of either five million or 10 million cells on both sides of the brain.

The patients were monitored for two years. Researchers found no major adverse effects, while four participants showed improvements in their symptoms, AFP reported.

Sumitomo Pharma said it plans to perform transplants in 20 to 30 patients by March 2029. The company is also conducting a clinical trial of the treatment in the United States.

The therapy will receive full approval in Japan if its safety and effectiveness are confirmed over the next seven years, according to local media reports.

Read More: Parkinson’s Disease: Women Have More Motor Complications, Depression

Japan Also Approves Stem Cell Therapy for Heart Failure

The announcement comes a month after a hospital in Osaka performed the world's first surgery using sheets of heart muscle cells derived from iPSCs.

The sheets are designed to promote new blood vessel formation and help restore heart function. The treatment also received conditional approval in Japan in March.

Conditional approval allows these therapies to be used clinically while additional data on their safety and effectiveness are collected.

What Is Parkinson's Disease?

Parkinson's disease is a progressive neurodegenerative disorder caused by the loss of dopamine-producing brain cells. It primarily affects people over the age of 60 and is estimated to affect more than 10 million people worldwide, according to the Parkinson's Foundation.

Dopamine plays an important role in controlling movement. Its loss can cause symptoms such as:

• Tremors, often beginning in one hand, foot or the jaw.
• Muscle stiffness and slowed movement.
• Difficulty maintaining balance, increasing the risk of falls.
• Changes in speech, including softer or slurred speech.
• Difficulty swallowing.

The disease can also cause cognitive decline, depression and anxiety. Currently available treatments help manage symptoms but do not stop or reverse disease progression, according to the Parkinson's Foundation.

For the first time in nearly three decades, the US Food and Drug Administration (FDA) is proposing changes to nutrient requirements for infant formula. The proposed changes cover vitamins A and D, iodine and manganese under the Trump administration's Operation Stork Speed initiative, announced in March 2025.

The FDA’s first phase of a three-phase review covers eight of the 30 nutrients required in infant formula. It proposes revising requirements for four nutrients and reaffirming existing limits for the other four. It is also seeking public input on nutrients commonly added by manufacturers but not currently required. The agency is accepting comments for 120 days.

“Parents deserve confidence in every bottle they feed their baby,” US Health and Human Services Secretary Robert F. Kennedy Jr. said in a statement.

What Are The Proposed Changes?

Also read: Major FDA Study Confirms Baby Formula In US Safe, Testing to Continue

The FDA's first phase covers eight nutrients. It proposes changes to four and retaining existing limits for the other four.

1. Iodine

• Minimum: Increased from 5 to 15 µg/100 kcal.
• Maximum: Reduced from 75 to 50 µg/100 kcal.

2. Manganese

• Minimum: Reduced from 5 to 1 µg/100 kcal.
• Maximum: A new limit of 50 µg/100 kcal.

3. Vitamin A

• Measurement unit changed from IU to micrograms of retinol activity equivalents (µg RAE).
• Minimum: Reduced from 250 IU (75 µg RAE) to 70 µg RAE/100 kcal.
• Maximum: Reduced from 750 IU (225 µg RAE) to 120 µg RAE/100 kcal.
• Only preformed vitamin A, not beta-carotene, will count towards the limits.

4. Vitamin D

• Measurement unit changed from IU to micrograms (µg).
• Minimum: Increased from 40 IU (1 µg) to 2 µg (80 IU)/100 kcal.
• Maximum: Increased from 100 IU (2.5 µg) to 3 µg (120 IU)/100 kcal.

The FDA also proposes updating formula labelling requirements to reflect the changes.

Which Nutrient Limits Will Remain Unchanged?

Read More: New International Food Pyramid Highlights Plant Foods, Counters Trump’s Meat-Heavy Diet Advice

The FDA proposes retaining existing levels for:

• Chloride: 55–150 mg/100 kcal.
• Potassium: 80–200 mg/100 kcal.
• Selenium: 2–7 µg/100 kcal.
• Sodium: 20–60 mg/100 kcal.

What Do Parents Need To Know?

The FDA says formulas currently sold in the US remain safe for babies. The proposed changes are not prompted by safety concerns but aim to align standards with current scientific evidence.

Parents do not need to change the formula they currently use.

When Will The Changes Take Effect?

The FDA is reviewing all 30 nutrients in three phases. The first covers eight, with the remaining 22 to follow.

The final rule will take effect 60 days after publication in the Federal Register. Manufacturers will have three years from that date to reformulate and relabel their products.

This means the proposed changes will not appear on formula packaging immediately.

Dr Steven Abrams, a paediatrician and professor at the University of Texas' Dell Medical School, called the update overdue. He described the first phase as “really well done” and “very well thought-out”, CNN reported.

However, he said the phased approach means manufacturers could take several years to implement the changes.

“These changes that they're recommending today are not going to be something that'll show up on the can of formula potentially for several years,” Abrams said.

He identified the proposed vitamin D increase as the most consequential change in this phase.

Meanwhile, the FDA is also seeking input on making commonly added nutrients such as DHA, ARA and L-carnitine mandatory. These are not currently required in infant formula.

The Ebola outbreak in the Democratic Republic of Congo (DRC), officially declared a Public Health Emergency in May 2026, has surpassed 10,000 cases and is approaching 5,000 deaths, making it the fastest-growing Ebola outbreak in history.

Driven by the Bundibugyo Ebola virus, the outbreak has spread beyond the DRC to Uganda, Kenya and Nigeria, raising concerns about cross-border transmission. There is currently no licensed vaccine against this strain, although candidates are in development.

More than 1,000 children have died, accounting for over one-quarter of recorded fatalities, according to Save the Children.

“It's extraordinarily serious. Over 1,000 children have died of Ebola,” Greg Ramm, Save the Children's Country Director in the DRC, told the media.

“The world needs to start paying attention. We will break 15,000 deaths by the new year. And just because Ebola isn’t going to become a pandemic doesn’t mean it is not a global health security threat as well as a humanitarian disaster,” Dr Angela Rasmussen, a virologist, warned in a post on X.

Africa CDC Warns of Wider Global Risk

Africa CDC Director-General Dr Jean Kaseya has warned that the outbreak's unprecedented geographical spread could put countries beyond Africa, including the UK, at risk.

“The geographic extension of this outbreak is unprecedented,” he said, noting that three African regions had been affected. Drawing parallels with COVID-19, he warned: “We don’t want to see the UK and other countries become the hotspot,” The Guardian reported.

In response, the UK Health Security Agency's (UKHSA) Dr Sam Collins stressed that the risk to the UK remains low and that the country “is well prepared to respond safely and effectively to the risk of imported cases arising here”.

Genetic Analysis Links Kenya, Nigeria Cases to Congo

Scientists have linked Ebola viruses detected in Kenya and Nigeria to those circulating in Beni, eastern DRC, raising questions about a possible shared transmission chain or an unidentified source, Bloomberg reported.

“Genomic sequencing shows that the Ebola virus from Nigeria’s recently reported only imported case is highly similar to that from Kenya’s first imported case, differing by only one mutation,” Muhammad Ali Pate, Nigeria's Coordinating Minister of Health and Social Welfare, said in a post on X.

How Was The Genetic Analysis Conducted?

Scientists from four countries, led by Congolese virologist Jean-Jacques Muyembe, analysed 1,126 viral genomes after an Ebola case was detected in Abuja, Nigeria.

The Beni samples share a distinctive genetic signature, including a mutation absent from other sequenced viruses from Congo.

The viruses also lack genetic markers associated with Uganda's documented Ebola transmission chains from May and June, suggesting they did not descend from those previously identified outbreaks.

Researchers have yet to establish where the patients contracted the virus or whether they were infected through the same transmission chain. Genetic sequencing alone cannot prove direct transmission.

Travel Histories Point To Possible Congo Uganda Connection

Investigators are examining the patients' movements through Uganda during their potential exposure periods.

The Nigerian patient was in Uganda from September 15 to October 3 and developed symptoms three days after returning to Abuja. The Kenyan patient travelled from Congo through Uganda between October 1 and 3 before flying to Nairobi from Entebbe.

Both patients reportedly travelled on flights on October 3. Authorities are checking their travel records for possible overlap and tracing potentially exposed passengers.

Nigeria, Kenya Step Up Ebola Response

Nigeria has traced 62 contacts of the infected woman, NCDC Director-General Jide Idris said. Of these, 50 are in isolation, five are being monitored at home and seven remain unlocated.

Uganda recorded 20 confirmed cases and two deaths before declaring the outbreak over in June.

Kenya has reported nine cases and two deaths. Seven patients, including three family members and four healthcare workers, are receiving treatment and responding well. Authorities have traced all 135 contacts linked to the first case, according to official data.