Japan could become one of the first countries in the world to end the HIV epidemic, says the president of Gilead Sciences Japan, Kennet Brysting. The idea for now could seem a little too ambitious, but it is not entirely unrealistic, given that the availability of medicines that can prevent transmission of HIV. Drugs are not the cure, but control over the spread of virus to the point where the disease is no longer a major public health threat.

What Is The Role Of Preventative HIV Medicines?

Gilead's have two key drugs, Truvada and lenacapavir. These two are playing a crucial role in prevention. Truvada is taken as a daily pill, while lenacapavir requires two injections per year. It can make the virus undetectable in infected individuals and prevent transmission to those who are not infected yet. In trials, lenacapavir showed 100% efficacy in preventing HIV infections. This is why it is describe as "almost a vaccine".

In 2024, Japan also approved Truvada for HIV prevention, but the country has yet to approve lenacapavir for the same. Until now, people in Japan had been importing generic versions of Truvada or purchasing it from clinics that source it from overseas.

HIV In Japan

Up until now, Japan reported around 25,000 HIV infections, whereas 669 new cases were reported in 2023. For seven consecutive years, the number of new infections remained under 1,000. The downward trend thus shows that the virus has been controlled, however, getting to zero new infections remains the ultimate goal.

Brysting too acknowledged that simply having effective drug is not enough. What is important is to have a proper implementation, access and healthcare support to make sure that these treatments are widely available and effective.

What Are The Challenges In Implementation?

The biggest challenges is testing rates. There is a need to increase testing rates. At this very moment, around 86% people infective with Japan have been tested, but the goal is to increase it up to 95%, with an ideal goal of 100%. Without widespread testing, many infected people may not even know that they are infected and it could transmit the virus.

Another measure issue is the cost of preventative medication. While Japan's health insurance covers treatments for diseases, it does not cover preventative drugs. Those who purchase Truvada for prevention, pay around $470 per month. Some clinics in Tokyo offer generic alternatives too, which is cheaper, but they are not ideal.

Better Healthcare Support

Brysting expressed concern that individuals importing medications might not be consulting doctors regularly, which is essential for monitoring HIV status and overall health. Truvada users need to be tested for HIV initially and every three months, along with screenings for other infections and kidney function checks. Without proper medical supervision, there is a risk of misuse and inadequate protection.

Gilead is in discussions with Japanese authorities to improve access and insurance coverage for Truvada, and progress is being made. Japan has shown efficiency in approving critical medicines, as seen during the COVID-19 pandemic when Gilead’s remdesivir was approved in just three days.

What Is The Way Ahead?

Gilead at this moment is not only focused on HIV and hepatitis C, but also expanding into oncology with innovative treatments like CAR-T cell therapy, which strengthens a patient's immune system to fight cancer.

However, Japan’s strict approval processes can slow down drug availability. Phase 3 clinical trials often need to be conducted within the country, and Japan tends to approve medicines much later than other regions. For instance, Truvada was approved for prevention in Japan 12 years after the U.S. and nearly 20 years after its approval for treatment. inancial factors also play a role. The Japanese government adjusts drug prices annually, often reducing them, which can make long-term investment challenging for pharmaceutical companies.

Amid raging wildfires, France is preparing for its fourth major heatwave of the year as extreme temperatures and bone-dry conditions in the southwest intensify the challenges faced by crews battling a massive wildfire in the Bordeaux region.

Temperatures in Bordeaux were expected to reach 33°C (91°F) during the day, around 7°C above the average high recorded between 1961 and 1990, according to the Reuters Climate Monitor.

"The situation we are dealing with today is the most severe we have ever recorded, the toughest since the Second World War," said President Emmanuel Macron.

Firefighters managed to contain the blaze overnight, but the situation remained difficult, with reports suggesting the wildfire threat could continue until November.

France is experiencing an unprecedented wildfire season, with the area affected by fires already surpassing the previous record set in 2022. Around 4000 more people were evacuated from tourist sites along the Atlantic coast, following the evacuation of more than 250,000 people earlier.

UK Faces Fourth Heatwave As Temperatures Rise

Also read: Europe Swelters Under Heatwave And Wildfires; 360,000+ Evacuated: What Are The Health Risks?

Meanwhile, the UK is also preparing for its fourth heatwave of the summer, with temperatures expected to climb to 34°C in parts of the country later this week.

Several amber and yellow heat alerts have been issued as the UK Health Security Agency (UKHSA) warned that rising temperatures could increase health risks, particularly for vulnerable groups.

Temperatures are forecast to reach 29°C in southeast England on Tuesday before rising further to 34°C on Wednesday.

Dry Conditions Raise Wildfire And Drought Concerns

Read More: Could Wildfire Smoke Trigger Your Migraine? Latest Study Finds A Strong Link

The heatwave follows an exceptionally hot and dry June, which has left some of the UK’s driest regions without rainfall for weeks. Forecasters have warned that parts of southern and southeast England could face “exceptionally severe” wildfire conditions this week due to extreme heat and prolonged dry weather.

Parts of Wales have already been placed under drought status, while large areas of England remain under “prolonged dry weather” status — the final stage before a drought declaration.

What Happens When Medicines Get Too Hot?

According to the Medicines and Healthcare products Regulatory Agency (MHRA), high temperatures can affect medicines and reduce how well they work.

Rising temperatures can affect how some medicines work in the body, posing potential risks for people with long-term health conditions. Experts say simple precautions can help prevent heat-related complications.

Medicines that do not require refrigeration, including tablets, inhalers, hormone replacement therapy (HRT) patches, and epinephrine, should generally be stored in a cool, dry place at room temperature, ideally between 15°C and 25°C. This is because high temperatures can reduce the potency and effectiveness of the active ingredients in medicines.

Alison Cave, Chief Safety Officer at the MHRA, said that when there’s a heatwave, medicines left in the heat – in cars, bags, or on sunny windowsills – might not work properly when you need them.

“Some medicines can also make you more likely to burn in the sun, feel dizzy, or get dehydrated, especially if you’re taking diuretics or have a condition like asthma, heart disease, or diabetes.”

To stay safe during hot weather, the MHRA advised people to:

• Store medicines in a cool, dry place away from direct sunlight, especially when travelling or spending time outdoors.
• Stay hydrated, recognise signs of heat-related illness, and listen to your body.
• Take extra precautions in the sun if medicines increase sensitivity to sunlight and raise the risk of burns.

Stroke is among the leading causes of disability worldwide, and many survivors are left struggling with speech difficulties. After a stroke, some people lose the ability to speak fluently despite being able to understand language and, remarkably, sing familiar songs they have known for years.

This connection between music and speech recovery forms the basis of Melodic Intonation Therapy (MIT), an evidence-based approach that uses melody, rhythm, and repetition to help patients regain communication abilities.

How Music Reconnects The Brain After Stroke

Music therapy works by activating brain networks that remain functional even when areas responsible for speech or movement are damaged.

Speaking to HealthandMe, Dr. Sudhir Kumar, Neurologist at Apollo Hospitals, Hyderabad, explained that rhythm helps retrain the brain’s motor circuits. In stroke patients with movement difficulties, rhythmic auditory stimulation — where movements are synchronised with a steady beat — can help improve walking patterns.

“Music therapy taps into brain networks that survive a stroke even when speech or movement pathways are damaged. Rhythm helps retrain the brain's motor circuits. Patients with gait difficulties often walk more fluidly when moving to a steady beat, a technique we call rhythmic auditory stimulation,” Dr. Sudhir said.

Dr. K. K. Jindal, Director – Neurology, CK Birla Hospital, Delhi, said that after a stroke, the brain can reorganize itself and form new neural connections through a process called neuroplasticity.

“Music, and in particular rhythm and melody, can cause several areas of the brain to be activated at once,” Dr. Jindal told HealthandMe.

He added that techniques like Melodic Intonation Therapy can support communication in patients with speech difficulties, while rhythmic auditory stimulation has helped improve gait, physical coordination, and balance during stroke recovery.

Dr Kumar said for patients with aphasia — a condition that affects speech and language after stroke — singing can engage the right hemisphere of the brain, allowing some patients to produce words through melody even when they are unable to speak normally.

Experts said that beyond neurological benefits, music may also help reduce anxiety and depression, which are common after stroke and can slow recovery.

“Music therapy is not a replacement for conventional rehabilitation, but a scientifically grounded complement to it,” Dr. Sudhir said.

Dr. Jindal also stated that while music therapy cannot substitute treatments such as physiotherapy or speech therapy, it can serve as an effective supportive measure during recovery.

IIT Delhi, AIIMS Develop First Hindi Version of Music Therapy

Building on this approach, researchers from IIT Delhi, in collaboration with AIIMS New Delhi and the Institute of Human Behaviour and Allied Sciences (IHBAS), have developed the first Hindi version of Melodic Intonation Therapy.

While MIT has traditionally been used in English, researchers adapted the therapy for Hindi by modifying words, melodies, and rhythmic patterns to match the language’s natural stress patterns and cadence.

The team developed exercises based on how Hindi speakers communicate in everyday life, making the therapy more culturally and linguistically relevant for Indian patients.

Pilot Study Shows Improvement

The pilot study, published in the international journal Aphasiology, was conducted between December 2023 and March 2024.

The study included six Hindi-speaking stroke survivors who underwent 40 therapy sessions each. Each session lasted 45 to 60 minutes and was conducted by trained speech therapists.

All participants completed the program and showed clinically meaningful improvements. Researchers reported improvements in sentence formation, speech fluency, and quality-of-life measures.

“Patients were able to string together longer sentences, spoke more freely, and reported gains in their quality of life. There were no adverse effects,” said Prof. Rahul Garg, one of the researchers leading the study.

Researchers cautioned that the findings are preliminary due to the small number of participants involved and said that further research is needed to confirm the results.

Industrial chicken farms may be fueling the spread of diarrhea-causing Campylobacter bacteria, according to a new study.

Researchers from the University of Oxford found that industrial poultry farming has driven more than a 100-fold increase in the spread of Campylobacter.

Published in the Proceedings of the National Academy of Sciences (PNAS), the study found that the expansion of commercial poultry production has enabled bacterial strains once largely confined to wild birds to mix extensively within farmed chicken populations.

"Industrial farming has created one of the largest animal habitats on the planet. Our findings provide new evidence that human-driven environmental change can increase the spread of infectious diseases," said Professor Sam Sheppard, senior author of the study from the University of Oxford.

"As chicken populations have grown, bacteria that were once largely confined to wild birds have gained far more opportunities to enter poultry flocks, spread and become established. Understanding these evolutionary consequences is essential if we are to reduce future risks from zoonotic disease and antimicrobial resistance," he added.

Poultry Farming Has Accelerated Bacterial Spread

Researchers analyzed nearly 2,800 Campylobacter genomes collected from chickens and wild birds across 30 countries, including the UK and the US, between 1979 and 2024.

The analysis showed that the rapid global expansion of chicken farming has created ideal conditions for the bacteria to spread, exchange genetic material, and acquire traits that improve survival in commercial poultry environments.

Since the 1960s, the global chicken population has increased sevenfold to around 31 billion birds, with chickens now accounting for about 70% of all bird biomass on Earth. While this growth has helped make animal protein more affordable, it has also created favorable conditions for bacterial adaptation and transmission, the researchers argued.

How Are the Bacteria Thriving?

The genomic analysis identified several genetic changes linked to adaptation in poultry, including genes associated with:

• Antimicrobial resistance
• Oxidative stress tolerance
• Metal acquisition
• Motility

According to the researchers, these traits may help Campylobacter survive and spread more efficiently in modern poultry production systems. The study also suggests that densely populated commercial chicken flocks may act as ecological "pathogen sponges," absorbing and amplifying bacterial strains from multiple sources.

Growing Concern Over Antimicrobial Resistance

The researchers warned that rising antimicrobial resistance (AMR)—when bacteria become resistant to drugs used to treat infections—is making Campylobacter infections increasingly difficult to treat.

They also cited an earlier University of Oxford study, which found that 80% of human Campylobacter infections in Oxfordshire were linked to poultry meat, with many of those infections resistant to antibiotics.

What Is Campylobacter?

Campylobacter is the world's leading bacterial cause of diarrhea. According to the World Health Organization (WHO), it is one of the four leading global causes of diarrheal disease. Nearly one in 10 people worldwide falls ill from foodborne diseases each year, resulting in the loss of an estimated 33 million healthy life years.

Although infections are usually mild, they can become severe or even fatal in very young children, older adults, and people with weakened immune systems.

Common Symptoms

• Diarrhea, which may be bloody
• Abdominal pain
• Fever
• Headache
• Nausea
• Vomiting

Symptoms typically last three to six days. Deaths are rare and generally occur in people with severe underlying health conditions or those at the extremes of age.

Campylobacter bacteria are destroyed by thorough cooking. The WHO recommends proper cooking, safe food handling, and good kitchen hygiene to reduce the risk of infection.