Japan could become one of the first countries in the world to end the HIV epidemic, says the president of Gilead Sciences Japan, Kennet Brysting. The idea for now could seem a little too ambitious, but it is not entirely unrealistic, given that the availability of medicines that can prevent transmission of HIV. Drugs are not the cure, but control over the spread of virus to the point where the disease is no longer a major public health threat.

What Is The Role Of Preventative HIV Medicines?

Gilead's have two key drugs, Truvada and lenacapavir. These two are playing a crucial role in prevention. Truvada is taken as a daily pill, while lenacapavir requires two injections per year. It can make the virus undetectable in infected individuals and prevent transmission to those who are not infected yet. In trials, lenacapavir showed 100% efficacy in preventing HIV infections. This is why it is describe as "almost a vaccine".

In 2024, Japan also approved Truvada for HIV prevention, but the country has yet to approve lenacapavir for the same. Until now, people in Japan had been importing generic versions of Truvada or purchasing it from clinics that source it from overseas.

HIV In Japan

Up until now, Japan reported around 25,000 HIV infections, whereas 669 new cases were reported in 2023. For seven consecutive years, the number of new infections remained under 1,000. The downward trend thus shows that the virus has been controlled, however, getting to zero new infections remains the ultimate goal.

Brysting too acknowledged that simply having effective drug is not enough. What is important is to have a proper implementation, access and healthcare support to make sure that these treatments are widely available and effective.

What Are The Challenges In Implementation?

The biggest challenges is testing rates. There is a need to increase testing rates. At this very moment, around 86% people infective with Japan have been tested, but the goal is to increase it up to 95%, with an ideal goal of 100%. Without widespread testing, many infected people may not even know that they are infected and it could transmit the virus.

Another measure issue is the cost of preventative medication. While Japan's health insurance covers treatments for diseases, it does not cover preventative drugs. Those who purchase Truvada for prevention, pay around $470 per month. Some clinics in Tokyo offer generic alternatives too, which is cheaper, but they are not ideal.

Better Healthcare Support

Brysting expressed concern that individuals importing medications might not be consulting doctors regularly, which is essential for monitoring HIV status and overall health. Truvada users need to be tested for HIV initially and every three months, along with screenings for other infections and kidney function checks. Without proper medical supervision, there is a risk of misuse and inadequate protection.

Gilead is in discussions with Japanese authorities to improve access and insurance coverage for Truvada, and progress is being made. Japan has shown efficiency in approving critical medicines, as seen during the COVID-19 pandemic when Gilead’s remdesivir was approved in just three days.

What Is The Way Ahead?

Gilead at this moment is not only focused on HIV and hepatitis C, but also expanding into oncology with innovative treatments like CAR-T cell therapy, which strengthens a patient's immune system to fight cancer.

However, Japan’s strict approval processes can slow down drug availability. Phase 3 clinical trials often need to be conducted within the country, and Japan tends to approve medicines much later than other regions. For instance, Truvada was approved for prevention in Japan 12 years after the U.S. and nearly 20 years after its approval for treatment. inancial factors also play a role. The Japanese government adjusts drug prices annually, often reducing them, which can make long-term investment challenging for pharmaceutical companies.

Flu activity is increasing all thanks to the holiday season. The Centers for Disease Control and Prevention (CDC) data shows that due to a surge in holiday travel and gathering, the flu cases have gone up. The CDC estimates that there have been at least 4.6 million illnesses, 49,000 hospitalizations and 1,900 deaths from flu this season so far.

Public health experts have also revealed that many of this season's cases are linked with the new flu strain, called the subclade K. This is a variant of the H3N2 virus, which is a subtype of influenza A.

According to the CDC, 89% of the 163 H3N2 virus samples collected and genetically analyzed since September 28 belonged to subclade K.

So far this season, three pediatric flu deaths have been reported, based on an ABC News tally. Last season, 288 children died from the flu in the U.S., matching the toll seen during the 2009 H1N1 pandemic. A CDC study published earlier this year found that about 90% of those children were unvaccinated.

Read: New Aggressive Flu Strain Is Now A Health Threat In US

Will The Old Flu Vaccine Protect You Against The New Subclade K?

The real reason why concerns are prompted about the effectiveness of the seasonal vaccine is because the virus underwent more mutation than scientists expected over summers. This mutant is called the 'subclade K' or 'super flu'. While it is true that most cases this season are of the 'super flu' strain, experts say that the flu jab is still offering a strong protection.

"The vaccine remains the most effective means to prevent disease. We still want to encourage people to get the vaccine," said Professor Antonia Ho, Professor and Honorary Consultant in Infectious Diseases at the University of Glasgow. Experts have stressed enough on the immunity that one can receive from the vaccine that that these flu jab remain the best defense against the flu, even though the current strain circulated may have drifted away from the strain included in this year's jab.

Data from the UK Health Security Agency (UKHSA) also show that vaccines is performing as expect, despite the emergence of subclade K.

Every year, experts from the World Health Organization, the Centers for Disease Control and Prevention, and other global health agencies closely track flu trends around the world. They study which strains are spreading and use that data to predict which ones are most likely to dominate the upcoming flu season. The annual flu vaccine is then designed to protect against three or four of those strains.

It’s also worth understanding that more than one influenza A strain usually circulates at the same time. So even if the vaccine is not an exact match for a newer H3N2 strain, it still protects against other common flu viruses, which matters, notes Stony Brook Medicine.

When a new variant emerges, the flu shot can still offer what doctors call cross-protection. In simple terms, the antibodies your body makes after vaccination can recognize similar flu viruses and respond to them. You might still get sick, but the vaccine greatly lowers the chances of severe illness, hospitalization, or worse.

The vaccine offers protection against both types of influenza, including A and B.

Claire Brosseau, 48, an actress, who lives in Toronto was hopeful when a new change to Canadian law allowed people who were living with incurable medical condition, but not near death to ask a doctor to end their lives. This happened in 2021. This gave her relief. But now, almost five years later, she is still alive, mostly surrounded with headlines and debates on who in Canada has the right to avail medically assisted death.

She suffers from a debilitating mental illness, which has no treatment. The sadness has succumbed her that sometimes she has tried to eat peanuts to trigger her severe allergy, in a hope that she would die. Other times she has overdosed on drugs or cut her wrists. A New York Times report notes that her sadness is so severe that sometimes she sobs until her bones ache.

What Happened To Claire Brosseau?

When she was just a 14-years-old honors student in Montreal, who enjoyed her life as wildly as any student of her own age would, she sometimes would turn rather cruel. Her parents took her to a psychotherapist who diagnosed her with manic depression. It came with diagnoses like eating disorder, anxiety disorder, personality disorder, substance abuse disorder, chronic suicidal ideation, and many more mental health issues.

It is not that she has not tried to get better. She has tried at least 25 medications, two dozen different talk, art behavioral therapies, even electroconvulsive therapy and guided psychedelics. She did feel better for sometime, only to return to the feeling of monsters stalking her when she is awake and in her dreams.

Read: Can Right To Die Be Practiced By Non-Terminally Ill Patients?

A shift in Canadian law briefly offered her another option. In 2019, three years after assisted death was legalized for people whose natural death was reasonably foreseeable, two people with chronic conditions challenged the law. They argued that excluding those suffering unbearably from incurable illnesses, simply because they were not dying, violated their right to equality. The courts agreed, and in 2021 the law was expanded to include people who were not at the end of life.

One group, however, remained excluded: people whose sole underlying condition was mental illness. The government said it needed time to draft special safeguards. Of the nine countries that allow assisted death for people not nearing death, only Canada made this distinction. The exclusion was set to end on March 17, 2023, and Ms. Brosseau planned to apply that day. But the deadline was delayed again, and then postponed once more the following year.

Childhood filled With Trauma

In hindsight, her family believes her illness began in early childhood. As a young girl, she cycled through rage and despair, sometimes sitting on train tracks, convinced everyone would be better off without her. At eight, she wrote in her diary that she wanted to die.

At home, her behavior created constant tension. Her older sister, Melissa Morris, recalls being perpetually anxious around her. At just 12, Ms. Morris used money from her first job to install a lock on her bedroom door to shield herself from the chaos.

Also Read: Australia Social Media Ban Explained: Why Government Plans to Restrict Accounts of Under-16s

At school, Ms. Brosseau appeared to flourish. She was popular, academically strong, and deeply involved in theater, even as she skipped classes and experimented with drugs. She was recruited into elite programs, studied theater in New York, and began acting professionally. But she struggled with eating disorders, periods of deep depression, and substance use.

In her early twenties, she returned to Montreal and experienced a severe manic depressive episode that led to months of hospitalization. She recovered enough to restart her career, performing comedy in two languages, acting in commercials, writing, and earning well. Manic episodes, however, continued, sometimes requiring friends to send her home for treatment. At 34, she underwent electroconvulsive therapy and returned to work soon after.

By 2021, she believed she was in remission. Then, during a downturn, her mother called police out of fear she might harm herself. Ms. Brosseau was involuntarily hospitalized, restrained twice despite no recorded threats, and left deeply traumatized. Complaints against the hospital were dismissed. For her, that decision marked the end of trust in the mental health system and any remaining desire to try to get better.

Amber cold health alerts have been announced for parts of northern England after forecasts warned that falling temperatures could lead to more deaths, particularly among older and vulnerable people. The UK Health Security Agency has issued two amber-level alerts for north-east and north-west England, which will be in effect from 8pm on Sunday until midday on Monday 5 January.

UK Under Amber Cold Health Alert: Elderly And Vulnerable People At Highest Risk

The agency said the expected cold spell is likely to increase pressure on healthcare services, with more vulnerable people needing medical attention. Officials warned this could lead to a rise in deaths, especially among those aged 65 and above and people with existing conditions such as heart disease, respiratory illnesses, and other long-term health problems.

UK Under Amber Cold Health Alert: UKHSA Gives Alert

UK Under Amber Cold Health Alert: Concerns Over Indoor Temperatures

The agency warned that indoor temperatures in buildings such as hospitals, care homes, and clinics are expected to drop. Maintaining the recommended indoor temperature of 18C may be difficult, increasing health risks for patients and residents. While all other regions in England will be under a lower-level yellow alert, officials said there is still potential for added pressure on health services. Staffing shortages linked to travel disruption were also flagged, along with possible impacts on essential services such as transport and energy.

How Does Cold Weather Affect People In The UK

Cold weather in the UK can worsen existing health problems and create new risks, particularly during prolonged spells of low temperatures. It places extra strain on the heart and lungs, increases the likelihood of infections, and can make daily life harder for people who struggle to keep warm. Those living in poorly insulated homes or facing high heating costs are often hit the hardest.

The Met Office said much of England will remain cloudy overnight, with patches of frost and fog likely to develop. These conditions could lead to difficult and potentially hazardous travel on Monday morning.

Sub-zero Temperatures Forecast In Parts Of The UK

Overnight temperatures are expected to fall to around minus 1C in Penrith and hover close to freezing in parts of the Lake District where the amber alert is in place. In northern areas of Scotland, temperatures are forecast to drop further, reaching between minus 6C and minus 7C, as per Sky News.

A brisk northerly breeze is also expected along the north-east coast of England, making conditions feel colder and more uncomfortable. Dr Agostinho Sousa, head of extreme events and health protection at UKHSA, as per Sky News, urged people to look out for friends, family, and neighbours as the cold weather sets in.

“The temperatures we are expecting can have a serious impact on health,” he said. “They increase the risk of heart attacks, strokes, and chest infections, particularly among people over 65 and those with existing health conditions.”