Japan could become one of the first countries in the world to end the HIV epidemic, says the president of Gilead Sciences Japan, Kennet Brysting. The idea for now could seem a little too ambitious, but it is not entirely unrealistic, given that the availability of medicines that can prevent transmission of HIV. Drugs are not the cure, but control over the spread of virus to the point where the disease is no longer a major public health threat.

What Is The Role Of Preventative HIV Medicines?

Gilead's have two key drugs, Truvada and lenacapavir. These two are playing a crucial role in prevention. Truvada is taken as a daily pill, while lenacapavir requires two injections per year. It can make the virus undetectable in infected individuals and prevent transmission to those who are not infected yet. In trials, lenacapavir showed 100% efficacy in preventing HIV infections. This is why it is describe as "almost a vaccine".

In 2024, Japan also approved Truvada for HIV prevention, but the country has yet to approve lenacapavir for the same. Until now, people in Japan had been importing generic versions of Truvada or purchasing it from clinics that source it from overseas.

HIV In Japan

Up until now, Japan reported around 25,000 HIV infections, whereas 669 new cases were reported in 2023. For seven consecutive years, the number of new infections remained under 1,000. The downward trend thus shows that the virus has been controlled, however, getting to zero new infections remains the ultimate goal.

Brysting too acknowledged that simply having effective drug is not enough. What is important is to have a proper implementation, access and healthcare support to make sure that these treatments are widely available and effective.

What Are The Challenges In Implementation?

The biggest challenges is testing rates. There is a need to increase testing rates. At this very moment, around 86% people infective with Japan have been tested, but the goal is to increase it up to 95%, with an ideal goal of 100%. Without widespread testing, many infected people may not even know that they are infected and it could transmit the virus.

Another measure issue is the cost of preventative medication. While Japan's health insurance covers treatments for diseases, it does not cover preventative drugs. Those who purchase Truvada for prevention, pay around $470 per month. Some clinics in Tokyo offer generic alternatives too, which is cheaper, but they are not ideal.

Better Healthcare Support

Brysting expressed concern that individuals importing medications might not be consulting doctors regularly, which is essential for monitoring HIV status and overall health. Truvada users need to be tested for HIV initially and every three months, along with screenings for other infections and kidney function checks. Without proper medical supervision, there is a risk of misuse and inadequate protection.

Gilead is in discussions with Japanese authorities to improve access and insurance coverage for Truvada, and progress is being made. Japan has shown efficiency in approving critical medicines, as seen during the COVID-19 pandemic when Gilead’s remdesivir was approved in just three days.

What Is The Way Ahead?

Gilead at this moment is not only focused on HIV and hepatitis C, but also expanding into oncology with innovative treatments like CAR-T cell therapy, which strengthens a patient's immune system to fight cancer.

However, Japan’s strict approval processes can slow down drug availability. Phase 3 clinical trials often need to be conducted within the country, and Japan tends to approve medicines much later than other regions. For instance, Truvada was approved for prevention in Japan 12 years after the U.S. and nearly 20 years after its approval for treatment. inancial factors also play a role. The Japanese government adjusts drug prices annually, often reducing them, which can make long-term investment challenging for pharmaceutical companies.

A new study suggests that rising temperatures, floods and droughts could affect the predictability and frequency of waterborne disease outbreaks. Climate change can alter the traditional patterns of disease transmission in ways that are more complex than previously understood.

Researchers state that public health systems can no longer rely on existing weather-disease relationships, as global warming has significantly changed the environmental conditions and their influence how pathogens survive, spread and infect people.

Effect Of Climate Change On Waterborne Diseases

The review says that increasing temperatures, extreme rainfall, prolonged droughts and flooding do not simply increase disease risk. Instead, they can alter the timing, intensity and location of outbreaks, making them less predictable.

"Climate change is resetting many of the environmental conditions that determine when and where waterborne diseases emerge," the researchers noted, emphasizing that disease surveillance systems must evolve to keep pace with these changing dynamics.

According to the researchers, several climate-related factors work together to increase the likelihood of contaminated water and disease transmission.

Also read: Cholera Outbreak In Sudan: 117 Dead, 838 Suspected Cases, Says WHO

Higher Temperatures

Warmer water allows bacteria, viruses and parasites to multiply more rapidly. Pathogens such as Vibrio cholerae, which causes cholera, thrive in warmer aquatic environments.

Heavy Rainfall And Floods

Extreme rainfall can overwhelm sewage systems and contaminate drinking water with human and animal waste. Floodwaters also spread pathogens into rivers, lakes and groundwater supplies.

Drought

Although drought reduces water availability, it can also increase disease risk. Limited water supplies often become more concentrated with pathogens, while communities may be forced to use unsafe water sources.

Poor Sanitation After Climate Disasters

Storms, cyclones and floods frequently damage sanitation infrastructure, creating conditions where waterborne infections can spread rapidly.

These factors interact in different ways depending on geography, infrastructure and local climate, making future outbreaks increasingly difficult to forecast.

Also read: How To Spot Leptospirosis, Dengue, Malaria During Monsoons? Early Symptoms Not To Neglect

What Diseases Are Likely To Be Affected By Climate Change?

Researchers say climate-sensitive waterborne illnesses include:

• Cholera
• Acute diarrheal diseases
• Typhoid fever
• Hepatitis A
• Gastroenteritis
• Other bacterial and parasitic infections spread through contaminated water

Children, older adults and people living in regions with limited access to safe drinking water and sanitation are expected to face the greatest risks.

What Do Experts Recommend?

The researchers stress that instead of reacting to outbreaks the governments should strengthen climate-friendly public health systems. The key recommendations include:

• Expanding water quality monitoring
• Improving disease surveillance
• Investing in resilient water and sanitation infrastructure
• Developing climate-informed early warning systems
• Strengthening emergency preparedness for floods and droughts

Researchers say that understanding the evolving relationship between climate and infectious diseases will be essential to protecting communities across the world as global temperatures continue to rise.

Climate change is increasingly being recognized as a major public health threat, extending beyond heatwaves and air pollution to affecting patterns of infectious diseases.

The new review suggests that future waterborne disease outbreaks may not simply become more frequent but also less predictable, requiring health systems to adapt quickly to a changing climate.

As extreme weather events become more common worldwide, researchers warn that protecting safe water supplies and strengthening surveillance will be critical to reducing the growing burden of waterborne diseases.

Nearly nine out of every 10 Indian adults have at least one abnormal blood lipid level, according to a recent nationwide study by ICMR-INDIAB.

The findings highlighted a massive looming public health crisis that could increase the risk of heart attacks, strokes and other cardiovascular diseases across the country in the near future.

India’s Silent Cholesterol Crisis

The findings, which were reported between July 17 and July 19, 2026, reveal that dyslipidemia, an unhealthy imbalance of cholesterol and triglycerides in the blood, affects an alarming number of Indian adults.

Despite being preventable and treatable, the condition often remains undiagnosed because it presents with little to no symptoms until serious complications surface.

The study was conducted by the Indian Council of Medical Research’s India Diabetes (ICMR-INDIAB) in what is one of the country’s largest community-based metabolic health surveys, involving over 113,000 adults from different states and Union Territories.

Also read: As Sonam Wangchuk's Indefinite Fast Continues, Doctors Explain When Hunger Strike Becomes Medically Dangerous

Women And Urban Residents At Greater Risk

According to the study, women, those living in urban areas, and residents of Central India carried a disproportionately higher burden of abnormal lipid levels.

Researchers also found that dyslipidemia was significantly more common among people with prediabetes or diabetes, obesity, and hypertension.

These metabolic conditions substantially increasing the risk of various cardiovascular diseases and complications.

What Is Dyslipidemia?

Dyslipidemia refers to unhealthy levels of fats circulating in the bloodstream. These include:

• High LDL (bad) cholesterol, which contributes to plaque buildup in the arteries.
• Low HDL (good) cholesterol, reducing the body’s ability to remove excess cholesterol.
• High triglycerides, another blood fat that contributes to cardiovascular disease and pancreatitis.
• Elevated total cholesterol

ICMR-INDIAB programme has already shown that lipid disorders remain one of the concerning health risks. However, the latest study highlights just how serious the problem has become, with nearly 90% of adults exhibiting at least one lipid abnormality.

Also read: US Senator & Trump's Close Ally Lindsey Graham Died Of Aortic Dissection: All About The Fatal Heart Emergency

Why Is India Facing A Cholesterol Crisis?

Factors like rapid urbanisation, sedentary lifestyles, unhealthy diets, obesity and rising diabetes rates are likely contributing to the worsening burden of cholesterol.

Unlike many chronic diseases, dyslipidemia can be managed through early detection and lifestyle change. Doctors recommend the following preventive measures:

• Regular lipid profile screening, especially after age 30 or earlier for high-risk individuals.
• Maintaining a healthy body weight.
• Exercising regularly.
• Eating a diet rich in fruits, vegetables, whole grains and healthy fats while limiting saturated and trans fats.
• Managing diabetes and blood pressure.
• Taking cholesterol-lowering medications such as statins when prescribed.

India has witnessed a steady rise in metabolic disorders over the past two decades, with cases of diabetes, obesity, hypertension and abnormal cholesterol increasingly surging.

Researchers warn that unless preventive measures are strengthened and strict lifestyle changes adopted, the country could face an even greater burden of heart disease and other related disorders in the future.

Climate activist and education reformer Sonam Wangchuk's indefinite hunger strike has entered a critical stage. After 20 days of without food, Wangchuk's condition worsened significantly. The spectacle drew nationwide attention as concerns over his deteriorating health continue to grow.

The protest, which began on June 28 at Delhi's Jantar Mantar, is aimed at demanding accountability over alleged irregularities in national entrance examinations like NEET and broader education reforms.

Wangchuk has experienced substantial weight loss ever since his hunger strike started. Doctors also warned that prolonged fasting could lead to serious complications, including organ involvement.

Sonam Wangchuk's Hospitalisation & 'Chalo Sansad' March

On July 18, Delhi Police shifted Sonam Wangchuk from the protest site to Safdarjung Hospital following medical advice and court-directed health monitoring. The move sparked controversy, with supporters alleging that he was moved to the hospital against his wishes.

According to the hospital, he’s receiving the necessary medical care, and his vital parameters remain stable.

“Sonam Wangchuk is being given the required medical intervention at VMMC & Safdarjung Hospital. His vital parameters are stable at present; however, his blood parameters remain marginally altered, and considering the physiological stress and systemic effects of prolonged fasting, he requires continuous medical care under the close observation of a multidisciplinary team of experts", the hospital's spokesperson said.

Despite being hospitalised, Wangchuk has remained firm on continuing his fast. In a handwritten note that was shared on his official X handle, he urged supporters to participate in the planned "Chalo Sansad" march on July 20.

When Does Hunger Strike Become Medically Concerning?

Also read: Watch: What Really Happens To Your Body After 72 Hours Without Food?

With Wangchuk's health continuing to deteriorate, his protest has renewed public interest in the medical dangers of prolonged hunger strikes.

The deterioration of one's health after a period of prolonged fasting is a medical emergency but it is highly variable.

Dr M Wali, Principal Director, Internal Medicine, Pacific One Health, says, "The timing of health deterioration becoming a medical emergency varies on various factors. It depends on age, existing health parameters before fasting, hydration, medications, environmental conditions and most important whether the person is taking only water or electrolytes. There is no fixed timeline for vitals to deteriorate."

24-72 Hours

In the first three days, the doctor says that the body suffers from spells of hunger, dizziness, and mild drop in blood pressure.

3 to 9 Days

During this period, fluctuations in blood sugar can start. The expert says that during this time, the body relies heavily on stored fats. Weight loss, low blood pressure, slow pulse, dehydration, and electrolytes imbalance start happening too.

10-14 days

Experts say that this is the critical period when serious complications can arise, especially like kidney injury, heart rhythm abnormalities, confusion, and collapse.

According to Dr Anshu Rohtagi, Sr Consultant at Department of Neurology, Sir Ganga Ram Hospital, "After sustained and prolonged complete fasting of couple of weeks, the risk of permanent organ damage and death increases manifold although survival depends on hydration and status of nutrition. Someone refusing both food and water can deteriorate much faster - sometimes in a few days also."

Also read: How Colonialism Continues To Bear An Impact On The South Asian Health Crisis

Another expert says that during this time, certain critical symptoms are evaluated that could cause serious complications.

According to Dr Niraj Tyagi, renowned critical care specialist, "The visiting medical team looks for signs that generally prompt urgent medical evacuations. Some of them are loss of consciousness or inability to stay awake, confusion or delirium, chest pain, abnormal heart rhythm, very low blood pressure causing fainting or shock, persistent low blood pressure, severe dehydration, little or no urine output, dangerous imbalance of electrolytes and kidney or other organs injury."

According to human rights experts, "Whether someone can be shifted to medical facility or treated against their wishes depends on local laws, court orders, and, most importantly, whether the person is in sound mental health to take informed decisions."

Treatment Plan

Dr. Wali explains how the treatment course looks like for someone who has been without food for weeks.

He says, "Once shifted to medical facility, treatment depends on the patient's condition and may include careful rehydration, correction of electrolytes imbalance, continuous cardiac and kidney monitoring, nutritional rehabilitation. Doctors usually monitor potassium, magnesium, and glucose closely during re-feeding."

He adds, "It is important to note that even after recovery, the person may remain medically vulnerable even if they feel well."