Japan could become one of the first countries in the world to end the HIV epidemic, says the president of Gilead Sciences Japan, Kennet Brysting. The idea for now could seem a little too ambitious, but it is not entirely unrealistic, given that the availability of medicines that can prevent transmission of HIV. Drugs are not the cure, but control over the spread of virus to the point where the disease is no longer a major public health threat.

What Is The Role Of Preventative HIV Medicines?

Gilead's have two key drugs, Truvada and lenacapavir. These two are playing a crucial role in prevention. Truvada is taken as a daily pill, while lenacapavir requires two injections per year. It can make the virus undetectable in infected individuals and prevent transmission to those who are not infected yet. In trials, lenacapavir showed 100% efficacy in preventing HIV infections. This is why it is describe as "almost a vaccine".

In 2024, Japan also approved Truvada for HIV prevention, but the country has yet to approve lenacapavir for the same. Until now, people in Japan had been importing generic versions of Truvada or purchasing it from clinics that source it from overseas.

HIV In Japan

Up until now, Japan reported around 25,000 HIV infections, whereas 669 new cases were reported in 2023. For seven consecutive years, the number of new infections remained under 1,000. The downward trend thus shows that the virus has been controlled, however, getting to zero new infections remains the ultimate goal.

Brysting too acknowledged that simply having effective drug is not enough. What is important is to have a proper implementation, access and healthcare support to make sure that these treatments are widely available and effective.

What Are The Challenges In Implementation?

The biggest challenges is testing rates. There is a need to increase testing rates. At this very moment, around 86% people infective with Japan have been tested, but the goal is to increase it up to 95%, with an ideal goal of 100%. Without widespread testing, many infected people may not even know that they are infected and it could transmit the virus.

Another measure issue is the cost of preventative medication. While Japan's health insurance covers treatments for diseases, it does not cover preventative drugs. Those who purchase Truvada for prevention, pay around $470 per month. Some clinics in Tokyo offer generic alternatives too, which is cheaper, but they are not ideal.

Better Healthcare Support

Brysting expressed concern that individuals importing medications might not be consulting doctors regularly, which is essential for monitoring HIV status and overall health. Truvada users need to be tested for HIV initially and every three months, along with screenings for other infections and kidney function checks. Without proper medical supervision, there is a risk of misuse and inadequate protection.

Gilead is in discussions with Japanese authorities to improve access and insurance coverage for Truvada, and progress is being made. Japan has shown efficiency in approving critical medicines, as seen during the COVID-19 pandemic when Gilead’s remdesivir was approved in just three days.

What Is The Way Ahead?

Gilead at this moment is not only focused on HIV and hepatitis C, but also expanding into oncology with innovative treatments like CAR-T cell therapy, which strengthens a patient's immune system to fight cancer.

However, Japan’s strict approval processes can slow down drug availability. Phase 3 clinical trials often need to be conducted within the country, and Japan tends to approve medicines much later than other regions. For instance, Truvada was approved for prevention in Japan 12 years after the U.S. and nearly 20 years after its approval for treatment. inancial factors also play a role. The Japanese government adjusts drug prices annually, often reducing them, which can make long-term investment challenging for pharmaceutical companies.

As Delhi continues to report above 200 AQI and locals suffer from a wealth of problems, a new IIT Delhi study suggests the air quality may be worse than what conventional surface monitoring stations capture.

During a post winter-haze day in March 2021, the researchers measured the vertical distribution of fine particulate matter at 20-metre intervals from the surface up to 100 meters through drones.

At 100 meters, PM2.5 concentrations were around 160 micrograms per cubic meter which is about 60 percent higher than surface readings on the same days. They also found that humidity levels were also higher by 70 percent, which promoted the concentration of ammonium nitrate and chloride.

Additionally, the study found that PM2.5 levels increased sharply near the top of this shallow layer, leading to higher concentrations at around 100 metres.

Based on these observations, the researchers concluded that residents in 28–30-storey buildings may face higher exposure to pollutants and inorganic material than indicated by ground-based monitors.

They also noted that drone-mounted low-cost sensors are a much better effective tool for studying the lower atmospheric boundary layer to improve air quality monitoring, model evaluation and mitigation strategies in cities such as Delhi.

How To Read AQI?

As per the Central Pollution Control Board (CPCB), here is how you can know what your AQI stands for

• 0 to 50: Good
• 51 to 100: Satisfactory
• 101 to 200: Moderate
• 201 to 300: Poor
• 301 to 400: Very Poor
• 401 to 500: Severe

Air quality is made of dust and small particles like PM2.5 and PM10, along with gases like nitrogen dioxide from car exhaust, sulphur dioxide from factories, and carbon monoxide from vehicles. The levels are measured through specialized machines. In India, the standard of the machines are carried out by the CPCB.

Pollution Could Harm Your Brain

While we all know the harm pollution could do to your lungs, doctors have also highlighted that pollution could also lead to cognitive ailments. Mental health impacts such as risk of depression, anxiety, ADHD, and neurodevelopmental disorders in children could rise.

Dr Deepika Dahima, a psychologist at AIIMS Delhi said that pollution could put mental health at risk. Prolonged exposure to fine particulate matter like PM10 or PM2.5 could lead to a rise in anxiety, depression, cognitive impairment and chronic stress. Children also show disrupted neural development and learning difficulties, while adults experience irritability, emotional fatigue and impaired decision-making.

Medical practitioner Dr Jitender Nagpal, deputy medical superintendent and pediatrician at Sitaram Bhartia Institute of Science, told Press Trust India: “Increasingly, a wide spectrum of behavioural and learning issues such as attention difficulties, irritability, and poor academic performance are being noticed in many children.”

Studies too have linked the exposure of particulate matter or PM2.5 with increased ADHD risk. There are research that show a 1.51 fold increase per 5 μg/m³ increase in PM2.5 and others indicating elevated risks when exposure exceeds 16 μg/m³.

A Environmental Research by Oregon Health & Science University study published in December 18 found that everyday exposure to urban air pollution gradually alters brain development in children and young adults.

The researchers of the Oregon Health & Science University discovered that exposure to air pollutants at ages 9 to 10 was associated with changes in cortical thickness in the frontal and temporal brain regions that are responsible for executive function, language, mood regulation, and socioemotional processing.

Another study published in Nature Communication notes that after four hours of exposure to particulate matter, it was found that people's ability to perform routine tasks and interpret emotions were highly impacted.

Study's co-author, Dr Thomas Faherty said, "Study provides compelling evidence that even short-term exposure to particulate matter can have immediate negative effects on brain functions essential for daily activities.”

Travel Restrictions To Canada: The top court of the land, that is the Supreme Court of Canada ruled that travel restrictions were violative of citizen's right, however, are reasonable during "grave emergency" like pandemic.

Travel Restrictions To Canada: What Happened That Led To Supreme Court Ruling?

During May 2020, in early days of the COVID-19 pandemic, Kimberley Taylor, who was living in Halifax, got the news of her mother Eileen's passing away at the age of 75 of natural causes at St John's, as reported by The Global Mail. Kimberley wanted to attend a small memorial service however was unable to go there due to the Newfoundland government's rejection of her initial request.

The memorial service and the burial was attended by her father, sister and niece. "I was denied the ability to join my family to grieve my mother," she said, as reported.

This is when she along with the Canadian Civil Liberties Association launched a legal challenge. They noted that strict travel restrictions were in violation of the mobility rights within Canada as guaranteed by Section 6 of the Charter of Rights and Freedoms.

Last week, on Friday, a nine judge bench in the Supreme Court of Canada provided an expansive view of the Canadians' Charter mobility rights.

Travel Restrictions To Canada: What Did The Canadian Supreme Court Say?

The top court said that while Kimberley's rights were in fact violated by Newfoundland's pandemic rules, these were within the reasonable limits. The court deemed the pandemic travels rules to be in bounds within the reasonable limits on rights and freedoms in Section 1 of the Charter.

Jessica Kuredjian, a lawyer at Cassels in Toronto, as reported by The Global Mail, said, "This is a great ruling, and an important one. It is very human case. It is a great example of where Charter rights impact the real rights of everyday citizens."

The ruling will serve as a precedent for the ambit of government actions and restrictions during potential health emergencies in the future.

In a majority ruling authored by Justices Andromache Karakatsanis and Sheilah Martin, the court noted that early pandemic deaths and scientific uncertainty created an “extraordinarily difficult situation,” requiring swift decisions to protect public health and prevent further loss of life.

The judgment marks the latest major court effort to define the balance between individual freedoms and government authority stemming from pandemic-era actions. Just last month, the Federal Court of Appeal found the federal government’s 2022 use of the Emergencies Act to curb large protests was not legally justified.

Friday’s ruling also adds to the legal interpretation of the 1982 Charter of Rights. While many Charter provisions have been heavily litigated over the years, Section 6 — mobility rights — has rarely been tested in court.

“There really was a dearth of jurisprudence on the topic,” said Anaïs Bussières McNicoll, director of the Civil Liberties Association’s fundamental-freedoms program.

The pandemic travel-restriction case effectively marks the Supreme Court’s first detailed examination of Section 6 as it applies to Canadians’ general freedom of movement within the country.

In their majority opinion, five judges stressed that Charter rights must receive “generous protection.” On mobility rights, they traced the concept back nearly a millennium, linking it to common-law traditions from the 1200s and even earlier “ancient customs.”

North London Measles Outbreak: 34 children have been infected by a "fast spreading" measles outbreak in several north London schools, confirmed health officials. The cases were first confirmed from Enfield in laboratory tests in January, as is reported by the UK Health Security Agency or the UKHSA.

A local GP, as reported by the BBC said that one in fiver children who contracted the illness had been admitted to hospital. The doctor also said that these children "had not been fully immunized".

Families are now asked to ensure that their children are up to date with their immunizations and vaccinations against this highly contagious disease. Measles could cause serious health complications.

North London Measles Outbreak: Who Can Get The Vaccines?

Measles vaccinations for children are available at the school, however, if they missed it, they can also get it at a number of catch-up clinics around the UK. The vaccinations are for free.

Enfield's NHS Ordnance Unity Centre For Health on its website noted that there is a "fast spreading measles outbreak in several schools" across the borough. The infections were confirmed in "at least" seven schools in Enfield, which means there could be more. Some reports also came from neighboring Haringey.

Enfield Councillor Alev Cazimoglu said that current outbreak had "mainly affected children and some have required additional care with a short stay in hospital". She also said, "Vaccination is the most effective way to protect yourself and your family. We urge everyone who is not fully vaccinated to act now."

The 34 cases of Enfield represent over a third of the 96 total cases which were confirmed in England in the first month of this year as per the UKHSA data.

As per the Enfield Council, it is working closely with UKHSA, the NHS and local partners to limit any further spread.

Read: UK Loses Measles Elimination Status: Why Is This Disease Making A Comeback?

North London Measles Outbreak: Who Are At Most Risk?

As per a UKHSA medical practitioner, Dr Vanessa Saliba, as also reported by the BBC, the "big" outbreak is "mostly affecting unvaccinated children under 10 in schools and nurseries". She also added, "Measles is a nasty illness for any child, but for some it can lead to long term complications and tragically death, but is so easily preventable with two doses of the MMRV [measles, mumps, rubella, chickenpox] vaccine."

Dr Saliba also suggested children to catch-up with their vaccine schedule in case they have missed it and also urged those travelling abroad over the Easter holidays to check their vaccination status.

North London Measles Outbreak: What Is It And What Are The Symptoms?

Measles is a highly contagious disease. It spreads by coughs or sneezes or by touching things that someone with measles has coughed or sneezed on.

Measles, also known as rubeola, is an extremely contagious viral illness that typically causes high fever, cough, runny nose, red and watery eyes, and a characteristic rash that begins on the face and spreads downward across the body. It spreads through respiratory droplets and can lead to severe and sometimes fatal complications, including pneumonia and inflammation of the brain known as encephalitis.

Symptoms include high fever, sore or red and watery eyes, coughing, sneezing, and small white spots in the mouth.