Japan could become one of the first countries in the world to end the HIV epidemic, says the president of Gilead Sciences Japan, Kennet Brysting. The idea for now could seem a little too ambitious, but it is not entirely unrealistic, given that the availability of medicines that can prevent transmission of HIV. Drugs are not the cure, but control over the spread of virus to the point where the disease is no longer a major public health threat.

What Is The Role Of Preventative HIV Medicines?

Gilead's have two key drugs, Truvada and lenacapavir. These two are playing a crucial role in prevention. Truvada is taken as a daily pill, while lenacapavir requires two injections per year. It can make the virus undetectable in infected individuals and prevent transmission to those who are not infected yet. In trials, lenacapavir showed 100% efficacy in preventing HIV infections. This is why it is describe as "almost a vaccine".

In 2024, Japan also approved Truvada for HIV prevention, but the country has yet to approve lenacapavir for the same. Until now, people in Japan had been importing generic versions of Truvada or purchasing it from clinics that source it from overseas.

HIV In Japan

Up until now, Japan reported around 25,000 HIV infections, whereas 669 new cases were reported in 2023. For seven consecutive years, the number of new infections remained under 1,000. The downward trend thus shows that the virus has been controlled, however, getting to zero new infections remains the ultimate goal.

Brysting too acknowledged that simply having effective drug is not enough. What is important is to have a proper implementation, access and healthcare support to make sure that these treatments are widely available and effective.

What Are The Challenges In Implementation?

The biggest challenges is testing rates. There is a need to increase testing rates. At this very moment, around 86% people infective with Japan have been tested, but the goal is to increase it up to 95%, with an ideal goal of 100%. Without widespread testing, many infected people may not even know that they are infected and it could transmit the virus.

Another measure issue is the cost of preventative medication. While Japan's health insurance covers treatments for diseases, it does not cover preventative drugs. Those who purchase Truvada for prevention, pay around $470 per month. Some clinics in Tokyo offer generic alternatives too, which is cheaper, but they are not ideal.

Better Healthcare Support

Brysting expressed concern that individuals importing medications might not be consulting doctors regularly, which is essential for monitoring HIV status and overall health. Truvada users need to be tested for HIV initially and every three months, along with screenings for other infections and kidney function checks. Without proper medical supervision, there is a risk of misuse and inadequate protection.

Gilead is in discussions with Japanese authorities to improve access and insurance coverage for Truvada, and progress is being made. Japan has shown efficiency in approving critical medicines, as seen during the COVID-19 pandemic when Gilead’s remdesivir was approved in just three days.

What Is The Way Ahead?

Gilead at this moment is not only focused on HIV and hepatitis C, but also expanding into oncology with innovative treatments like CAR-T cell therapy, which strengthens a patient's immune system to fight cancer.

However, Japan’s strict approval processes can slow down drug availability. Phase 3 clinical trials often need to be conducted within the country, and Japan tends to approve medicines much later than other regions. For instance, Truvada was approved for prevention in Japan 12 years after the U.S. and nearly 20 years after its approval for treatment. inancial factors also play a role. The Japanese government adjusts drug prices annually, often reducing them, which can make long-term investment challenging for pharmaceutical companies.

Childhood obesity in India is expected to surge to a whopping 56 million by 2040 -- nearly a 20 percent rise from 2025, according to an alarming new global report released today by the World Obesity Federation.

The World Obesity Atlas 2026, released on World Obesity Day -- observed globally on March 4 -- revealed that of the 56 million, about 20 million children in the country will be obese, while the remaining will be overweight.

Globally, the number of children aged 5-19 years living with obesity or overweight is predicted to increase to 507 million by 2040 -- from 419 million in 2025.

Overweight Children: India Second-Highest Globally In 2025

Among children aged 5-9 years, 14.921 million were overweight or obese in 2025

In children aged 10-19 years, more than 26.402 million were overweight or obese.

India was among the top 10 countries -- second after China -- that accounted for over 200 million school-age children, aged 5-19 years, with high Body Mass Index (BMI).

Between 2010 and 2025, India had a 4.8 percent increase in the prevalence of high BMI and obesity among children aged 5-19 years.

"The increase in childhood obesity worldwide shows we have failed to take seriously a disease that affects one in five children," said Johanna Ralston, chief executive at the World Obesity Federation.

"Governments urgently need to step up prevention and management efforts for children living with overweight and obesity, and ensure that they receive the care they need," Ralston added.

High BMI To Surge Chronic Disease By 2040 In India

By 2040, the report also projected a substantial increase in the risk of diseases among children aged 5-19 years due to a high BMI in India. This includes:

• Hypertension (high blood pressure) expected to spike by 4.21 million from 2.99 million
• hyperglycemia (high blood sugar) to 1.91 million from 1.39 million
• high triglycerides (excess fats in the blood) to 6.07 million from 4.39 million
• metabolic dysfunction-associated steatotic liver disease (MASLD) to 11.88 million from 8.39 million

The key preventable risk factors in the country include:

• 74 percent of adolescents aged 11-17 fail to meet recommended physical activity levels
• Only 35.5 percent of school-age children (primary and secondary) receive school meals
• 32.6 percent of infants aged 1-5 months experience sub-optimal breastfeeding
• 13.4 percent of women aged 15-49 are exposed to high BMI
• 4.2 percent of women aged 15-49 live with Type 2 diabetes
• Children aged 6-10 consume an average of 0-50 ml of sugary drinks per day

Obesity: A Global Health Concern

Globally, the number of school-age children living with obesity now exceeds those living underweight.

Currently, more than one in five (20.7 per cent) 5-19 year-olds worldwide are living with obesity and overweight -- an increase from 14.6 per cent in 2010.

In 2025, about 177 million children aged 5-19 years were living with obesity. The number is expected to jump to 228 million in 2040.

By 2040, the Atlas also predicts that 227 million children aged 5-19 years will be living with obesity compared to 142 million living with underweight.

Notably, most of the world’s school-age children aged 5-19 living with obesity reside in the middle-income countries. By 2040, this is estimated to be as many as 169 million children.

Call To Action

The World Obesity Federation called for strong action to reverse current trends. These include imposing:

• taxes on sugar-sweetened beverages,
• restrictions on marketing to children (including digital platforms), implementation of global physical activity recommendations for children, protection of breastfeeding,
• healthier school food standards,
• integration of prevention and care into primary health systems.

Tamil Nadu health authorities have ramped up surveillance efforts and implemented preventive and control measures to curb rising chickenpox cases in the state.

The Directorate of Public Health (DPH) and Preventive Medicine has instructed all health officers to intensify active and passive surveillance in all government and private health facilities, schools, colleges and hostels.

They were also directed to ensure that all suspected and confirmed cases are entered into the Integrated Disease Surveillance Programme (IDSP) line list with complete demographic and clinical details.

All medical officers across the state have further been asked to be alert to differentiate chickenpox from other rash illnesses such as measles, rubella, and hand, foot and mouth disease.

This comes weeks after doctors across Pune also warned against the exponential rise in chickenpox cases this winter.

Dr Shirish Kankariya, head of paediatrics at Apollo Hospital Swargate, said he had seen around 15 chickenpox patients in Jan alone, and the current season has brought a visible uptick in cases.

"Chickenpox cases have risen. We are also seeing infections in older children and adult family members, who never had the disease earlier," he told Times of India.

Dr Prateek Kataria, consultant pediatrician and neonatologist at Sahyadri Hospital also noted that out-patient departments (OPDs) have recently seen a large increase confirmed chickenpox cases this year.

He also told the publication: "We are seeing many children with chickenpox in the OPD even among those who have taken both doses of the vaccine. This is expected because the vaccine does not guarantee 100% protection, but vaccinated children usually develop milder illness and do not need hospitalization."

What Is Chickenpox And How Does It Spread?

Chickenpox, caused by the varicella-zoster virus, is extremely contagious and spreads through respiratory droplets or direct contact with someone who is infected. In children, it often starts as a mild rash accompanied by fever, but it can spread quickly in crowded areas.

The virus can also be transmitted through coughing or sneezing, and it is most infectious a day or two before the rash appears and in the early days of the rash. In individuals with weak immunity, the dormant virus may reactivate later in life, causing shingles (herpes zoster).

How To Detect Chickenpox Symptoms Early?

Spotting chickenpox early means looking for general warning signs like fever, fatigue, headache, and loss of appetite, which usually appear one to two days before the rash.

The rash itself starts as tiny red spots that later form fluid-filled blisters and eventually scab over. Paying attention to these early symptoms, especially after known exposure, can help identify the infection sooner.

How To Spot A Chickenpox Rash

The first rash usually shows up as small red bumps on the face, chest, or back. These bumps quickly turn into blisters filled with fluid, which are contagious. Over a few days, the blisters break and crust over, forming scabs. It’s common to see spots, blisters, and scabs all at the same time, according to the CDC.

Stages Of Chickenpox

The Mayo Clinic explains that chickenpox progresses in three main stages:

• Incubation Stage (10–21 days): After exposure, the virus remains inactive. Infected individuals typically show no symptoms during this period.
• Prodromal Stage (1–2 days): Early signs include fever, tiredness, headache, loss of appetite, and body aches. This is also when the virus can start spreading to others.
• Rash Stage (5–10 days): Red, itchy spots appear first on the face and chest, spreading across the body. These spots develop into fluid-filled blisters that scab over within a few days. Mild fever, itching, and discomfort are common during this stage.

A new study published in The Lancet Oncology journal today revealed that breast cancer continues to be the most common cancer among women worldwide, and predicted that the number of new cases of the deadly disease will reach more than 3.5 million globally in 2050 -- rising by a third from 2.3 million in 2023.

The Global Burden of Disease analysis with data from 204 countries revealed that despite advancements in breast cancer treatments, yearly deaths from the disease will rise by 44 percent -- from around 764,000 to 1.4 million.

While breast cancer disproportionately impacts countries with limited resources, maintaining a healthy lifestyle, including not smoking, getting sufficient physical activity, lowering red meat consumption, and having a healthy weight were found to prevent over a quarter of healthy years lost to illness and premature death.

“Breast cancer continues to take a profound toll on women’s lives and communities,” said lead author Kayleigh Bhangdia from the Institute for Health Metrics and Evaluation (IHME), University of Washington, US.

“While those in high-income countries typically benefit from screening and more timely diagnosis and comprehensive treatment strategies, the mounting burden of breast cancer is shifting to low- and lower middle-income countries where individuals often face later-stage diagnosis, more limited access to quality care, and higher death rates that are threatening to eclipse progress in women’s health,” Bhangdia added.

Inequalities In Breast Cancer Burden

The study revealed that the rates of new cases remain highest in high-income countries (HICs), but are growing fastest in low-income countries (LICs).

Women in low- and lower-middle-income countries accounted for 27 percent (around 628,000) of new cases globally, exposing likely disparities in timely diagnosis and shortages of quality treatment, including radiotherapy machines, chemotherapy drugs, and pathology labs, and standard treatments.

In 2023, an estimated 2.3 million new breast cancers were diagnosed worldwide in women (with 73 percent or 1.67 million cases occurring in high- and upper-middle-income countries). Of these, 764,000 ended in deaths (with 39 percent or 300,000 deaths occurring in low- and lower-middle-income countries).

Further, the number of years of healthy life lost due to poor health and early death more than doubled from 11.7 million years in 1990 to 24 million years in 2023.

Women in low- and lower-middle-income countries also contribute to more than 45 percent of all the ill-health and early deaths from breast cancer globally (nearly 11 million years of healthy life lost).

Three-fold Rise In Pre-menopausal Breast Cancer

The study reported a three-fold rise in pre-menopausal breast cancer in women aged 55 or older in 2023 -- compared to women aged 20-54 years.

However, rates of new cases have risen in women aged 20-54 years (up 29 percent) since 1990, with rates in older women remaining relatively unchanged.

Major Lifestyle Risk Factors

In 2023, 28 percent of the global breast cancer burden (6.8 million years of healthy life lost to disability, illness, and early death) was linked to six potentially modifiable risk factors. These include:

• High red meat consumption -- linked to nearly 11 percent of all healthy life lost
• tobacco use (including second-hand smoke; 8 percent),
• high blood sugar (6 percent),
• high body mass index (4 percent),
• high alcohol use and low physical activity (both 2 percent)

Substantial progress has been made in reducing the global breast cancer burden linked to high alcohol use and tobacco between 1990 and 2023, which declined by 47 percent and 28 percent, respectively.