Japan could become one of the first countries in the world to end the HIV epidemic, says the president of Gilead Sciences Japan, Kennet Brysting. The idea for now could seem a little too ambitious, but it is not entirely unrealistic, given that the availability of medicines that can prevent transmission of HIV. Drugs are not the cure, but control over the spread of virus to the point where the disease is no longer a major public health threat.

What Is The Role Of Preventative HIV Medicines?

Gilead's have two key drugs, Truvada and lenacapavir. These two are playing a crucial role in prevention. Truvada is taken as a daily pill, while lenacapavir requires two injections per year. It can make the virus undetectable in infected individuals and prevent transmission to those who are not infected yet. In trials, lenacapavir showed 100% efficacy in preventing HIV infections. This is why it is describe as "almost a vaccine".

In 2024, Japan also approved Truvada for HIV prevention, but the country has yet to approve lenacapavir for the same. Until now, people in Japan had been importing generic versions of Truvada or purchasing it from clinics that source it from overseas.

HIV In Japan

Up until now, Japan reported around 25,000 HIV infections, whereas 669 new cases were reported in 2023. For seven consecutive years, the number of new infections remained under 1,000. The downward trend thus shows that the virus has been controlled, however, getting to zero new infections remains the ultimate goal.

Brysting too acknowledged that simply having effective drug is not enough. What is important is to have a proper implementation, access and healthcare support to make sure that these treatments are widely available and effective.

What Are The Challenges In Implementation?

The biggest challenges is testing rates. There is a need to increase testing rates. At this very moment, around 86% people infective with Japan have been tested, but the goal is to increase it up to 95%, with an ideal goal of 100%. Without widespread testing, many infected people may not even know that they are infected and it could transmit the virus.

Another measure issue is the cost of preventative medication. While Japan's health insurance covers treatments for diseases, it does not cover preventative drugs. Those who purchase Truvada for prevention, pay around $470 per month. Some clinics in Tokyo offer generic alternatives too, which is cheaper, but they are not ideal.

Better Healthcare Support

Brysting expressed concern that individuals importing medications might not be consulting doctors regularly, which is essential for monitoring HIV status and overall health. Truvada users need to be tested for HIV initially and every three months, along with screenings for other infections and kidney function checks. Without proper medical supervision, there is a risk of misuse and inadequate protection.

Gilead is in discussions with Japanese authorities to improve access and insurance coverage for Truvada, and progress is being made. Japan has shown efficiency in approving critical medicines, as seen during the COVID-19 pandemic when Gilead’s remdesivir was approved in just three days.

What Is The Way Ahead?

Gilead at this moment is not only focused on HIV and hepatitis C, but also expanding into oncology with innovative treatments like CAR-T cell therapy, which strengthens a patient's immune system to fight cancer.

However, Japan’s strict approval processes can slow down drug availability. Phase 3 clinical trials often need to be conducted within the country, and Japan tends to approve medicines much later than other regions. For instance, Truvada was approved for prevention in Japan 12 years after the U.S. and nearly 20 years after its approval for treatment. inancial factors also play a role. The Japanese government adjusts drug prices annually, often reducing them, which can make long-term investment challenging for pharmaceutical companies.

Tampons contain trace amounts of arsenic, lead and other metals, but they are not released at levels that pose a health risk, according to a new study by the US Food and Drug Administration (FDA).

Published in the peer-reviewed journal Toxicological Sciences, the study found that while 19 metals—including arsenic, cadmium and lead—were detected in tampons, “the amount released during use is too small to cause harm”.

The FDA said the findings are consistent with an earlier independent systematic literature review it commissioned.

What Did The FDA Study Find?

The FDA evaluated 11 tampon products legally marketed in the United States to determine whether trace metals present in the products could be released during use and whether they posed any toxicological risk.

Researchers measured metal levels using inductively coupled plasma mass spectrometry (ICP-MS). To assess the maximum possible release, tampons were tested under exaggerated laboratory conditions by placing them in acidified water at 50°C (122°F) for 24 hours, simulating a worst-case exposure scenario.

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The study detected 19 metals, including:

• Arsenic
• Cadmium
• Lead
• Titanium
• Calcium
• Iron
• Lithium
• Zinc

"Based on the in-depth toxicological risk assessment, all detected metals had margins of safety indicating that there is negligible toxicological concern from the presence of metals in tampon materials," the researchers wrote.

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How Are Metals Present In Tampons?

According to the FDA, trace metals may enter tampon materials naturally because plants such as cotton absorb minerals and metals from the soil. Some metals may also be introduced unintentionally during manufacturing.

Researchers noted that titanium dioxide, which is sometimes used to whiten tampons, may explain the presence of titanium in certain products.

In October 2025, the FDA issued a draft guidance titled, Menstrual Products — Performance Testing and Labeling Recommendations.

This draft guidance provides recommendations to industry to support the safety and effectiveness of menstrual products, including recommendations for evaluating these products for contaminants and promoting transparency in menstrual product ingredients.

What Is a Tampon Made Of?

Tampons are typically made of cotton, rayon, or a blend of the two. While rayon-based tampons generally contained higher levels of lithium and zinc, cotton-rich tampons had higher concentrations of calcium and iron.

Despite these differences, the FDA concluded that exposure from all products tested remained well below levels of health concern.

Single-use vs Reusable Tampons

The FDA emphasized that only single-use tampons are authorized for sale in the United States. The agency discourages the use of reusable tampons because they may carry a higher risk of infections, including:

• Yeast infections
• Fungal infections
• Bacterial infections

The FDA regulates menstrual products as medical devices but has limited authority over their composition. While tampons undergo a premarket review process, the agency doesn't approve individual materials used in these products.

The FDA's primary focus regarding menstrual products has been on addressing the risk of Toxic Shock Syndrome (TSS). They have implemented labeling requirements and educational campaigns to minimize this risk. However, the recent findings of heavy metals in tampons highlight a potential gap in regulatory oversight.

The Ebola outbreak in the Democratic Republic of the Congo (DRC) has reached another concerning milestone. With a surging number of deaths and confirmed infections, the healthcare workers in the affected regions have threatened to declare a strike due to nonpayment of dues, making it challenging to contain a deadly and aggressive outbreak.

DRC Ebola Death Toll Reaches 600 With 1759 Confirmed Cases

According to Reuters, the total confirmed number of deaths due to Bundibugyo Ebola has reached 600, with 1,759 confirmed infections as of July 9.

This comes amid protests demonstrated by healthcare workers in the affected regions, who have threatened to walk off the job due to months of unpaid wages and unsafe working conditions.

The outbreak initially affected Ituri, North Kivu and South Kivu provinces, but authorities are now investigating suspected cases in Tshopo province, including Kisangani, sparking concerns that new areas may be affected.

The outbreak, caused by the Bundibugyo species of the Ebola virus, has been spreading rapidly since it was declared on May 15.

Unlike the Zaire strain, there is currently no approved vaccine or specific treatment for Bundibugyo Ebola virus, making containment and treatment efforts particularly challenging. Currently, experimental therapies are being examined through ongoing clinical trials.

Also read: Uganda Says Ebola Is Contained After Nearly Two Months Of Outbreak; Seeks To Get Travel Restrictions Removed

Healthcare Workers Protests

The worsening outbreak could be even more challenging to contain as the frontline healthcare workers, including treatment staff, laboratory personnel, and burial teams, have been protesting nonpayment of salaries, insufficient protective equipment, and difficult working conditions.

According to several reports, many workers say they have not been paid since the outbreak began nearly two months ago. While some have already stopped working, others have warned that a mass walkout could further weaken the country’s Ebola response.

The administrative disruption significantly threatens critical epidemic operations like patient care, lab testing, contact tracing, and safe burial procedures, all of which are essential for slowing transmission and effectively containing the outbreak.

WHO Says Ebola Outbreak Is Still In Expansion Phase

The World Health Organization has repeatedly warned that the outbreak remains in an “expansion phase” due to several reasons, including overwhelmed treatment facilities, population movement, and delays in identifying and isolating infected individuals.

WHO also said that the treatment centers in some of the hardest-hit regions are operating near 90% capacity. Infection cases among healthcare workers are another concern that highlights the risks faced by frontline responders.

Misinformation about the disease has been rife in several Congolese communities. According to the Council on Foreign Relations, there have been reports that some local communities believe that the disease is a hoax or was brought into the country by Western aid workers who wanted to make a profit.

While Ebola is not a new disease, the current outbreak poses a significant threat because it is caused by a rare strain of the virus, Bundibugyo. The rarity of the strain has created scientific and emergency public health challenges, as there is currently no licensed vaccine to protect against the Bundibugyo Ebola virus.

Danish pharmaceutical giant Novo Nordisk has launched Awiqli (insulin icodec) in India, introducing the world's first once-weekly basal insulin for adults with diabetes.

Individuals with Type 2 diabetes require daily insulin to manage their blood glucose when diet, exercise, and oral medications are no longer sufficient.

The daily basal insulin injections are typically taken once every 24 hours. But Awiqli is designed to provide background insulin support throughout the week, reducing the ‌number ⁠of injections from 365 per year to 52, Novo said.

More than 101 million people in India are living with diabetes, ⁠while another 136 million have prediabetes, Novo said in a statement.

Insulin initiation in India is delayed by an average of 7-9 years, partly due to fear of injections, anticipated pain, and cost concerns, it said.

"We believe Awiqli will reduce the psychological and physical barriers to insulin initiation," Novo Nordisk India Managing Director Vikrant Shrotriya said.

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What is Awiqli?

Awiqli (insulin icodec) is a long-acting basal insulin designed to help adults with diabetes maintain stable blood sugar levels with just one injection every week. It is administered using the Awiqli FlexTouch pen on the same day each week.

The treatment is intended to simplify insulin therapy, potentially improving treatment adherence among people who struggle with daily injections.

Global Approval

Earlier this year, the US Food and Drug Administration (FDA) approved Awiqli (insulin icodec-abae) 700 units/mL as the first and only once-weekly basal insulin for adults with type 2 diabetes. The therapy is indicated as an adjunct to diet and exercise to improve glycemic control.

The approval offers a new treatment option for patients seeking an alternative to daily basal insulin, allowing diabetes care to be tailored to different lifestyles and treatment preferences.

"Awiqli may address challenges associated with the frequency of daily basal injections by reducing them from seven to one per week. It is an important advancement for adults with type 2 diabetes who may benefit from an alternative treatment option," said Anna Windle, Group Vice President, Clinical Development, Medical & Regulatory Affairs at Novo Nordisk Inc.

Where Is It Available?

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The therapy has now been launched in India. Awiqli has also received regulatory approval in the US, the European Union, and 13 other countries, with indications varying according to local regulatory approvals.

Clinical Evidence

The approval is supported by Novo Nordisk's ONWARDS Phase 3a clinical program, which enrolled nearly 2,680 adults with uncontrolled type 2 diabetes across four randomized, active-controlled trials.

The studies compared once-weekly Awiqli with daily basal insulin and demonstrated effective reductions in HbA1c, a key measure of long-term blood sugar control. The overall safety profile was found to be consistent with existing daily basal insulin therapies.

Who Can Use It?

Awiqli is prescribed for adults with diabetes and should be used exactly as directed by a healthcare professional.

Patients should inject the medicine once every week on the same day. The dosage should not be adjusted without medical advice, the company said.

Are There Any Side Effects

Like other insulin therapies, Awiqli may cause side effects, including:

• Low blood sugar (hypoglycemia)
• Injection-site reactions
• Weight gain
• Skin thickening or pitting at injection sites (lipodystrophy)
• Allergic reactions
• Swelling of the hands or feet

Patients are advised to monitor their blood sugar regularly and seek immediate medical attention if they experience symptoms of severe allergic reactions or persistent hypoglycemia.

Who should not take Awiqli?

Do not take Awiqli if you:

• are having an episode of low blood sugar (hypoglycemia)
• have an allergy to Awiqli or any of the ingredients in Awiqli.