Japan could become one of the first countries in the world to end the HIV epidemic, says the president of Gilead Sciences Japan, Kennet Brysting. The idea for now could seem a little too ambitious, but it is not entirely unrealistic, given that the availability of medicines that can prevent transmission of HIV. Drugs are not the cure, but control over the spread of virus to the point where the disease is no longer a major public health threat.

What Is The Role Of Preventative HIV Medicines?

Gilead's have two key drugs, Truvada and lenacapavir. These two are playing a crucial role in prevention. Truvada is taken as a daily pill, while lenacapavir requires two injections per year. It can make the virus undetectable in infected individuals and prevent transmission to those who are not infected yet. In trials, lenacapavir showed 100% efficacy in preventing HIV infections. This is why it is describe as "almost a vaccine".

In 2024, Japan also approved Truvada for HIV prevention, but the country has yet to approve lenacapavir for the same. Until now, people in Japan had been importing generic versions of Truvada or purchasing it from clinics that source it from overseas.

HIV In Japan

Up until now, Japan reported around 25,000 HIV infections, whereas 669 new cases were reported in 2023. For seven consecutive years, the number of new infections remained under 1,000. The downward trend thus shows that the virus has been controlled, however, getting to zero new infections remains the ultimate goal.

Brysting too acknowledged that simply having effective drug is not enough. What is important is to have a proper implementation, access and healthcare support to make sure that these treatments are widely available and effective.

What Are The Challenges In Implementation?

The biggest challenges is testing rates. There is a need to increase testing rates. At this very moment, around 86% people infective with Japan have been tested, but the goal is to increase it up to 95%, with an ideal goal of 100%. Without widespread testing, many infected people may not even know that they are infected and it could transmit the virus.

Another measure issue is the cost of preventative medication. While Japan's health insurance covers treatments for diseases, it does not cover preventative drugs. Those who purchase Truvada for prevention, pay around $470 per month. Some clinics in Tokyo offer generic alternatives too, which is cheaper, but they are not ideal.

Better Healthcare Support

Brysting expressed concern that individuals importing medications might not be consulting doctors regularly, which is essential for monitoring HIV status and overall health. Truvada users need to be tested for HIV initially and every three months, along with screenings for other infections and kidney function checks. Without proper medical supervision, there is a risk of misuse and inadequate protection.

Gilead is in discussions with Japanese authorities to improve access and insurance coverage for Truvada, and progress is being made. Japan has shown efficiency in approving critical medicines, as seen during the COVID-19 pandemic when Gilead’s remdesivir was approved in just three days.

What Is The Way Ahead?

Gilead at this moment is not only focused on HIV and hepatitis C, but also expanding into oncology with innovative treatments like CAR-T cell therapy, which strengthens a patient's immune system to fight cancer.

However, Japan’s strict approval processes can slow down drug availability. Phase 3 clinical trials often need to be conducted within the country, and Japan tends to approve medicines much later than other regions. For instance, Truvada was approved for prevention in Japan 12 years after the U.S. and nearly 20 years after its approval for treatment. inancial factors also play a role. The Japanese government adjusts drug prices annually, often reducing them, which can make long-term investment challenging for pharmaceutical companies.

Indian researchers have created the world's most detailed three-dimensional atlas of the human brainstem. This breakthrough could significantly advance research into neurological conditions like Parkinson's disease, sleep disorders, stroke, and Alzheimer's disease.

Developed by researchers at the Sudha Gopalakrishnan Brain Centre at IIT Madras, the atlas is called ANCHOR (Atlas of Neurochemical Characterization of the Human Brainstem with 3D Reconstruction).

It offers an unprecedented view of one of the brain's most vital yet least understood regions. The atlas integrates MRI scans, microscopic tissue imaging, and neurochemical mapping to reveal the brainstem at cellular resolution across prenatal, childhood, and adult stages.

About The Human Brainstem

The brainstem controls all the essential functions that keep us alive, including breathing, heart rate, sleep, consciousness, body temperature, and movement. It also serves as the communication bridge between the brain and the spinal cord.

Dr. Mihail Bota, neuroanatomist at IIT Madras and one of the project's lead researchers, told BBC News, “It's a huge controller of the brain. Without it, it's impossible to live.”

Despite its importance, the brainstem has remained understudied because of its highly complex structure.

According to Prof. Mohanasankar Sivaprakasam, Head of the Sudha Gopalakrishnan Brain Centre, mapping it required overcoming major technological challenges. He also believes the atlas will open the door to many future discoveries.

“The brainstem is very heterogeneous and very densely packed,” Sivaprakasam explained. “To image it properly, digitise it, and then put it all back together is a pretty tough technological and engineering challenge.”

How The Atlas Can Help Study Neurological Diseases Better?

Also read: Long COVID May Be Damaging The Brain's Dopamine System, Major Study Finds

The atlas maps more than 200 tiny brainstem structures, known as nuclei and fibre tracts, allowing researchers to zoom from whole-brain MRI images down to individual brain cells. Experts say this level of detail could help scientists locate exactly which cells and neural circuits are affected in diseases.

One of the key examples is Parkinson's disease, where the degeneration of neurons in a brainstem region called the substantia nigra causes the symptomatic movements.

Researchers believe the atlas can also help understand the damage to the brainstem that occurs with stroke, sleep disorders, Alzheimer's disease, and age-related neurological decline.

“There are so many discoveries waiting to happen,” he said, noting that the research team now plans to expand the project by mapping brains affected by neurological diseases, including stroke, while creating similar atlases across different stages of human development.

A Major Milestone

Independent experts have also celebrated this milestone in neurology. Martin Parent, a neuroscientist at the CERVO Brain Research Center who was not involved in the project, described it as “really important work” because “we don't know that much about the brainstem.”

He added that the newly developed atlas could eventually become an important component in brainstem surgeries and improve the placement of electrodes used in deep-brain stimulation for neurological disorders.

Researchers hope the freely accessible ANCHOR atlas will become a valuable global resource, accelerating discoveries that could ultimately improve diagnosis and treatment of a wide range of brain disorders.

Veteran Republican Senator Lindsey Graham, one of President Donald Trump's closest allies, has died at the age of 71. As per the preliminary findings released by the District of Columbia's medical examiner, he passed away after suffering an aortic dissection.

Lindsey Graham Dies At 71

His office said, “On the evening of Saturday, July 11, Senator Lindsey Graham passed away after a brief and sudden illness. Senator Graham's family appreciates prayers at this time and asks for privacy during this incredibly difficult period.”

Graham was a prominent South Carolina Republican and former Air Force lawyer who served in Congress for more than three decades. He had turned 71 years old just two days before his death.

In a statement on Truth Social, US President Donald Trump wrote: "Melania and I are deeply saddened by the sudden passing of Senator Lindsey Graham. Lindsey was a true American Patriot, one of the best people and Senators I have ever known. He was always there when our Nation needed him, and he gave everything he had to the people of South Carolina and the United States. We will miss him greatly. Our prayers are with his family, friends, and everyone who loved this truly great man."

The preliminary medical examiner’s report later confirmed that the underlying cause was aortic dissection due to arteriosclerotic cardiovascular disease, commonly known as the hardening of the arteries.

According to reports, a final death certificate will be issued after additional toxicological and microscopic testing.

Graham’s passing has sparked discussion about aortic dissection, a rare but extremely dangerous cardiovascular emergency that requires immediate medical treatment.

What Is An Aortic Dissection?

An aortic dissection occurs when a tear develops in the inner layer of the aorta, the body's largest artery that carries blood from the heart to the rest of the body. Blood surges through this tear, forcing the layers of the artery wall apart, effectively “dissecting” them.

When the wall of this aorta tears, blood flow to vital organs can become compromised, and the weakened artery may rupture, often leading to a fatal internal bleeding.

Why Is Aortic Dissection Dangerous?

Cardiologists consider aortic dissection to be one of the most life-threatening cardiovascular emergencies. The condition can rapidly lead to complications like:

• Rupture of the aorta
• Stroke
• Heart attack
• Multiple organ failure
• Sudden death

The risk of death significantly increases if the condition is not diagnosed and treated quickly.

There are several causes of aortic dissection. Major risk factors include hypertension, atherosclerosis, smoking, high cholesterol, connective tissue disorders like Marfan syndrome or Ehlers-Danlos syndrome, congenital abnormalities of the aortic valve or previous heart surgery

In Graham's case, preliminary findings stated that the aortic dissection was caused due to arteriosclerotic cardiovascular disease, indicating that long-term hardening of the arteries likely contributed to the fatal tear.

Also read: Donald Trump Says Physical Checkup At Walter Reed 'Checked Out Perfectly' Amid Recent Health Scrutiny

Symptoms That Should Never Be Ignored

An aortic dissection often begins suddenly. As the symptoms of an aortic dissection can mimic those of a heart attack, immediate medical evaluation is essential. Symptoms may include:

• Pain that spreads to the back, neck, or abdomen
• Shortness of breath
• Fainting
• Sweating
• Weakness or paralysis on one side of the body
• Difficulty speaking
• Weak pulse in one arm compared with the other
• Leg pain or loss of circulation

How To Prevent It?

According to experts, the risk of aortic dissection can be reduced by making several lifestyle changes early on:

• Keeping blood pressure under control
• Managing cholesterol levels
• Quitting smoking
• Maintaining a healthy weight
• Exercising regularly
• Eating a heart-healthy diet
• Treating pre-existing cardiovascular disease
• Undergoing regular screening if there is a family history of aortic disease

For many people with COPD, vigorous exercise can feel impossible because of breathlessness and fatigue. However, a latest study suggests that replacing sedentary time with light physical activity could still have substantial health benefits.

Why People With COPD Should Engage In Light Exercise?

People living with chronic obstructive pulmonary disease (COPD) may not need intense workouts to improve their longevity anymore.

A new study involving more than 800 adults with COPD has found that even light physical activity, like walking, doing household chores, or simply spending less time sitting, was linked to a significantly lower risk of early death.

The findings offer hope for millions of people with COPD, a progressive lung disease that makes breathing difficult, discouraging patients from being physically active. This study highlights an important message for COPD patients: every bit of movement matters.

How Was The Study Conducted?

After analyzing data from more than 800 participants, researchers found that those who spent more time engaged in light-intensity activities had better long-term survival than those who were largely inactive. The association remained even after accounting for factors including age, smoking history, disease severity, and other medical conditions.

"Our findings suggest that even modest increases in light physical activity may improve long-term survival in patients with COPD," the researchers said.

They added that encouraging patients to reduce the amount of time they spend sitting may be a realistic goal, especially for those who are unable to perform moderate or vigorous exercise.

Examples of light physical activity include slow walks around the neighborhood, gardening, light housework, standing while talking on the phone, or taking frequent movement breaks throughout the day. While these activities may seem small, researchers say they can add up to meaningful health benefits over time.

Also read: Who Was Martha Lillard? Last U.S. Polio Survivor To Depend On An Iron Lung Who Breathed Her Last At 78

Staying Active Matters for COPD

COPD, which includes emphysema and chronic bronchitis, is one of the leading causes of illness and death worldwide. The disease gradually damages the lungs, making everyday activities increasingly difficult.

As symptoms worsen, many patients become less active, creating a cycle that can lead to weaker muscles, poorer physical function, and an even greater loss of independence.

The new findings promotes existing recommendations from respiratory health experts, who have always pushed people with COPD to remain as active as their condition safely allows.

Regular movement has been shown to improve muscle strength, reduce breathlessness during daily activities, enhance energy levels, support better sleep, and improve overall quality of life.

"This study reinforces the idea that every movement counts," experts say. Instead of focusing only on structured exercise sessions, patients may benefit from finding simple ways to move more throughout the day.

However, researchers caution that the study found an association rather than proving that light physical activity directly causes longer survival.

For people living with COPD, the takeaway is that improving health does not always require intense workouts. Sometimes, taking a few extra steps, standing up more often, or staying gently active throughout the day may be enough to make a meaningful difference and improve the quality of life.