Japan could become one of the first countries in the world to end the HIV epidemic, says the president of Gilead Sciences Japan, Kennet Brysting. The idea for now could seem a little too ambitious, but it is not entirely unrealistic, given that the availability of medicines that can prevent transmission of HIV. Drugs are not the cure, but control over the spread of virus to the point where the disease is no longer a major public health threat.

What Is The Role Of Preventative HIV Medicines?

Gilead's have two key drugs, Truvada and lenacapavir. These two are playing a crucial role in prevention. Truvada is taken as a daily pill, while lenacapavir requires two injections per year. It can make the virus undetectable in infected individuals and prevent transmission to those who are not infected yet. In trials, lenacapavir showed 100% efficacy in preventing HIV infections. This is why it is describe as "almost a vaccine".

In 2024, Japan also approved Truvada for HIV prevention, but the country has yet to approve lenacapavir for the same. Until now, people in Japan had been importing generic versions of Truvada or purchasing it from clinics that source it from overseas.

HIV In Japan

Up until now, Japan reported around 25,000 HIV infections, whereas 669 new cases were reported in 2023. For seven consecutive years, the number of new infections remained under 1,000. The downward trend thus shows that the virus has been controlled, however, getting to zero new infections remains the ultimate goal.

Brysting too acknowledged that simply having effective drug is not enough. What is important is to have a proper implementation, access and healthcare support to make sure that these treatments are widely available and effective.

What Are The Challenges In Implementation?

The biggest challenges is testing rates. There is a need to increase testing rates. At this very moment, around 86% people infective with Japan have been tested, but the goal is to increase it up to 95%, with an ideal goal of 100%. Without widespread testing, many infected people may not even know that they are infected and it could transmit the virus.

Another measure issue is the cost of preventative medication. While Japan's health insurance covers treatments for diseases, it does not cover preventative drugs. Those who purchase Truvada for prevention, pay around $470 per month. Some clinics in Tokyo offer generic alternatives too, which is cheaper, but they are not ideal.

Better Healthcare Support

Brysting expressed concern that individuals importing medications might not be consulting doctors regularly, which is essential for monitoring HIV status and overall health. Truvada users need to be tested for HIV initially and every three months, along with screenings for other infections and kidney function checks. Without proper medical supervision, there is a risk of misuse and inadequate protection.

Gilead is in discussions with Japanese authorities to improve access and insurance coverage for Truvada, and progress is being made. Japan has shown efficiency in approving critical medicines, as seen during the COVID-19 pandemic when Gilead’s remdesivir was approved in just three days.

What Is The Way Ahead?

Gilead at this moment is not only focused on HIV and hepatitis C, but also expanding into oncology with innovative treatments like CAR-T cell therapy, which strengthens a patient's immune system to fight cancer.

However, Japan’s strict approval processes can slow down drug availability. Phase 3 clinical trials often need to be conducted within the country, and Japan tends to approve medicines much later than other regions. For instance, Truvada was approved for prevention in Japan 12 years after the U.S. and nearly 20 years after its approval for treatment. inancial factors also play a role. The Japanese government adjusts drug prices annually, often reducing them, which can make long-term investment challenging for pharmaceutical companies.

NHS expanded access of a life-extending prostate cancer drug after a campaign ran by a patient and a charity. This drug is abiraterone, which had been available on the NHS in Scotland and Wales since 2023, but now in England and Northern Ireland, except in the most severe cases.

In the UK, the cancer drug is prescribed for patients with prostate cancer at a very advanced stage. However, now, the drug will be available to prostate cancer patients in England on the NHS, even for those where cancer has not metastasized or spread. This could save hundreds of lives.

The assistant director of health improvement at charity Prostate Cancer UK, Amy Rylance said that the decision was "a momentous, life-saving victory for the thousands of men whose lives will not be saved".

The charity estimated that this will enable 7,000 men a year to start their treatment, with around 1,470 cancers being avoided rom getting worse. This could save somewhere around 560 lives.

The drug is soon to be available on NHS England in weeks.

What Is Abiraterone?

As per the Cancer Research UK, abiraterone is a hormone therapy drug. The Prostate Cancer UK notes that this is most commonly offered to men whose cancer has stopped responding to other types of cancer drugs.

As per Mayo Clinic, it is used in combination with prednisone to treat patients with metastatic castration-resistant prostate cancer and metastatic high risk castration-sensitive prostate cancer. This medicine is only available on doctor's prescription and is available as a tablet.

What Is Prostate Cancer?

The prostate is a small walnut-shaped gland in men that produces seminal fluid that nourishes and transports sperm. It occurs when abnormal cells form and grow in that gland.

Experts say that not all prostate cancer is deadly. There are cancers that are slow-growing and will not affect a man's lifespan, which is found in 1 in 3 men over 50. Then there is a small number of very aggressive prostate cancers which move quickly and cause harm, this is why regular screening is important.

Read: Olympic Cyclist Sir Chris Hoy Shares His Diagnosis Of Prostate Cancer From A Common Shoulder Pain

Are There Any Tests For Prostate Cancer?

In the UK, there is no prostate cancer screening programme like those for breast, bowel and cervical cancer. The onus is therefore on men to request a blood test from their general practitioner once they are over 50. When not aware, it can become life-threatening as it did for Sir Chris Hoy, the six-time Olympic cyclist, who opened up on his diagnosis of the same through a shoulder pain last year.

Despite more men dying from prostate cancer than women from breast cancer, as per BBC, there are no reliable tests for this. The blood test that men over 50 request from their general practitioner measure prostate-specific antigen (PSA), released by the prostate, a small gland located below the bladder involved in the production of semen.

However, experts say that PSA levels can be high for many other reasons too, including enlarged prostate, inflammation, infection, recent vigorous exercise or sex.

The latest vaccine recommendation are confusing, children should not be dying because of such ambiguity, say experts. Doctors have noted that the recent vaccine recommendation which removed four vaccines, including influenza vaccine from recommended shots compulsory for children is giving mixed signals. This is at the time when the country has reached record-breaking rates of illness and hospitals are struggling to keep up with the surge of flu patients.

Seema Lakdawala, associate professor of microbiology and immunology at Emory School of Medicine, as reported by The Guardian said, "We are in the midst of a very severe flu season". However, she pointed, despite this, the US has dismantled many of its vaccine recommendation, now the flu vaccine must have a "shared clinical decision-making".

While the secretary of the US Department of Health and Human Services and vaccine critic Robert F Kennedy Jr told CBS News "that's a better thing" upon being asked if these new restrictions would mean fewer children getting vaccination against the flu. However, doctors say otherwise. Mehmet Oz, administrator for the Centers for Medicare & Medicaid Services also said, "Every year, there is a flu vaccine. It does not always work very well. That's why it's been controversial of late". Instead, Oz told Newsmax that Americans must "take care" of themselves, so they can "overwhelm" the flu when they encounter it.

While the Centers for Disease Control and Prevention (CDC)'s press statement reads: "the decision to vaccinate is a personal one”. The press statement has asked people to consult their GPs and doctors and understand the "potential risks and benefits associated with vaccines".

Also Read: Flu Symptoms In Kids Could Be Deadly, Doctors Say Shot Is Still The Best Protection

What Are Experts Saying On CDC's Latest Vaccine Recommendation?

Megan Berman, professor of internal medicine at the University of Texas Medical Branch, and faculty with the Sealy Institute for Vaccine Sciences told The Guardian, that vaccine rates have already gone down and with these new changes, it will further dampen the vaccination rates because it "gives the message that it is not important". Yet, "nothing has changed from the science, and I know that physicians are still strongly recommending it to everyone six months and older...Children should not be dying from a preventable illness".

Dr. Yvonne Maldonado, a pediatric infectious disease epidemiologist and professor at Stanford University, told TODAY.com, “It’s more than unfortunate; it's tragic," for the CDC to change its flu shot guidance for kids. “(Flu shots) probably are the most effective intervention in the last 100 years to reduce child deaths in this country.”

Experts have warned that the new guidance creates confusion, which could lead to fewer children getting vaccinated. However, doctors time and again have said that the best line of defense remains to be the flu shots. Dr Pedro Piedra, professor of molecular virology and pediatrics at Baylor College of Medicine told Today.com, "There is plenty of data showing the effectiveness... of the influenza vaccine in children." The CDC website also states that the "flu vaccine can prevent severe, life-threatening complications in children."

At a press conference in September 2025, President Donald Trump announced of a connection between the use of Tylenol, a popular pain medicine during pregnancy and autism. The active ingredient acetaminophen, while, many studies, have shown does not have any link with childhood autism if consumed during pregnancy. However, Trump insisted that "They", [read the FDA], "are strongly recommending that women limit Tylenol use during pregnancy unless medically necessary...if you cannot tough it out..."

However, a scientific review of 43 studies on acetaminophen use during pregnancy concluded that there was no evidence that the painkiller increased the risk of autism or any other neurodevelopmental disorders.

The lead author of the report, Dr Asma Khalil, professor of obstetrics and maternal fetal medicine at St George's Hospital, University of London, in a news briefing said, "We found no clinically important increase in the risk of autism, ADHD, or intellectual disability." The findings were published on Friday in British medical journal The Lancet.

Dr Khalil said that acetaminophen, which is an active ingredient in Tylenol, remains "the first line treatment that we would recommend if the pregnant women have pain or fever in pregnancy".

Read: Tylenol And Autism: Trump Announces Link Between The Two, Science Does Not Back Him

What Have Earlier Studies Said About Tylenol Use And Autism?

Earlier studies too, including one of which is published in American Family Physician in 2014 also noted that during pregnancy most people used acetaminophen, sold under the brand name Tylenol. Acetaminophen is considered the one safe over-the-counter option for pain or fever for pregnant people. Other common pain relief options like ibuprofen or regular-dose-aspirin is available, however, they can pose serious risk in pregnancy and could lead to complications.

2024 study published in JAMA Network, titled Acetaminophen Use During Pregnancy and Children’s Risk of Autism, ADHD, and Intellectual Disability, there is no risk of autism for mothers who consume the medicine during pregnancy. The study notes: "Acetaminophen use during pregnancy was not associated with children’s risk of autism, ADHD, or intellectual disability in sibling control analyses."

James Cusack, chief executive of Autistica, a UK autism research and campaigning charity in London, who is autistic told Nature: "There is no definitive evidence to suggest that paracetamol use in mothers is a cause of autism, and when you see any associations, they are very, very small. At the heart of this is people trying to look for simple answers to complex solutions.”

Read More: Trump's Claim On Linking Tylenol And Autism Is Unscientific, According To Doctors

Helen Tager-Flusberg, a psychologist who studies autism at Boston University, Massachusetts told Nature, "he better controlled studies are less likely to find even a small risk. And even then, what we're talking about is a minor association. … We do not think that taking acetaminophen is in any way contributing to actually causing autism.”

A study led by Viktor Ahlqvist, an epidemiologist at the Karolinska Institute in Stockholm (mentioned above, published in JAMA Network) is considered one of the biggest studies in this subject have also found no such link.

Ahlqvist’s team analyzed data from nearly 2.5 million children born in Sweden between 1995 and 2019, drawing from the nation’s detailed health records. These included acetaminophen prescriptions during pregnancy, self-reported use collected by midwives, and later autism diagnoses in children.

The findings showed autism in about 1.42% of children exposed to acetaminophen prenatally, compared to 1.33% among those not exposed, a difference Ahlqvist described as “very small.”

Medical Institutions Rejected Trump's Tylenol And Autism Claim: Why Is This Medicine Recommended To Pregnant Women Over Other Painkillers?

Medical bodies across the world, including the American College of Obstetricians and Gynecologists, were quick to push back against the president’s remarks. They stressed that doctors already advise pregnant women to use acetaminophen carefully and warned that leaving a fever untreated during pregnancy can pose serious risks to both the mother and the baby.

Because acetaminophen can enter the brain and cross the placenta, researchers have been studying its potential impact on fetal brain development for over a decade. However, reaching clear conclusions has proved challenging.

One major reason is the ethical limits on research involving pregnant women. Randomized controlled trials, considered the gold standard in medical science, have not been carried out in this case, making it harder to establish cause-and-effect relationships.

Another complication is how commonly acetaminophen is used. Many other painkillers are known to be harmful during pregnancy, which is why acetaminophen has long been recommended as the safest first option. Its over-the-counter availability also makes it difficult for researchers to accurately track how much is taken, how often, and at what stage of pregnancy.