Japan could become one of the first countries in the world to end the HIV epidemic, says the president of Gilead Sciences Japan, Kennet Brysting. The idea for now could seem a little too ambitious, but it is not entirely unrealistic, given that the availability of medicines that can prevent transmission of HIV. Drugs are not the cure, but control over the spread of virus to the point where the disease is no longer a major public health threat.

What Is The Role Of Preventative HIV Medicines?

Gilead's have two key drugs, Truvada and lenacapavir. These two are playing a crucial role in prevention. Truvada is taken as a daily pill, while lenacapavir requires two injections per year. It can make the virus undetectable in infected individuals and prevent transmission to those who are not infected yet. In trials, lenacapavir showed 100% efficacy in preventing HIV infections. This is why it is describe as "almost a vaccine".

In 2024, Japan also approved Truvada for HIV prevention, but the country has yet to approve lenacapavir for the same. Until now, people in Japan had been importing generic versions of Truvada or purchasing it from clinics that source it from overseas.

HIV In Japan

Up until now, Japan reported around 25,000 HIV infections, whereas 669 new cases were reported in 2023. For seven consecutive years, the number of new infections remained under 1,000. The downward trend thus shows that the virus has been controlled, however, getting to zero new infections remains the ultimate goal.

Brysting too acknowledged that simply having effective drug is not enough. What is important is to have a proper implementation, access and healthcare support to make sure that these treatments are widely available and effective.

What Are The Challenges In Implementation?

The biggest challenges is testing rates. There is a need to increase testing rates. At this very moment, around 86% people infective with Japan have been tested, but the goal is to increase it up to 95%, with an ideal goal of 100%. Without widespread testing, many infected people may not even know that they are infected and it could transmit the virus.

Another measure issue is the cost of preventative medication. While Japan's health insurance covers treatments for diseases, it does not cover preventative drugs. Those who purchase Truvada for prevention, pay around $470 per month. Some clinics in Tokyo offer generic alternatives too, which is cheaper, but they are not ideal.

Better Healthcare Support

Brysting expressed concern that individuals importing medications might not be consulting doctors regularly, which is essential for monitoring HIV status and overall health. Truvada users need to be tested for HIV initially and every three months, along with screenings for other infections and kidney function checks. Without proper medical supervision, there is a risk of misuse and inadequate protection.

Gilead is in discussions with Japanese authorities to improve access and insurance coverage for Truvada, and progress is being made. Japan has shown efficiency in approving critical medicines, as seen during the COVID-19 pandemic when Gilead’s remdesivir was approved in just three days.

What Is The Way Ahead?

Gilead at this moment is not only focused on HIV and hepatitis C, but also expanding into oncology with innovative treatments like CAR-T cell therapy, which strengthens a patient's immune system to fight cancer.

However, Japan’s strict approval processes can slow down drug availability. Phase 3 clinical trials often need to be conducted within the country, and Japan tends to approve medicines much later than other regions. For instance, Truvada was approved for prevention in Japan 12 years after the U.S. and nearly 20 years after its approval for treatment. inancial factors also play a role. The Japanese government adjusts drug prices annually, often reducing them, which can make long-term investment challenging for pharmaceutical companies.

The two legendary German twins, Alice and Ellen Kessler, the greatest of entertainers, who rose to fame in the post war era died at the age of 89. They truly were inseparable, as they chose to leave the world in the same way they came, together. The sisters chose medically assisted dying on November 17, as reported by the German newspaper Bild.

The twin had shared that they "no longer wanted to live" and the decision to die together was made together with clarity and intention.

How Does Assisted Dying Work?

In terms of the Kessler Sisters, the police confirmed that there were no signs of foul play. The German Society for Humane Dying also stated that the sisters had chosen assisted suicide. This practice is legal in the country since 2019.

Read: Uruguay Becomes The First Catholic Latin American Country To Legalize Euthanasia

How Is Assisted Dying Different Than Euthanasia?

In assisting dying, the law allows and enables the individuals to self-administer the medication, so the choice and the agency to die remains with the individuals.

What Is Assisted Dying?

This refers to the practice of ending a person's life through medication. However, when the term 'dying' is replaced by 'suicide', the medication is then administered by self, whereas in other procedures, it may be done by a medical professional. Thus the term 'assisted dying' refers to both assisted suicide and euthanasia.

In assisted suicide, the person's will to die matters, and it may not require a terminal diagnosis. However, this definition to varies from country to country.

Also Read: Can Right To Die Be Practiced By Non-Terminally Ill Patients?

In many ways can assisted suicide be practiced including providing lethal medication, or helping the individual travel to another jurisdiction to die.

What Does The Law In Germany Say About Assisted Suicide?

In 2020, Germany's Federal Constitutional Court determined that individual autonomy should include the choice to die. This means that every person could decide for themselves. The law has a wider scope, which also includes any person helping an individual who has chosen to end their life, and they cannot be penalized for doing so. However, this condition only comes from the person who wants to end their life, and the decision must be taken freely.

The debate was introduced in 2015 due to the section 271 of the criminal code, which made assisted suicide almost impossible in Germany. The law stated that anyone who aided someone to take their own life could be jailed for up to three years.

Palliative sedation is administered to prevent suffering and ensure a dignified death. However, medication aims to relieve patients of unbearable pain, this is why its use as an alternative medically assisted suicide raises concerns. Currently, there is no approved medication for medically assisted suicide in Germany. though several medications are could be used, for instance in the United States, severely ill patients receive high doses of sodium pentobarbital and thiopental. However, pentobarbital is only approved for veterinary use in Germany.

In Germany, the intravenous route is often chosen, where the medication is administered through IV, and the patient must be the one opening the infusion. Doctors can assist but should not be directly involved in the act.

Every year on November 19, World COPD Day is organized to raise awareness, share knowledge and discuss ways to reduce the burden of COPD worldwide. COPD stands for Chronic Obstructive Pulmonary Disease, and as per the World Health Organization (WHO), it is the fourth leading cause of death worldwide and has caused 3.5 million deaths in 2021 alone, of the 213 million people who were diagnosed with it. Projections indicate that the number of cases will increase to nearly 600 million by 2050, with a disproportionate rise expected among women and in low-and middle-income countries.

World COPD Day 2025 Theme

The theme for World COPD Day 2025 is 'Short of Breath, Think COPD'.

This year’s theme highlights a crucial issue: despite being the third leading cause of death globally, COPD is still widely overlooked and often misdiagnosed. Although it is a common, preventable, and treatable condition, many patients either remain undiagnosed or receive the wrong treatment. Early and accurate diagnosis can make a major public health difference, leading to better symptom control, improved lung function, and a higher quality of life.

Doctors stress that COPD should be suspected in anyone with persistent breathlessness, chronic cough, sputum production, recurrent lower respiratory infections, or a history of exposure to risk factors such as tobacco smoke, indoor cooking fuels, or occupational pollutants.

World COPD Day Origin

World COPD Day was launched in 2002 by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) in partnership with the WHO. The first event marked a turning point in global respiratory health awareness, encouraging collaboration across continents.

Importance Of World COPD Day

The importance lies in its ability to draw attention to one of the top causes of deaths worldwide. Furthermore, this day promotes awareness by educating the public about COPD symptoms, persistent cough, breathlessness, and chest tightness, which may be mistaken as symptoms of normal aging.

It also encourages prevention of COPD, especially by emphasizing on quitting smoking, improving air quality, and reducing workplace exposures that contribute to COPD.

It also helps in the improvement of healthcare access, supports research and innovation by encouraging collaborations, and reduces stigma by helping patients overcome psychological barrier and seek timely help.

What Is COPD?

As per NHS UK, it is the name for a group of lung conditions that cause breathing difficulties. It includes:

• emphysema – damage to the air sacs in the lungs
• chronic bronchitis – long-term inflammation of the airways

COPD is a common condition that mainly affects middle-aged or older adults who smoke. Many people do not realize they have it.

The breathing problems tend to get gradually worse over time and can limit your normal activities, although treatment can help keep the condition under control.

Common Symptoms of COPD

• shortness of breath, particularly when you're active
• a persistent chesty cough with phlegm – some people may dismiss this as just a "smoker's cough"
• frequent chest infections
• persistent wheezing

Talking about things makes you feel better, and the Thor star Chris Hemsworth is right at it. Now 42, he is opening up about his father, Craig's diagnosis of Alzheimer's and have seen the corrosive effects on his memory and perception already. He is now making the best of it, by having it all documented on film. While he was in the middle of making National Geographic longevity series Limitless, he learned that he too carried two copies of the Alzheimer's signifying gene APOE4, one from each parent. Back then he confronted this on camera, while on shoot, and this feels like a great idea for him to do it again on A Road Trip To Remember, an hour-long documentary that will air on NatGeo.

“There was apprehension about how this would be portrayed,” Hemsworth admits. “I asked Dad what he felt, and he was actually enthusiastic. He wanted to do it.”

The Australian actor is now taking steps to stay mentally and physically fit, especially after knowing that he is predisposed for Alzheimer's disease.

Living With More Awareness Now

Chris, who shares three children with wife Elsa Pataky, says his father's struggles have made him reflect deeply on how he lives. Some hardships in life, he notes, simply can’t be avoided.

“For me, the biggest takeaway was the comfort crisis we face,” he says, as reported in Esquire. “We settle for what’s familiar, even when it’s wrong, because the unknown feels scarier. But pushing against that is where growth happens.”

His father’s reaction to the diagnosis has also taught him that even a grim prognosis can be approached with courage. “It causes fear, but it’s also a reminder not to take anything for granted,” Hemsworth says. “While he can, Dad wants to capture as many memories as possible.”

A Trip Down The Memory Lane

At the time of filming, Craig’s symptoms were sporadic—some memory lapses, moments of confusion, but overall lucidity remained. Alzheimer’s, however, does not improve with time. Knowing this, the father-son duo set out on a cross-country motorbike trip across Australia.

They retraced old memories:

• A house in Melbourne where the family lived in the early ’90s
• A Northern Territory ranch where Craig once wrangled bulls
• A specific bend in an Outback creek where the family played when the boys—Chris, Luke, and Liam—were small

Guided only by a fading photograph and half-recalled memories, they attempted to reconnect with moments that shaped their family’s early years.

The documentary also explores reminiscence therapy, guided by Dr. Suraj Samtani from the Centre for Healthy Brain Ageing at the University of Sydney. The technique uses personal memories, photos, and familiar environments to stimulate the hippocampus, the part of the brain most affected by Alzheimer’s.

“One-on-one time with Dad was special,” Chris says. “Growing up, it was always all of us together.”

For Hemsworth, the experience has made one truth clear: the importance of connection.

“It became less about the science and more about the moments together,” he says. “Whether it’s 20 years or 20 days, hold on to every moment. Connect deeply, as often as you can.”