Japan could become one of the first countries in the world to end the HIV epidemic, says the president of Gilead Sciences Japan, Kennet Brysting. The idea for now could seem a little too ambitious, but it is not entirely unrealistic, given that the availability of medicines that can prevent transmission of HIV. Drugs are not the cure, but control over the spread of virus to the point where the disease is no longer a major public health threat.

What Is The Role Of Preventative HIV Medicines?

Gilead's have two key drugs, Truvada and lenacapavir. These two are playing a crucial role in prevention. Truvada is taken as a daily pill, while lenacapavir requires two injections per year. It can make the virus undetectable in infected individuals and prevent transmission to those who are not infected yet. In trials, lenacapavir showed 100% efficacy in preventing HIV infections. This is why it is describe as "almost a vaccine".

In 2024, Japan also approved Truvada for HIV prevention, but the country has yet to approve lenacapavir for the same. Until now, people in Japan had been importing generic versions of Truvada or purchasing it from clinics that source it from overseas.

HIV In Japan

Up until now, Japan reported around 25,000 HIV infections, whereas 669 new cases were reported in 2023. For seven consecutive years, the number of new infections remained under 1,000. The downward trend thus shows that the virus has been controlled, however, getting to zero new infections remains the ultimate goal.

Brysting too acknowledged that simply having effective drug is not enough. What is important is to have a proper implementation, access and healthcare support to make sure that these treatments are widely available and effective.

What Are The Challenges In Implementation?

The biggest challenges is testing rates. There is a need to increase testing rates. At this very moment, around 86% people infective with Japan have been tested, but the goal is to increase it up to 95%, with an ideal goal of 100%. Without widespread testing, many infected people may not even know that they are infected and it could transmit the virus.

Another measure issue is the cost of preventative medication. While Japan's health insurance covers treatments for diseases, it does not cover preventative drugs. Those who purchase Truvada for prevention, pay around $470 per month. Some clinics in Tokyo offer generic alternatives too, which is cheaper, but they are not ideal.

Better Healthcare Support

Brysting expressed concern that individuals importing medications might not be consulting doctors regularly, which is essential for monitoring HIV status and overall health. Truvada users need to be tested for HIV initially and every three months, along with screenings for other infections and kidney function checks. Without proper medical supervision, there is a risk of misuse and inadequate protection.

Gilead is in discussions with Japanese authorities to improve access and insurance coverage for Truvada, and progress is being made. Japan has shown efficiency in approving critical medicines, as seen during the COVID-19 pandemic when Gilead’s remdesivir was approved in just three days.

What Is The Way Ahead?

Gilead at this moment is not only focused on HIV and hepatitis C, but also expanding into oncology with innovative treatments like CAR-T cell therapy, which strengthens a patient's immune system to fight cancer.

However, Japan’s strict approval processes can slow down drug availability. Phase 3 clinical trials often need to be conducted within the country, and Japan tends to approve medicines much later than other regions. For instance, Truvada was approved for prevention in Japan 12 years after the U.S. and nearly 20 years after its approval for treatment. inancial factors also play a role. The Japanese government adjusts drug prices annually, often reducing them, which can make long-term investment challenging for pharmaceutical companies.

A team of scientists at South Africa’s National Institute for Communicable Diseases has identified the strain of the Hantavirus that has caused three deaths and infected seven so far aboard the MV Hondius ship in the Atlantic Ocean.

In a presentation to the parliament today, the South African Health Minister revealed that the Andes strain of hantavirus, which spreads human-to-human, has been identified in two people who came off the cruise ship.

“Incredible work of @nicd_sa, South Africa, in sequencing the #hantavirus. There has been excellent collaboration as @WHO

works to coordinate efforts and actions of governments, experts around the world, the Ship to keep people safe,” said Dr. Maria Van Kerkhove, director of epidemic and pandemic preparedness and prevention at the World Health Organization (WHO), in a post on social media platform X.

The NICD scientists found that the Andes strain was the cause of infection in a Dutch woman who died in Johannesburg, and a British man who is still in hospital. Both had become ill on the ship, Reuters reported.

“This is the only strain that is known to cause human-to-human transmission, but such transmission is very rare and, as said earlier, only happens due to very close contact,” the Minister said.

Other strains of hantavirus are more commonly transmitted to humans through contact with infected rodents or their urine, droppings, or saliva.

Also read: Hantavirus Outbreak: WHO Flags 6 Suspected Cases; How The Rare Rodent-Borne Virus Spreads

What is Hantavirus? How Deadly Is The Andes Strain?

As per the WHO, hantaviruses are zoonotic viruses that naturally infect rodents and are occasionally transmitted to humans.

Globally, an estimated 100,000 to 200,000 hantavirus infections occur each year. The majority of these cases are in Asia, particularly China. Most are sporadic or occur in small clusters, linked to contact with infected rodents.

“Hantaviruses are a group of viruses carried by rodents that can cause severe disease in humans. Infection with hantaviruses is found in many parts of the world. Thousands of infections are estimated to occur each year," Van Kerkhove said.

The Ande virus is the only strain of virus with documented human-to-human transmission. It is more common in South America.

"Although uncommon, limited human‑to‑human transmission of HPS due to the Andes virus has been reported in community settings involving close and prolonged contact. Secondary infections among healthcare workers have been previously documented in healthcare facilities, though they remain rare,” WHO said in its situation report.

The WHO also currently assesses the risk to the global population from this event as low and will continue to monitor the epidemiological situation and update the risk assessment as more information becomes available.

"People really do need to understand that there are different degrees of person-to-person transmission," said Angela Rasmussen, a virologist with the University of Saskatchewan's Vaccine and Infectious Disease Organization, as quoted by CBS News.

Read More: Hantavirus on Cruise Ship: Symptoms, Risks, and Prevention

In the case of hantavirus, individual people are usually the end of the line, Rasmussen said, noting that this makes this cluster of cases unusual.

"So this virus — right now anyways — doesn't seem to be as big a risk as something like flu," the expert said.

While symptoms might not appear for weeks, the strain can escalate quickly, leading to severe respiratory failure with a death rate of roughly 40 per cent.

Long day at work? Let's order in. Not feeling happy? How about a cheat meal! And so on - nowadays, the concept of cooking for oneself seems to have become outdated. But little do we realise that these ordering-in habits can cost you a great deal later - it turns out these can speed up ageing. And it does not end here; eating takeaway food regularly can take away months of your life, and even undo all the health benefits of regular exercise. Researchers at the Peking University Third Hospital in China studied 43,000 adults in the UK to come to this conclusion.

How does eating takeaway food affect health?

Researchers conducted blood tests on people who regularly eat takeaway food. They found that their biological age was about three months ahead compared to people who ate home-cooked food. This means that their kidney, liver and immune systems were getting worse at a faster rate than usual. Researchers said that treating yourself to junk food every day could undo the benefits of regular workouts, too. Over the years, these effects could knock off months from your life.

The study, which was published in the BMC Medicine journal, also noted that the three-month difference in biological ageing, driven by dietary habits, might appear insignificant, but it translates to about a 2.2 to 2.7 per cent increase in early death risk. Over time, this can account for 16 per cent of the severe ageing caused by smoking. Some of the effects, as per experts, were linked to obesity and weight gain. However, people's health was worse even if they were not fat. Some of the effects were because of the weight gain and obesity link, but in the case of some participants, the effects were worse, even when they were not fat.

Why is takeaway food discouraged?

The study shows that takeaway food is harmful because of its high fat, salt, sugar and calorie content. But more importantly, it is about the absence of nutrients like fibre and protein. These foods are more likely to be eaten quickly and alone, without paying much attention to the poor quality of ingredients used. To make matters worse, plastic packaging contains harmful chemicals like PFAS - upon heating, these can release cancer-causing components. Researchers said that these factors could be associated with inflammation in blood vessels, a dip in levels of healthy gut bacteria, and a heightened risk of heart disease or type-2 diabetes.

Experts noted that the effects in terms of accelerated ageing and regular consumption of junk food can cancel the benefits of even regular workouts.

In yet another milestone in India’s digital healthcare, the government has launched the Swasth Bharat Portal, which aims to bring together the fragmented health systems in the country.

The portal, unveiled during the recent 10th National Summit on Innovation and Inclusivity by Union Minister for Health and Family Welfare JP Nadda, signifies a decisive shift towards a more integrated, efficient, and scalable digital public health architecture.

The portal aims to enable seamless integration with the Ayushman Bharat Digital Mission (ABDM) and support the exchange of patient records through the ABHA health account system.

What Is The Swasth Bharat Portal?

The Swasth Bharat Portal has been conceptualized as an aggregator platform that integrates existing program systems through an API-based federated architecture.

It enables interoperability and convergence, creating a unified digital layer across programs.

It is a one-stop integrated platform that brings multiple national health programs onto a single interface.

It eliminates the need for multiple logins and repetitive data entry, and significantly reduces the administrative burden on healthcare providers while enhancing efficiency at all levels.

The portal also provides a single platform for easy access, along with data visualisation tools and the use of data at the local level for monitoring and evidence-based planning.

It is ABDM-compliant and supports integration with ABHA (Ayushman Bharat Health Account), enabling seamless and secure exchange of patient health records.

It is designed to evolve into a comprehensive and interoperable digital health ecosystem, further integrating with national registries such as the Healthcare Professionals Registry (HPR) and Health Facility Registry (HFR).

Also read: India AI Summit: Union Health Minister Nadda Launches SAHI And BODH Initiatives To Boost AI In Healthcare

How Swasth Bharat Portal Will Boost Healthcare

The new portal will help:

• Reduce infrastructure duplication by 20–30 per cent: Independent hosting, storage, and compute resources are maintained across programs, which will be reduced when they are aggregated through Swasth Bharat

• Reduce Repetitive Data Entry: Similar beneficiary data that was entered across multiple systems will be entered on a single platform, thus reducing repetitive tasks by ~20–40 per cent.

• Unify HR Deployment: Separate development and maintenance teams are required in all programs; a unified system will reduce the HR burden and reduce duplication by ~20–40 per cent.

• Increase Interoperability: As the system is designed on a federated architecture via APIs, the interoperability will be higher.

Read More: Medical Miracle: World First Frozen Testicular Implant Gives ‘Infertile’ UK Man Hope of Fatherhood

The Swasth Bharat portal will also lead to substantial government savings both in terms of human resources, time, and IT infrastructure as compared to the current individual portals being managed by different program divisions, the Health Ministry said.

Further, the portal enables a shift towards an integrated, efficient, and scalable digital public infrastructure with significant efficiency gains.

The Swasth Bharat Portal thus represents a transformative step towards convergence, efficiency, and data-driven governance in India’s public health system.