Is 'Sticky Gunk' In Your Brain The Reason Behind Alzheimer's Disease?

Updated Mar 20, 2025 | 08:53 AM IST

SummaryThe new findings is based on a subset of 22 participants who received amyloid-removing drugs the longest, on average eight years.
Alzheimer's Disease

Credits: Canva

An experimental treatment happens to be the solution to delay Alzheimer's symptoms in some people. These people are the ones who are genetically destined to get the disease in their 40s or 50s. These new findings form ongoing research has now been caught up in Trump administration funding delas. The early results of the study has been published on Wednesday and the participants too are worried that politics could cut their access to a possible lifeline.

One of the participants had said, "It is still a study but it has given me an extension to my life that I never banked on having." The participant is named Jake Henrichs, form New York City, who is 50 years old. He is one of them to be treated in that study for more than a decade now and has remained symptom-free despite inheriting an Alzheimer's-causing gene that had killed his father and brother around the same age.

Slowing Down The Symptoms

Two drugs which can modestly slow down early-stage Alzheimer's are sold in the United States. These drugs clear the brain of one of its hallmarks, a sticky gunk-like part called the amyloid. However, there have not been any hints that removing amyloid far earlier, way many years before the first symptoms appear, may postpone the disease.

How Was The Research Conducted?

The research is led by Washington University in St Louis, which involved families that passed down rare gene mutation as participants. This meant it was almost guaranteed that they will develop symptoms at the same age their affected relatives did.

The new findings is based on a subset of 22 participants who received amyloid-removing drugs the longest, on average eight years. Long-term amyloid removal cut in half their risk of symptom onset. The study is published in the journal Lancet Neurology.

Washington University's Dr Randall Bateman, who directs the Dominantly Inherited Alzheimer's Network of studies involving families with these rare genes says, "What we want to determine over the next five years is how strong is the protection. Will they ever get the symptoms of Alzheimer’s disease if we keep treating them?”

The researchers before though did not know what exactly caused Alzheimer's which affects nearly 7 million Americans, most of them in their later life. However, it is clear that these silent changes occur in the brain at least two decades before the first symptom shows up. The big contributor. At some point amyloid buildup can trigger a protein named tau that then starts to kill neurons, which can lead to cognitive decline.

Researchers are now thus studying the Tau-fighting drugs and are looking into other factors, like inflammation, brain's immune cells and certain virus.

The National Institute of Health (NIH) has expanded its focus as researchers have found more reasons for Alzheimer's. In 2013, the NIH's National Institute on Aging funded 14 trials of possible Alzheimer's drugs over a third targeting amyloid. By last fall, there were 68 drugs and 18% of them target amyloid. However, there are scientists too who think that amyloid is not everything and their is way more in the brain tissue, immune cells, and more which can be studied.

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British Woman Gives Birth After Rare Womb Transplant Surgery

Updated Feb 25, 2026 | 03:51 PM IST

SummaryWeighing merely 3.09kg (6lb 13oz), Hugo Powell was born to Grace Bell and Steve Powell from Kent, right before Christmas 2025. Bell was born with Mayer-Rokitansky-Kuster-Hauser (MRKH), a disorder that causes the vagina and uterus to be underdeveloped or absent. MRKH syndrome is also called:
British Woman Gives Birth After Rare Womb Transplant Surgery

Credit: PA Media

For the first time, a baby boy has been born to a mother with a womb transplanted from a deceased donor at Queen Charlotte’s and Chelsea hospital in London.

Weighing merely 3.09kg (6lb 13oz), Hugo Powell was born to Grace Bell and Steve Powell from Kent, right before Christmas 2025. "It's simply a miracle. I never, ever thought that this would be possible," Bell said. "I'm the happiest I've ever been in my life. When I was 16, I was told that this would never be possible," she said of her son's birth.

The father added: "When he came over the curtain, it was just sort of overwhelming emotions. I felt like I wanted to cry, but couldn't. From where we started - first meeting - to where we are today, with Hugo, is nothing short of a miracle after everything we've been through. It just felt quite unreal at the time, because this has been a long journey for us both."

The couple also paid tribute to the "kindness and selflessness" of their transplant donor and her family for their "incredible gift", while also thanking medical teams in Oxford and London who supported their journey.

"There are no words to say thank you enough to my donor and her family. Their kindness and selflessness to a complete stranger is the reason I have been able to fulfil my lifelong dream of being a mum.

"I hope they know that my child will always know of their incredible gift, and the miracle that brought him into this world," Bell said.

What Is Mayer-Rokitansky-Kuster-Hauser Disorder?

Bell, an IT programme manager, was born with Mayer-Rokitansky-Kuster-Hauser (MRKH), a disorder that causes the vagina and uterus to be underdeveloped or absent. MRKH syndrome is also called:

  • Müllerian agenesis
  • Müllerian aplasia
  • Congenital absence of the uterus and vagina
  • Rokitansky syndrome
Without a uterus, the affected women do not have menstrual periods. Often, the first noticeable sign of MRKH syndrome is that menstruation does not begin by age 15 (primary amenorrhea).

While women with MRKH syndrome have normal external genitalia, functioning ovaries, breast and pubic hair development, they are unable to carry a pregnancy and rely on either surrogacy or a womb transplant, as in the case of Bell.

There are two versions of the disorder:

  • Type 1: The patient has normally functioning ovaries and fallopian tubes but a blocked or missing upper vagina, cervix and uterus. No other organs are affected.
  • Type 2: The patient has a blocked or missing upper vagina, cervix and uterus as well as issues with ovaries, fallopian tubes, spine, kidneys or other organs.
Researchers are yet to determine a cause for the disorder. Originally, scientists suspected that MRKH syndrome was caused by environmental factors during pregnancy, such as medication or maternal illness, however certain studies suggest that genetic changes can pave the way for the disorder to develop in women.

However, these genetic changes have been found in only a small number of affected people and subsequent studies have not identified a clear association between MRKH syndrome and any specific environmental factors. It remains unclears whether they actually cause MRKH syndrome.

Treatment for MRKH depends on the patient's goals and symptoms and some options include:

  • Vaginal dilators: Dilators are made of plastic or silicone and vary in length and width. These tubelike devices help expand and stretch the inside of the vagina.
  • Vaginoplasty: This is a surgical procedure to create a vagina. There are several ways surgeons perform vaginoplasty, but most involve creating a hole and lining it with tissue from another part of your body.
  • Uterus transplant: This is a major surgery that involves placing a donor uterus inside someone without a uterus. Uterine transplants give people with MRKH an opportunity to carry and deliver a child. Uterus transplants are rare.

How Did Bell Conceive Her Child?

Recalling her initial diagnosis, Bell said: "About 16 years ago, I was diagnosed with MRKH. It was a tough journey. I must admit, a very sad journey. I remember the story of the first womb transplant in Sweden, many years ago now, and following that story intently.

"I still can't believe that I'm here today and I've gone through this. It's just amazing."

At the age of 16, the new mother was told she wouldn't be able to carry her own child. However, in 2024 she received a phone call saying a womb had been donated and a transplant was possible, a moment she recalls left her "in complete shock" and "really excited".

Bell's womb transplant operation lasted 10 hours and took place at The Churchill Hospital in Oxford in June 2024 After her transplant surgery, she began fertility treatments several months after the transplant in 2024 and her son was born a year later.

According to The Guardian, Bell's transplanted womb will be removed when the couple have finished having children, to save her from a lifetime of taking immunosuppressant drugs.

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Indore Food Contamination: 6 People Hospitalized In Bhagirathpura

Updated Feb 25, 2026 | 08:11 PM IST

SummarySix hospitalized after contaminated food at Indore Bhagirathpura party, area earlier hit by deadly water contamination linked to sewage mixing. Bacteria including E coli involved. Officials investigating infrastructure lapses; patients stable after treatment and monitoring.
Indore Food Contamination: 6 People Hospitalized In Bhagirathpura

Credits: Canva

Not too long ago, Indore made headlines in water contamination case where a 67-year-old woman, identified as Parvati Bai Kondla also showed signs of Guillain-Barré syndrome. Bacteria like E coli. and Klebsiella were found in the water sample of Bhagirathpura, the epicentre of water contamination.

Indore's Bhagirathpura is again on the news, this time for food contamination.

Indore Food Contamination: What Happened?

Six people have been admitted to a hospital after they consumed contaminated food in Bhagirathpura. At a birthday party in Bhagirathpura on a late Saturday night, 60 people ate the food and some of them developed health problems. Chief Medical and Health Officer (CMHO) Dr Madhav Hasani stated on Monday.

Bhagirathpura was the epicentre of water contamination that claimed 22 lives earlier. The minister said that affected individuals were treated and as a precaution, six of them were admitted to the Government Maharaja Yashwantrao Hospital.

Indore Municipal Corporation Commissioner Dilip Kumar said, “We have found that in case of the construction of the toilet, no safety tank was constructed beneath it. We are also probing the other lapses.”

As per the official statement, all patients are doing well after the treatment.

Indore Food Contamination: What Happened In Indore Before?

Earlier in January, Mayor Pushyamitra Bhargav reported that due to lapses in civic infrastructure. Investigation revealed that a toilet constructed directly above a main drinking pipeline near a police outpost, without a mandatory safety tank resulted in the sewage mixing with drinking water.

Read: Sewage Mixing With Drinking Water Kills 7 in Madhya Pradesh’s Indore, Over 100 Remain Hospitalized

Speaking to The Indian Express, Indore Municipal Corporation Commissioner Dilip Kumar said, “We have found that in case of the construction of the toilet, no safety tank was constructed beneath it. We are also probing the other lapses.”

What Is E. Coli Bacteria?

Escherichia coli, commonly known as E. coli, refers to a group of bacteria that naturally live in the intestines of humans and animals. Most of these strains are harmless and even play a role in digestion. However, certain types can trigger illness when they enter parts of the body where they do not belong or release harmful toxins.

These disease-causing strains attach themselves to body cells and produce toxins, leading to infection and inflammation.

What Is Guillain-Barré syndrome?

Guillain-Barré syndrome is a rare autoimmune condition in which your immune system attacks your peripheral nerves, leading to symptoms like numbness, tingling, and muscle weakness that progress to paralysis. However, with treatment, most people fully recover from the condition.

Doctors say GBS occurs at any age, but it most commonly affects people between 30 and 50 years of age.

Guillain-Barré syndrome is rare. About 100,000 people worldwide develop GBS every year. To put that into perspective, the world population is about 7.8 billion. That means healthcare providers diagnose GBS in about 1 in 78,000 people each year.

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15 States Sue Trump Administration Over Revised Vaccine Schedule

Updated Feb 25, 2026 | 11:18 AM IST

SummaryFifteen Democratic led states sued the Trump administration after HHS reduced routine childhood vaccine coverage from 17 to 11 diseases. Lawsuit calls decision unscientific, challenges advisory committee changes, and seeks court reversal to protect children.
15 States Sue Trump Administration Over Revised Vaccine Schedule

Credits: iStock

15 US states sued President Donald Trump led administration after the Department of Health and Human Services led by Health Secretary Robert F Kennedy Jr. revised vaccine schedule that led to coverage fall from 17 to 11 diseases for children. These 15 states are led Democrats and on Tuesday, they announced suing the Trump administration over unscientific grounds of releasing a new vaccine schedule.

The lawsuit has been filed by a coalition of 14 attorneys general and the governor of Pennsylvania. They have asked the courts to nullify the administration's decision to reduce the number of diseases children are routinely immunized from 17 to 11.

The lawsuit also challenges "the unlawful replacement" of members of the federal Advisory Committee on Immunization Practices, who recommend vaccines for Americans. The lawsuit names the Department of Health and Human Services and Health Secretary Robert F Kennedy Jr as defendants. It also names the Centers for Disease Control and Prevention and its acting director, Dr Jay Bhattacharya.

Read: CDC Vaccine Schedule: Coverage Falls From 17 to 11 Diseases For Children

15 States Sue Trump Administration Over Revised Vaccine Schedule: What Do The States Want?

In a news briefing on Tuesday, Rob Bonta, attorney general of California said, "H.H.S. Secretary R.F.K. Jr. and his C.D.C. are flouting decades of scientific research, ignoring credible medical experts, and threatening to strain state resources and make America’s children sicker.” Bonta continued, "The fact is, vaccines save lives and save our state’s money."

The lawsuit also notes that the administration's revised vaccination schedule was unscientific and relied instead on comparisons to countries that are different than the United States.

Kris Mayes, attorney general of Arizona, as reported by The New York Times said that the latest vaccine schedule "copies" Denmark's recommendation, where the country already has a nationalized health care and the population is fraction of that of the US. "Copying Denmark’s vaccine schedule without copying Denmark’s health care system doesn’t give families more options — it just leaves kids unprotected from serious diseases."

Also Read: Wegovy And Ozempic Will Cost Less In 2027, Novo Nordisk Slashes Weight Loss Drugs Prices By Half

15 States Sue Trump Administration Over Revised Vaccine Schedule: What Is The Revised Vaccine Schedule?

15 States Sue Trump Administration Over Revised Vaccine Schedule

On January 5, 2026, the federal health officials led by RFK Jr. announced that the new Centers for Disease Control and Prevention (CDC), vaccine schedule will include routine shots for 11 diseases for children. This is down from 17 diseases, which were earlier included.

Under the revised schedule, vaccines for a limited number of diseases remain universally recommended for children. These include protection against measles, polio, and whooping cough, which are still considered essential routine immunizations.

Vaccines No Longer Recommended for All Children

The most controversial change is the narrowing of recommendations for several common childhood vaccines. Immunization against the following illnesses is now advised only for high-risk children or after consultation with a health care provider:

  • Hepatitis A
  • Hepatitis B
  • Meningococcal disease
  • Rotavirus
  • Influenza
  • Respiratory syncytial virus, or RSV

Covid-19 vaccination has also shifted to a consultation-based recommendation rather than routine use for all children.

This means shots that were once automatically given at set ages, including at birth, during infancy, and in adolescence, may now depend on individual medical discussions rather than standard guidance.

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