Is 'Sticky Gunk' In Your Brain The Reason Behind Alzheimer's Disease?

Updated Mar 20, 2025 | 08:53 AM IST

SummaryThe new findings is based on a subset of 22 participants who received amyloid-removing drugs the longest, on average eight years.
Alzheimer's Disease

Credits: Canva

An experimental treatment happens to be the solution to delay Alzheimer's symptoms in some people. These people are the ones who are genetically destined to get the disease in their 40s or 50s. These new findings form ongoing research has now been caught up in Trump administration funding delas. The early results of the study has been published on Wednesday and the participants too are worried that politics could cut their access to a possible lifeline.

One of the participants had said, "It is still a study but it has given me an extension to my life that I never banked on having." The participant is named Jake Henrichs, form New York City, who is 50 years old. He is one of them to be treated in that study for more than a decade now and has remained symptom-free despite inheriting an Alzheimer's-causing gene that had killed his father and brother around the same age.

Slowing Down The Symptoms

Two drugs which can modestly slow down early-stage Alzheimer's are sold in the United States. These drugs clear the brain of one of its hallmarks, a sticky gunk-like part called the amyloid. However, there have not been any hints that removing amyloid far earlier, way many years before the first symptoms appear, may postpone the disease.

How Was The Research Conducted?

The research is led by Washington University in St Louis, which involved families that passed down rare gene mutation as participants. This meant it was almost guaranteed that they will develop symptoms at the same age their affected relatives did.

The new findings is based on a subset of 22 participants who received amyloid-removing drugs the longest, on average eight years. Long-term amyloid removal cut in half their risk of symptom onset. The study is published in the journal Lancet Neurology.

Washington University's Dr Randall Bateman, who directs the Dominantly Inherited Alzheimer's Network of studies involving families with these rare genes says, "What we want to determine over the next five years is how strong is the protection. Will they ever get the symptoms of Alzheimer’s disease if we keep treating them?”

The researchers before though did not know what exactly caused Alzheimer's which affects nearly 7 million Americans, most of them in their later life. However, it is clear that these silent changes occur in the brain at least two decades before the first symptom shows up. The big contributor. At some point amyloid buildup can trigger a protein named tau that then starts to kill neurons, which can lead to cognitive decline.

Researchers are now thus studying the Tau-fighting drugs and are looking into other factors, like inflammation, brain's immune cells and certain virus.

The National Institute of Health (NIH) has expanded its focus as researchers have found more reasons for Alzheimer's. In 2013, the NIH's National Institute on Aging funded 14 trials of possible Alzheimer's drugs over a third targeting amyloid. By last fall, there were 68 drugs and 18% of them target amyloid. However, there are scientists too who think that amyloid is not everything and their is way more in the brain tissue, immune cells, and more which can be studied.

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Ebola Death Toll In DRC Hits 600 With 1759 Confirmed Cases As Healthcare Workers Threaten To Go On Strike

Updated Jul 9, 2026 | 01:30 PM IST

SummaryAs the Democratic Republic of the Congo finds itself in the throes of the Bundibugyo Ebola outbreak, the frontline responders have threatened to withdraw their services due to delayed salaries and unsafe work environment.
Ebola Death Toll Hits 600 With 1759 Confirmed Cases As Healthcare Workers In DRC Threaten To Walk Off

Credit: AI

The Ebola outbreak in the Democratic Republic of the Congo (DRC) has reached another concerning milestone. With a surging number of deaths and confirmed infections, the healthcare workers in the affected regions have threatened to declare a strike due to nonpayment of dues, making it challenging to contain a deadly and aggressive outbreak.

DRC Ebola Death Toll Reaches 600 With 1759 Confirmed Cases

According to Reuters, the total confirmed number of deaths due to Bundibugyo Ebola has reached 600, with 1,759 confirmed infections as of July 9.

This comes amid protests demonstrated by healthcare workers in the affected regions, who have threatened to walk off the job due to months of unpaid wages and unsafe working conditions.

The outbreak initially affected Ituri, North Kivu and South Kivu provinces, but authorities are now investigating suspected cases in Tshopo province, including Kisangani, sparking concerns that new areas may be affected.

The outbreak, caused by the Bundibugyo species of the Ebola virus, has been spreading rapidly since it was declared on May 15.

Unlike the Zaire strain, there is currently no approved vaccine or specific treatment for Bundibugyo Ebola virus, making containment and treatment efforts particularly challenging. Currently, experimental therapies are being examined through ongoing clinical trials.

Also read: Uganda Says Ebola Is Contained After Nearly Two Months Of Outbreak; Seeks To Get Travel Restrictions Removed

Healthcare Workers Protests

The worsening outbreak could be even more challenging to contain as the frontline healthcare workers, including treatment staff, laboratory personnel, and burial teams, have been protesting nonpayment of salaries, insufficient protective equipment, and difficult working conditions.

According to several reports, many workers say they have not been paid since the outbreak began nearly two months ago. While some have already stopped working, others have warned that a mass walkout could further weaken the country’s Ebola response.

The administrative disruption significantly threatens critical epidemic operations like patient care, lab testing, contact tracing, and safe burial procedures, all of which are essential for slowing transmission and effectively containing the outbreak.

WHO Says Ebola Outbreak Is Still In Expansion Phase

The World Health Organization has repeatedly warned that the outbreak remains in an “expansion phase” due to several reasons, including overwhelmed treatment facilities, population movement, and delays in identifying and isolating infected individuals.

WHO also said that the treatment centers in some of the hardest-hit regions are operating near 90% capacity. Infection cases among healthcare workers are another concern that highlights the risks faced by frontline responders.

Misinformation about the disease has been rife in several Congolese communities. According to the Council on Foreign Relations, there have been reports that some local communities believe that the disease is a hoax or was brought into the country by Western aid workers who wanted to make a profit.

While Ebola is not a new disease, the current outbreak poses a significant threat because it is caused by a rare strain of the virus, Bundibugyo. The rarity of the strain has created scientific and emergency public health challenges, as there is currently no licensed vaccine to protect against the Bundibugyo Ebola virus.

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Novo Nordisk Launches Awiqli In India: All About The World's First Once-Weekly Insulin

Updated Jul 9, 2026 | 01:12 PM IST

SummaryAwiqli is designed to provide background insulin support throughout the week, reducing the ‌number ⁠of injections from 365 per year to 52.​​ It is administered using the Awiqli FlexTouch pen on the same day each week.
Novo Nordisk Launches Awiqli In India: All About The World's First Once-Weekly Insulin

Credit: iStock/Novo Nordisk

Danish pharmaceutical giant Novo Nordisk has launched Awiqli (insulin icodec) in India, introducing the world's first once-weekly basal insulin for adults with diabetes.

Individuals with Type 2 diabetes require daily insulin to manage their blood glucose when diet, exercise, and oral medications are no longer sufficient.

The daily basal insulin injections are typically taken once every 24 hours. But Awiqli is designed to provide background insulin support throughout the week, reducing the ‌number ⁠of injections from 365 per year to 52, Novo said.

More than 101 million people in India are living with diabetes, ⁠while another 136 million have prediabetes, Novo said in a statement.

Insulin initiation in India is delayed by an average of 7-9 years, partly due to fear of injections, anticipated pain, and cost concerns, it said.

"We believe Awiqli will reduce the psychological and physical barriers to insulin initiation," Novo Nordisk India Managing Director Vikrant Shrotriya said.

Also read: Can Ozempic-Like GLP-1 Drugs Slow Aging, Boost Longevity?

What is Awiqli?

Awiqli (insulin icodec) is a long-acting basal insulin designed to help adults with diabetes maintain stable blood sugar levels with just one injection every week. It is administered using the Awiqli FlexTouch pen on the same day each week.

The treatment is intended to simplify insulin therapy, potentially improving treatment adherence among people who struggle with daily injections.

Global Approval

Earlier this year, the US Food and Drug Administration (FDA) approved Awiqli (insulin icodec-abae) 700 units/mL as the first and only once-weekly basal insulin for adults with type 2 diabetes. The therapy is indicated as an adjunct to diet and exercise to improve glycemic control.

The approval offers a new treatment option for patients seeking an alternative to daily basal insulin, allowing diabetes care to be tailored to different lifestyles and treatment preferences.

"Awiqli may address challenges associated with the frequency of daily basal injections by reducing them from seven to one per week. It is an important advancement for adults with type 2 diabetes who may benefit from an alternative treatment option," said Anna Windle, Group Vice President, Clinical Development, Medical & Regulatory Affairs at Novo Nordisk Inc.

Where Is It Available?

Read More: Cancer Kills Over 26,000 Daily; Cases to Hit 35 Million by 2050, Says WHO Report

The therapy has now been launched in India. Awiqli has also received regulatory approval in the US, the European Union, and 13 other countries, with indications varying according to local regulatory approvals.

Clinical Evidence

The approval is supported by Novo Nordisk's ONWARDS Phase 3a clinical program, which enrolled nearly 2,680 adults with uncontrolled type 2 diabetes across four randomized, active-controlled trials.

The studies compared once-weekly Awiqli with daily basal insulin and demonstrated effective reductions in HbA1c, a key measure of long-term blood sugar control. The overall safety profile was found to be consistent with existing daily basal insulin therapies.

Who Can Use It?

Awiqli is prescribed for adults with diabetes and should be used exactly as directed by a healthcare professional.

Patients should inject the medicine once every week on the same day. The dosage should not be adjusted without medical advice, the company said.

Are There Any Side Effects

Like other insulin therapies, Awiqli may cause side effects, including:

  • Low blood sugar (hypoglycemia)
  • Injection-site reactions
  • Weight gain
  • Skin thickening or pitting at injection sites (lipodystrophy)
  • Allergic reactions
  • Swelling of the hands or feet

Patients are advised to monitor their blood sugar regularly and seek immediate medical attention if they experience symptoms of severe allergic reactions or persistent hypoglycemia.

Who should not take Awiqli?

Do not take Awiqli if you:

  • are having an episode of low blood sugar (hypoglycemia)
  • have an allergy to Awiqli or any of the ingredients in Awiqli.

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Cancer Kills Over 26,000 Daily; Cases to Hit 35 Million by 2050, Says WHO Report

Updated Jul 9, 2026 | 10:32 AM IST

SummaryThe Global Status Report on Cancer 2026 estimates that almost 40% of cancer cases worldwide are linked to preventable risk factors, including tobacco use, alcohol consumption, high body weight, physical inactivity, HPV, Hepatitis B and C infections.
Cancer Kills Over 26,000 Daily; Cases to Hit 35 Million by 2050, Says WHO Report

Credit: iStock

Global cancer cases could reach nearly 35 million a year by 2050, without urgent action to improve cancer prevention, early diagnosis and access to treatment, according to the World Health Organization (WHO) Global Status Report on Cancer 2026.

The report warns that cancer remains the world's second leading cause of death, claiming more than 26,000 lives every day and nearly 10 million annually.

The report, jointly released by the WHO and the International Agency for Research on Cancer (IARC), warned that major inequalities in cancer prevention, diagnosis, treatment and supportive care continue to leave millions of people without access to life-saving services.

It also noted that ageing populations, population growth and persistent health inequalities are driving the cancer cases.

"Cancer is a deeply personal disease that touches nearly all of us. But whether a person survives cancer should never depend on where they were born or what they earn," said WHO Director-General Dr Tedros Adhanom Ghebreyesus.

"The inequities documented in this report are not inevitable; they are the consequence of choices, and they can be reversed through stronger and unified action."

Global Status Report on Cancer 2026: Key Findings

Also read: At 2026 NATO Summit, Trump's Neck Rash and Bruised Hand Draw Attention; White House Responds

Cancer survival varies sharply across countries

The report highlights major disparities in cancer outcomes.

  • 87% of women diagnosed with breast cancer survive at least five years in high-income countries.
  • In low-income countries, the five-year survival rate falls to around 42%.
  • Fewer than one in three countries include comprehensive cancer care under universal health coverage.

Cancer places a heavy financial burden on families

Beyond its health impact, cancer also creates significant economic and emotional challenges.

  • At least 45% of people living with cancer experience financial hardship.
  • More than half report mental health challenges.
  • Nearly all caregivers experience strain, including unpaid caregiving responsibilities and social isolation.

Read More: US Cyclospora Parasite Outbreak Nears 900 Cases: Experts Say Handwashing Key to Prevention

Which Regions Have the Highest Cancer Burden?

The report shows that the burden of cancer varies significantly across regions.

Asia

  • Accounts for 50.7% of global cancer cases.
  • Records 56.5% of cancer deaths worldwide.

Europe

Although home to only about 9% of the world's population, Europe accounts for:

  • 21% of global cancer cases.
  • 20% of global cancer deaths.

Africa

Many African countries continue to experience comparatively lower cancer incidence but disproportionately higher mortality because of delayed diagnosis and limited access to treatment.

Most Common Types of Cancer Worldwide

READ: Don't Ignore These Cancer Symptoms: Oncologist Shares The Early Warning Signs

According to the WHO report:

  • Lung cancer remains the leading cause of cancer deaths globally.
  • Among men, the most common cancers are:
    • Lung
    • Prostate
    • Colorectal
  • Among women, the leading cancers are:
    • Breast
    • Lung
    • Colorectal

Nearly Four in Ten Cancer Cases Are Preventable

The report estimates that almost 40% of cancer cases worldwide are linked to preventable risk factors, including:

  • Tobacco use
  • Alcohol consumption
  • High body weight
  • Physical inactivity
  • Human papillomavirus (HPV)
  • Hepatitis B and Hepatitis C infections
  • Helicobacter pylori infection

WHO's Recommendations to Improve Global Cancer Care

The WHO has urged governments, health organizations, researchers and the private sector to work together to strengthen cancer care through three broad priorities:

Better capabilities

  • Integrate cancer control into universal health coverage.
  • Invest in cancer prevention, early detection and the healthcare workforce.

Better protections

  • Put people living with cancer and caregivers at the centre of health systems.
  • Expand financial and social protection for affected families.

Better value

  • Align cancer research and innovation with public health priorities.
  • Ensure equitable access to effective, evidence-based cancer treatments worldwide.

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