Is 'Sticky Gunk' In Your Brain The Reason Behind Alzheimer's Disease?

Updated Mar 20, 2025 | 08:53 AM IST

SummaryThe new findings is based on a subset of 22 participants who received amyloid-removing drugs the longest, on average eight years.
Alzheimer's Disease

Credits: Canva

An experimental treatment happens to be the solution to delay Alzheimer's symptoms in some people. These people are the ones who are genetically destined to get the disease in their 40s or 50s. These new findings form ongoing research has now been caught up in Trump administration funding delas. The early results of the study has been published on Wednesday and the participants too are worried that politics could cut their access to a possible lifeline.

One of the participants had said, "It is still a study but it has given me an extension to my life that I never banked on having." The participant is named Jake Henrichs, form New York City, who is 50 years old. He is one of them to be treated in that study for more than a decade now and has remained symptom-free despite inheriting an Alzheimer's-causing gene that had killed his father and brother around the same age.

Slowing Down The Symptoms

Two drugs which can modestly slow down early-stage Alzheimer's are sold in the United States. These drugs clear the brain of one of its hallmarks, a sticky gunk-like part called the amyloid. However, there have not been any hints that removing amyloid far earlier, way many years before the first symptoms appear, may postpone the disease.

How Was The Research Conducted?

The research is led by Washington University in St Louis, which involved families that passed down rare gene mutation as participants. This meant it was almost guaranteed that they will develop symptoms at the same age their affected relatives did.

The new findings is based on a subset of 22 participants who received amyloid-removing drugs the longest, on average eight years. Long-term amyloid removal cut in half their risk of symptom onset. The study is published in the journal Lancet Neurology.

Washington University's Dr Randall Bateman, who directs the Dominantly Inherited Alzheimer's Network of studies involving families with these rare genes says, "What we want to determine over the next five years is how strong is the protection. Will they ever get the symptoms of Alzheimer’s disease if we keep treating them?”

The researchers before though did not know what exactly caused Alzheimer's which affects nearly 7 million Americans, most of them in their later life. However, it is clear that these silent changes occur in the brain at least two decades before the first symptom shows up. The big contributor. At some point amyloid buildup can trigger a protein named tau that then starts to kill neurons, which can lead to cognitive decline.

Researchers are now thus studying the Tau-fighting drugs and are looking into other factors, like inflammation, brain's immune cells and certain virus.

The National Institute of Health (NIH) has expanded its focus as researchers have found more reasons for Alzheimer's. In 2013, the NIH's National Institute on Aging funded 14 trials of possible Alzheimer's drugs over a third targeting amyloid. By last fall, there were 68 drugs and 18% of them target amyloid. However, there are scientists too who think that amyloid is not everything and their is way more in the brain tissue, immune cells, and more which can be studied.

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US Appeals Court Revives Over 500 Tylenol Lawsuits Over Autism Claims

Updated Jul 14, 2026 | 10:00 AM IST

SummaryThe lawsuits gained attention after President Donald Trump and Health and Human Services Secretary Robert F. Kennedy Jr. issued guidance last year discouraging pregnant women from using acetaminophen, citing it as a possible contributor to autism.
US Appeals Court Revives Over 500 Tylenol Lawsuits Over Autism Claims

Credit: iStock

While there is no firm scientific evidence linking Tylenol use during pregnancy to autism, a US federal appeals court has revived more than 500 private lawsuits against the painkiller's maker, Kenvue, over claims that prenatal exposure to acetaminophen contributed to autism and attention-deficit/hyperactivity disorder (ADHD) in children.

The ruling does not determine that Tylenol causes autism or ADHD. Rather, it held that expert testimony supporting the plaintiffs should not have been excluded from the lawsuits.

What Did The US Appeals Court Say

On July 13, the 2nd US Circuit Court of Appeals in Manhattan overturned a December 2024 ruling by US District Judge Denise Cote, who had dismissed the lawsuits after rejecting the methodology of the plaintiffs' expert witnesses.

In its 64-page decision, the three-judge panel said the district court had improperly excluded expert testimony from three doctors presented by parents and guardians seeking to link prenatal Tylenol use with autism and ADHD.

Circuit Judge Guido Calabresi wrote that the experts' methods reflected approaches used by other scientists and "constitute acceptable interpretations of scientific evidence where scientists may, and in fact do, disagree."

Court Did Not Rule That Tylenol Causes Autism

The appeals court emphasized that it was not deciding whether acetaminophen causes autism or ADHD, nor was it making any public health determination.

Instead, the ruling focused solely on whether the expert testimony met the legal standards required to be considered in court.

The three experts whose testimony was reinstated include:

  • Andrea Baccarelli, Dean of Harvard University's School of Public Health
  • Eric Hollander, Professor of Psychiatry at Albert Einstein College of Medicine
  • Brandon Pearson, Toxicologist at Columbia University

Ashley Keller, a lawyer representing the families, said the panel unanimously found that the experts had reliably applied accepted scientific methods.

Kenvue Defends Tylenol's Safety

Kenvue, which was spun off from Johnson & Johnson in 2023, said it continues to stand by the safety of Tylenol.

"We stand behind the safety of our product and will continue to defend these cases," the company said in a statement.

Several retailers and pharmacy chains—including CVS, Kroger, Target, Walgreens, and Walmart—have also been named as defendants.

Trump Administration's Remarks Sparked Debate

The lawsuits gained attention after President Donald Trump and Health and Human Services Secretary Robert F. Kennedy Jr. issued guidance last year discouraging pregnant women from using acetaminophen, citing it as a possible contributor to autism.

The remarks triggered concern among expectant mothers and prompted criticism from many healthcare experts and medical organizations, which said the evidence does not support such definitive claims.

Is Acetaminophen Linked to Autism or ADHD?

The scientific evidence remains inconclusive. Some observational studies have reported a possible association between prolonged acetaminophen use during pregnancy and an increased risk of autism or ADHD in children. However, many other studies have found no significant link.

Importantly, an association does not prove that acetaminophen causes these conditions. Researchers note that factors such as maternal illness, genetics, underlying medical conditions, and other environmental influences may also affect a child's neurodevelopment.

As a result, experts say more high-quality research is needed before any causal relationship can be established.

What Do Medical Experts Recommend?

Major medical associations continue to consider acetaminophen the preferred pain reliever and fever reducer during pregnancy when used appropriately.

Doctors advise pregnant women to:

  • Use the lowest effective dose for the shortest necessary duration.
  • Avoid prolonged or unnecessary use without medical advice.
  • Consult their healthcare provider before taking any medication during pregnancy.

Medical societies have also cautioned against avoiding acetaminophen altogether, noting that untreated high fever or severe pain during pregnancy can pose risks to both the mother and the developing baby.

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Michigan Health Officials May Have Traced The Possible Source Behind Massive Cyclospora Outbreak

Updated Jul 14, 2026 | 08:14 AM IST

SummaryMichigan health officials say lettuce and other salad greens are the likely source of a Cyclospora outbreak that has affected over 2,600 people.
Michigan Health Officials May Have Traced The Possible Source Behind Massive Cyclospora Outbreak

Credit: AI

Michigan health officials say that they may have identified the possible source behind one of the largest Cyclosporiasis outbreaks the state has ever recorded. Thousands of people were sickened by a parasitic infection that can cause severe, watery, or even “explosive” diarrhea.

Source Behind Cyclospora Outbreak Traced

On July 13, the Michigan Department of Health and Human Services (MDHHS) announced preliminary findings from its investigation point to lettuce or other salad greens as the possible source of Cyclospora outbreak.

However, officials stressed that the investigation is in progress, and no specific product, grower, distributor, or supplier has yet been identified for certain.

Health officials also interviewed more than 1,000 patients to identify common exposures.

Early analysis also repeatedly identified lettuce and salad greens as foods consumed before illness, prompting the state to issue precautionary guidance while the investigation continues.

"Although we do not have a definite product identified as the source of the outbreak, we want to let Michiganders know what we have learned so far so they can take steps to protect their families," said Dr. Natasha Bagdasarian, Michigan's chief medical executive, in a state statement.

Also read: As Cyclospora Cases Surge In The US, Expert Explains Why India's Monsoon Raises Risk Of The Parasitic Infection

Cyclospora Cases Continue To Surge

The outbreak has continued to expand at an extraordinary pace since late June. As of July 13, Michigan reported 2,640 cases of Cyclosporiasis, with 44 hospitalizations.

No deaths have been reported so far. The number represents a dramatic increase from the state's usual annual number, which is around 40 to 50 cases.

Preventing Cyclospora

Cyclospora is a parasite that infects people after they consume food or water contaminated with human feces containing the parasite's eggs (oocysts).

Although the illness is usually not life-threatening, it can cause prolonged diarrhea, stomach cramps, nausea, fatigue, bloating, and weight loss.

According to recent reports, fresh produce like salad greens and lettuce are being considered the most common source of infection, though contaminated water can also spread the parasite.

Also read: Explosive Diarrhea Parasite Spreads Across US: Why CDC Is Unable To Find The Source?

Health officials have advised people to avoid fresh produce. Previous Cyclospora outbreaks in the US have frequently been linked to imported fresh produce, including:

  • Basil
  • Cilantro
  • Mesclun lettuce
  • Raspberries
  • Snow peas

How To Clean Fresh Produce Safely?

While washing produce cannot eliminate all risks, experts say it can reduce contamination. They advised washing fruits and vegetables thoroughly under clean running water and washing hands before and after handling fresh produce.

According to the Michigan Department of Health and Human Services, cooking produce whenever possible during an active outbreak is crucial, as heating food to at least 158°F (70°C) kills Cyclospora.

For specific produce, it suggested:

  • Cilantro and basil: Separate the leaves and rinse each thoroughly under running water.
  • Green onions: Trim off the roots, remove the outer layer, and rinse well.
  • Snow peas: Rub the surface gently while washing under running water.
  • Raspberries: Because of their delicate, uneven surface, raspberries are difficult to clean thoroughly. Cooking them in pies or jams is safer. Freezing may reduce the number of parasites but is unlikely to eliminate them completely.
  • Leafy greens: If possible, choose whole heads of lettuce instead of bagged salad mixes. Discard the outer leaves and wash the remaining leaves under running water before eating.

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Not Lyme Disease, Canada Sees Rise in Another Tick-Borne Infection As Temperatures Increase

Updated Jul 14, 2026 | 07:37 AM IST

SummaryDue to a warmer weather, Canada is currently seeing an increase in anaplasmosis which is transmitted through the bite of infected black-legged ticks.
Not Lyme Disease, Canada Sees Rise in Another Tick-Borne Infection As Temperatures Increase

Credit: AI

Due to climate change, the range of disease-carrying ticks across Canada have increased. Health experts have recently warned about a lesser-known infection that is spreading across the country rapidly. It is called anaplasmosis.

For years, Lyme disease has dominated conversations around tick bites. Experts are now saying that another illness transmitted by the same black-legged tick is spreading into new regions as warmer temperatures create favorable conditions for ticks to thrive.

Tick-Borne Infection Plagues Canada

The warning comes after a recently published report in the Canadian Medical Association Journal (CMAJ) highlighted anaplasmosis as an emerging disease in Canada. Experts urged healthcare providers to diagnose it early as delayed treatment can lead to severe complications.

The report described a patient who developed heart inflammation (myocarditis), after contracting the infection, highlighting the fact that while many cases are mild, some can become life-threatening.

What Is Anaplasmosis?

Anaplasmosis is caused by the bacterium Anaplasma phagocytophilum. It is transmitted through the bite of infected black-legged ticks (Ixodes scapularis) and western black-legged ticks (Ixodes pacificus).

Unlike Lyme disease, which primarily affects the skin, joints and nervous system, anaplasmosis infects white blood cells, weakening the body's immune system.

The symptoms of anaplasmosis commonly develop within one to two weeks after a tick bite and often resemble the flu. They include:

  • Fever and chills
  • Severe headache
  • Muscle aches
  • Fatigue
  • Nausea or loss of appetite

Also read: Bella Hadid Opens Up About Challenges Of Living With Lyme Disease

Why Anaplasmosis Cases Are Rising In Canada?

Warmer and longer spring and summer and shorter winters are creating the ideal breeding grounds for black-legged ticks. These ticks are expanding farther north into regions where they previously could not survive.

At the same time, warmer conditions are extending the period during which ticks remain active. Public health officials say that ticks can now be active whenever temperatures remain consistently above freezing.

The Public Health Agency of Canada has reported that the geographic range of ticks carrying diseases such as Lyme disease, anaplasmosis and babesiosis continues to expand across several provinces, including Ontario, Quebec, Manitoba, New Brunswick and parts of Atlantic Canada.

Early Detection And Diagnosis Are The Key

Although many people recover completely with prompt treatment, anaplasmosis, if left untreated, can cause serious complications affecting the lungs, kidneys, nervous system and heart.

Older adults, people with weakened immune systems and those whose treatment is delayed face the highest risk of severe illness.

Canadian health authorities recommend that treatment begin as soon as doctors suspect anaplasmosis rather than waiting for laboratory confirmation, since early intervention significantly improves outcomes.

Protecting yourself during tick season is one of the ways to ward off risk of infection. Health officials recommend several simple precautions to reduce the risk of tick bites:

  • Wear long sleeves and long pants in wooded or grassy areas.
  • Apply insect repellents containing DEET or icaridin.
  • Perform thorough tick checks after spending time outdoors.
  • Remove attached ticks immediately.

As Canada's climate continues to warm, experts say the country's tick-borne disease landscape is changing rapidly. While Lyme disease remains the most recognized threat, physicians warn that anaplasmosis is no longer a rare infection.

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