Is 'Sticky Gunk' In Your Brain The Reason Behind Alzheimer's Disease?

Updated Mar 20, 2025 | 08:53 AM IST

SummaryThe new findings is based on a subset of 22 participants who received amyloid-removing drugs the longest, on average eight years.
Alzheimer's Disease

Credits: Canva

An experimental treatment happens to be the solution to delay Alzheimer's symptoms in some people. These people are the ones who are genetically destined to get the disease in their 40s or 50s. These new findings form ongoing research has now been caught up in Trump administration funding delas. The early results of the study has been published on Wednesday and the participants too are worried that politics could cut their access to a possible lifeline.

One of the participants had said, "It is still a study but it has given me an extension to my life that I never banked on having." The participant is named Jake Henrichs, form New York City, who is 50 years old. He is one of them to be treated in that study for more than a decade now and has remained symptom-free despite inheriting an Alzheimer's-causing gene that had killed his father and brother around the same age.

Slowing Down The Symptoms

Two drugs which can modestly slow down early-stage Alzheimer's are sold in the United States. These drugs clear the brain of one of its hallmarks, a sticky gunk-like part called the amyloid. However, there have not been any hints that removing amyloid far earlier, way many years before the first symptoms appear, may postpone the disease.

How Was The Research Conducted?

The research is led by Washington University in St Louis, which involved families that passed down rare gene mutation as participants. This meant it was almost guaranteed that they will develop symptoms at the same age their affected relatives did.

The new findings is based on a subset of 22 participants who received amyloid-removing drugs the longest, on average eight years. Long-term amyloid removal cut in half their risk of symptom onset. The study is published in the journal Lancet Neurology.

Washington University's Dr Randall Bateman, who directs the Dominantly Inherited Alzheimer's Network of studies involving families with these rare genes says, "What we want to determine over the next five years is how strong is the protection. Will they ever get the symptoms of Alzheimer’s disease if we keep treating them?”

The researchers before though did not know what exactly caused Alzheimer's which affects nearly 7 million Americans, most of them in their later life. However, it is clear that these silent changes occur in the brain at least two decades before the first symptom shows up. The big contributor. At some point amyloid buildup can trigger a protein named tau that then starts to kill neurons, which can lead to cognitive decline.

Researchers are now thus studying the Tau-fighting drugs and are looking into other factors, like inflammation, brain's immune cells and certain virus.

The National Institute of Health (NIH) has expanded its focus as researchers have found more reasons for Alzheimer's. In 2013, the NIH's National Institute on Aging funded 14 trials of possible Alzheimer's drugs over a third targeting amyloid. By last fall, there were 68 drugs and 18% of them target amyloid. However, there are scientists too who think that amyloid is not everything and their is way more in the brain tissue, immune cells, and more which can be studied.

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Meet Audrey Zheng: 17-YO Who Developed Blood Test For Pancreatic Cancer That Correctly Identified 87% Of Patients

Updated Aug 20, 2026 | 07:00 PM IST

SummaryUS-based high school student Audrey Zheng achieved a new milestone in pancreatic cancer detection by developing a promising new blood test.
Meet Audrey Zheng: 17-YO Who Developed Blood Test For Pancreatic Cancer That Correctly Identified 87% Of Patients

Credit: X

A 17-year-old high school student from Pennsylvania has developed a blood test for detecting pancreatic cancer. Its early testing indicated it correctly identified 87% of patients with the disease.

Audrey Zheng, a senior at North Allegheny Senior High School in Wexford, Pennsylvania, developed the test as part of her bioengineering research. Her work focuses on detecting tiny tumour-derived particles circulating in the blood, potentially offering a less invasive way of identifying pancreatic cancer.

In clinical testing, the method correctly identified 87% of people with pancreatic ductal adenocarcinoma (PDAC) and correctly ruled out the disease in 87.5% of people who did not have it.

Her research has earned her a place as a national finalist in the 2026 Regeneron Science Talent Search, one of the major science competitions for US high school students.

Audrey Zheng's Blood Test Uses Tiny Tumour-Derived Particles

The blood testdeveloped by Audrey Zheng uses tiny magnetic beads to separate tumour-derived particles from blood samples.

These particles can carry biological information released by cancer cells. Zheng's research then focuses on analysing genetic mutations within this material to identify pancreatic cancer in patients.

The milestone is noteworthy as pancreatic cancer is notoriously difficult to detect early. Many patients do not develop obvious symptoms until the disease has already advanced, reducing the chances of successful treatment.

Also read: Moderna and Merck’s Custom-Made mRNA Cancer Vaccine Shows Promise In Late-Stage Melanoma Trial

Early Detection Is A Major Challenge In Pancreatic Cancer

Pancreatic ductal adenocarcinoma is one of the most aggressive forms of pancreatic cancer. There is currently no standard screening test for pancreatic cancer for people at average risk.

Researchers have therefore been exploring blood-based biomarkers, imaging techniques, and artificial intelligence tools that could identify the disease earlier.

Although Zheng's work is still at the research stage and would require much larger independent studies and trials before it could be considered for clinical use.

Also read: Why Flight Attendants, Pilots Face Higher Risk Of Radiation-Linked Cancer Deaths Than Other Occupations?

A Significant Milestone

The reported 87% figure refers to sensitivity, meaning the proportion of people with pancreatic cancer whom the test correctly identified. Its reported ability to correctly rule out cancer was 87.5%.

Current diagnosis methods for pancreatic cancer involve imaging scans, endoscopic procedures, and tissue sampling, depending on the patient's symptoms and clinical situation. A blood test would be much less invasive and could potentially be easier to repeat.

Researchers around the world are already investigating this area. For example, Harvard researchers have developed artificial intelligence approaches that can identify people at increased risk of pancreatic cancer years before diagnosis using clinical information.

Zheng's work takes a different route by looking for molecular signals associated with the tumour directly in blood. The reported results are encouraging, but the method would need extensive validation before doctors could use it routinely.

Researchers would need to establish its accuracy across larger populations and determine whether it can reliably detect pancreatic cancer at stages when treatment is most effective.

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From Dog Food To Fruit Bars: Over 10 Products Recalled In US Over Contamination

Updated Aug 20, 2026 | 06:00 PM IST

SummaryIn 2026, the US FDA has posted 20 foodborne illness investigations, while work remains active on 18 foodborne illness clusters. Combined data from the FDA and the US CDC show that more than 10,000 foodborne illness cases have been associated with outbreaks so far this year.
From Dog Food To Fruit Bars: Over 10 Products Recalled In US Over Contamination

Credit: AI Image

The US continues to report food recalls and foodborne illness investigations involving a range of products, from salsa, guacamole and lettuce to fruit bars, eggs, nut butter and even dog food. Recent recalls have been linked to pathogens including Salmonella, Listeria and E. coli, as well as foreign-material contamination.

According to the US Food and Drug Administration (FDA), about 48 million cases of foodborne illness occur in the US each year — equivalent to about 1 in 6 Americans. These illnesses result in an estimated 128,000 hospitalizations and 3,000 deaths annually.

Foodborne Illness Investigations Rise

Between 2021 and 2025, the FDA investigated an average of about 25 foodborne illness outbreaks each year. This year, the agency has already posted 20 investigations and says work remains active for 18 foodborne illness clusters.

There have been about 10,500 cases of foodborne illness associated with outbreaks so far this year, according to data from the FDA and the US Centers for Disease Control and Prevention. The annual average has been 1,500 cases between 2021 and 2025.

The vast majority of these cases are linked to fresh jalapeños associated with a multistate Salmonella outbreak and fresh lettuce from Taylor Farms linked to Cyclospora.

Also read: Amid Cyclospora, Salmonella Outbreaks, US FDA Issues Guidance on Ready-to-Eat Produce

Here is a look at some of the other foods recently recalled or linked to contamination concerns in the US.

  • Outshine Fruit Bars: Select Outshine Fruit Bars were recalled over concerns they may contain pieces of glass, posing a potential injury risk.
  • Pillsbury Bread Rolls: General Mills recalled nearly 736,000 Pillsbury rolls due to possible glass contamination. The recall included 3,080 cases of Pillsbury Bread Rolls “Hard Roll Dough.”
  • Oma’s Pride Dog Food: A lot of Oma’s Pride frozen dog food was recalled after testing found Salmonella contamination, which can affect both pets and people.
  • Lacnola Lactation Granola: The granola was recalled over possible Salmonella contamination linked to moringa powder used in the product.
  • Pastrami & Corned Beef: Ready-to-eat pastrami and corned beef products were recalled over concerns about possible Listeria contamination.
  • Chicken Salad: A chicken salad product was subject to a public health alert because it may be contaminated with Listeria, a potentially serious foodborne pathogen.
  • Shell Eggs: Nearly 1.59 million dozen eggs were recalled because they may be contaminated with Salmonella Enteritidis.

Why Are There So Many Foodborne Illnesses?

Read More: US Foodborne Illnesses Surge: Salmonella Hits 431, Cyclospora Cases Top 15,700

While FDA investigations into the outbreaks are underway, top Trump health officials have said that the US food supply remains safe and that fresh produce is safe to eat. Health Secretary Robert F. Kennedy Jr. told reporters last month that the situation was “under control.”

However, experts blamed federal funding cuts under the Trump administration, which reduced budgets for food inspections by federal agencies and grants to state and local health departments that conduct traceback investigations to determine where outbreaks originate.

Democratic Sen. Elizabeth Warren wrote a letter to HHS Secretary Robert F. Kennedy Jr. seeking more information about what she called the administration’s “calamitous” response to the cyclosporiasis outbreak and expressing concern that politics could be to blame.

The number of outbreak investigations “represents an increase from previous years,” the FDA said in an email to CNN. The agency said it is constantly working to improve laboratory detection of foodborne illness and that stronger surveillance efforts can lead to increased detection. It also noted that ensuring food safety is a shared responsibility across the global supply chain.

Warren said the administration’s handling of the outbreak had been marked by missteps that raised questions about its decision-making.

More: Nearly 40,000 Bottles Of Popular Eye Drops Recalled Due To Potential Contamination

How To Stay Safe

To stay safe, the best way to avoid the foodborne illness is to:

  • Discard or return any recalled products.
  • Wash all fresh fruits and vegetables thoroughly under running water, even if labeled pre-washed.
  • Avoid bagged greens when possible.
  • Cook produce whenever possible; a temperature of 158 degrees Fahrenheit is the most effective way.
  • Follow safe food-handling practices and stay updated on food recalls.

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Rare Inflammatory Disease Mimicked TB In Vizag Man For 6 Years: What Is Kikuchi-Fujimoto Disease?

Updated Aug 20, 2026 | 05:26 PM IST

SummaryA young man in his early thirties got repeatedly misdiagnosed and treated for tuberculosis before doctors found out that he had a rare inflammatory condition.
Rare Inflammatory Disease Mimicked TB In Vizag Man For 6 Years: What Is Kikuchi-Fujimoto Disease?

Credit: AI

A 32-year-old man from Visakhapatnam was treated repeatedly for suspected tuberculosis for nearly six years before doctors diagnosed him with a rare inflammatory disease called Kikuchi-Fujimoto disease.

The man complained of recurrent swelling of his lymph nodes and was treated for tuberculosis despite the symptoms continuing to return.

In 2026, he was treated at KIMS Hospitals after developing a painful swelling in his right armpit. A lymph-node biopsy eventually led to the diagnosis of Kikuchi-Fujimoto disease.

The case highlights a concerning but noteworthy issue of misdiagnosis, especially when a rare condition resembles infections like TB and even certain cancers.

Kikuchi-Fujimoto Disease Affects Lymph Nodes

It is most commonly seen in young adults and frequently involves the lymph nodes in the neck. It is characterised by fever and tender lymph-node swelling. Some patients may also experience fatigue, weight loss, night sweats, or skin rashes.

The exact cause of the disease is still unknown. Researchers have proposed that infections may trigger an abnormal immune response, but no single infectious agent has been established as the cause.

Also read: TB Usually Attacks The Lungs, But It Can Affect The Skin Too- 1.5% People Are Living With The Struggle

Kikuchi Disease Can Be Mistaken For TB And Cancer

The condition can be particularly difficult to distinguish from other causes of enlarged lymph nodes. In countries like India, where tuberculosis is common, TB lymphadenitis is widely suspected when someone develops persistent or recurrent lymph-node swelling.

Kikuchi-Fujimoto disease can present with similar symptoms and inflammatory changes. There have been documented cases in which KFD was initially mistaken for tuberculosis. It can also resemble lymphoma and lymph-node involvement associated with systemic lupus erythematosus (SLE).

Kikuchi disease is not cancer, but its presentation can sometimes look similar to lymphoma, particularly when a patient has persistent lymph-node enlargement. This is one reason doctors may need a biopsy rather than relying only on symptoms or imaging.

Also read: Every Cough Or Episode Of Breathlessness Is Not Asthma

How Is Kikuchi Disease Diagnosed?

There is no specific blood test that can definitively diagnose Kikuchi-Fujimoto disease. Doctors generally rely on histopathological examination of an affected lymph node, usually following an excisional biopsy.

Under the microscope, characteristic areas of necrosis and specific immune cells called histiocytes and plasmacytoid dendritic cells can help establish the diagnosis. The absence of certain inflammatory cells, particularly neutrophils, also helps distinguish KFD from some infections. This is noteworthy as just the presence of an enlarged lymph node cannot reveal its underlying cause.

Symptoms of this disease generally improve without aggressive treatment, and with supportive care, including medicines to control pain and fever. Corticosteroids may be considered in severe or complicated cases.

However, patients diagnosed with KFD may need follow-up as it is associated with autoimmune conditions, particularly systemic lupus erythematosus.

Vizag Case Puts Focus On The Importance Of Reassessment

The Visakhapatnam man's prolonged treatment for suspected TB illustrates the difficulty of diagnosing rare inflammatory diseases when their symptoms overlap with more common conditions.

Persistent or recurring lymph-node swelling despite treatment should prompt doctors to reassess the diagnosis and consider other possibilities, including inflammatory disorders, autoimmune disease and malignancy.

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