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An experimental treatment happens to be the solution to delay Alzheimer's symptoms in some people. These people are the ones who are genetically destined to get the disease in their 40s or 50s. These new findings form ongoing research has now been caught up in Trump administration funding delas. The early results of the study has been published on Wednesday and the participants too are worried that politics could cut their access to a possible lifeline.
One of the participants had said, "It is still a study but it has given me an extension to my life that I never banked on having." The participant is named Jake Henrichs, form New York City, who is 50 years old. He is one of them to be treated in that study for more than a decade now and has remained symptom-free despite inheriting an Alzheimer's-causing gene that had killed his father and brother around the same age.
Two drugs which can modestly slow down early-stage Alzheimer's are sold in the United States. These drugs clear the brain of one of its hallmarks, a sticky gunk-like part called the amyloid. However, there have not been any hints that removing amyloid far earlier, way many years before the first symptoms appear, may postpone the disease.
The research is led by Washington University in St Louis, which involved families that passed down rare gene mutation as participants. This meant it was almost guaranteed that they will develop symptoms at the same age their affected relatives did.
The new findings is based on a subset of 22 participants who received amyloid-removing drugs the longest, on average eight years. Long-term amyloid removal cut in half their risk of symptom onset. The study is published in the journal Lancet Neurology.
Washington University's Dr Randall Bateman, who directs the Dominantly Inherited Alzheimer's Network of studies involving families with these rare genes says, "What we want to determine over the next five years is how strong is the protection. Will they ever get the symptoms of Alzheimer’s disease if we keep treating them?”
The researchers before though did not know what exactly caused Alzheimer's which affects nearly 7 million Americans, most of them in their later life. However, it is clear that these silent changes occur in the brain at least two decades before the first symptom shows up. The big contributor. At some point amyloid buildup can trigger a protein named tau that then starts to kill neurons, which can lead to cognitive decline.
Researchers are now thus studying the Tau-fighting drugs and are looking into other factors, like inflammation, brain's immune cells and certain virus.
The National Institute of Health (NIH) has expanded its focus as researchers have found more reasons for Alzheimer's. In 2013, the NIH's National Institute on Aging funded 14 trials of possible Alzheimer's drugs over a third targeting amyloid. By last fall, there were 68 drugs and 18% of them target amyloid. However, there are scientists too who think that amyloid is not everything and their is way more in the brain tissue, immune cells, and more which can be studied.
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The UK government has confirmed a case of hantavirus infection in Tristan da Cunha, a remote British Overseas Territory in the South Atlantic Ocean, World Health Organization (WHO) Director-General Tedros Adhanom Ghebreyesus has said.
In a post on social media platform X, Tedros said the patient had previously been classified as a probable case and had been exposed aboard the MV Hondius.
“As of June 10, the total number of confirmed cases remains 13, including three deaths,” he said. “No new deaths have been reported since May 2,” when a cluster of severe respiratory illnesses linked to the Dutch-flagged cruise ship MV Hondius was reported to the WHO.
While the outbreak aboard the luxury vessel had raised concerns about wider transmission. However, the WHO has assessed the overall risk to the public as low. The global health body recommended active health monitoring for all evacuated passengers for 42 days from their last exposure date, either in designated quarantine facilities or at home. The monitoring period is scheduled to continue until June 21.
The outbreak, which claimed three lives and infected 13 people, was driven by the Andes strain, which carries a risk of human-to-human transmission. There is currently no specific antiviral drug or vaccine for the Andes virus.
Also read: Can Hantavirus Spread Through Semen And Breast Milk? What Experts Say
A recent study published in The Lancet Infectious Diseases reported early promising results for tocilizumab as a treatment for severe hantavirus pulmonary syndrome (HPS).
The study is based on a case series involving 10 hantavirus patients treated at Hospital Zonal de Bariloche, Argentina, between June 1, 2024, and May 6, 2026.
Tocilizumab is an immunosuppressive medication used to treat severe inflammatory conditions, including severe COVID-19 and autoimmune diseases such as rheumatoid arthritis.
Researchers from San Carlos de Bariloche, Argentina, said that under an ethical framework allowing the emergency use of unproven medications outside clinical trials when no satisfactory alternatives exist, tocilizumab was administered to five eligible patients with laboratory-confirmed severe hantavirus pulmonary syndrome.
Five other patients received standard supportive care without tocilizumab because they were too sick or the medication was unavailable when treatment was being considered. The researchers said tocilizumab warrants further evaluation as a treatment for severe hantavirus pulmonary syndrome.
According to the WHO, hantaviruses are zoonotic viruses that naturally infect rodents and are occasionally transmitted to humans.
Globally, an estimated 100,000 to 200,000 hantavirus infections occur each year. The majority of these cases are in Asia, particularly China. Most are sporadic or occur in small clusters linked to contact with infected rodents.
Infection in people can result in severe illness and often death, although the diseases vary by type of virus and geographical location.
The WHO has confirmed that the Andes strain of hantavirus—the only strain known to spread from person to person—is responsible for the outbreak. There is currently no vaccine available for the strain.
Notably, the WHO has not specified the type of hantavirus or syndrome involved in the cruise ship incident, but it did mention respiratory risks.
Hantavirus is primarily spread by rodents through:
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Two orphaned babies have died of Ebola in the Democratic Republic of Congo, in an outbreak that could rival the worst on record.
Baby Buswaza was brought to a church-run orphanage in eastern Congo after her mother died in late May. The newborn was running a fever and, within days, died from what was later found to be Ebola, Reuters reported.
Buswaza was buried in late May in a sealed, waterproof body bag to prevent the spread of the disease.
Six more babies have been identified as suspected Ebola cases at the orphanage of 69 children in Bunia, a city in Ituri province at the epicentre of the outbreak in Congo.
They were taken to hospital, where five of them later tested negative and were discharged from an isolation tent at the Evangelical Medical Centre (CME) by medics.
Another baby—an orphaned triplet girl nicknamed "Cherie" or "darling" who was less than a year old—with confirmed Ebola died on June 10, Dr. Freddy Kibwana, head of the CME, told Reuters. "The child has left us," he said.
Children and babies can easily become vectors for the disease through bodily fluids like vomit, faeces and saliva, which are highly infectious when people have Ebola.
"This epidemic has hit an area already in humanitarian crisis," said Babou Rukengeza, a senior health adviser with Save the Children aid group. "This place is the only refuge for these children."
“This outbreak is moving at a terrifying speed. I have responded to several Ebola outbreaks over the years, but this is the fastest spread I have ever seen. Children are paying a devastating price," he added.
The expert noted that “when parents die, children suddenly lose the biggest support system they could possibly have and face fear, grief, stigma, and social exclusion".
In addition to fluids like blood and saliva, Ebola has also been detected in amniotic fluid and the placenta, as per the World Health Organization, so it is possible Buswaza's mother transmitted the virus to her in the womb or during childbirth.
If the mother caught the virus after giving birth, she may also have transmitted it to her child through breastmilk, where the virus has also been detected.
According to the US CDC, the confirmed cases in Congo have risen to 635, while there are 127 confirmed deaths. In Uganda, there are 19 confirmed cases and two confirmed deaths, along with one probable case and one probable death.
Using genetic fingerprinting, the illnesses have been identified as Bundibugyo virus, one of the four types of orthoebolaviruses that cause Ebola disease in people. There is no vaccine for Bundibugyo virus, and treatment consists of supportive care.
Meanwhile, the WHO has revised the risk assessment in Congo and Uganda. The risk has been revised to “very high at the national level in DRC and high for Uganda,” the WHO said.
It is also high for countries sharing land borders with DRC and Uganda, while low for the rest of the Africa region and at the global level.
The WHO explained that the risk in DRC remains very high because “the outbreak has continued to expand rapidly in terms of numbers of cases and geographical spread with more areas affected. Epidemiological links and the full chain of transmission are not yet clearly established, and the source of the outbreak remains under investigation”.
Moreover, the ongoing conflict is restricting movement of frontline responders and surveillance teams, while community fear and misinformation are hindering case detection, contact tracing and isolation, and potentially facilitating disease spread.
There are also other challenges such as limited healthcare infrastructure and delays in laboratory confirmation, although these are being scaled up by DRC with support from partners, the WHO said.
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Health authorities in Kerala have reported a positive case of Nipah virus infection in a man from Kozhikode, triggering precautionary measures across the district.
The patient tested positive in a preliminary test conducted in Kozhikode and is currently undergoing treatment at Kozhikode Medical College Hospital, officials said.
With the fresh scare, health authorities have initiated extensive contact tracing and surveillance measures to prevent any potential spread of the infection.
According to officials, the patient arrived at the hospital through the outpatient department and is believed to have interacted with several people before being identified as a suspected Nipah case.
While the initial test indicated the presence of the virus, confirmation from a specialized virology laboratory is still awaited. Despite the pending confirmatory result, the state government has activated containment protocols as a precaution. Close contacts of the patient are being identified, monitored, and assessed as part of the standard public health response.
Also read: Bangladesh Battles Growing Measles Outbreak As Confirmed Cases Approach 10,000
Kerala Health Minister K. Muralidharan said the patient had extensive contacts but stressed that there was no reason for panic at this stage. The minister noted that the patient had visited multiple departments of the private hospital where he first sought treatment, raising concerns about possible exposure to others.
As a precautionary measure, hospital staff who may have come into contact with the patient have been asked to undergo quarantine and monitoring.
According to the World Health Organization, Nipah virus is a zoonotic disease, meaning it can spread from animals to humans. It can also be transmitted through contaminated food and, in some cases, directly from person to person.
In humans, Nipah infection can range from asymptomatic illness to severe respiratory disease and fatal encephalitis (brain inflammation). The virus can also infect animals such as pigs, causing significant economic losses for farmers.
Although only a limited number of outbreaks have been reported in Asia, the virus is known for its high fatality rate and potential to cause severe disease.
Symptoms of Nipah virus infection may include:
Nipah virus is considered a major public health threat because of its high mortality rate, ability to spread through close contact, and the absence of a specific antiviral treatment or approved vaccine for widespread use.
Early detection, isolation of suspected cases, contact tracing, and strict infection-control measures remain the most effective tools for preventing outbreaks.
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