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An experimental treatment happens to be the solution to delay Alzheimer's symptoms in some people. These people are the ones who are genetically destined to get the disease in their 40s or 50s. These new findings form ongoing research has now been caught up in Trump administration funding delas. The early results of the study has been published on Wednesday and the participants too are worried that politics could cut their access to a possible lifeline.
One of the participants had said, "It is still a study but it has given me an extension to my life that I never banked on having." The participant is named Jake Henrichs, form New York City, who is 50 years old. He is one of them to be treated in that study for more than a decade now and has remained symptom-free despite inheriting an Alzheimer's-causing gene that had killed his father and brother around the same age.
Two drugs which can modestly slow down early-stage Alzheimer's are sold in the United States. These drugs clear the brain of one of its hallmarks, a sticky gunk-like part called the amyloid. However, there have not been any hints that removing amyloid far earlier, way many years before the first symptoms appear, may postpone the disease.
The research is led by Washington University in St Louis, which involved families that passed down rare gene mutation as participants. This meant it was almost guaranteed that they will develop symptoms at the same age their affected relatives did.
The new findings is based on a subset of 22 participants who received amyloid-removing drugs the longest, on average eight years. Long-term amyloid removal cut in half their risk of symptom onset. The study is published in the journal Lancet Neurology.
Washington University's Dr Randall Bateman, who directs the Dominantly Inherited Alzheimer's Network of studies involving families with these rare genes says, "What we want to determine over the next five years is how strong is the protection. Will they ever get the symptoms of Alzheimer’s disease if we keep treating them?”
The researchers before though did not know what exactly caused Alzheimer's which affects nearly 7 million Americans, most of them in their later life. However, it is clear that these silent changes occur in the brain at least two decades before the first symptom shows up. The big contributor. At some point amyloid buildup can trigger a protein named tau that then starts to kill neurons, which can lead to cognitive decline.
Researchers are now thus studying the Tau-fighting drugs and are looking into other factors, like inflammation, brain's immune cells and certain virus.
The National Institute of Health (NIH) has expanded its focus as researchers have found more reasons for Alzheimer's. In 2013, the NIH's National Institute on Aging funded 14 trials of possible Alzheimer's drugs over a third targeting amyloid. By last fall, there were 68 drugs and 18% of them target amyloid. However, there are scientists too who think that amyloid is not everything and their is way more in the brain tissue, immune cells, and more which can be studied.
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While there is no firm scientific evidence linking Tylenol use during pregnancy to autism, a US federal appeals court has revived more than 500 private lawsuits against the painkiller's maker, Kenvue, over claims that prenatal exposure to acetaminophen contributed to autism and attention-deficit/hyperactivity disorder (ADHD) in children.
The ruling does not determine that Tylenol causes autism or ADHD. Rather, it held that expert testimony supporting the plaintiffs should not have been excluded from the lawsuits.
On July 13, the 2nd US Circuit Court of Appeals in Manhattan overturned a December 2024 ruling by US District Judge Denise Cote, who had dismissed the lawsuits after rejecting the methodology of the plaintiffs' expert witnesses.
In its 64-page decision, the three-judge panel said the district court had improperly excluded expert testimony from three doctors presented by parents and guardians seeking to link prenatal Tylenol use with autism and ADHD.
Circuit Judge Guido Calabresi wrote that the experts' methods reflected approaches used by other scientists and "constitute acceptable interpretations of scientific evidence where scientists may, and in fact do, disagree."
The appeals court emphasized that it was not deciding whether acetaminophen causes autism or ADHD, nor was it making any public health determination.
Instead, the ruling focused solely on whether the expert testimony met the legal standards required to be considered in court.
The three experts whose testimony was reinstated include:
Ashley Keller, a lawyer representing the families, said the panel unanimously found that the experts had reliably applied accepted scientific methods.
Kenvue, which was spun off from Johnson & Johnson in 2023, said it continues to stand by the safety of Tylenol.
"We stand behind the safety of our product and will continue to defend these cases," the company said in a statement.
Several retailers and pharmacy chains—including CVS, Kroger, Target, Walgreens, and Walmart—have also been named as defendants.
The lawsuits gained attention after President Donald Trump and Health and Human Services Secretary Robert F. Kennedy Jr. issued guidance last year discouraging pregnant women from using acetaminophen, citing it as a possible contributor to autism.
The remarks triggered concern among expectant mothers and prompted criticism from many healthcare experts and medical organizations, which said the evidence does not support such definitive claims.
The scientific evidence remains inconclusive. Some observational studies have reported a possible association between prolonged acetaminophen use during pregnancy and an increased risk of autism or ADHD in children. However, many other studies have found no significant link.
Importantly, an association does not prove that acetaminophen causes these conditions. Researchers note that factors such as maternal illness, genetics, underlying medical conditions, and other environmental influences may also affect a child's neurodevelopment.
As a result, experts say more high-quality research is needed before any causal relationship can be established.
Major medical associations continue to consider acetaminophen the preferred pain reliever and fever reducer during pregnancy when used appropriately.
Doctors advise pregnant women to:
Medical societies have also cautioned against avoiding acetaminophen altogether, noting that untreated high fever or severe pain during pregnancy can pose risks to both the mother and the developing baby.
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Michigan health officials say that they may have identified the possible source behind one of the largest Cyclosporiasis outbreaks the state has ever recorded. Thousands of people were sickened by a parasitic infection that can cause severe, watery, or even “explosive” diarrhea.
On July 13, the Michigan Department of Health and Human Services (MDHHS) announced preliminary findings from its investigation point to lettuce or other salad greens as the possible source of Cyclospora outbreak.
However, officials stressed that the investigation is in progress, and no specific product, grower, distributor, or supplier has yet been identified for certain.
Health officials also interviewed more than 1,000 patients to identify common exposures.
Early analysis also repeatedly identified lettuce and salad greens as foods consumed before illness, prompting the state to issue precautionary guidance while the investigation continues.
"Although we do not have a definite product identified as the source of the outbreak, we want to let Michiganders know what we have learned so far so they can take steps to protect their families," said Dr. Natasha Bagdasarian, Michigan's chief medical executive, in a state statement.
The outbreak has continued to expand at an extraordinary pace since late June. As of July 13, Michigan reported 2,640 cases of Cyclosporiasis, with 44 hospitalizations.
No deaths have been reported so far. The number represents a dramatic increase from the state's usual annual number, which is around 40 to 50 cases.
Cyclospora is a parasite that infects people after they consume food or water contaminated with human feces containing the parasite's eggs (oocysts).
Although the illness is usually not life-threatening, it can cause prolonged diarrhea, stomach cramps, nausea, fatigue, bloating, and weight loss.
According to recent reports, fresh produce like salad greens and lettuce are being considered the most common source of infection, though contaminated water can also spread the parasite.
Also read: Explosive Diarrhea Parasite Spreads Across US: Why CDC Is Unable To Find The Source?
Health officials have advised people to avoid fresh produce. Previous Cyclospora outbreaks in the US have frequently been linked to imported fresh produce, including:
While washing produce cannot eliminate all risks, experts say it can reduce contamination. They advised washing fruits and vegetables thoroughly under clean running water and washing hands before and after handling fresh produce.
According to the Michigan Department of Health and Human Services, cooking produce whenever possible during an active outbreak is crucial, as heating food to at least 158°F (70°C) kills Cyclospora.
For specific produce, it suggested:
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Due to climate change, the range of disease-carrying ticks across Canada have increased. Health experts have recently warned about a lesser-known infection that is spreading across the country rapidly. It is called anaplasmosis.
For years, Lyme disease has dominated conversations around tick bites. Experts are now saying that another illness transmitted by the same black-legged tick is spreading into new regions as warmer temperatures create favorable conditions for ticks to thrive.
The warning comes after a recently published report in the Canadian Medical Association Journal (CMAJ) highlighted anaplasmosis as an emerging disease in Canada. Experts urged healthcare providers to diagnose it early as delayed treatment can lead to severe complications.
The report described a patient who developed heart inflammation (myocarditis), after contracting the infection, highlighting the fact that while many cases are mild, some can become life-threatening.
Anaplasmosis is caused by the bacterium Anaplasma phagocytophilum. It is transmitted through the bite of infected black-legged ticks (Ixodes scapularis) and western black-legged ticks (Ixodes pacificus).
Unlike Lyme disease, which primarily affects the skin, joints and nervous system, anaplasmosis infects white blood cells, weakening the body's immune system.
The symptoms of anaplasmosis commonly develop within one to two weeks after a tick bite and often resemble the flu. They include:
Also read: Bella Hadid Opens Up About Challenges Of Living With Lyme Disease
Warmer and longer spring and summer and shorter winters are creating the ideal breeding grounds for black-legged ticks. These ticks are expanding farther north into regions where they previously could not survive.
At the same time, warmer conditions are extending the period during which ticks remain active. Public health officials say that ticks can now be active whenever temperatures remain consistently above freezing.
The Public Health Agency of Canada has reported that the geographic range of ticks carrying diseases such as Lyme disease, anaplasmosis and babesiosis continues to expand across several provinces, including Ontario, Quebec, Manitoba, New Brunswick and parts of Atlantic Canada.
Although many people recover completely with prompt treatment, anaplasmosis, if left untreated, can cause serious complications affecting the lungs, kidneys, nervous system and heart.
Older adults, people with weakened immune systems and those whose treatment is delayed face the highest risk of severe illness.
Canadian health authorities recommend that treatment begin as soon as doctors suspect anaplasmosis rather than waiting for laboratory confirmation, since early intervention significantly improves outcomes.
Protecting yourself during tick season is one of the ways to ward off risk of infection. Health officials recommend several simple precautions to reduce the risk of tick bites:
As Canada's climate continues to warm, experts say the country's tick-borne disease landscape is changing rapidly. While Lyme disease remains the most recognized threat, physicians warn that anaplasmosis is no longer a rare infection.
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