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An experimental treatment happens to be the solution to delay Alzheimer's symptoms in some people. These people are the ones who are genetically destined to get the disease in their 40s or 50s. These new findings form ongoing research has now been caught up in Trump administration funding delas. The early results of the study has been published on Wednesday and the participants too are worried that politics could cut their access to a possible lifeline.
One of the participants had said, "It is still a study but it has given me an extension to my life that I never banked on having." The participant is named Jake Henrichs, form New York City, who is 50 years old. He is one of them to be treated in that study for more than a decade now and has remained symptom-free despite inheriting an Alzheimer's-causing gene that had killed his father and brother around the same age.
Two drugs which can modestly slow down early-stage Alzheimer's are sold in the United States. These drugs clear the brain of one of its hallmarks, a sticky gunk-like part called the amyloid. However, there have not been any hints that removing amyloid far earlier, way many years before the first symptoms appear, may postpone the disease.
The research is led by Washington University in St Louis, which involved families that passed down rare gene mutation as participants. This meant it was almost guaranteed that they will develop symptoms at the same age their affected relatives did.
The new findings is based on a subset of 22 participants who received amyloid-removing drugs the longest, on average eight years. Long-term amyloid removal cut in half their risk of symptom onset. The study is published in the journal Lancet Neurology.
Washington University's Dr Randall Bateman, who directs the Dominantly Inherited Alzheimer's Network of studies involving families with these rare genes says, "What we want to determine over the next five years is how strong is the protection. Will they ever get the symptoms of Alzheimer’s disease if we keep treating them?”
The researchers before though did not know what exactly caused Alzheimer's which affects nearly 7 million Americans, most of them in their later life. However, it is clear that these silent changes occur in the brain at least two decades before the first symptom shows up. The big contributor. At some point amyloid buildup can trigger a protein named tau that then starts to kill neurons, which can lead to cognitive decline.
Researchers are now thus studying the Tau-fighting drugs and are looking into other factors, like inflammation, brain's immune cells and certain virus.
The National Institute of Health (NIH) has expanded its focus as researchers have found more reasons for Alzheimer's. In 2013, the NIH's National Institute on Aging funded 14 trials of possible Alzheimer's drugs over a third targeting amyloid. By last fall, there were 68 drugs and 18% of them target amyloid. However, there are scientists too who think that amyloid is not everything and their is way more in the brain tissue, immune cells, and more which can be studied.
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Amid raging wildfires, France is preparing for its fourth major heatwave of the year as extreme temperatures and bone-dry conditions in the southwest intensify the challenges faced by crews battling a massive wildfire in the Bordeaux region.
Temperatures in Bordeaux were expected to reach 33°C (91°F) during the day, around 7°C above the average high recorded between 1961 and 1990, according to the Reuters Climate Monitor.
"The situation we are dealing with today is the most severe we have ever recorded, the toughest since the Second World War," said President Emmanuel Macron.
Firefighters managed to contain the blaze overnight, but the situation remained difficult, with reports suggesting the wildfire threat could continue until November.
France is experiencing an unprecedented wildfire season, with the area affected by fires already surpassing the previous record set in 2022. Around 4000 more people were evacuated from tourist sites along the Atlantic coast, following the evacuation of more than 250,000 people earlier.
Also read: Europe Swelters Under Heatwave And Wildfires; 360,000+ Evacuated: What Are The Health Risks?
Meanwhile, the UK is also preparing for its fourth heatwave of the summer, with temperatures expected to climb to 34°C in parts of the country later this week.
Several amber and yellow heat alerts have been issued as the UK Health Security Agency (UKHSA) warned that rising temperatures could increase health risks, particularly for vulnerable groups.
Temperatures are forecast to reach 29°C in southeast England on Tuesday before rising further to 34°C on Wednesday.
Read More: Could Wildfire Smoke Trigger Your Migraine? Latest Study Finds A Strong Link
The heatwave follows an exceptionally hot and dry June, which has left some of the UK’s driest regions without rainfall for weeks. Forecasters have warned that parts of southern and southeast England could face “exceptionally severe” wildfire conditions this week due to extreme heat and prolonged dry weather.
Parts of Wales have already been placed under drought status, while large areas of England remain under “prolonged dry weather” status — the final stage before a drought declaration.
According to the Medicines and Healthcare products Regulatory Agency (MHRA), high temperatures can affect medicines and reduce how well they work.
Rising temperatures can affect how some medicines work in the body, posing potential risks for people with long-term health conditions. Experts say simple precautions can help prevent heat-related complications.
Medicines that do not require refrigeration, including tablets, inhalers, hormone replacement therapy (HRT) patches, and epinephrine, should generally be stored in a cool, dry place at room temperature, ideally between 15°C and 25°C. This is because high temperatures can reduce the potency and effectiveness of the active ingredients in medicines.
Alison Cave, Chief Safety Officer at the MHRA, said that when there’s a heatwave, medicines left in the heat – in cars, bags, or on sunny windowsills – might not work properly when you need them.
“Some medicines can also make you more likely to burn in the sun, feel dizzy, or get dehydrated, especially if you’re taking diuretics or have a condition like asthma, heart disease, or diabetes.”
To stay safe during hot weather, the MHRA advised people to:
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Stroke is among the leading causes of disability worldwide, and many survivors are left struggling with speech difficulties. After a stroke, some people lose the ability to speak fluently despite being able to understand language and, remarkably, sing familiar songs they have known for years.
This connection between music and speech recovery forms the basis of Melodic Intonation Therapy (MIT), an evidence-based approach that uses melody, rhythm, and repetition to help patients regain communication abilities.
Music therapy works by activating brain networks that remain functional even when areas responsible for speech or movement are damaged.
Speaking to HealthandMe, Dr. Sudhir Kumar, Neurologist at Apollo Hospitals, Hyderabad, explained that rhythm helps retrain the brain’s motor circuits. In stroke patients with movement difficulties, rhythmic auditory stimulation — where movements are synchronised with a steady beat — can help improve walking patterns.
“Music therapy taps into brain networks that survive a stroke even when speech or movement pathways are damaged. Rhythm helps retrain the brain's motor circuits. Patients with gait difficulties often walk more fluidly when moving to a steady beat, a technique we call rhythmic auditory stimulation,” Dr. Sudhir said.
Dr. K. K. Jindal, Director – Neurology, CK Birla Hospital, Delhi, said that after a stroke, the brain can reorganize itself and form new neural connections through a process called neuroplasticity.
“Music, and in particular rhythm and melody, can cause several areas of the brain to be activated at once,” Dr. Jindal told HealthandMe.
He added that techniques like Melodic Intonation Therapy can support communication in patients with speech difficulties, while rhythmic auditory stimulation has helped improve gait, physical coordination, and balance during stroke recovery.
Dr Kumar said for patients with aphasia — a condition that affects speech and language after stroke — singing can engage the right hemisphere of the brain, allowing some patients to produce words through melody even when they are unable to speak normally.
Experts said that beyond neurological benefits, music may also help reduce anxiety and depression, which are common after stroke and can slow recovery.
“Music therapy is not a replacement for conventional rehabilitation, but a scientifically grounded complement to it,” Dr. Sudhir said.
Dr. Jindal also stated that while music therapy cannot substitute treatments such as physiotherapy or speech therapy, it can serve as an effective supportive measure during recovery.
Building on this approach, researchers from IIT Delhi, in collaboration with AIIMS New Delhi and the Institute of Human Behaviour and Allied Sciences (IHBAS), have developed the first Hindi version of Melodic Intonation Therapy.
While MIT has traditionally been used in English, researchers adapted the therapy for Hindi by modifying words, melodies, and rhythmic patterns to match the language’s natural stress patterns and cadence.
The team developed exercises based on how Hindi speakers communicate in everyday life, making the therapy more culturally and linguistically relevant for Indian patients.
The pilot study, published in the international journal Aphasiology, was conducted between December 2023 and March 2024.
The study included six Hindi-speaking stroke survivors who underwent 40 therapy sessions each. Each session lasted 45 to 60 minutes and was conducted by trained speech therapists.
All participants completed the program and showed clinically meaningful improvements. Researchers reported improvements in sentence formation, speech fluency, and quality-of-life measures.
“Patients were able to string together longer sentences, spoke more freely, and reported gains in their quality of life. There were no adverse effects,” said Prof. Rahul Garg, one of the researchers leading the study.
Researchers cautioned that the findings are preliminary due to the small number of participants involved and said that further research is needed to confirm the results.
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Industrial chicken farms may be fueling the spread of diarrhea-causing Campylobacter bacteria, according to a new study.
Researchers from the University of Oxford found that industrial poultry farming has driven more than a 100-fold increase in the spread of Campylobacter.
Published in the Proceedings of the National Academy of Sciences (PNAS), the study found that the expansion of commercial poultry production has enabled bacterial strains once largely confined to wild birds to mix extensively within farmed chicken populations.
"Industrial farming has created one of the largest animal habitats on the planet. Our findings provide new evidence that human-driven environmental change can increase the spread of infectious diseases," said Professor Sam Sheppard, senior author of the study from the University of Oxford.
"As chicken populations have grown, bacteria that were once largely confined to wild birds have gained far more opportunities to enter poultry flocks, spread and become established. Understanding these evolutionary consequences is essential if we are to reduce future risks from zoonotic disease and antimicrobial resistance," he added.
Researchers analyzed nearly 2,800 Campylobacter genomes collected from chickens and wild birds across 30 countries, including the UK and the US, between 1979 and 2024.
The analysis showed that the rapid global expansion of chicken farming has created ideal conditions for the bacteria to spread, exchange genetic material, and acquire traits that improve survival in commercial poultry environments.
Since the 1960s, the global chicken population has increased sevenfold to around 31 billion birds, with chickens now accounting for about 70% of all bird biomass on Earth. While this growth has helped make animal protein more affordable, it has also created favorable conditions for bacterial adaptation and transmission, the researchers argued.
The genomic analysis identified several genetic changes linked to adaptation in poultry, including genes associated with:
According to the researchers, these traits may help Campylobacter survive and spread more efficiently in modern poultry production systems. The study also suggests that densely populated commercial chicken flocks may act as ecological "pathogen sponges," absorbing and amplifying bacterial strains from multiple sources.
The researchers warned that rising antimicrobial resistance (AMR)—when bacteria become resistant to drugs used to treat infections—is making Campylobacter infections increasingly difficult to treat.
They also cited an earlier University of Oxford study, which found that 80% of human Campylobacter infections in Oxfordshire were linked to poultry meat, with many of those infections resistant to antibiotics.
Campylobacter is the world's leading bacterial cause of diarrhea. According to the World Health Organization (WHO), it is one of the four leading global causes of diarrheal disease. Nearly one in 10 people worldwide falls ill from foodborne diseases each year, resulting in the loss of an estimated 33 million healthy life years.
Although infections are usually mild, they can become severe or even fatal in very young children, older adults, and people with weakened immune systems.
Symptoms typically last three to six days. Deaths are rare and generally occur in people with severe underlying health conditions or those at the extremes of age.
Campylobacter bacteria are destroyed by thorough cooking. The WHO recommends proper cooking, safe food handling, and good kitchen hygiene to reduce the risk of infection.
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