An experimental treatment happens to be the solution to delay Alzheimer's symptoms in some people. These people are the ones who are genetically destined to get the disease in their 40s or 50s. These new findings form ongoing research has now been caught up in Trump administration funding delas. The early results of the study has been published on Wednesday and the participants too are worried that politics could cut their access to a possible lifeline.

One of the participants had said, "It is still a study but it has given me an extension to my life that I never banked on having." The participant is named Jake Henrichs, form New York City, who is 50 years old. He is one of them to be treated in that study for more than a decade now and has remained symptom-free despite inheriting an Alzheimer's-causing gene that had killed his father and brother around the same age.

Slowing Down The Symptoms

Two drugs which can modestly slow down early-stage Alzheimer's are sold in the United States. These drugs clear the brain of one of its hallmarks, a sticky gunk-like part called the amyloid. However, there have not been any hints that removing amyloid far earlier, way many years before the first symptoms appear, may postpone the disease.

How Was The Research Conducted?

The research is led by Washington University in St Louis, which involved families that passed down rare gene mutation as participants. This meant it was almost guaranteed that they will develop symptoms at the same age their affected relatives did.

The new findings is based on a subset of 22 participants who received amyloid-removing drugs the longest, on average eight years. Long-term amyloid removal cut in half their risk of symptom onset. The study is published in the journal Lancet Neurology.

Washington University's Dr Randall Bateman, who directs the Dominantly Inherited Alzheimer's Network of studies involving families with these rare genes says, "What we want to determine over the next five years is how strong is the protection. Will they ever get the symptoms of Alzheimer’s disease if we keep treating them?”

The researchers before though did not know what exactly caused Alzheimer's which affects nearly 7 million Americans, most of them in their later life. However, it is clear that these silent changes occur in the brain at least two decades before the first symptom shows up. The big contributor. At some point amyloid buildup can trigger a protein named tau that then starts to kill neurons, which can lead to cognitive decline.

Researchers are now thus studying the Tau-fighting drugs and are looking into other factors, like inflammation, brain's immune cells and certain virus.

The National Institute of Health (NIH) has expanded its focus as researchers have found more reasons for Alzheimer's. In 2013, the NIH's National Institute on Aging funded 14 trials of possible Alzheimer's drugs over a third targeting amyloid. By last fall, there were 68 drugs and 18% of them target amyloid. However, there are scientists too who think that amyloid is not everything and their is way more in the brain tissue, immune cells, and more which can be studied.

Health officials in Kerala have reported two deaths caused by West Nile fever in Ernakulam district.

The deceased was identified as Muraleedharan, a 70-year-old man from Kadangalloor near Aluva. The elderly man died while undergoing treatment on Monday at Kalamassery Medical College, officials said.

Muraleedharan, who was suffering from cancer and had respiratory problems, was admitted to the Medical College Hospital a few days ago with symptoms of West Nile fever. This is the second death from West Nile fever in the Ernakulam district in a week.

Saraswathiyamma, a native of Paravur, died of West Nile fever the other day. Many people have reportedly sought treatment at various hospitals in Ernakulam district with West Nile fever and dengue fever symptoms.

Health Department Issues Advisory

Following the incident, the state health department urged people to remain cautious and also issued an advisory urging the public to take precautions against the mosquito-borne disease.

The West Nile Fever "is caused by a flavivirus commonly found in migratory birds and is transmitted to humans through the bite of infected mosquitoes," the department said, in a statement.

It clarified that "the disease does not spread from person to person and that preventing mosquito bites is the most effective way to avoid infection".

According to health authorities, symptoms may include fever, high body temperature, stiffness of the neck, behavioral changes, confusion, semi-consciousness, or loss of consciousness, PTI reported.

The statement warned that severe infection could affect the nervous system and lead to conditions such as encephalitis and meningitis.

"Elderly persons, those with low immunity, individuals with underlying illnesses, pregnant women, and children have been identified as high-risk groups requiring special attention. Culex mosquitoes, which breed in stagnant and polluted water bodies, drainage channels, septic tanks, marshy areas, paddy fields, and overgrown vegetation, are the primary carriers of the disease," the statement said.

What Is West Nile Fever?

The disease is spread through mosquito bites, and most who get infected do not have any symptoms. However, one in every five infected people has a fever, headache, body aches, and other flu-like symptoms.

The West Nile virus also infects the nervous system and is capable of causing serious brain or spinal cord inflammation.

According to the WHO, West Nile Virus is a member of the flavivirus genus and belongs to the Japanese encephalitis antigenic complex of the family Flaviviridae.

The mosquitoes become infected when they feed on birds that carry the virus in their blood, and then bite humans and infect them.

West Nile Fever: The Symptoms

The symptoms include fever, headache, muscle aches, nausea and vomiting, diarrhoea, rash around the chest and back, swollen lymph nodes, sore throats, and pain behind the eyes.

In severe cases, individuals may have an intense headache, high fever, stiff neck, making you unable to move your chin towards your chest, confusion, muscle weakness, loss of control over your muscle movements, seizures, paralysis, and coma.

West Nile Fever: How Does It Spread?

While the mosquitoes that feed on infected birds are the carriers, there is still a lack of evidence to determine whether it comes directly from the birds. The incubation period for symptoms to show up is two to six days, but it can extend to 14 days, too.

It can be transmitted from a pregnant person to their fetus, through human milk, blood transfusion, and organ transplant. People who are over the age of 60, have cancer, diabetes, or high blood pressure are more prone to the virus.

West Nile Fever: Treatment

There are no treatments or antiviral medications available for it. However, one can treat the mild symptoms at home with over-the-counter medications that you take for a cold or the flu. The best way to prevent is to protect yourself from mosquito bites.

Dr. Ravi Vij, an Indian-origin cancer specialist and an alumnus of Maulana Azad Medical College in New Delhi, has been given the prestigious honor of a professorship for his contributions to advancing treatments for blood cancers.

He has been appointed as the inaugural Jeffrey S. and Prue H. Gershman Distinguished Professor in the John T. Milliken Department of Medicine at Washington University School of Medicine.

Vij is currently a professor of medicine in the department’s Division of Oncology. The professorship has been funded by St. Louis philanthropists Jeffrey and Prue Gershman, who support local education, health, and arts organizations.

In a statement, Chancellor Andrew D. Martin stated that this professorship, "will accelerate progress against blood cancers by supporting Dr. Vij’s work to bring new, more effective treatments to patients".

Martin also lauded Dr. Vij’s leadership, noting that it has "helped grow WashU Medicine’s reputation as a national force in stem cell transplantation and immunotherapy".

Leading Blood Cancer Research

Dr Vij's work includes studying the genetic underpinnings and cellular microenvironment of multiple myeloma — a cancer of the plasma cells in bone marrow.

He also treats patients at Siteman Cancer Center, based at Barnes-Jewish Hospital and WashU Medicine, and is the principal investigator of the Multiple Myeloma Tissue Banking initiative at Siteman.

He has led several clinical trials of investigational therapies for blood cancers, including immunotherapy agents and novel stem cell transplant strategies, that later became standard treatments. He has authored more than 300 scientific publications in the field of blood cancers.

Also read:I’m Cancer-Free After 14 Years, Says Robin Quivers

Contributions Beyond Research

Beyond his research into blood cancer, Dr. Vij has served on the American Society of Clinical Oncology education and scientific committees and on the myeloma committees of the Clinical Trials Network and Alliance for Clinical Trials in Oncology.

He currently serves as senior editor of the journal Clinical Lymphoma, Myeloma and Leukemia and is a past chair of the American Society of Hematology scientific committee on plasma cell dyscrasias, a group of disorders linked to blood cancers.

His accolades include the Multiple Myeloma Research Foundation Innovator Award, the Center of Excellence Award, and the Leukemia & Lymphoma Society Visionary of the Year Award.

A respected educator, Vij has mentored 25 early-career researchers and received the Teacher of the Year Award from the Hematology and Oncology Fellowship Program at WashU Medicine in 2007.

Read More: Benjamin Netanyahu Undergoes Treatment For Early-stage Prostate Cancer: Symptoms You Should Not Ignore

Education and Career

Dr. Vij completed his medical education at Maulana Azad Medical College in New Delhi, India, followed by postgraduate training at Halifax General Hospital and Royal Infirmary in the United Kingdom.

He completed an internal medicine residency at Rush University in Chicago and fellowships in medical oncology, hematology, and bone marrow transplantation at WashU Medicine. He joined the WashU Medicine faculty in 2000.

What Is Blood Cancer?

Blood cancer is broadly classified into three main types: leukemia, lymphoma, and myeloma. Leukemia is a cancer of the blood and bone marrow, while lymphoma affects the lymphatic system, particularly the lymph nodes and immune cells. Myeloma is a cancer of plasma cells found in the bone marrow.

These cancers disrupt normal blood cell function and can cause symptoms such as fatigue, infections, and unexplained bleeding.

Symptoms And Treatment

Common symptoms of blood cancer include:

• Persistent fatigue
• Frequent infections
• Unexplained bruising or bleeding
• Weight loss
• Swollen lymph nodes

The causes and risk factors for blood cancer vary. Genetic mutations, exposure to radiation or harmful chemicals, certain infections, and a family history of blood cancer are known risk factors. The risk of developing blood cancer generally increases with age.

Advanced treatment options for blood cancers include immunotherapies such as CAR-T cell therapy and stem cell transplantation.

Health officials in Kerala have reported two deaths caused by West Nile fever in Ernakulam district.

The deceased was identified as Muraleedharan, a 70-year-old man from Kadangalloor near Aluva. The elderly man died while undergoing treatment on Monday at Kalamassery Medical College, officials said.

Muraleedharan, who was suffering from cancer and had respiratory problems, was admitted to the Medical College Hospital a few days ago with symptoms of West Nile fever. This is the second death from West Nile fever in the Ernakulam district in a week.

Saraswathiyamma, a native of Paravur, died of West Nile fever the other day. Many people have reportedly sought treatment at various hospitals in Ernakulam district with West Nile fever and dengue fever symptoms.

Health Department Issues Advisory

Following the incident, the state health department urged people to remain cautious and also issued an advisory urging the public to take precautions against the mosquito-borne disease.

In a statement, the department said the disease is caused by a flavivirus commonly found in migratory birds and is transmitted to humans through the bite of infected mosquitoes.

It clarified that the disease does not spread from person to person and that preventing mosquito bites is the most effective way to avoid infection.

According to health authorities, symptoms may include fever, high body temperature, stiffness of the neck, behavioral changes, confusion, semi-consciousness, or loss of consciousness, PTI reported.

Also read: Shigella: The Infection That Claimed A 4-Year-Old's Life In Kerala; Government On Alert

The statement warned that severe infection could affect the nervous system and lead to conditions such as encephalitis and meningitis.

"Elderly persons, those with low immunity, individuals with underlying illnesses, pregnant women, and children have been identified as high-risk groups requiring special attention. Culex mosquitoes, which breed in stagnant and polluted water bodies, drainage channels, septic tanks, marshy areas, paddy fields, and overgrown vegetation, are the primary carriers of the disease," the statement said.

What Is West Nile Fever?

The disease is spread through mosquito bites, and most who get infected do not have any symptoms. However, one in every five infected people has a fever, headache, body aches, and other flu-like symptoms.

The West Nile virus also infects the nervous system and is capable of causing serious brain or spinal cord inflammation.

According to the WHO, West Nile Virus is a member of the flavivirus genus and belongs to the Japanese encephalitis antigenic complex of the family Flaviviridae.

The mosquitoes become infected when they feed on birds that carry the virus in their blood, and then bite humans and infect them.

It is found in different parts of the world, including North America, Europe, Africa, Central Asia, Australia, and Asia. Cases in 49 states in the US have been reported, and the total number of symptomatic cases in the US is 51,000 since the first cases were detected in the country in 1999.

Read More: Salmonella Outbreak: Instant Noodles Sicken Over 80 In The UK, Europe

What Are The Symptoms?

The symptoms include fever, headache, muscle aches, nausea and vomiting, diarrhea, rash around the chest and back, swollen lymph nodes, sore throats, and pain behind the eyes.

In severe cases, individuals may have an intense headache, high fever, stiff neck, making you unable to move your chin towards your chest, confusion, muscle weakness, loss of control over your muscle movements, seizures, paralysis, and coma.

How Can It Spread?

While the mosquitoes that feed on infected birds are the carriers, there is still a lack of evidence to determine whether it comes directly from the birds. The incubation period for symptoms to show up is two to six days, but it can extend to 14 days, too.

It can be transmitted from a pregnant person to their fetus, through human milk, blood transfusion, and organ transplant. People who are over the age of 60, have cancer, diabetes, or high blood pressure are more prone to the virus.

Treatment

There are no treatments or antiviral medications available for it. However, you can treat the mild symptoms at home with over-the-counter medications that you take for a cold or the flu. The best way to prevent is to protect yourself from mosquito bites.