Is 'Sticky Gunk' In Your Brain The Reason Behind Alzheimer's Disease?

Updated Mar 20, 2025 | 08:53 AM IST

SummaryThe new findings is based on a subset of 22 participants who received amyloid-removing drugs the longest, on average eight years.
Alzheimer's Disease

Credits: Canva

An experimental treatment happens to be the solution to delay Alzheimer's symptoms in some people. These people are the ones who are genetically destined to get the disease in their 40s or 50s. These new findings form ongoing research has now been caught up in Trump administration funding delas. The early results of the study has been published on Wednesday and the participants too are worried that politics could cut their access to a possible lifeline.

One of the participants had said, "It is still a study but it has given me an extension to my life that I never banked on having." The participant is named Jake Henrichs, form New York City, who is 50 years old. He is one of them to be treated in that study for more than a decade now and has remained symptom-free despite inheriting an Alzheimer's-causing gene that had killed his father and brother around the same age.

Slowing Down The Symptoms

Two drugs which can modestly slow down early-stage Alzheimer's are sold in the United States. These drugs clear the brain of one of its hallmarks, a sticky gunk-like part called the amyloid. However, there have not been any hints that removing amyloid far earlier, way many years before the first symptoms appear, may postpone the disease.

How Was The Research Conducted?

The research is led by Washington University in St Louis, which involved families that passed down rare gene mutation as participants. This meant it was almost guaranteed that they will develop symptoms at the same age their affected relatives did.

The new findings is based on a subset of 22 participants who received amyloid-removing drugs the longest, on average eight years. Long-term amyloid removal cut in half their risk of symptom onset. The study is published in the journal Lancet Neurology.

Washington University's Dr Randall Bateman, who directs the Dominantly Inherited Alzheimer's Network of studies involving families with these rare genes says, "What we want to determine over the next five years is how strong is the protection. Will they ever get the symptoms of Alzheimer’s disease if we keep treating them?”

The researchers before though did not know what exactly caused Alzheimer's which affects nearly 7 million Americans, most of them in their later life. However, it is clear that these silent changes occur in the brain at least two decades before the first symptom shows up. The big contributor. At some point amyloid buildup can trigger a protein named tau that then starts to kill neurons, which can lead to cognitive decline.

Researchers are now thus studying the Tau-fighting drugs and are looking into other factors, like inflammation, brain's immune cells and certain virus.

The National Institute of Health (NIH) has expanded its focus as researchers have found more reasons for Alzheimer's. In 2013, the NIH's National Institute on Aging funded 14 trials of possible Alzheimer's drugs over a third targeting amyloid. By last fall, there were 68 drugs and 18% of them target amyloid. However, there are scientists too who think that amyloid is not everything and their is way more in the brain tissue, immune cells, and more which can be studied.

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18-Year-Old Dies From Rare Measles Brain Complication As Pennsylvania Death Toll Hits 4

Updated Sep 16, 2026 | 06:17 AM IST

SummaryAfter the death of an infant and a 40-year-old woman, Pennsylvania has reported its fourth measles-related death after an 18-year-old died due to rare brain complication.
18-Year-Old Dies From Rare Measles Brain Complication As Pennsylvania Death Toll Hits 4

Credit: iStock

Pennsylvania has reported its fourth measles-associated death after an 18-year-old from Mifflin County died from a rare and severe neurological complication of the infection.

The Pennsylvania Department of Health confirmed two additional measles-associated deaths on September 15, including the 18-year-old and an unvaccinated person from Jefferson County. The state has now recorded four measles-associated deaths in 2026 as its outbreak continues to expand.

The latest casualty highlights acute disseminated encephalomyelitis (ADEM), one of the most serious complications of measles can cause. In this condition, the inflammation damages the brain and spinal cord.

How Can Measles Affect The Brain?

According to Mifflin County Coroner Andrea Alcalde, a review of medical records and available investigative information determined that the 18-year-old died from acute disseminated encephalomyelitis, which she described as a rare and severe neurological complication of measles.

Ruled as a natural death, the individual was unvaccinated, according to Pennsylvania health officials. ADEM entails inflammation of the brain and spinal cord. It can cause neurological symptoms and in extreme cases, can become life-threatening.

Measles itself is highly contagious and can cause complications that could impact multiple organs. Pennsylvania health officials say serious complications can include pneumonia and brain swelling, while around 20% of people identified with measles in the state have required hospitalisation during the current outbreak.

Also read: Chile Eliminates Dog-Transmitted Rabies: What Other Countries Can Learn

Pennsylvania Has Now Recorded 4 Deaths

The latest deaths come as Pennsylvania continues to experience its worst measles outbreak in more than three decades. The state has recorded 693 confirmed measles cases across 38 counties in 2026, according to the Pennsylvania Department of Health.

The four deaths include two infants from Lancaster County reported in August, a 40-year-old woman from Jefferson County who died from measles complications, and the 18-year-old from Mifflin County. The outbreak has been concentrated in Lancaster and Mifflin counties, although infections have now been reported across more than half of Pennsylvania's counties.

The state health department said all four individuals were unvaccinated. The two infants were too young to receive routine measles vaccination.

Pennsylvania Secretary of Health Dr Debra Bogen said, “My thoughts are with the two families who lost loved ones to this highly-contagious virus, as Pennsylvania faces the worst measles outbreak in more than three decades.”

She added, “We remain committed to working with our partners across Pennsylvania to stem this outbreak and prevent more deaths. That means ensuring people have the facts about measles and access to the MMR vaccine – which kept measles outbreaks at bay for decades.”

Also read: 3D-Printed Mosquito ‘Toilets’ Track West Nile, Find New Virus In Americas

Worst Measles Outbreak In History

Measles is among the world's most contagious infectious diseases. It spreads through respiratory droplets and airborne particles when an infected person coughs, sneezes or breathes.

The Pennsylvania Department of Health says measles-associated deaths, while rare, occur in around one to three people per 1,000 cases.

The department also says two doses of the measles, mumps and rubella (MMR) vaccine provide 97% lifetime protection. The state has identified four breakthrough infections among appropriately vaccinated people during the current outbreak.

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Bouncy Castles Linked To MRSA Outbreak In 48 Children In Ireland

Updated Sep 15, 2026 | 11:20 PM IST

SummaryIn 27 cases, legs were most commonly affected, particularly the thighs. Some children also developed fever, nausea or vomiting. While 15 required hospital care, four were admitted. None required intensive care, and there were no deaths.
Bouncy Castles Linked To MRSA Outbreak In 48 Children In Ireland

Credit: iStock

Ireland experienced its largest reported community-acquired MRSA outbreak in 2025, with researchers linking 48 skin and soft-tissue infections to bouncy castles at an outdoor gathering, according to a report published in Eurosurveillance.

The outbreak sickened children and teenagers aged 5 to 16, with 15 requiring hospital care and four being admitted. None required intensive care, and there were no deaths.

Health officials traced the cluster to an outdoor social gathering in eastern Ireland in fall 2025, where children and teens played on three inflatable bouncy castles, many for several hours.

Nearly everyone who fell ill had attended the event, and all 47 cases who were at the gathering had played on the inflatables, researchers said.

The infections were caused by methicillin-resistant Staphylococcus aureus (MRSA), a drug-resistant form of staph bacteria that can cause painful skin infections and, in serious cases, spread deeper into the body.

The strain involved in the outbreak also carried Panton-Valentine leukocidin (PVL), a toxin associated with skin and soft-tissue infections. Researchers said the strain is rare in Ireland.

MRSA Symptoms Appeared Quickly

Read More: Bill Gates Says Vaccine Hesitancy Could Make Ending Measles Impossible

The illnesses developed rapidly. Thirty-four of the 48 cases developed symptoms within two days of the gathering, with some children becoming sick within 24 hours.

Among the 27 cases where doctors recorded the location of infection, the legs were most commonly affected, particularly the thighs.

Some children also developed fever, nausea or vomiting.

Thirty-three children were treated by a general practitioner, while 15 went to a hospital emergency department or day ward. Four were admitted, with a median hospital stay of four days.

How The Outbreak May Have Spread

Researchers said the gathering took place on a warm, humid and intermittently rainy day. Parents recalled that children playing outside were noticeably wet.

About 120 people were believed to have attended the gathering, roughly half of them children and teenagers.

What Is MRSA?

MRSA is a type of Staphylococcus aureus (staph), a common bacterium that can cause infections. It is resistant to several commonly used antibiotics.

According to the US CDC, anyone can develop or carry an MRSA infection. The risk is higher with factors such as recent hospitalization or nursing home stays, skin-to-skin contact including during contact sports, and exposure to crowded or unhygienic settings.

Signs And Symptoms

Symptoms of a S. aureus infection, including MRSA, depend on the part of the body affected.

MRSA skin infections often develop through broken skin, such as cuts or scrapes. They may appear as a bump or infected area that is:

  • Red
  • Swollen
  • Painful
  • Warm to the touch
  • Filled with pus or other drainage
  • Accompanied by fever.

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DRC Says Ebola Outbreak Has Peaked, UN Warns It’s Still Growing

Updated Sep 15, 2026 | 08:57 PM IST

SummaryThe Bundibugyo virus outbreak was declared by WHO on May 15. It is the DRC’s 17th Ebola outbreak since 1976 and the second-deadliest on record, after West Africa’s 2014–2016 outbreak.
DRC Says Ebola Outbreak Has Peaked, UN Warns It’s Still Growing

Credit: iStock

Health officials in the Democratic Republic of the Congo (DRC) have stated that the Ebola outbreak has reached its peak, with the number of new cases slowing for the first time since May.

However, the UN has warned that the epidemic remains “massive” and is still growing in some areas, while the World Health Organization (WHO) said it is too early to confidently conclude that the outbreak has passed its peak.

The outbreak, caused by the rare Bundibugyo virus, was declared by the WHO on May 15. It is the DRC’s 17th Ebola outbreak since the virus was first identified in 1976.

It is also the second-deadliest Ebola outbreak on record, behind the West African outbreak that lasted from 2014 to 2016.

While clinical trials are ongoing for vaccines and treatments against Bundibugyo virus, the DRC received more than 70,000 doses of the Ervebo vaccine last month. Ervebo is approved for protection against the more common Zaire Ebola virus.

Are Ebola Cases Slowing?

Also read: Ebola Bundibugyo Virus: American Health Worker Had 10x Higher Viral Load In Throat Than Blood

According to the latest data from the Congolese health ministry, more than 7,200 confirmed cases and over 3,475 deaths had been reported as of September 14.

Congolese Health Minister Samuel Roger Kamba said transmission of the Bundibugyo virus had declined, with daily cases falling from about 120 at the peak in mid-August to around 80.

“We are fighting a very dangerous virus that is killing many of our people. Today, we can say that the outbreak is under control,” he said.

“At one point, we were recording about 120 cases per day; today, we’re seeing about 80 per day. So the number of new cases is decreasing every day.”

Kamba said 10 of the 62 affected health zones had reported no new cases for more than 22 days. Six health zones had gone more than 42 days without a new case, while four had gone more than 21 days without one.

He said the figures were “encouraging” but stressed that people must remain fully mobilized and not lower their guard.

Concerns Over Government Claim

Read More: Chile Eliminates Dog-Transmitted Rabies: What Other Countries Can Learn

Last week, Sud-Ubangi province, which borders Congo-Brazzaville and the Central African Republic, became the sixth province to report Ebola cases.

While welcoming the progress, Iracan Gratien de Saint-Nicolas, an MP for Bunia, warned against “triumphalism” and called for greater transparency over the outbreak data, The Guardian reported.

“Claims that an epidemic is under control must be supported by objective indicators. If the indicators show that the epidemic is indeed under control, let’s make them public. Transparency in the data will strengthen public confidence,” he said.

He also called for lessons to be learned from failures in epidemiological surveillance that contributed to the rapid spread of the disease.

What Is The UN Saying?

UN officials acknowledged that response efforts were showing results but warned that the epidemic remained “massive” and could take months to bring under control.

“It remains a deadly and a massive epidemic. There are some areas of progress, but nonetheless, in other areas, we continue to see growth in cases,” Julien Harneis, the UN special Ebola coordinator, told a Geneva press briefing.

Asked about reports that the epidemic had reached a turning point, WHO's Olivier le Polain said: “It's too early to confidently say we have passed a peak”, Reuters reported.

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