Is 'Sticky Gunk' In Your Brain The Reason Behind Alzheimer's Disease?

Updated Mar 20, 2025 | 08:53 AM IST

SummaryThe new findings is based on a subset of 22 participants who received amyloid-removing drugs the longest, on average eight years.
Alzheimer's Disease

Credits: Canva

An experimental treatment happens to be the solution to delay Alzheimer's symptoms in some people. These people are the ones who are genetically destined to get the disease in their 40s or 50s. These new findings form ongoing research has now been caught up in Trump administration funding delas. The early results of the study has been published on Wednesday and the participants too are worried that politics could cut their access to a possible lifeline.

One of the participants had said, "It is still a study but it has given me an extension to my life that I never banked on having." The participant is named Jake Henrichs, form New York City, who is 50 years old. He is one of them to be treated in that study for more than a decade now and has remained symptom-free despite inheriting an Alzheimer's-causing gene that had killed his father and brother around the same age.

Slowing Down The Symptoms

Two drugs which can modestly slow down early-stage Alzheimer's are sold in the United States. These drugs clear the brain of one of its hallmarks, a sticky gunk-like part called the amyloid. However, there have not been any hints that removing amyloid far earlier, way many years before the first symptoms appear, may postpone the disease.

How Was The Research Conducted?

The research is led by Washington University in St Louis, which involved families that passed down rare gene mutation as participants. This meant it was almost guaranteed that they will develop symptoms at the same age their affected relatives did.

The new findings is based on a subset of 22 participants who received amyloid-removing drugs the longest, on average eight years. Long-term amyloid removal cut in half their risk of symptom onset. The study is published in the journal Lancet Neurology.

Washington University's Dr Randall Bateman, who directs the Dominantly Inherited Alzheimer's Network of studies involving families with these rare genes says, "What we want to determine over the next five years is how strong is the protection. Will they ever get the symptoms of Alzheimer’s disease if we keep treating them?”

The researchers before though did not know what exactly caused Alzheimer's which affects nearly 7 million Americans, most of them in their later life. However, it is clear that these silent changes occur in the brain at least two decades before the first symptom shows up. The big contributor. At some point amyloid buildup can trigger a protein named tau that then starts to kill neurons, which can lead to cognitive decline.

Researchers are now thus studying the Tau-fighting drugs and are looking into other factors, like inflammation, brain's immune cells and certain virus.

The National Institute of Health (NIH) has expanded its focus as researchers have found more reasons for Alzheimer's. In 2013, the NIH's National Institute on Aging funded 14 trials of possible Alzheimer's drugs over a third targeting amyloid. By last fall, there were 68 drugs and 18% of them target amyloid. However, there are scientists too who think that amyloid is not everything and their is way more in the brain tissue, immune cells, and more which can be studied.

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137 Cancer Drugs To Cost Up To 70% Less From November 9: NPPA Caps Trade Margins

Updated Oct 18, 2026 | 12:59 PM IST

SummaryThe National Pharmaceutical Pricing Authority has capped the trade margins on 137 anti-cancer drugs including pembrolizumab, ribociclib, abemaciclib, atezolizumab and bevacizumab and others from November 9.
137 Cancer Drugs To Cost Up To 70% Less From November 9: NPPA Caps Trade Margins

Credit: AI

The National Pharmaceutical Pricing Authority (NPPA) has capped trade margins on 137 non-scheduled anti-cancer drugs at 30%. The move is expected to reduce the maximum retail prices (MRPs) of the cancer medicines by up to 70%.

Announced by the Department of Pharmaceuticals under the Ministry of Chemicals and Fertilizers, the measure aims to curb excessive mark-ups in the distribution and sale of cancer medicines.

It covers a range of anti-cancer drugs, including patented treatments, and is intended to ease the financial burden on patients and their families.

The revised prices is reported to come into effect on November 9, 2026. Manufacturers have been directed to submit revised prices to the NPPA within seven days of the notification.

Indian Government Caps Trade Margins On Cancer Drugs

Also read: Dr Rachna Shroff: Indian-American Cancer Researcher Who Turned Her Diagnosis Into Advocacy

Trade margins are the difference between the price at which a medicine enters the distribution chain and the price charged as it moves further along that chain. These margins reflect in the final cost of the medicines to the patients.

According to the government, an analysis of market data found that non-scheduled anti-cancer medicines had an average trade mark-up of around 170%, some even reaching as high as 700%.

Non-scheduled medicines are drugs that do not fall under the scheduled list of medicines subject to specific ceiling prices under the Drug Price Control Order.

The latest intervention uses the government's powers under Paragraph 19 of the Drugs (Prices Control) Order, 2013, to cap trade margins in the affordable healthcare in serious illnesses like cancer.

By limiting these margins, the government expects to bring down prices of these medicines and help patients to avoid switching to different medicines solely because of cost.

The list includes 137 non-scheduled anti-cancer drugs recommended by an expert committee under the Directorate General of Health Services (DGHS). The committee included oncologists, medical specialists, hospital experts and government officials. The medicines covered include pembrolizumab, ribociclib and abemaciclib, which are used in the management of certain cancers. Other medicines on the list include atezolizumab and bevacizumab.

Expected Savings Of Nearly ₹2,500 Crore For Patients

Also read: H. pylori And Cancer: US Gastroenterologist Explains How A Common Stomach Infection Raises Risk

With this measure, the government expects to generate annual savings of approximately ₹2,500 crore for patients. The expected reduction in MRP ranges roughly from 20% to 70%, depending on the medicine.

This is not the first the government has intervened in the pricing of anti-cancer drugs. In 2019, trade margins on 42 anti-cancer drugs were capped at 30%. After that, the MRPs of 526 brands of non-scheduled anti-cancer medicines were reduced by up to 90%, which generated annual estimated annual savings of ₹984 crore.

The latest measure expands the rule to a larger group of medicines to improve affordability and better access to cancer treatment.

NPPA's Directives To Drug Manufacturers

The NPPA has asked drug manufacturers to submit revised MRPs within seven days of the announcement and make the updated prices available through their websites, hospital pharmacies and retailers.

From November 9, hospitals and pharmacies must sell the cancer medicines at the revised prices without fail. Hospitals and retailers who sell anti-cancer medicines in substantial amounts everyday have specifically been asked to comply with the notification.

The government has also asked manufacturers to maintain production and supply levels to prevent shortages after the price changes. State drug controllers will monitor compliance among manufacturers, distributors, retailers and healthcare institutions.

Patients must confirm the exact brand, strength and formulation prescribed, as prices can differ across products from November 9. They should not change or discontinue cancer treatment on their own without consulting their oncologist.

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Washington Reports Human Bird Flu Case After Dairy Cattle Exposure: Should You Be Worried?

Updated Oct 16, 2026 | 10:49 PM IST

SummaryThe human case follows highly pathogenic avian influenza H5N1 detection in dairy cattle on two Yakima County farms, where the resident was exposed to infected animals. Authorities have quarantined both farms and implemented biosecurity measures, while veterinarians treat sick cows.
Washington Reports Human Bird Flu Case After Dairy Cattle Exposure: Should You Be Worried?

Credit: iStock

A Yakima County resident in Washington has tested positive for avian influenza after exposure to infected dairy cattle, the Yakima Health District (YHD) and Washington State Department of Health (DOH) announced.

The resident has not developed severe illness, has not required hospitalization and is isolating at home, officials said.

“We are working closely with our public health partners to follow up with people who have been in close contact with this individual. We want to make sure they know what symptoms to watch for and can access testing and treatment if needed,” said Dr. Dave Atteberry, health officer at the Yakima Health District.

H5N1 Detected In Washington Dairy Cattle

The case follows the detection of highly pathogenic avian influenza (HPAI) H5N1 in dairy cattle on two Yakima County farms. The resident was exposed to the infected cattle.

The Washington State Department of Agriculture has placed both farms under quarantine and implemented biosecurity measures, officials said. Veterinarians are treating sick cows.

Washington State Veterinarian Amber Itle urged farms to strengthen biosecurity measures and promptly report symptoms in animals.

Also read: H5N1 Bird Flu Reaches New Zealand; 12 Human Infections Reported Worldwide

Should You Be Worried About Bird Flu?

The risk to the general public remains low, health officials said. Dairy workers and others who have close or prolonged contact with infected animals or contaminated environments face a higher risk.

Public health officials are contacting people who had close contact with the patient and monitoring them for symptoms for 14 days after their last exposure.

Have Human Bird Flu Cases Been Reported Before In The US?

Read More: H5 Bird Flu Spreads To Australian Mammals: Is It Nearing Humans?

Yes. The first reported human H5N1 case in the US was detected in April 2022 in a Colorado poultry worker exposed to infected birds. The first presumed cow-to-human H5N1 transmission in the country was reported in Texas in April 2024, involving a dairy worker exposed to infected cattle.

According to the Pan American Health Organization (PAHO), 1,002 laboratory-confirmed human H5N1 infections and 479 deaths were reported across 25 countries between 2003 and August 7, 2026. In 2026 alone, nine cases, including two deaths, were reported worldwide.

The US Centers for Disease Control and Prevention (CDC) reported 12 human H5N1 infections outside the US between August 4, 2025, and June 10, 2026: eight in Cambodia, three in Bangladesh and one in India. Three cases were fatal. The infections were associated with exposure to infected poultry or their environments; no person-to-person transmission was identified.

What Is Avian Influenza?

Avian influenza, commonly called bird flu, is caused by Type A influenza viruses found naturally in wild birds. The virus can spread to poultry and mammals, including dairy cattle. Humans can become infected through close contact with infected animals or contaminated environments.

Sustained human-to-human transmission of currently circulating H5N1 viruses has not been established.

How Can You Reduce Your Risk?

People who have close or prolonged contact with infected animals or contaminated environments face a higher risk. They include agricultural workers, backyard flock owners, hunters and wildlife workers.

To prevent the risk, it is recommended to:

  • Avoid touching wild birds or other animals, including those that appear healthy. Stay away from sick or dead animals, bird droppings and potentially contaminated surfaces.
  • Workers exposed to infected animals should follow recommended precautions, wear appropriate personal protective equipment (PPE) and report suspected illness in animals.
  • Hunters should wear disposable gloves when handling harvested birds and practice good hygiene.
  • Ask your healthcare provider about seasonal flu vaccination. It does not prevent bird flu but can reduce the risk of simultaneous infection with human and avian influenza viruses.

Are Dairy Products Safe To Consume?

Pasteurization kills HPAI viruses in milk, helping protect the commercial dairy supply. However, infected cows can shed the virus in their milk, making raw milk and unpasteurized dairy products unsafe.

Avoid raw dairy products. Do not give pets raw milk, unpasteurized dairy products or raw meat.

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Teen Girls in US Have Lower Heart Health Scores Than Boys: CDC Study

Updated Oct 16, 2026 | 06:00 PM IST

Summary​The findings of the 2025 biennial Youth Risk Behavior Survey showed that approximately 21% of students had high overall cardiovascular health scores, while 61% had moderate scores and 18% had low scores.
Teen Girls in US Have Lower Heart Health Scores Than Boys: CDC Study

Credit: iStock

Female high school students in the United States had lower overall cardiovascular health scores than male students, with mean scores of 64.2 and 66.2, respectively, according to a nationwide survey by the US Centers for Disease Control and Prevention (CDC).

The findings, based on the American Heart Association’s Life’s Essential 8 framework, showed that female students had lower mean scores for physical activity and sleep health but higher, more favorable BMI scores than male students.

Lower physical activity and sleep health scores were also observed among students in higher grades, while nicotine exposure scores were lower among students in higher grades.

CDC Study Assesses Heart Health Among US Teenagers

Also read: 4 in 10 US High School Students Report Binge Eating: What Are the Risks?

The 2025 biennial Youth Risk Behavior Survey included 10,710 students in grades 9–12. Of these, 5,192 had complete data for all five cardiovascular health measures: physical activity, diet, sleep health, body mass index (BMI), and nicotine exposure.

The findings, published in the CDC’s Morbidity and Mortality Weekly Report, showed that approximately 21% of students had high overall cardiovascular health scores, while 61% had moderate scores and 18% had low scores.

The prevalence of high overall scores was lower among female students and those in grades 10–12 than among male students and ninth-graders, respectively. Overall, approximately four in five students had low or moderate scores across the five assessed cardiovascular health measures.

Why Sleep, Diet and Exercise Matter for Teen Heart Health

Read More: The Silent Struggle Of Raising A Child With Mental Health Challenges: How Parents Can Cope With Stigma

Cardiovascular diseases (CVDs) are the leading causes of mortality in the US, and many CVD risk factors emerge in childhood and adolescence. Adolescence is a crucial period during which health behaviors develop and persist into adulthood.

A March 2026 study published in the European Journal of Preventive Cardiology suggested that even small, combined improvements in daily habits may benefit cardiovascular health.

Sleeping an additional 11 minutes, engaging in five more minutes of moderate-to-vigorous physical activity, and eating an extra quarter-cup of vegetables daily were associated with a 10% lower risk of heart attacks, strokes and other serious cardiovascular problems compared with less healthy habits.

Sleep is particularly important during adolescence, when the body and brain undergo significant developmental changes. Adequate sleep supports physical recovery, immune function, concentration and emotional well-being.

Teenagers generally need eight to 10 hours of sleep each night. However, schoolwork, extracurricular activities and screen time can interfere with sufficient rest. Research has also linked insufficient sleep with less healthy food choices and a greater tendency to eat later at night.

Elsie Taveras, a pediatrician at Mass General Brigham, highlights the importance of adequate sleep in reducing the risk of chronic conditions, including obesity and cardiovascular risk factors. Children from racial minority and lower-income households may face additional barriers to healthy sleep.

“Sleep health is something we need to pay attention to, and that we counsel teenagers and their families about,” Taveras said.

“We’ve found that shorter sleep duration and lower sleep quality in children and adolescents are associated with a higher risk of obesity and risk factors for heart disease. These are substantial effects that can affect children for years to come,” she added.

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