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An experimental treatment happens to be the solution to delay Alzheimer's symptoms in some people. These people are the ones who are genetically destined to get the disease in their 40s or 50s. These new findings form ongoing research has now been caught up in Trump administration funding delas. The early results of the study has been published on Wednesday and the participants too are worried that politics could cut their access to a possible lifeline.
One of the participants had said, "It is still a study but it has given me an extension to my life that I never banked on having." The participant is named Jake Henrichs, form New York City, who is 50 years old. He is one of them to be treated in that study for more than a decade now and has remained symptom-free despite inheriting an Alzheimer's-causing gene that had killed his father and brother around the same age.
Two drugs which can modestly slow down early-stage Alzheimer's are sold in the United States. These drugs clear the brain of one of its hallmarks, a sticky gunk-like part called the amyloid. However, there have not been any hints that removing amyloid far earlier, way many years before the first symptoms appear, may postpone the disease.
The research is led by Washington University in St Louis, which involved families that passed down rare gene mutation as participants. This meant it was almost guaranteed that they will develop symptoms at the same age their affected relatives did.
The new findings is based on a subset of 22 participants who received amyloid-removing drugs the longest, on average eight years. Long-term amyloid removal cut in half their risk of symptom onset. The study is published in the journal Lancet Neurology.
Washington University's Dr Randall Bateman, who directs the Dominantly Inherited Alzheimer's Network of studies involving families with these rare genes says, "What we want to determine over the next five years is how strong is the protection. Will they ever get the symptoms of Alzheimer’s disease if we keep treating them?”
The researchers before though did not know what exactly caused Alzheimer's which affects nearly 7 million Americans, most of them in their later life. However, it is clear that these silent changes occur in the brain at least two decades before the first symptom shows up. The big contributor. At some point amyloid buildup can trigger a protein named tau that then starts to kill neurons, which can lead to cognitive decline.
Researchers are now thus studying the Tau-fighting drugs and are looking into other factors, like inflammation, brain's immune cells and certain virus.
The National Institute of Health (NIH) has expanded its focus as researchers have found more reasons for Alzheimer's. In 2013, the NIH's National Institute on Aging funded 14 trials of possible Alzheimer's drugs over a third targeting amyloid. By last fall, there were 68 drugs and 18% of them target amyloid. However, there are scientists too who think that amyloid is not everything and their is way more in the brain tissue, immune cells, and more which can be studied.
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Health officials in England have confirmed that an adult with an underlying immunological condition has died from measles, marking the third measles-related death this year after two children died in June.
According to the latest figures from the UK Health Security Agency (UKHSA), England has recorded 883 confirmed measles cases between the start of the year and July 6. More than half of the cases have been reported in London, with most infections occurring in children aged 10 years and under.
All regions of England, including London (52 per cent), the West Midlands 17 per cent, and the North West 10 per cent, have now reported measles cases.
The UK was declared measles-free in 2017 but lost that status in 2019 after vaccination rates declined and outbreaks resumed.
In January, the World Health Organization (WHO) confirmed that the UK was no longer considered to have eliminated measles, citing stagnant vaccination coverage and rising case numbers.
Also read: Experts Say US Cyclospora Parasite Outbreak Is Unusual: How To Clean Fresh Produce
In response to the surge in infections, NHS leaders have launched a nationwide catch-up campaign targeting children aged two to 11 years who have missed one or both doses of the measles, mumps and rubella (MMR) vaccine.
The program will contact around one million families whose children are not fully vaccinated.
Current figures show that 84.1% of five-year-olds in England had received both doses of the MMR vaccine during the first three months of the year—well below the 95% coverage recommended to prevent outbreaks.
"We urge all parents to ensure their children are up to date with their MMR or MMRV vaccines, giving them the best and safest protection against measles," said Dr Vanessa Saliba, consultant epidemiologist at UKHSA.
"Anyone who has missed their measles vaccines can catch up through their GP practice, whatever their age. Getting vaccinated also helps protect babies who are too young to be vaccinated and people who cannot receive the vaccine because of certain health conditions," Dr Saliba added.
Read More: Crusted Scabies Outbreak: UK Reports Rare Highly Contagious Skin Disease
Measles (rubeola) is one of the world's most contagious viral infections. It spreads through respiratory droplets released when an infected person coughs or sneezes and can also spread by touching contaminated surfaces before touching the eyes, nose, or mouth.
Symptoms usually develop 7 to 14 days after exposure and include:
While many people recover fully, measles can cause serious complications, including pneumonia, encephalitis (brain inflammation), hearing loss, and, in rare cases, death.
The MMRV is a safe, live-attenuated immunizations that protect against severe viral infections. The shot combines Measles, Mumps, and Rubella, and also adds protection against Varicella (chickenpox).
According to the UKHSA, children receive:
Children who miss these doses can receive a catch-up vaccination at their 3-year and 4-month appointment. The MMRV vaccine contains weakened forms of the measles, mumps, rubella, and chickenpox viruses, which stimulate immunity without causing disease.
Two MMRV vaccines are available:
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An outbreak of Cyclospora, a microscopic parasite that causes prolonged watery diarrhea, has sickened more than 1,400 people across the United States, with infectious disease experts describing the surge in cases as "definitely abnormal."
While the US Centers for Disease Control and Prevention (CDC) is still investigating the source, officials believe the outbreak is likely linked to multiple sources of contamination rather than a single food product.
Health officials in Michigan have reported 1,251 Cyclospora infections, a dramatic increase from around 170 cases recorded on June 30. The state typically reports only about 50 cases annually.
Ohio has confirmed nearly 200 cases, while New York, Illinois, Indiana, North Carolina, and Texas have also reported an increase in infections. More than 40 people have been hospitalized.
Dr. Thomas Moore, an infectious disease specialist and clinical professor of medicine at the University of Kansas School of Medicine-Wichita, described the spike as "definitely abnormal" and concerning, according to The New York Times.
Keith R. Schneider, professor of food safety at the University of Florida, noted that Cyclospora infections usually increase between May and August in the United States. However, he said the current surge—particularly in Michigan—is far beyond what is normally expected.
"Something is going on right now in that area," Schneider told The New York Times.
Experts also warned that the reported infections may represent only the "tip of the iceberg," with additional cases expected in the coming weeks, because the infection takes long to manifest.
Also read: Crusted Scabies Outbreak: UK Reports Rare Highly Contagious Skin Disease
Cyclospora is a microscopic parasite that infects people after they consume food or water contaminated with human feces containing the parasite's eggs (oocysts).
Unlike many foodborne bacteria, Cyclospora infections often takes two days to two weeks or more to cause illness after exposure, making it difficult for investigators to identify the original source.
Although the illness is usually not life-threatening, it can cause prolonged diarrhea, stomach cramps, nausea, fatigue, bloating, and weight loss.
Fresh produce is the most common source of infection, though contaminated water can also spread the parasite. Health officials have not advised people to avoid fresh produce, as investigators have not yet identified the exact food responsible for the current outbreak.
Yet, previous US Cyclospora outbreaks have frequently been linked to imported fresh produce, including:
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Experts emphasize that proper handwashing with soap and water remains one of the most effective ways to reduce the risk of infection.
Alcohol-based hand sanitizers do not kill Cyclospora, making soap and water essential after using the bathroom and before preparing or eating food.
"This type of parasite doesn't easily go away with alcohol-based hand sanitizer. So, good old handwashing is really key here," ABC News medical correspondent Dr. Darien Sutton said.
While washing produce cannot eliminate all risk, experts say it can reduce contamination. They advised washing fruits and vegetables thoroughly under clean running water, and washing hands before and after handling fresh produce.
According to the Michigan Department of Health and Human Services, cooking produce whenever possible during an active outbreak is crucial, as heating food to at least 158°F (70°C) kills Cyclospora.
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The UK has reported an outbreak of crusted scabies, a rare and highly contagious form of scabies, prompting the temporary closure of a hospital ward in Wales.
According to the Hywel Dda University Health Board, Steffan Ward at Glangwili Hospital in Carmarthen has been temporarily closed while the outbreak is managed under established infection prevention and control measures, according to the BBC.
Health officials said all patients and staff identified as close contacts have been informed and offered treatment, even if they are not showing symptoms. Enhanced infection control measures, including monitoring, treatment of identified contacts, and specialist support, have also been put in place.
Officials added that a recent rise in scabies cases across Carmarthenshire, Pembrokeshire, and Ceredigion has contributed to outbreaks in healthcare settings. The ward will reopen once it is deemed safe under infection control guidance.
Also read: Radio Broadcaster Paul Gambaccini Reveals Alzheimer's Disease Diagnosis
Scabies is a highly contagious skin infestation caused by the microscopic mite Sarcoptes scabiei. The mites burrow into the upper layer of the skin, where they lay eggs, triggering an allergic reaction that causes intense itching and a rash.
However, the crusted scabies—previously known as Norwegian scabies—is a severe form of the infestation in which the skin develops thick, crusted plaques that may crack and become inflamed, according to the US Centers for Disease Control and Prevention (CDC).
Unlike classic scabies, patients with crusted scabies may not experience severe itching or develop the typical rash, making the condition more difficult to recognize. However, they can carry up to two million mites and eggs, making them extremely contagious.
Because of the heavy mite burden, crusted scabies can rapidly spread in healthcare facilities and long-term care homes if not identified and treated promptly. It may also lead to serious complications, including secondary bacterial infections and sepsis.
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People at increased risk of developing crusted scabies include:
Preventing outbreaks requires rapid diagnosis, prompt treatment, and strict infection control measures.
Health authorities recommend:
Early diagnosis is critical to preventing further transmission. Since crusted scabies may not present with the classic symptoms of itching and rash, healthcare professionals play an important role in recognizing the condition.
Only a qualified healthcare provider can confirm the diagnosis and prescribe appropriate treatment. Prompt medical care helps reduce the risk of complications and prevents outbreaks in hospitals, nursing homes, and other communal settings.
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