An experimental treatment happens to be the solution to delay Alzheimer's symptoms in some people. These people are the ones who are genetically destined to get the disease in their 40s or 50s. These new findings form ongoing research has now been caught up in Trump administration funding delas. The early results of the study has been published on Wednesday and the participants too are worried that politics could cut their access to a possible lifeline.

One of the participants had said, "It is still a study but it has given me an extension to my life that I never banked on having." The participant is named Jake Henrichs, form New York City, who is 50 years old. He is one of them to be treated in that study for more than a decade now and has remained symptom-free despite inheriting an Alzheimer's-causing gene that had killed his father and brother around the same age.

Slowing Down The Symptoms

Two drugs which can modestly slow down early-stage Alzheimer's are sold in the United States. These drugs clear the brain of one of its hallmarks, a sticky gunk-like part called the amyloid. However, there have not been any hints that removing amyloid far earlier, way many years before the first symptoms appear, may postpone the disease.

How Was The Research Conducted?

The research is led by Washington University in St Louis, which involved families that passed down rare gene mutation as participants. This meant it was almost guaranteed that they will develop symptoms at the same age their affected relatives did.

The new findings is based on a subset of 22 participants who received amyloid-removing drugs the longest, on average eight years. Long-term amyloid removal cut in half their risk of symptom onset. The study is published in the journal Lancet Neurology.

Washington University's Dr Randall Bateman, who directs the Dominantly Inherited Alzheimer's Network of studies involving families with these rare genes says, "What we want to determine over the next five years is how strong is the protection. Will they ever get the symptoms of Alzheimer’s disease if we keep treating them?”

The researchers before though did not know what exactly caused Alzheimer's which affects nearly 7 million Americans, most of them in their later life. However, it is clear that these silent changes occur in the brain at least two decades before the first symptom shows up. The big contributor. At some point amyloid buildup can trigger a protein named tau that then starts to kill neurons, which can lead to cognitive decline.

Researchers are now thus studying the Tau-fighting drugs and are looking into other factors, like inflammation, brain's immune cells and certain virus.

The National Institute of Health (NIH) has expanded its focus as researchers have found more reasons for Alzheimer's. In 2013, the NIH's National Institute on Aging funded 14 trials of possible Alzheimer's drugs over a third targeting amyloid. By last fall, there were 68 drugs and 18% of them target amyloid. However, there are scientists too who think that amyloid is not everything and their is way more in the brain tissue, immune cells, and more which can be studied.

There has been a long-running belief that COVID-19 vaccines are behind sudden deaths in young adults. Posts circulating on social media and unverified online claims have repeatedly linked vaccination to sudden collapses, heart attacks, or unexpected deaths, particularly among people aged 18 to 45 who seemed otherwise healthy.

These claims have caused anxiety among families, despite the absence of solid scientific backing. A new study published by AIIMS now brings much-needed clarity on whether COVID vaccines have any connection to sudden deaths in young adults.

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AIIMS Study Finds No Link Between Covid Vaccination And Sudden Deaths In Adults

Worries around sudden deaths in young adults have increased in recent years, especially in the period following the COVID-19 pandemic. Speculation blaming COVID vaccines gained traction across platforms, adding to public concern. However, fresh findings from a study carried out by the All India Institute of Medical Sciences (AIIMS), New Delhi, offer a clear answer. After examining detailed autopsy reports, researchers concluded that underlying heart disease, and not COVID-19 vaccination, is the leading cause of sudden deaths in younger individuals.

Heart Problems Leading Cause Among Deaths In Young People

The AIIMS study found that heart-related conditions were responsible for 42.6 per cent of sudden deaths among people aged 18 to 45 years. Within this group, heart attacks accounted for nearly 85 per cent of cardiac-related deaths. Other contributing factors included structural abnormalities of the heart, congenital defects, and inflammation of the heart muscle. Respiratory illnesses made up around 21.3 per cent of sudden deaths, with choking, pneumonia, and tuberculosis emerging as the main causes. In close to one-fifth of the cases, doctors were unable to determine the exact cause of death.

No Evidence Linking Deaths To Covid Or Vaccines

Crucially, the researchers observed no meaningful rise in sudden deaths among individuals who had previously contracted COVID-19 or received the vaccine. Of the cases analysed, only 4.3 per cent had a history of COVID infection, while 82.8 per cent had been vaccinated. Dr Sudheer Arava, Professor of Pathology at AIIMS, explained that the year-long study reviewed nearly 100 cases and found no signs of vaccine-related complications, with just one instance of myocarditis reported. The findings also pointed to differences across age groups.

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Among those aged 46 to 65, nearly three-quarters of sudden deaths were linked to heart disease, while unexplained deaths were far fewer. Notably, the proportion of women among sudden deaths was higher in the younger age group than among older adults. The study carries weight as it directly challenges claims blaming COVID-19 vaccines for sudden deaths.

Doctors emphasise that lifestyle-related issues such as unhealthy eating habits, lack of physical activity, and chronic stress continue to play a major role in heart disease among younger people. This, they say, highlights the importance of early prevention and regular health screenings. Dr Arava also urged the public to rely on credible scientific information and steer clear of misinformation that could erode trust in proven public health measures, including vaccination.

zDelhi woke up again to a yet another thick smoggy morning, with visibility dropping low. On Monday morning, the city's average air quality index or AQI stood at 'severe' category for the third consecutive day. As of 6am, the data from the Air Quality Early Warning System for Delhi stood at 457. As per the Central Pollution Control Board (CPCB), at least four stations, including Ashok Vihar, Jahangirpuri, Rohini, Wazirpur, recorded AQI of 500 at 7am.

As of 10am on Monday morning, Delhi stood at 480, Noida at 551, Greater Noida at 568, Gurugram at 454, Faridabad at 546, and Ghaziabad at 569, all under 'severe' category.

As a result, the Commission for Air Quality Management has issued directives to Delhi and NCR state governments on Sunday, December 14. The directives suggest for an immediate halt on all outdoor physical sports activity. This move has come after concerns were raised around schools that are still continuing outdoor activities despite poor air quality.

Amid this, a Lancet study also revealed that 15 lakh annual deaths in India are due to long-term exposure to air pollution. The particulate matter or PM2.5 found in air pollution is linked to many health issues. Since the particles are so small in size, it could easily penetrate deep into the lungs and enter the bloodstream, and cause serious health impacts. However, despite the global studies highlighting the country's ever-growing pollution problem, the Centre stated that "there is no conclusive data available in the country to establish direct correlation if death/disease exclusively due to air pollution."

What Does The Lancet Study Say About Air Pollution And Health?

The comprehensive Lancet study conducted an analysis from 2009 to 2019, and measured the consequence of long-term exposure to fine particulate matter or PM2.5.

The study estimated: “1·5 million deaths occurred annually due to long-term exposure to PM2·5 in India every year in excess of the 5 μg/m3 that is recommended by the WHO ambient air quality guidelines.”

The study noted that every 10μg/m³ increase in annual PM2·5 concentration was associated with an 8.6 pc higher risk of all-cause mortality.

Using India’s National Ambient Air Quality Standards, researchers estimate that about 3.8 million deaths between 2009 and 2019 were linked to PM2.5 exposure. When WHO guidelines were applied, the number rose sharply to 16.6 million, nearly one-fourth of all deaths in the country. The analysis relied on advanced causal methods and high-resolution models that mapped district-level PM2.5 exposure across India, while accounting for factors such as socioeconomic status, age distribution, and indoor air pollution.

These findings are backed by a 2017 time-series study from Delhi that examined the short-term impact of air pollution on deaths from natural causes. The researchers pointed out that studies worldwide have consistently shown a clear link between common urban air pollutants and harmful health effects. Despite Delhi’s well-documented air quality crisis, they noted that limited local evidence on how specific pollutants affect health had long slowed meaningful policy action.

Different Pollutants Impact Different Age Groups

To bridge this gap, the study analyzed data from 2008 to 2010, focusing on key pollutants: particulate matter under 10 micrometres (PM10), sulphur dioxide (SO2), nitrogen dioxide (NO2), carbon monoxide (CO), and ozone (O3). Using a semi-parametric regression model that adjusted for non-linear factors such as time trends, temperature, and humidity, the researchers found strong links between short-term exposure to both particulate and gaseous pollutants and daily all-cause mortality.

They estimated that every 10 μg/m³ rise in PM10 levels was associated with a 0.14 per cent increase in all-cause deaths. Among gaseous pollutants, NO2 had the strongest impact, with a 1 per cent rise in mortality for every 10 μg/m³ increase in daily concentration. Ozone and carbon monoxide also showed significant effects, even after accounting for NO2 levels. The analysis that was done based on age also revealed that particulate matter affected older adults aged 65 and above. Whereas, gaseous pollutants had a greater impact on people aged 5 to 44.

Overall, the researchers concluded that the evidence clearly reinforces the link between poor ambient air quality and increased all-cause mortality.