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An experimental treatment happens to be the solution to delay Alzheimer's symptoms in some people. These people are the ones who are genetically destined to get the disease in their 40s or 50s. These new findings form ongoing research has now been caught up in Trump administration funding delas. The early results of the study has been published on Wednesday and the participants too are worried that politics could cut their access to a possible lifeline.
One of the participants had said, "It is still a study but it has given me an extension to my life that I never banked on having." The participant is named Jake Henrichs, form New York City, who is 50 years old. He is one of them to be treated in that study for more than a decade now and has remained symptom-free despite inheriting an Alzheimer's-causing gene that had killed his father and brother around the same age.
Two drugs which can modestly slow down early-stage Alzheimer's are sold in the United States. These drugs clear the brain of one of its hallmarks, a sticky gunk-like part called the amyloid. However, there have not been any hints that removing amyloid far earlier, way many years before the first symptoms appear, may postpone the disease.
The research is led by Washington University in St Louis, which involved families that passed down rare gene mutation as participants. This meant it was almost guaranteed that they will develop symptoms at the same age their affected relatives did.
The new findings is based on a subset of 22 participants who received amyloid-removing drugs the longest, on average eight years. Long-term amyloid removal cut in half their risk of symptom onset. The study is published in the journal Lancet Neurology.
Washington University's Dr Randall Bateman, who directs the Dominantly Inherited Alzheimer's Network of studies involving families with these rare genes says, "What we want to determine over the next five years is how strong is the protection. Will they ever get the symptoms of Alzheimer’s disease if we keep treating them?”
The researchers before though did not know what exactly caused Alzheimer's which affects nearly 7 million Americans, most of them in their later life. However, it is clear that these silent changes occur in the brain at least two decades before the first symptom shows up. The big contributor. At some point amyloid buildup can trigger a protein named tau that then starts to kill neurons, which can lead to cognitive decline.
Researchers are now thus studying the Tau-fighting drugs and are looking into other factors, like inflammation, brain's immune cells and certain virus.
The National Institute of Health (NIH) has expanded its focus as researchers have found more reasons for Alzheimer's. In 2013, the NIH's National Institute on Aging funded 14 trials of possible Alzheimer's drugs over a third targeting amyloid. By last fall, there were 68 drugs and 18% of them target amyloid. However, there are scientists too who think that amyloid is not everything and their is way more in the brain tissue, immune cells, and more which can be studied.
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BidenAmid rising prostate cancer cases, the American Cancer Society (ACS) has revised its screening guidelines, recommending earlier testing for men at higher risk to improve early detection.
Prostate cancer is the most common cancer among men after skin cancer and the second-leading cause of cancer deaths among men in the US. An estimated 333,830 men will be diagnosed and more than 36,000 will die from the disease in 2026.
Updated for the first time since 2010, the guidelines, published in CA: A Cancer Journal for Clinicians, introduce age- and risk-based screening schedules. They aim to detect potentially aggressive cancers while limiting unnecessary tests and treatment.
Former President Joe Biden urged men to get tested for prostate cancer after the American Cancer Society changed its screening guidelines, four days after he said his own fight with the disease has been slowing him down.
"I know firsthand the toll of this disease, and I know that catching it early saves lives. So talk to your doctor, get screened, and let’s keep working to end cancer as we know it," Biden shared in a post on X.
Previously, the ACS recommended that men discuss the benefits and risks of screening with their doctors without prescribing a specific schedule.
The revised guidelines recommend prostate-specific antigen (PSA) blood tests at different intervals based on age and risk.
1. Men At Average Risk: Ages 50–69: PSA testing every two years.
2. Men At Higher Risk
Black men:
Men with an affected father, brother or son should begin screening at 45 and continue through age 69.
Men with inherited genetic risk:
Men with inherited conditions such as BRCA2 mutations, or those with a close relative carrying a high-risk mutation who have not been tested, should discuss screening with their doctor.
3. Screening After Age 70
Screening is also not recommended at any age for men in poor health who are not expected to live another 10 years.
An elevated PSA does not necessarily mean prostate cancer or an immediate need for a biopsy. The ACS considers PSA levels high at:
If elevated, the test should be repeated, preferably within two weeks to three months. If levels remain high, further evaluation may include:
These additional steps can help avoid unnecessary biopsies and reduce screening-related harms.
For men diagnosed with low-risk prostate cancer, the ACS recommends active surveillance as the initial management approach. This involves:
Treatment may be considered if monitoring shows that the cancer is becoming more aggressive.
"Early prostate cancer usually doesn't cause signs and symptoms, which is why screening is important," said Dr. William Dahut, chief scientific officer at the ACS.
When symptoms occur, they may include:
Advanced prostate cancer may cause bone pain if the disease spreads to the bones or other organs.
However, these symptoms can also indicate conditions other than cancer. Men experiencing them should consult a doctor.
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India has intensified its efforts to eliminate tuberculosis (TB) through early detection, advanced diagnostics, nutritional support and community participation under the Pradhan Mantri TB Mukt Bharat Abhiyaan, launched in September 2022, the Union Health Ministry said.
Citing the WHO Global Tuberculosis Report 2026, the ministry said India recorded a 38% decline in TB mortality since 2015, outperforming the global reduction of 35%. The country also achieved a 94% treatment success rate among patients with drug-susceptible TB.
The campaign has expanded its screening efforts through intensified 100-day campaigns, including initiatives launched on December 7, 2024, and March 24, 2026.
Between December 7, 2024, and November 8, 2026, more than 25 crore people were brought under TB screening activities.
According to the ministry, the screening drive resulted in:
"The detection of nearly 15 lakh asymptomatic cases is particularly significant, demonstrating the effectiveness of proactive screening in identifying individuals who might otherwise remain undiagnosed. Early identification facilitates timely treatment and provides opportunities to reduce TB transmission and prevent severe disease," the ministry said.
The first intensified 100-day campaign was launched on December 7, 2024, across 347 high-priority districts in 33 states and Union Territories. It was subsequently expanded nationwide to strengthen early detection, particularly among vulnerable and high-risk populations.
A second intensified 100-day campaign, launched on March 24, 2026, focused on screening in 1.58 lakh high-risk villages and wards, congregate settings and vulnerable populations.
Technology And Innovation In TB Diagnosis And Care
The campaign uses chest X-rays and rapid molecular diagnostic tests to identify and diagnose TB cases. Portable AI-enabled digital X-rays and other technology-enabled tools have also been deployed to strengthen screening and diagnosis.
The campaign focuses on prompt treatment initiation, differentiated patient care, nutritional assistance and continued community-based support to improve treatment outcomes.
Through the Ni-kshay Poshan Yojana, eligible patients receive financial assistance towards their nutritional requirements during treatment. The Ni-kshay Mitra initiative encourages individuals, institutions and organisations to provide nutritional and psychosocial support.
The ministry said 67,933 panchayats were declared TB-free in 2025, reflecting efforts to involve communities in India's TB elimination programme.
According to the WHO Global Tuberculosis Report 2026, India's estimated TB mortality rate declined from 28 per lakh population in 2015 to 18 per lakh in 2025, representing a 38% reduction.
The country also recorded a 94% treatment success rate among patients with drug-susceptible TB.
The government said 96% of the TB programme's funding requirements are being met through domestic resources.
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Several viral social media trends promoting physical appearance and self-improvement have raised health concerns, with some encouraging potentially dangerous practices.
One such trend, known as "heightmaxxing", has prompted warnings from doctors after reports emerged of teenage boys taking black-market cancer drugs in an attempt to grow taller.
Aolescents are reportedly experimenting with erdafitinib, often referred to online as "ERDA" or "Erta", a prescription drug approved to treat advanced bladder cancer. The trend appears to have gained traction following online discussions suggesting the medication could increase height.
"It's extremely concerning that teenagers are experimenting with powerful cancer medications in an attempt to grow taller," Dr. Stephanie Widmer, a New York City-based emergency medicine physician, told Fox News.
"These drugs were developed to treat serious medical conditions, not to enhance physical appearance, and taking them without a legitimate medical indication or physician supervision can have devastating consequences," Widmer added.
In a statement to magazine Rolling Stone, drugmaker Johnson & Johnson emphasised that erdafitinib has never been approved to stimulate height growth and that its safety and effectiveness have not been established in children or adolescents.
Also read: After Ferritin Face, Doctors Warn About 'Ferritin Hair': What Are The Signs?
Medical research has documented unexpected growth spurts in children receiving erdafitinib for brain tumours. A 2024 study published in Hormone Research in Paediatrics described accelerated growth in two paediatric patients.
A separate case report documented a teenager who grew more than five inches during treatment but also developed serious skeletal complications.
However, doctors caution that these unexpected growth spurts do not necessarily indicate healthy skeletal development.
Dr. Jessica Gray, a family physician in Lubbock, Texas, warned that rapid, drug-induced growth could trigger dangerous structural problems, including premature growth plate damage and bone fractures, Fox News reported.
Widmer noted that height is largely determined by genetics and that there are no shortcuts to increasing it. Once the growth plates close towards the end of puberty, medications cannot reopen them. This means older adolescents taking erdafitinib could face serious health risks without any prospect of gaining height, she said.
"One of the biggest concerns is that these medications can cause serious side effects, including potentially permanent vision damage, elevated phosphate levels and other metabolic abnormalities," Widmer said.
"We're talking about adolescents whose bodies are still developing, and exposing them to these risks for a cosmetic goal is particularly troubling."
Erdafitinib works by blocking specific cellular signalling pathways involved in cancer cell growth. These pathways also play a role in bone development, which may help explain the unexpected growth observed in some paediatric patients.
Other reported side effects include skeletal pain, particularly in the hips or knees, mouth sores, loose nails and skin disorders.
Doctors advise parents to watch for unusual joint pain or unexplained physical changes and speak openly with their children if they suspect they are using medications obtained online.
Teenagers concerned about their height or growth should consult a paediatrician rather than experiment with prescription drugs.
"We should be encouraging teenagers to prioritize their health, not teaching them to gamble with it," Widmer said. "No amount of additional height is worth risking permanent damage to your vision or other serious and potentially unknown medical complications."
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