Credits: Canva
An experimental treatment happens to be the solution to delay Alzheimer's symptoms in some people. These people are the ones who are genetically destined to get the disease in their 40s or 50s. These new findings form ongoing research has now been caught up in Trump administration funding delas. The early results of the study has been published on Wednesday and the participants too are worried that politics could cut their access to a possible lifeline.
One of the participants had said, "It is still a study but it has given me an extension to my life that I never banked on having." The participant is named Jake Henrichs, form New York City, who is 50 years old. He is one of them to be treated in that study for more than a decade now and has remained symptom-free despite inheriting an Alzheimer's-causing gene that had killed his father and brother around the same age.
Two drugs which can modestly slow down early-stage Alzheimer's are sold in the United States. These drugs clear the brain of one of its hallmarks, a sticky gunk-like part called the amyloid. However, there have not been any hints that removing amyloid far earlier, way many years before the first symptoms appear, may postpone the disease.
The research is led by Washington University in St Louis, which involved families that passed down rare gene mutation as participants. This meant it was almost guaranteed that they will develop symptoms at the same age their affected relatives did.
The new findings is based on a subset of 22 participants who received amyloid-removing drugs the longest, on average eight years. Long-term amyloid removal cut in half their risk of symptom onset. The study is published in the journal Lancet Neurology.
Washington University's Dr Randall Bateman, who directs the Dominantly Inherited Alzheimer's Network of studies involving families with these rare genes says, "What we want to determine over the next five years is how strong is the protection. Will they ever get the symptoms of Alzheimer’s disease if we keep treating them?”
The researchers before though did not know what exactly caused Alzheimer's which affects nearly 7 million Americans, most of them in their later life. However, it is clear that these silent changes occur in the brain at least two decades before the first symptom shows up. The big contributor. At some point amyloid buildup can trigger a protein named tau that then starts to kill neurons, which can lead to cognitive decline.
Researchers are now thus studying the Tau-fighting drugs and are looking into other factors, like inflammation, brain's immune cells and certain virus.
The National Institute of Health (NIH) has expanded its focus as researchers have found more reasons for Alzheimer's. In 2013, the NIH's National Institute on Aging funded 14 trials of possible Alzheimer's drugs over a third targeting amyloid. By last fall, there were 68 drugs and 18% of them target amyloid. However, there are scientists too who think that amyloid is not everything and their is way more in the brain tissue, immune cells, and more which can be studied.
Credits: X
Ahmedabad toddler, one-and-a-half-year-old boy swallowed a 'Hulk' toy, which is based on a popular comic superhero. The toy was stuck in his stomach when his parents took him to the Civil Hospital. According to reports by News18, the child is identified as Vansh who showed the signs of discomfort and began vomiting. This is what alarmed the parents.
As per the News18 report, his mother Bhavika was suspicious when she noticed that one of his toys was missing. The child was rushed to the hospital and an X-ray revealed that he had swallowed the entire plastic toy. The toy was not broken.
Hindustan Times reported that Dr Rakesh Joshi, Head of the Department of Pediatric Surgery removed the toy through upper GI endoscopy. "Had it been a little late, the toy could have moved further from the stomach and got stuck in the intestines. In that case, there would have been a risk of intestinal blockage and even rupture," the senior doctor said.
"There is a natural valve between the esophagus and the stomach. The biggest challenge was to take out a whole toy through this valve. When we tried to grab it with the endoscope, the toy kept slipping because of the air in the stomach. Pulling the toy by its hand or foot raised the possibility of it getting stuck in the valve and causing it permanent damage," he said.
The doctor noted that if the toy had further slipped down, it would have increased the risk of intestine rupturing.
Under the Toys (Quality Control) Order, 2020 issued by the Department for Promotion of Industry and Internal Trade under the Ministry of Commerce and Industry, toy safety in India was brought under mandatory BIS certification from September 1, 2020. The move aims to ensure safer toys for children while also supporting the government’s policy of curbing non-essential imports.
Industry sources estimate that more than 85 percent of toys sold in India are imported. Officials say the Toys Quality Control Order is a key step in preventing the entry of cheap and substandard toys into the domestic market, many of which fail to meet basic safety requirements.
The quality control order clearly defines safety standards based on the type of toy. Non-electric toys such as dolls, rattles, puzzles, and board games must comply with IS 9873 (Part 1):2019. These toys do not rely on electricity for any of their functions.
Electric toys, which include at least one function powered by electricity, are required to meet the standards outlined under IS 15644:2006. Compliance with these standards is mandatory before such toys can be sold in the Indian market.
Toys that are not tested by NABL-accredited toy testing laboratories can pose serious health risks to children. Sharp edges and poorly finished parts can cause cuts and injuries. PVC toys may contain phthalates, which are considered harmful chemicals.
Many low-quality toys have also been found to contain lead, a substance known to be particularly damaging to brain development in children. Soft toys with fur or hair can trigger allergies or become choking hazards. In some cases, small body parts can get stuck in gaps or holes, increasing the risk of injury.
Testing by NABL-accredited laboratories ensures that toys are safe, durable, and suitable for specific age groups. Parents are advised to check for IS marks on toys before purchasing, as this indicates compliance with Indian safety standards.
Experts recommend avoiding toys with small detachable parts for toddlers and young children, as they are more likely to put objects in their mouths. Toys should always match the child’s age, skill level, and interests.
Parents are also urged to look for IS marks, which confirm that the toy has been tested and certified. Loud toys should be avoided, as prolonged exposure to sounds above 85 decibels can harm a child’s hearing.
Electric toys with heating elements should be used with caution or avoided altogether due to burn risks. Finally, toys with sharp edges or shooting components should be carefully examined to prevent cuts and injuries.
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Nipah virus outbreak in India triggered airport screenings of travelers, including in Myanmar. Many reports claim that passengers are being checked in similar ways as they were during the COVID-19 virus spread. Health and Me reported how in Thailand the health screenings of foreign travelers were taken seriously, a similar case is seen in Myanmar.
Myanmar has tightened its health screenings and surveillance at Yangon International Airport to prevent any possible entry of Nipah virus case, reported The Global New Light of Myanmar. Travelers who are arriving from India, especially West Bengal are given special attention to check for any fever or other Nipah-related symptoms, read the report by the Ministry of Health.
The ministry also noted that health screening of passengers arriving from abroad is being conducted in line with the established guidelines for infectious diseases that could give rise to public health emergencies, Xinhua news agency reported.
Informational leaflets too are being distributed among travelers to be aware of the symptoms. Posters are also displayed at the airport. Along with all that, disease prevention and control measures are also being carried out in the airport.
Screening measures are also enhanced and implemented at Mandalay International Airport.
As per the World Health Organization (WHO), Nipah virus infection is a zoonotic illness that is transmitted to people from animals, and can also be transmitted through contaminated food or directly from person to person.
In infected people, it causes a range of illnesses from asymptomatic (subclinical) infection to acute respiratory illness and fatal encephalitis. The virus can also cause severe disease in animals such as pigs, resulting in significant economic losses for farmers.
Although Nipah virus has caused only a few known outbreaks in Asia, it infects a wide range of animals and causes severe disease and death in people.
Nipah virus is infectious and can spread from animals like bats and pigs to humans through bodily fluids or contaminated food. It can also pass between people through close contact, especially in caregiving settings. While it can spread via respiratory droplets in enclosed spaces, it is not considered highly airborne and usually requires close, prolonged contact for transmission. Common routes include direct exposure to infected animals or their fluids, consuming contaminated fruits or date palm sap, and contact with bodily fluids such as saliva, urine, or blood from an infected person.
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Measles Outbreak in Disneyland: Health officials in Orange County sounded alarmed after they confirmed a recent measles case in a child who visited Disneyland last week. The Orange County Health Care Agency said on Saturday that the child was an international traveler who arrived at Los Angeles International Airport (LAX). The child then went to Disneyland on Wednesday and that is what became the potential exposure window.
As per the health authorities there could be two possibilities of getting the disease:
Health authorities said they are coordinating with Disneyland to contact employees who may have been exposed to measles. According to Orange County health officials, visitors present at the theme park during the identified period could develop symptoms between seven and 21 days after exposure.
Dr Danielle Curitore, a pediatrician at St Joseph Heritage Providence, explained NBC Los Angeles that measles is highly contagious and spreads through respiratory droplets.
“Very similar to these respiratory viruses, but even more so because it can be in a close setting and if that person with measles sneezes or coughs and transmits some respiratory droplets, you are exposed,” she said. “And that room that they’ve been in is also contagious for at least two hours after they left.”
Doctors emphasize that individuals who have received the measles vaccine, particularly the recommended two doses, are generally well protected against the disease. Those who have not been vaccinated face a significantly higher risk of infection.
Read: Measles Elimination Status In The US Is ‘Not Really’ At Risk, CDC Says As Cases Surge
“Your best protection is to be vaccinated, so if you’ve been vaccinated against measles and you’ve received your two doses of measles vaccine at any point, those are usually given in childhood but you do continue to be immune as you get older,” Dr Curitore added.
Health officials have confirmed at least five new measles cases in Southern California, prompting renewed warnings and surveillance. Authorities are closely monitoring the situation to limit further spread and identify potential exposure chains.
Measles, also known as rubeola, is an extremely contagious viral illness that typically causes high fever, cough, runny nose, red and watery eyes, and a characteristic rash that begins on the face and spreads downward across the body. It spreads through respiratory droplets and can lead to severe and sometimes fatal complications, including pneumonia and inflammation of the brain known as encephalitis.
Although it is preventable through the safe and effective MMR vaccine, measles remains a serious threat in many regions. There is no specific cure, and treatment focuses on managing symptoms, according to the Cleveland Clinic.
Experts say measles symptoms often begin with signs similar to a common cold, including cough, congestion, and high fever. Some patients may also develop conjunctivitis.
“Sometimes it just starts out like the common cold cough congestion: high fever sometimes conjunctivitis can be part of it,” Dr Curitore said. “Then day three to five, you get that very classic measles rash, which usually starts on the face, center of the body.”
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