Is 'Sticky Gunk' In Your Brain The Reason Behind Alzheimer's Disease?

Updated Mar 20, 2025 | 08:53 AM IST

SummaryThe new findings is based on a subset of 22 participants who received amyloid-removing drugs the longest, on average eight years.
Alzheimer's Disease

Credits: Canva

An experimental treatment happens to be the solution to delay Alzheimer's symptoms in some people. These people are the ones who are genetically destined to get the disease in their 40s or 50s. These new findings form ongoing research has now been caught up in Trump administration funding delas. The early results of the study has been published on Wednesday and the participants too are worried that politics could cut their access to a possible lifeline.

One of the participants had said, "It is still a study but it has given me an extension to my life that I never banked on having." The participant is named Jake Henrichs, form New York City, who is 50 years old. He is one of them to be treated in that study for more than a decade now and has remained symptom-free despite inheriting an Alzheimer's-causing gene that had killed his father and brother around the same age.

Slowing Down The Symptoms

Two drugs which can modestly slow down early-stage Alzheimer's are sold in the United States. These drugs clear the brain of one of its hallmarks, a sticky gunk-like part called the amyloid. However, there have not been any hints that removing amyloid far earlier, way many years before the first symptoms appear, may postpone the disease.

How Was The Research Conducted?

The research is led by Washington University in St Louis, which involved families that passed down rare gene mutation as participants. This meant it was almost guaranteed that they will develop symptoms at the same age their affected relatives did.

The new findings is based on a subset of 22 participants who received amyloid-removing drugs the longest, on average eight years. Long-term amyloid removal cut in half their risk of symptom onset. The study is published in the journal Lancet Neurology.

Washington University's Dr Randall Bateman, who directs the Dominantly Inherited Alzheimer's Network of studies involving families with these rare genes says, "What we want to determine over the next five years is how strong is the protection. Will they ever get the symptoms of Alzheimer’s disease if we keep treating them?”

The researchers before though did not know what exactly caused Alzheimer's which affects nearly 7 million Americans, most of them in their later life. However, it is clear that these silent changes occur in the brain at least two decades before the first symptom shows up. The big contributor. At some point amyloid buildup can trigger a protein named tau that then starts to kill neurons, which can lead to cognitive decline.

Researchers are now thus studying the Tau-fighting drugs and are looking into other factors, like inflammation, brain's immune cells and certain virus.

The National Institute of Health (NIH) has expanded its focus as researchers have found more reasons for Alzheimer's. In 2013, the NIH's National Institute on Aging funded 14 trials of possible Alzheimer's drugs over a third targeting amyloid. By last fall, there were 68 drugs and 18% of them target amyloid. However, there are scientists too who think that amyloid is not everything and their is way more in the brain tissue, immune cells, and more which can be studied.

End of Article

FSSAI Tightens Pan Masala Packaging Rules; Maharashtra FDA Flags Blinkit, Reliance Retail Due To Cockroach Infestation

Updated Aug 12, 2026 | 01:30 PM IST

SummaryFSSAI recently implemented stricter rules for pan masala packaging. Maharashtra FDA suspended the license of a Mumbai-based Blinkit facility over food hygiene concerns.
Why FSSAI has tightened packaging rules for pan masala?

Credit: AI

India’s food safety regulators have stepped up scrutiny on multiple fronts this week. The Food Safety and Standards Authority of India (FSSAI) has tightening packaging rules for pan masala and Maharashtra’s Food and Drug Administration (FDA) taking action against retail outlets over alleged hygiene violations.

From what goes into packaged products to how food is stored and handled before it reaches consumers, these developments come at a time when food safety in India is under tight scrutiny.

FSSAI Bans Plastic And Aluminium Foil In Pan Masala Packaging

Under the new Food Safety and Standards (Packaging) Amendment Regulations, 2026, notified on August 10, pan masala packaging can no longer use plastic-based materials, plastic laminates, aluminium foil or metallised layers.

Pan masala can now be packaged in materials made of paper, paperboard, cellulose and other naturally derived materials, provided they are completely free from plastic and synthetic polymers. Tin and glass containers are also allowed.

The decision follows an earlier draft notification issued by FSSAI in April, which proposed adding specific packaging materials for pan masala to the food packaging regulations.

Also read: Why FSSAI Seized 18,000 Boxes Of Diageo Whisky, Vodka Bottles

Why FSSAI Is Targeting Pan Masala's Packaging?

Pan masala sachets have traditionally relied heavily on plastic and foil materials as they are lightweight, inexpensive and the contents are shielded from moisture.

However, such multilayer plastic packaging is difficult to recycle and contributes to persistent plastic waste. The new rules push manufacturers towards packaging made of paper and other naturally derived materials that won't harm the environment.

This does not mean that pan masala itself safer to consume. Pan masala, particularly those containing tobacco or areca nut, continues to be harmful. The regulation is primarily about packaging standards and waste.

Also read: From Liquor to Dabur to VKC Nuts, FSSAI Crackdown Puts Food Safety in Focus: Why It Matters

Maharashtra FDA Cracks Down On Retail Food Safety

On the other hand, Maharashtra FDA suspended the food license of a Blinkit facility in Malad West after it reportedly found cockroach infestation, improper storage and other hygiene violations that posed health safety dangers.

Officials also flagged expired and damaged products, inadequate pest control, poor waste management and improper food storage practices. The license was suspended under Section 32(3) of the Food Safety and Standards Act, 2006.

The incident highlights why storage conditions matter even when food has already passed manufacturing and packaging checks.

Also read: Why Indian Doctors Are Seeking A Ban On Junk Food Ads And Mandatory Warning Labels On Packaging?

Reliance Retail Outlet Under Investigation Over Kaju Katli Complaint

In a separate case in Buldhana, Maharashtra FDA flagged a Reliance Retail outlet after a consumer complaint alleging fungal growth and live larvae in packaged kaju katli.

Officials inspected the outlet on August 8 and seized 54 kaju katli boxes reportedly. The specific batch mentioned in the complaint was no longer available, while another batch of the same product was found in stock.

These incidents underscore an important point: food safety does not end when a product leaves the factory. Packaging, transportation, storage, pest control, temperature management, expiry checks and hygiene at retail outlets all form part of the food-safety chain.

For consumers, checking the product's packaging, expiry dates, storage instructions and signs of contamination remains important. If a packaged food looks, smells or tastes abnormal, it is safer not to consume it and to report it to the food-safety authority.

End of Article

England Set To Become One Of The First Countries To Eliminate Hepatitis C; Here's How

Updated Aug 12, 2026 | 12:08 PM IST

SummaryEngland is on the way to become one of the first countries to eliminate hepatitis C as a public health emergency.
England Set To Become One Of The First Countries To Eliminate Hepatitis C

Credit: AI

England is on the verge of becoming one of the first countries in the world to eliminate hepatitis C, after more than 100,000 people received the life-saving pioneering antiviral drugs through the NHS that was rolled out in 2015.

NHS England said the country has already surpassed the World Health Organization’s target of treating at least 80% of patients diagnosed with hepatitis C. The latest numbers show that 81.5% of people diagnosed with chronic hepatitis C between 2015 and 2024 had started treatment.

Professor Frankie Swords, NHS national medical director, said hepatitis C can cause serious complications including liver failure and cancer. She also said that many people may live with the infection for years without knowing they have it.

“That’s why the NHS has worked hard alongside public health teams and charities to find and treat hidden cases,” she said, adding that England is now “leading the world” on the path to eliminate the disease.

“We are making significant progress towards eliminating Hepatitis C as a public health threat,” said Dr Sema Mandal, Deputy Director – Blood Safety, Hepatitis, STIs and HIV Division at UK Health Security Agency (UKHSA).

She added, "The sharp fall in cases since 2015 shows the impact of expanded testing and sustained access to modern curative treatments, and the commitment of health services and community partners across England."

“Treating over 100,000 people in just 10 years is a remarkable achievement and brings England closer than ever to becoming one of the first countries in the world to eliminate this disease as a public health threat,” Mandal said.

UK's Public Health Milestone

Also read: How Chronic Hepatitis Quietly Progresses To Liver Cirrhosis: Why Early Action Can Save Your Liver

Hepatitis C is a blood-borne virus that primarily affects the liver. If the infection becomes chronic and remains untreated, it may lead to cirrhosis, liver failure and liver cancer. But hepatitis C differs from many other chronic viral infections as it can be cured.

Since 2015, England has significantly expanded access to direct-acting antiviral medicines. These tablets are generally taken for just 8 to 12 weeks and can clear the virus in more than 90% of the patients.

An estimated 50,200 adults were living with chronic hepatitis C in England in 2024, down 61.1% from an estimated 129,000 in 2015.

Deaths linked to hepatitis C have also fallen, with NHS England reporting a 36% reduction over the past decade.

Testing Still Remains Crucial

The biggest challenge for the health officials right now is finding people who do not know they are infected with hepatitis C.

The UKHSA estimates that 84.6% of people living with chronic hepatitis C had been diagnosed between 2015 and 2024. While the number is is encouraging, it still below the WHO target of 90%.

Past or current injecting drug use remains the most important risk factor in England. People who received blood transfusions or blood products before widespread hepatitis C screening was introduced are also considered at risk.

Elimination does not mean that hepatitis C will disappear completely. Under WHO criteria, it means reducing transmission, illness and deaths to very low levels while maintaining strong testing, treatment and prevention systems in public health.

The progress is especially significant because the world is currently far away from WHO’s 2030 viral hepatitis elimination targets. WHO estimates that about 47 million people were living with hepatitis C globally in 2024, while around 240,000 people died from hepatitis C-related causes.

End of Article

Amid Cyclospora, Salmonella Outbreaks, US FDA Issues Guidance on Ready-to-Eat Produce

Updated Aug 12, 2026 | 09:04 AM IST

Summary​The FDA recommendations are not legally binding and are aimed at manufacturers and processors of products such as chopped lettuce, sliced cantaloupe, diced onions, shredded carrots, coleslaw mixes and fruit salads.
Amid Cyclospora, Salmonella Outbreaks, US FDA Issues Guidance on Ready-to-Eat Produce

Credit: iStock

Even as the US faces major outbreaks of Cyclospora and Salmonella infections, the Food and Drug Administration (FDA) has finalized safety guidance for operations handling ready-to-eat (RTE) fresh-cut produce.

The guidance incorporates public comments received on the October 2018 draft and replaces the FDA’s 2008 guidance on fresh-cut produce.

“This guidance represents the agency’s current thinking on the issues related to preventing contamination in fresh-cut produce,” the FDA said.

The agency also encouraged the industry to continue advancing food safety practices, including through best-practice documents tailored to specific commodities and processes.

The FDA’s guidance targets manufacturers and processors of fresh-cut produce and recommends measures such as sanitation controls, supplier verification and refrigeration amid ongoing outbreaks of cyclosporiasis and salmonella linked to fresh produce.

What Does the FDA Guidance Include?

The FDA recommendations are not legally binding and are aimed at manufacturers and processors of products such as chopped lettuce, sliced cantaloupe, diced onions, shredded carrots, coleslaw mixes and fruit salads.

Fresh-cut produce can include a single commodity, such as cut lettuce, sliced cantaloupe, diced celery, diced onions and shredded carrots, or combinations of two or more produce items, such as coleslaw mixes and fruit salads.

The FDA has focused on contamination with pathogens including salmonella, cyclospora, E. coli and listeria.

Fresh-cut produce processors should assess whether these pathogens pose potential hazards that require preventive measures, including supply-chain controls, the FDA said.

The recommended measures include:

  • Using safe water
  • Washing fruits and vegetables with antimicrobial solutions
  • Training personnel
  • Improving facility design
  • Implementing sanitation controls
  • Verifying suppliers
  • Maintaining appropriate refrigeration
However, cyclospora may require supply-chain controls because antimicrobial treatments used in wash water may not adequately control the parasite, the FDA said. Research into how fresh produce becomes contaminated with cyclospora is ongoing.

Why Is Fresh-Cut Produce at Risk?

Fresh-cut produce can be particularly susceptible to contamination because pathogens may be introduced at multiple points, including during growing, transportation, manufacturing, commingling with other products or at retail.

The opportunity for contamination can increase at each stage before the food reaches consumers.

Fresh-cut produce also does not undergo a kill step to eliminate pathogens that may be introduced during these processes, and most products are sold ready to eat.

The guidance provides recommendations and examples of how Preventive Controls for Human Food can be implemented to protect fresh-cut RTE produce from biological hazards.

Cyclospora and Salmonella Outbreaks

The guidance comes as the US investigates outbreaks linked to contaminated lettuce and jalapenos that have sickened thousands of people.

The cyclospora outbreak linked to iceberg lettuce from Taylor Farms has spread to 15 states, with Michigan hit the hardest.

“Americans should feel confident in eating fresh produce, including leafy greens at this point,” Diamantas said during an appearance on CNBC. The FDA said it remains confident that iceberg lettuce linked to the cyclospora outbreak had been effectively removed from the market following the July 17 recall.

The US Department of Health and Human Services also said Tuesday on X: “Cyclospora: contained, American food: safe.”

However, the FDA and CDC say the investigation into the cyclospora outbreak remains ongoing.

Separately, Taylor Farms said Monday that it was recalling prepared foods containing jalapenos from retailers in several states because of potential salmonella contamination.

End of Article