An experimental treatment happens to be the solution to delay Alzheimer's symptoms in some people. These people are the ones who are genetically destined to get the disease in their 40s or 50s. These new findings form ongoing research has now been caught up in Trump administration funding delas. The early results of the study has been published on Wednesday and the participants too are worried that politics could cut their access to a possible lifeline.

One of the participants had said, "It is still a study but it has given me an extension to my life that I never banked on having." The participant is named Jake Henrichs, form New York City, who is 50 years old. He is one of them to be treated in that study for more than a decade now and has remained symptom-free despite inheriting an Alzheimer's-causing gene that had killed his father and brother around the same age.

Slowing Down The Symptoms

Two drugs which can modestly slow down early-stage Alzheimer's are sold in the United States. These drugs clear the brain of one of its hallmarks, a sticky gunk-like part called the amyloid. However, there have not been any hints that removing amyloid far earlier, way many years before the first symptoms appear, may postpone the disease.

How Was The Research Conducted?

The research is led by Washington University in St Louis, which involved families that passed down rare gene mutation as participants. This meant it was almost guaranteed that they will develop symptoms at the same age their affected relatives did.

The new findings is based on a subset of 22 participants who received amyloid-removing drugs the longest, on average eight years. Long-term amyloid removal cut in half their risk of symptom onset. The study is published in the journal Lancet Neurology.

Washington University's Dr Randall Bateman, who directs the Dominantly Inherited Alzheimer's Network of studies involving families with these rare genes says, "What we want to determine over the next five years is how strong is the protection. Will they ever get the symptoms of Alzheimer’s disease if we keep treating them?”

The researchers before though did not know what exactly caused Alzheimer's which affects nearly 7 million Americans, most of them in their later life. However, it is clear that these silent changes occur in the brain at least two decades before the first symptom shows up. The big contributor. At some point amyloid buildup can trigger a protein named tau that then starts to kill neurons, which can lead to cognitive decline.

Researchers are now thus studying the Tau-fighting drugs and are looking into other factors, like inflammation, brain's immune cells and certain virus.

The National Institute of Health (NIH) has expanded its focus as researchers have found more reasons for Alzheimer's. In 2013, the NIH's National Institute on Aging funded 14 trials of possible Alzheimer's drugs over a third targeting amyloid. By last fall, there were 68 drugs and 18% of them target amyloid. However, there are scientists too who think that amyloid is not everything and their is way more in the brain tissue, immune cells, and more which can be studied.

Actor Shreyas Talpade recalls that during a shoot for Single Salma in Lucknow, he felt unusually drained after an intense action sequence. In an interview with the Times of India, he revealed, along with the fatigue, there was an odd sensation in his throat, something he had never experienced before. He sat down briefly, brushed it aside, and convinced himself that he was fine.

Yet, something did not sit right with him. Concerned, Shreyas decided to consult a doctor. He underwent an ECG and a 2D echo, and both reports came back normal. While he did not completely ignore what his body was telling him, he also did not probe further. He assumed the medical reports meant there was nothing to worry about.

Months later, in December 2023, Shreyas Talpade suffered a major cardiac episode, an experience that would alter his life in ways he never imagined.

Shreyas Talpade Had No Classic Risk Factors, Yet He Suffered a Heart Attack

Shreyas was only in his mid-40s when the incident occurred, but it changed him both physically and emotionally.

Physically, he now follows lifelong precautions to ensure such an episode does not recur. Regular medication, scheduled follow-ups, routine checkups, and strict adherence to medical advice have become a permanent part of his life.

Emotionally, the impact was even more intense. Shreyas points out that he had none of the four common risk factors associated with heart attacks. He did not smoke or drink. He was neither diabetic nor hypertensive. And yet, the cardiac episode happened.

Shreyas Talpade’s Five Mantras For Heart Health

• Listen to your body: If something feels unusual, do not delay or dismiss it.
• Get tested early: The sooner you detect a problem, the faster you can respond.
• Stay consistent: Fixed timings for meals, medicines, and sleep are essential. A healthy life depends on routine, not randomness.
• Rest adequately: Seven to eight hours of uninterrupted sleep is non-negotiable. It plays a vital role in healing and recovery.
• Monitor your heart regularly: ECGs, 2D echo tests, stress tests, and calcium score screenings can save lives. Prevention is always better than cure.
• Manage stress: Stress is unavoidable, but learning to manage it is crucial. Focus on what you can control and let go of the rest.

Shreyas believes that while life brings uncertainty, many aspects of health remain within our control. After an experience like his, priorities naturally shift. Family becomes the top priority, and staying healthy becomes essential to spend meaningful time with loved ones. That, he says, means sleeping well, exercising four to five times a week, and eating nutritious meals on time.

Heart Attack: Why Timely Meals Matter More Than Extreme Diets

He stresses that while nutritious food is important, eating at regular times is even more critical. Maintaining fixed meal schedules helps the body function better. Having dinner early allows the digestive system enough time to rest. Even the healthiest food, he notes, loses its benefit if meal timings are irregular.

His earlier discipline with clean eating and regular workouts played a significant role in his recovery. Shreyas also believes that post-pandemic health changes and the Covid vaccine may have triggered complications, but his active lifestyle helped him bounce back faster.

According to him, proper nutrition, regular exercise, quality sleep, and balance strengthen the body. Without these habits, the outcome could have been very different. He firmly believes the body responds to the care it receives.

Learning To Handle Stress And Let Go

Shreyas acknowledges that stress is an unavoidable part of life. However, he believes learning how to manage it is essential.

Over time, he has realised that not everything lies within one’s control. Letting go of what cannot be changed is just as important as addressing what can be managed. Wisdom often comes with age, but when someone shares their experiences, he feels it is important to listen.

His message is clear: do not wait for a personal crisis to learn lessons the hard way.

The United States under President Donald Trump’s administration has completed its withdrawal from the World Health Organization (WHO). The US Department of Health and Human Services confirmed the news on Thursday. This has been a longstanding goal of President Trump.

Trump’s Goal To Exit From WHO

During Trump’s first term, he tried to leave WHO, then gave a notice through an executive order on the first day of his second term. It noted that the US would leave the organization. As per law, the US must give WHO a one-year notice and pay all outstanding fees before its departure. This means the US still owes WHO roughly $260 million. However, legal experts said that US is unlikely to pay up and WHO will have little recourse.

Dr. Lawrence Gostin, an expert on global health law and public health at Georgetown University told CNN, “As a matter of law, it is very clear that the United States cannot officially withdraw from WHO unless it pays its outstanding financial obligations. But WHO has no power to force the US to pay what it owes.”

WHO could pass a resolution saying that US cannot withdraw until it pays, however, it won’t risk creating any further tension that there already is.

The HHS on Thursday confirmed that all US government funding to WHO has been terminated and all personnel and contractors assigned or embedded within the organization have been recalled. It also said the US had ceased official participation in WHO-sponsored committees, leadership bodies, governance structures and technical working groups.

What the US Exit From WHO Means for the World

The US government has said it is moving ahead with its decision to exit the World Health Organization (WHO), arguing that the country has not received enough value for the money, staff, and support it has given to the global health body over the years.

Senior officials from HHS said the WHO acted against US interests, especially during the Covid-19 pandemic. They accused the organization of delaying the declaration of a global public health emergency and of praising China’s early response despite signs of underreporting, information suppression, and delays in confirming human-to-human transmission.

HHS also criticized the WHO for being slow to acknowledge airborne spread of Covid-19 and for downplaying the role of people without symptoms in spreading the virus. According to officials, these missteps cost the world precious time as the virus spread rapidly.

While the US has been the WHO’s largest funder, officials pointed out that no American has ever served as the organization’s director-general. “A promise made and a promise kept,” one senior official said, adding that US health policies should not be shaped by “unaccountable foreign bureaucrats.”

That said, the administration has not completely ruled out cooperation with the WHO. When asked whether the US would take part in an upcoming WHO meeting on next year’s flu vaccine composition, officials said discussions are still ongoing.

The government has insisted that leaving the WHO does not mean stepping away from global health leadership. Instead, the US plans to work directly with individual countries, health ministries, non-governmental organizations, and religious groups on disease surveillance and data sharing. This effort is expected to be led by the US Centers for Disease Control and Prevention’s Global Health Center. Officials have promised more announcements on this strategy in the coming months.

However, many public health experts are deeply concerned. Some warn that replacing the WHO with country-by-country agreements will create a fragmented system that lacks coordination and adequate funding. Former CDC officials note that the CDC has staff in about 60 countries, far fewer than the global reach of the WHO.

Critics say the move could leave both the US and the world vulnerable to future outbreaks. Experts argue that infectious diseases do not respect borders and that global cooperation is essential for early detection, data sharing, and rapid response.

Several health leaders have called the decision dangerous and short-sighted, warning that without WHO membership, the US could lose timely access to critical data, virus samples, and genomic information needed to develop vaccines and treatments. WHO’s director-general has described the US withdrawal as a “lose-lose” situation, saying both America and the rest of the world stand to suffer.

Sunita L Williams has retired from NASA after 27 year of spacefaring career. The astronaut went on three long missions to the International Space Station (ISS), which meant she logged 608 days in space, with a record breaking nine spacewalks. She was also stranded in ISS with Butch Wilmore. The mission was supposed to be 8-day-long, however it extended up to nine months due to a Starliner spacecraft problem. During this stay, she faced certain health issues. Photos showed significant weight loss, with sunken cheekbones.

Recently, Williams appeared on Raj Shamani podcast, where she talked about her experience of spending 286 days in space.

Also Read: Law on Assisted Dying in Jersey Could Be Passed Soon After Draft Approval

What Health Challenges Sunita Williams Faced In Space?

When Shamani asked her about her health challenges, she pointed out that it is when you land back on earth is when you feel the most uncomfortable. “Initially when you come back, you are not feeling very good. But then it goes away pretty good,” she said.

Shamani then asked how does she feel when she lands on earth. “For me it is nauseas. When we were landing in the water, everyone was focusing on the dolphins, but I was thinking if the capsule goes upside down, it is not going to be very good. The capsule was bobbing for a few seconds like a cork,” she said.

She explains that when you are in the space, your neuro vestibular system, which is body’s internal balance and orientation system, located in the inner ear does not work. “When you are out in space, gravity and inner balance are not needed and when you come back, it is suddenly there.”

She said that she felt nauseas for 24 to 48 hours. Furthermore, she said that when she wears the spacesuit and pinches her head through that, it makes her a “little sick”.

While in space, she explains, “all the balance muscles that you use here on earth, you do not even realize are not in use. After landing, they suddenly have to be put to use, so they have to be recharged. For me, it takes about a month to get used to it.”

How Does The Space To Earth Transition Work?

“We also get trainers who examine our progress and how we are doing back on earth. It is actually pretty cool to see how your body works and to human yourself again or to earth yourself again.”

Shamani asked if coming back to earth and adapting to gravity takes time. He asked, “do you feel like if you pick something and leave it, it won’t drop, rather it will flow?” “It happens, but you get back to gravity pretty quickly,” she said.

What Are The Health Risks Of Staying In Space?

Space agencies like NASA and the German Space Agency (DLR) studied the effects of space on human body. In 2024, the journal Nature published over 40 studies focused on aerospace medicine and space biology. One such study, called TWINS compared astronaut Scott Kelly, who spent a year on the ISS with his identical twin, Mark, who stayed on Earth.

The study highlighted a significant risk of prolonged space missions: radiation exposure.

Read: NASA Astronaut Sunita Williams’ Health Deteriorates During Extended Mission: Experts Raise Concerns

Radiation in space can damage DNA, increasing cancer risks and oxidative stress in the body. Bailey explained that space radiation exposure is a major concern for astronauts. Space agencies must find ways to protect astronauts during space travel and long-term stays on the Moon or Mars. They have set limits on the amount of radiation astronauts can be exposed to over their careers.

Another challenge is microgravity that causes bone density loss of 1-1.5% per month. When astronauts come down to Earth. They may struggle with physical activities like dancing due to weak bones and it can also affect vision. The fluids that shift to the head put pressure on the eyes. This can also lead to Spaceflight Associated Neuro-ocular Syndrome, which can permanently impact vision.

Other risks involve fluid redistribution that can lead to facial puffiness and decreased fluid volume in legs, disruption of cardiovascular functions, complicating blood pressure and even risks to the urinary systems. The risk of kidney stone too is high.

Nutrition deficiencies was another concern which was raised when photos of Williams revealed a significant weight loss. Her sunken cheekbones raised worries about her eating habits. There were also speculations of her being on a calorie-deficit diet. This meant that she ate less than her body required to sustain the high energy she needs for space travels.

In terms of physical activities, astronauts in microgravity must exercise for 2.5 hours daily. This helps them maintain muscle bone health. However, challenging environment could lead to weight loss.