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An experimental treatment happens to be the solution to delay Alzheimer's symptoms in some people. These people are the ones who are genetically destined to get the disease in their 40s or 50s. These new findings form ongoing research has now been caught up in Trump administration funding delas. The early results of the study has been published on Wednesday and the participants too are worried that politics could cut their access to a possible lifeline.
One of the participants had said, "It is still a study but it has given me an extension to my life that I never banked on having." The participant is named Jake Henrichs, form New York City, who is 50 years old. He is one of them to be treated in that study for more than a decade now and has remained symptom-free despite inheriting an Alzheimer's-causing gene that had killed his father and brother around the same age.
Two drugs which can modestly slow down early-stage Alzheimer's are sold in the United States. These drugs clear the brain of one of its hallmarks, a sticky gunk-like part called the amyloid. However, there have not been any hints that removing amyloid far earlier, way many years before the first symptoms appear, may postpone the disease.
The research is led by Washington University in St Louis, which involved families that passed down rare gene mutation as participants. This meant it was almost guaranteed that they will develop symptoms at the same age their affected relatives did.
The new findings is based on a subset of 22 participants who received amyloid-removing drugs the longest, on average eight years. Long-term amyloid removal cut in half their risk of symptom onset. The study is published in the journal Lancet Neurology.
Washington University's Dr Randall Bateman, who directs the Dominantly Inherited Alzheimer's Network of studies involving families with these rare genes says, "What we want to determine over the next five years is how strong is the protection. Will they ever get the symptoms of Alzheimer’s disease if we keep treating them?”
The researchers before though did not know what exactly caused Alzheimer's which affects nearly 7 million Americans, most of them in their later life. However, it is clear that these silent changes occur in the brain at least two decades before the first symptom shows up. The big contributor. At some point amyloid buildup can trigger a protein named tau that then starts to kill neurons, which can lead to cognitive decline.
Researchers are now thus studying the Tau-fighting drugs and are looking into other factors, like inflammation, brain's immune cells and certain virus.
The National Institute of Health (NIH) has expanded its focus as researchers have found more reasons for Alzheimer's. In 2013, the NIH's National Institute on Aging funded 14 trials of possible Alzheimer's drugs over a third targeting amyloid. By last fall, there were 68 drugs and 18% of them target amyloid. However, there are scientists too who think that amyloid is not everything and their is way more in the brain tissue, immune cells, and more which can be studied.
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A new British study has discovered that social media use or video gaming is not causing mental health problems in young teenagers.
For decades, experts across industries have warned that time spent on social media platforms such as TikTok, Instagram or gaming platforms could be driving a rise in anxiety and depression among teenagers.
However, researchers from the University of Manchester claim to have found little to no evidence over links of such claims.
Lead author Dr Qiqi Cheng said: "We know families are worried, but our results do not support the idea that simply spending time on social media or gaming leads to mental health problems, the story is far more complex than that."
The researchers tracked pupils’ self-reported social media habits, gaming frequency and emotional difficulties over three school years to find out whether technology use genuinely predicted later mental health difficulties.
The researchers found no proof that heavy social media use or more frequent gaming caused increases in symptoms of anxiety or depression over the following year - for both boys or girls.
Girls who gamed more often went on to spend slightly less time on social media the following yea and boys who reported more emotional difficulties were more likely to cut back on gaming in the future. This suggested links between losing interest in hobbies when feeling low or parents limiting screen time when they notice their child is struggling.
The research team also explored whether actively chatting on social media or just passively scrolling made a difference but results stayed the same
The authors emphasize that this does not mean online experiences are harmless. Hurtful messages, online pressures and extreme content can still impact wellbeing but they argue that focusing simply blaming screen time is not enough and more attention needs to be paid.
Constant comparison on social media, cyberbullying and pressure to fit in online or offline significantly impact self-esteem and increase anxiety. Apart from this, exposure to violence, neglect, abuse or poverty during these formative years is a major risk factor for developing mental illnesses like PTSD, depression and anxiety.
Additionally, some adolescents are also genetically more susceptible to mental health conditions, which can be triggered by environmental stressors.
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Flu has now reached California, officials at the California Department of Public Health (CDPH) confirmed on Tuesday. The mutated influenza strain, which is dubbed as the 'super flu' is now spreading in California.
The CDPH confirmed a second pediatric death related to flu since the season of this respiratory virus had started. The 'super flu' strain is the mutation of seasonal influenza A H3N2 virus, called the subclade K. While the cases are on the rise, with some record breaking ER visits and hospitalizations, the Centers for Disease Control and Prevention (CDC) noted that the season has not peaked yet, and that there might be more cases in the coming week.
Dr Monica Gandhi, who is an infectious disease expert at UC San Francisco told SFGATE that people infected with the mutated strain will likely get common flu symptoms, such as body aches, fever, cough and headache. "I think this particular strain makes people feel pretty horrible," Gandhi said, and further added, "And the reason that subclade K is important is it may not be covered by the current flu vaccine."
However, experts are still asking people to get vaccinated. In fact, the CDC has also noted that vaccination "has been shown to reduce the risk of flu and its potentially serious complications". However, only 130 million doses of vaccine have been distributed, which covers less than 40% of the US population. "The vaccine remains the most effective means to prevent disease. We still want to encourage people to get the vaccine," said Professor Antonia Ho, Professor and Honorary Consultant in Infectious Diseases at the University of Glasgow. Experts have stressed enough on the immunity that one can receive from the vaccine that that these flu jab remain the best defense against the flu, even though the current strain circulated may have drifted away from the strain included in this year's jab.
Data from the UK Health Security Agency (UKHSA) also show that vaccines is performing as expect, despite the emergence of subclade K.
K variant causes more intense flu symptoms, they include:
This year's flu came after the flu vaccination was made, which means the current vaccination does not align with the mutation, however, experts have pointed out that it still continues to offer protection against the illness.
Flu activity in the state has shown a downtick from the season high at the end of the December. 15% of flu tests have come back positive by January 3, which is down from 17% rate seen during the week ending with December 27. However, the CDC noted that this downtick does not mean the end of flu season, it could rather mean that less cases were reported due to the holiday season. As the agency has warned more such cases to show up in the coming week.
In fact, hospitalization have been on the rise and hit a season high with 3.8 admissions per 100,000 in the state as of January 3.
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Diabetes isn't just costing Indians their lifelong savings, it's also costing the country INT11.4 trillion.
According to a Nature Medicine study, India faces the second highest economic burden due to this chronic condition. Only the United States ranks higher, with costs touching INT 16.5 trillion, while China comes in third at INT 11 trillion.
While excluding informal care provided by family members, the global costs comes around INT 10 trillion which is about 0.2 per cent of the world’s annual gross domestic product (GDP).
However, if informal care is factored in, costs goes up to INT152 trillion or 1.7 per cent of the world’s yearly GDP, as per the study. (An international dollar, or INT$, is a statistical unit that has the same purchasing power as a US dollar).
The scientists estimated that the economic impact of diabetes was much more than Alzheimer’s disease or cancer in the top three countries.
Diabetes is a chronic condition affecting several aspects of physical and mental health. It occurs when either the body can’t make enough insulin or can’t use it effectively, which impairs several functions.
Often referred to as the 'Diabetes capital of the world', over 100 million people across India suffer from the chronic condition while another 136 million are living with prediabetes.
According to Pharmeasy 2025 Diabetes Report, one in two people show high blood sugar levels when tested and over 90 percent of reports with high blood sugar also showed abnormality in one or the other parameters for liver, lipid, heart or thyroid issues.
Also known as a 'Silent Killer', diabetes can develop and progress quietly in the body, often without clear or early symptoms. Multiple studies show that over 50 percent of people with diabetes in India are undiagnosed or unaware of their condition.
When left undiagnosed and untreated, diabetes can cause severe complications across the body including heart disease, kidney damage or vision loss. These complications disproportionately affect vulnerable parts of the population, especially those in rural areas without access to proper testing and treatment.
Despite the growing economic burden, India faces systemic challenges in addressing diabetes, including inadequate healthcare infrastructure, low public awareness and fragmented policy responses.
They evaluated costs based on medical expenses, productivity losses and caregiving.
While the burden in the US is largely due to high treatment costs and loss of physical capital, the high costs are mainly driven by the sheer number of people affected in India and China, the researchers said.
Author Klaus Prettner, professor of macroeconomics and digitalization at the Vienna University of Economics and Business noted of the results: "Caregivers often drop out of the labor market, at least partially, which creates additional economic costs."
"This is a stark illustration of how medical treatment regimes for chronic diseases such as diabetes are accessible to high income countries only," co-author Michael Kuhn, acting economic frontiers research group leader at the International Institute for Applied Systems Analysis, added.
Based on the results, the scientists said promoting healthier lifestyle, regular physical activity and a balanced diet is the most effective way to prevent diabetes and reduce its economic impact in each country in the long run.
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