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An experimental treatment happens to be the solution to delay Alzheimer's symptoms in some people. These people are the ones who are genetically destined to get the disease in their 40s or 50s. These new findings form ongoing research has now been caught up in Trump administration funding delas. The early results of the study has been published on Wednesday and the participants too are worried that politics could cut their access to a possible lifeline.
One of the participants had said, "It is still a study but it has given me an extension to my life that I never banked on having." The participant is named Jake Henrichs, form New York City, who is 50 years old. He is one of them to be treated in that study for more than a decade now and has remained symptom-free despite inheriting an Alzheimer's-causing gene that had killed his father and brother around the same age.
Two drugs which can modestly slow down early-stage Alzheimer's are sold in the United States. These drugs clear the brain of one of its hallmarks, a sticky gunk-like part called the amyloid. However, there have not been any hints that removing amyloid far earlier, way many years before the first symptoms appear, may postpone the disease.
The research is led by Washington University in St Louis, which involved families that passed down rare gene mutation as participants. This meant it was almost guaranteed that they will develop symptoms at the same age their affected relatives did.
The new findings is based on a subset of 22 participants who received amyloid-removing drugs the longest, on average eight years. Long-term amyloid removal cut in half their risk of symptom onset. The study is published in the journal Lancet Neurology.
Washington University's Dr Randall Bateman, who directs the Dominantly Inherited Alzheimer's Network of studies involving families with these rare genes says, "What we want to determine over the next five years is how strong is the protection. Will they ever get the symptoms of Alzheimer’s disease if we keep treating them?”
The researchers before though did not know what exactly caused Alzheimer's which affects nearly 7 million Americans, most of them in their later life. However, it is clear that these silent changes occur in the brain at least two decades before the first symptom shows up. The big contributor. At some point amyloid buildup can trigger a protein named tau that then starts to kill neurons, which can lead to cognitive decline.
Researchers are now thus studying the Tau-fighting drugs and are looking into other factors, like inflammation, brain's immune cells and certain virus.
The National Institute of Health (NIH) has expanded its focus as researchers have found more reasons for Alzheimer's. In 2013, the NIH's National Institute on Aging funded 14 trials of possible Alzheimer's drugs over a third targeting amyloid. By last fall, there were 68 drugs and 18% of them target amyloid. However, there are scientists too who think that amyloid is not everything and their is way more in the brain tissue, immune cells, and more which can be studied.
Amid the scare of hantavirus infection, US health officials informed that they are investigating a potential case in an Illinois resident.
The Illinois Department of Public Health (IDPH) noted that the incident is not linked to the MV Hondius cruise ship outbreak.
MV Hondius had 18 American nationals, and all have been medically evacuated back to the US. While 16 people are in Nebraska at the nation's only national quarantine unit, two people are being monitored in Atlanta.
In a statement, the IDPH said that the person “lives in Winnebago County, has not travelled internationally, and has not come in contact with individuals associated with the MV Hondius outbreak”.
Officials suspect that the possible hantavirus infection in the Illinois person to be a case of the North American strain of the virus while cleaning a home where rodent droppings were present.
“Unlike the Andes strain of Hantavirus responsible for the cruise outbreak, the North American strains are not known to spread from person to person. The risk of contracting Hantavirus of any kind remains very low for Illinois residents,” the officials said.
However, they added that the CDC is conducting additional testing to confirm that the resident is positive for Hantavirus. CDC staff told IDPH its confirmatory test result could take up to 10 days to complete.
Excluding this latest potential case, Illinois has had 7 positive cases of Hantavirus since 1993, most recently in March 2025.
Since surveillance began in 1993, the US has recorded 890 cases of Hantavirus over 30 years (1993-2023)
The Hantavirus strain most commonly seen in the US is caused by exposure to rodent droppings and is NOT contagious from person to person.
The rodent species (long-tailed pygmy rice rat) known to carry the Andes strain of the virus in South America does not live in the U.S.
Also read: Donald Trump Says Hantavirus Is 'Under Control'; Questions Grow Over CDC Research Cuts
Earlier, a case of hantavirus was also reported from Israel, that was not linked to the MV Hondius ship.
The case in Israel, reported by the local newspaper Maariv, is believed to have been infected during a stay in Eastern Europe several months ago. It is reportedly not linked to the ongoing outbreak linked to the MV Hondius cruise ship in the Atlantic Ocean.
The patient underwent an antibody test after the symptoms appeared, which showed exposure to hantavirus, the report said. A PCR (polymerase chain reaction) test was then conducted to detect the virus’s genetic material, confirming the infection, the report said.
The patient was said to be in stable condition, not in need of intensive care or strict isolation, and was being kept under medical observation.
Details about the patient and the medical center where the diagnosis was made could not yet be published, but have been reported to the country's Health Ministry.
Also read: Fact Check: Can Ivermectin Help Treat Hantavirus?
Hantavirus is primarily transmitted through contact with infected rodents or exposure to their urine, droppings, and saliva, though rare cases of person-to-person transmission have also been reported.
According to the World Health Organization (WHO), 11 cases — including three deaths — have been confirmed so far. However, additional suspected and confirmed cases are continuing to emerge across countries.
“At the moment, there is no sign that we are seeing the start of a larger outbreak,” said Tedros Adhanom Ghebreyesus, WHO Chief, in the latest media briefing.
However, he said that the situation could still change.
“Given the long incubation period of the virus, we might see more cases in the coming weeks,” he said.
Credit: AI generated image
Polycystic Ovary Syndrome (PCOS), a condition affecting more than 170 million women worldwide, has now been officially renamed Polyendocrine Metabolic Ovarian Syndrome (PMOS), according to a global study published today in The Lancet.
The new name reflects a major shift in understanding the condition — from being viewed primarily as a gynecological disorder to being recognized as a complex, multisystem condition affecting several aspects of health.
The new term PMOS acknowledges that the condition involves:
“For too long, the narrow definition of PCOS has overlooked its metabolic and hormonal complexity, leaving many patients undiagnosed or misunderstood,” Cree added.
Calls to rename PCOS date back to the 1990s and early 2000s. In 2012, the U.S. National Institutes of Health (NIH) recommended a name change after experts concluded that the term PCOS was misleading and confusing for both patients and healthcare providers.
“The name focuses on a criterion — polycystic ovarian morphology — which is neither necessary nor sufficient to diagnose the syndrome,” NIH experts wrote in the report.
Although PCOS has long been understood as a metabolic condition, experts said the name inaccurately narrowed its scope and overemphasized ovarian cysts and fertility issues.
This often led to:
The renaming process involved consultations with thousands of patients and healthcare professionals across the world.
The effort was supported by 56 academic, clinical, and patient organizations.
Experts said the transition from PCOS to PMOS will occur over the next three years through a phased global implementation strategy.
The new name aims to explain the condition more accurately and comprehensively.
Polyendocrine means it affects multiple hormones in the body.
Metabolic refers to issues linked to weight, insulin, blood sugar, and heart health.
Ovarian highlights its impact on ovulation and reproductive health.
Syndrome refers to a group of symptoms occurring together.
In simple terms, PMOS is a hormonal and metabolic condition that can affect periods, fertility, skin, mood, weight, and long-term health.
Experts said the new terminology intends to:
According to the study, PMOS could also:
Credit: X
Hantavirus cases have climbed to 11, including three deaths, WHO Director-General Tedros Adhanom Ghebreyesus said today.
During a media briefing on hantavirus, Tedros stated that all eleven cases are among passengers or crew members onboard the MV Hondius.
Also Read: Hantavirus Can Linger Indoors, Spread Through Contaminated Dust, Says Infectious Disease Expert
“Nine of the eleven have been confirmed as Andes virus, and the other two are probable,” he added.
All suspected and confirmed cases have been isolated and managed under strict medical supervision, minimizing any risk of further transmission.
Tedros said individual countries were now responsible for their citizens after the evacuation, adding: “I hope they will take care of the patients and the passengers, helping them and also protecting their citizens as well. That’s what we expect.”
Noting that “at the moment, there is no sign that we are seeing the start of a larger outbreak,” Tedros said the situation could still change.
“Given the long incubation period of the virus, it’s possible we might see more cases in the coming weeks,” he said.
Acclaimed vaccine scientist Prof. Peter Hotez from the Texas Medical Center (TMC) also said more cases could emerge, but ruled out the risk of a major epidemic.
“We might see additional cases, but I don't think this will be a major epidemic beyond the obvious human tragedy of those who lost their lives, and possibly a few others who could still get very sick,” he said in a post on social media platform X.
“New World hantavirus infections are rough stuff. Once symptoms begin, the resulting cytokine storm and ARDS means there's not much of a window before getting patients into an ICU, and often on ECMO (extracorporeal membrane oxygenation), which requires a high level of skill,” Prof. Peter said.
He also linked increasing zoonotic spillovers and rising arthropod-borne illnesses to “climate change pushing animal reservoirs to explore new habitats, together with deforestation and urbanization.”
“It's animals and vectors closer to humans and people coming closer to animals and vectors,” he added.
“I don't think this particular hantavirus outbreak will accelerate much beyond where it is now, but that's not the point.”
Meanwhile, Radboud University Medical Center (Radboudumc) in the Netherlands has placed 12 employees in quarantine for six weeks as a precaution after incorrect procedures were followed while caring for a hantavirus-infected patient from the Dutch cruise ship.
The hospital said on Monday that the issue involved procedures for drawing and processing blood samples, as well as the disposal of the patient's urine, according to Xinhua news agency.
Also read: Fact Check: Can Ivermectin Help Treat Hantavirus?
“This blood was processed according to standard procedure. Due to the nature of the virus, this blood should have been processed according to a stricter procedure,” Radboudumc said in a statement, without specifying what the stricter measures should have entailed.
Read More: Donald Trump Says Hantavirus Is 'Under Control'; Questions Grow Over CDC Research Cuts
The WHO recommends that people exposed to hantavirus should be:
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