Credits: Canva
An experimental treatment happens to be the solution to delay Alzheimer's symptoms in some people. These people are the ones who are genetically destined to get the disease in their 40s or 50s. These new findings form ongoing research has now been caught up in Trump administration funding delas. The early results of the study has been published on Wednesday and the participants too are worried that politics could cut their access to a possible lifeline.
One of the participants had said, "It is still a study but it has given me an extension to my life that I never banked on having." The participant is named Jake Henrichs, form New York City, who is 50 years old. He is one of them to be treated in that study for more than a decade now and has remained symptom-free despite inheriting an Alzheimer's-causing gene that had killed his father and brother around the same age.
Two drugs which can modestly slow down early-stage Alzheimer's are sold in the United States. These drugs clear the brain of one of its hallmarks, a sticky gunk-like part called the amyloid. However, there have not been any hints that removing amyloid far earlier, way many years before the first symptoms appear, may postpone the disease.
The research is led by Washington University in St Louis, which involved families that passed down rare gene mutation as participants. This meant it was almost guaranteed that they will develop symptoms at the same age their affected relatives did.
The new findings is based on a subset of 22 participants who received amyloid-removing drugs the longest, on average eight years. Long-term amyloid removal cut in half their risk of symptom onset. The study is published in the journal Lancet Neurology.
Washington University's Dr Randall Bateman, who directs the Dominantly Inherited Alzheimer's Network of studies involving families with these rare genes says, "What we want to determine over the next five years is how strong is the protection. Will they ever get the symptoms of Alzheimer’s disease if we keep treating them?”
The researchers before though did not know what exactly caused Alzheimer's which affects nearly 7 million Americans, most of them in their later life. However, it is clear that these silent changes occur in the brain at least two decades before the first symptom shows up. The big contributor. At some point amyloid buildup can trigger a protein named tau that then starts to kill neurons, which can lead to cognitive decline.
Researchers are now thus studying the Tau-fighting drugs and are looking into other factors, like inflammation, brain's immune cells and certain virus.
The National Institute of Health (NIH) has expanded its focus as researchers have found more reasons for Alzheimer's. In 2013, the NIH's National Institute on Aging funded 14 trials of possible Alzheimer's drugs over a third targeting amyloid. By last fall, there were 68 drugs and 18% of them target amyloid. However, there are scientists too who think that amyloid is not everything and their is way more in the brain tissue, immune cells, and more which can be studied.
Credit: Alan Brazil/Instagram
Former Scotland striker Alan Brazil revealed that he has had a liver transplant and that his heart stopped during the surgery.
"My heart stopped for a bit," said Brazil, who described himself as "incredibly lucky" to have survived a life-saving liver transplant surgery.
He announced his surgery last month, after disappearing from the airwaves while covering the Cheltenham Festival in March.
During the video announcement, he also revealed a transformation in appearance, having lost weight during the process of the transplant, The Telegraph reported.
“I’d been having ongoing trials, so many specialists, and I decided I needed a transplant. I didn’t want to do it, but my kids and Jill [his wife] said, ‘You’ve got to do it, you have to do it, you are doing it," said the 66-year-old, in his first appearance on the radio station since leaving.
"I finished [work] at quarter to 10, and at 10 I had to phone Addenbrooke's Hospital. They said, 'Get in right now'".
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"At two thirty that afternoon, I was on the slab, and they opened me up. I was under for something like eight hours.
"They transplanted my liver. My heart did stop for a bit, and it came back on its own. I'll be frank, I'm very, very lucky to be here," said Brazil, who has presented Talksport’s breakfast show since 2000.
He further said: “I’m taking loads of meds ...I’ve just got to be a good boy, rest up, and go and see these people. Hopefully, I’ll get back to 100 per cent. I never realized how bad I was. I feel totally different now. I’m incredibly lucky.”
What Is A Liver Transplant?
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As per the National Institute of Diabetes and Digestive and Kidney Diseases, a liver transplant is a surgical procedure to replace a diseased liver with a healthy one from a donor. It’s often the last resort when liver failure occurs—whether due to chronic illness or sudden injury.
When Is It Needed?
People may need a liver transplant for:
In children, biliary atresia is the most common reason.
Types of Liver Transplants
Deceased Donor Transplant:
The most common type is where a full or partial liver is taken from someone who has recently died.
Living Donor Transplant:
A healthy person donates a portion of their liver—typically to a close relative. Both the donor’s and recipient’s liver regenerates to normal size in a few weeks.
What Must Be Kept In The Mind?
Credit: iStock
Tick bites are becoming a huge health care issue, as they can cause diseases like Lyme. Due to the recent surge in tick bites throughout the United States, it has become more important to know everything about the situation and the disease.
The Centers for Disease Control and Prevention (CDC) has already issued a warning about a surge in tick bite cases and possible Lyme disease in the Northeastern states, where tick-related emergency room visits have risen. The Midwest is the second most affected region.
Harvard Health states that about 90% of cases have been reported in 14 states: Connecticut, Maine, Virginia, Maryland, Massachusetts, Minnesota, New Jersey, New Hampshire, New York, Pennsylvania, Rhode Island, Vermont, Wisconsin, and West Virginia.
CDC reports ER visits related to tick bites hit their highest levels for spring since 2017. The United States has been fighting with tick-related issues for decades. The nation sees an estimated 476,000 people treated for Lyme disease each year.
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Lyme disease is caused by a bacterium called Borrelia burgdorferi. This infectious disease is spread by infected ticks. The most common cause of these diseases in humans is bites from blacklegged ticks, though other variants can also be carriers. The Harvard Health says that most patients do not remember being bitten by a tick.
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Lyme can impact the cardiac, neurologic, and rheumatologic systems. The CDC says that 1 out of 100 patients has Lyme bacteria in their heart tissues. The condition is also called Lyme carditis.
Advanced brain imaging shows that Lyme disease brain fog is real. It can lead to various effects, including difficulty focusing, thinking, reading, and absorbing information.
There are 12 essential nerves, also known as the cranial nerves, that originate in the brain and play a crucial role in sensory functions and movements in the different parts of the head, face, neck, and torso. Lyme disease can also affect those nerves, leading to Bell's Palsy.
Lyme can cause sudden vision loss, damage to the optic nerve, and neurotrophic keratitis. Other symptoms include blurry vision, eye floaters, tearing, and extreme sensitivity to light.
The most common Lyme-related hearing issues are tinnitus, vertigo and dizziness, headache, and unilateral sensorineural hearing or hearing loss in one ear.
The disease can cause swollen knees, a low-grade fever, or a limp. It usually starts in the fourth week after being bitten.
This is not just any fatigue, but a weakness that is debilitating. People with a history of Lyme were 8 to 15 times more likely to report severe or moderate fatigue than those who have never had the disease.
Credits: White House
President Donald Trump's recent physical examination has been in the news, and now it is about a drug that was omitted in the test, which is making headlines. This very drug is raising questions about the health condition of President Trump, as he has been taking this drug for years. This medication is finasteride, a generic name for Propecia, which is a hair loss drug.
President Trump's recent test report at Walter Reed National Military Medical Center contains a list of drugs that he takes, but in that list, one important name was missing, and that is his hair loss drug, Propecia. According to The Washington Post, when they asked officials if the president still takes that drug, the White House said it was not obligated to reveal the full range of medications the president was taking.
The White House said, “The current report reflects all medications deemed clinically relevant to disclose at this time.” It added, “No additional undisclosed conditions or procedures materially affecting his health status were omitted from this report.”
Though even after the statement of the White House, experts are still questioning his health condition and the hair loss drug. Robert Klitzman, a psychiatrist who leads Columbia University’s master’s program in bioethics, said, “It raises significant questions of what else is possibly not being revealed.”
Steve Joffe, a physician and bioethicist at the University of Pennsylvania Perelman School of Medicine, said to the Post, “There’s a certain level of openness and disclosure that people have a right to expect from someone in whom they place such profound trust.”
President Trump's mysterious drug list, with many omissions, concerns experts as it lacks what matters the most.
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President Donald Trump is saying that he has achieved a full score in a very difficult test. He said, “Unlike other US Presidents, none of whom have ever taken an approved, high difficulty, Cognitive Test, I scored a perfect 30 out of 30, considered ‘extreme intelligence.’”
“In fact, this is my fourth such test, all PERFECT or 120 correct answers out of 120 questions asked! Anyone rarely gets a Perfect Score, especially when achieved four times in a row.” He wrote in his post.
He also demanded that the candidates for president and vice president should also go through this kind of test by saying, “In fact, this is my fourth such test, all PERFECT or 120 correct answers out of 120 questions asked! Anyone rarely gets a Perfect Score, especially when achieved four times in a row.”
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Trump’s claims were immediately questioned by experts like Dr. Jonathan Reiner and Abby Phillip of CNN. They argued that repeated tests may not provide the same value. According to them, as the president had taken the test several times and the questions didn't change that much, it was easy. Other than that, the test is not designed to calculate intellect; it is more of a dementia screening test.
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