Smokers who make the decision to quit will experience immediate health benefits, including a rapid reduction in their risk of atrial fibrillation (A-Fib), according to new research published in JACC: Clinical Electrophysiology. The study, conducted by Dr. Gregory Marcus, a cardiologist at the University of California, San Francisco, offers compelling evidence for smokers to quit, showing that it’s never too late to avoid the damaging effects of smoking on heart health.

Dr. Marcus, the senior author of the study, emphasized that A-Fib can be prevented even in individuals who have smoked for years. "The findings provide a compelling new reason to show current smokers that it’s not too late to quit, and that having smoked in the past doesn’t mean you’re ‘destined’ to develop A-Fib," Marcus explained. "Even for the current and longtime smoker, A-Fib can still be avoided."

What is Atrial Fibrillation (A-Fib)?

"There’s strong evidence that smoking increases the risk of A-Fib," Marcus said. "But the benefits of quitting smoking have been less certain." With this in mind, his team sought to determine whether quitting could significantly lower a person’s risk of developing A-Fib, or if the risk would remain the same.

The research team analyzed data from over 146,700 current and former smokers, tracking their smoking habits and health over a 12-year period using data from the UK Biobank database. The results were promising: former smokers had a 13% lower risk of developing A-Fib compared to current smokers, while those who quit during the study saw an 18% reduction in their risk.

"This is likely a testament to the potency of reducing atrial fibrillation risk pretty shortly after quitting," Marcus said in a statement from the American College of Cardiology.

The findings highlight the importance of quitting smoking, not only for general health but specifically for reducing the risk of serious heart conditions like A-Fib.

Tips for Quitting Smoking

Quitting smoking is one of the most effective ways to lower the risk of A-Fib and improve overall heart health. While it can be challenging, the benefits of quitting are clear and immediate. Here are some tips to help you quit smoking successfully:

1. Choose a specific date to quit smoking and stick to it. Prepare yourself mentally and physically for this change.

2. Reach out to family, friends, or a support group to help keep you accountable. Sharing your goals with others can provide encouragement.

3. Options like nicotine patches, gum, or lozenges can help ease withdrawal symptoms and reduce cravings.

4. Identify situations that make you want to smoke, such as stress or social gatherings, and find healthy ways to cope with them.

5. Regular exercise can help distract you from cravings and improve your mood during the quitting process.

6. Drinking water can help flush nicotine out of your system faster, reducing cravings.

7. Activities like yoga, meditation, or deep breathing exercises can help manage stress, a common trigger for smoking.

Quitting smoking offers immediate and significant benefits, particularly in reducing the risk of atrial fibrillation. The latest research provides smokers with more motivation to quit, showing that it's never too late to take control of their heart health.

Type 2 diabetes may be the same disorder, but it may look quite different in men and women. A new study based on 28,720 people newly diagnosed with type 2 diabetes has found distinct patterns in the complications that come after diagnosis.

Men were more likely to follow a trajectory involving cardiovascular disease or end-stage kidney disease, while women were more likely to develop mental health conditions like anxiety, depression or somatoform disorders.

The study, published in PLOS Medicine, followed patients diagnosed between 2010 and 2020 using linked UK healthcare records.

Participants were followed for a median of 6.8 years, allowing researchers to examine not just which complications occurred, but also the order in which they developed.

Men Saw Stronger Heart And Kidney Disease Complications

Among men, 8.4% followed a trajectory involving cardiovascular disease or end-stage renal disease, compared with 5.3% of women. Men also tended to develop these complications earlier than women.

Hypertension, however, remained the most common complication across both sexes, affecting 21.1% of men and 20.2% of women.

The finding matters because type 2 diabetes can damage blood vessels over time, increasing the risk of cardiovascular disease and kidney problems. But the study suggests that the sequence and timing of these complications may not be identical in men and women.

Also read: US FDA Approves Eli Lilly’s Mounjaro To Reduce Cardiovascular Risk In Diabetics

Women Were More Likely To Develop Mental Health Conditions

8.1% of women developed a mental health condition compared with 5.3% of men. These included anxiety, depression and somatoform disorders.

Prof Ravinder Goswami, senior endocrinologist at AIIMS, told the Times of India that diabetes can affect men and women differently. He noted that men may develop diabetes at a younger age, while women with diabetes can lose the natural cardiovascular protection generally associated with the premenopausal period.

Also read: Lowering Cholesterol May Protect Your Brain As Study Links Statins To 15% Lower Dementia Risk

Why Could Diabetes Behave Differently In Men And Women?

Sex hormones, body-fat distribution, age at diabetes diagnosis, cardiovascular risk factors and differences in seeking healthcare can all influence how complications related to type 2 diabetes emerge.

The study found that women had higher average healthcare utilisation. On the other hand, lower healthcare engagement among some men could represent a missed opportunity to detect complications earlier.

The researchers also found that people who developed a mental health condition after their diabetes diagnosis had a shorter survival trajectory. Among people following the same disease pathway, men died on average nine years younger than women.

That does not mean depression or anxiety automatically shortens a person's life by nine years. Rather, the finding highlights how the combination of diabetes and subsequent health problems can identify a particularly vulnerable group.

Should Diabetes Be Treated Differently In Men And Women?

The researchers say their study supports sex-specific complications of diabetes and earlier intervention, rather than completely separate treatments.

For men, that could mean paying particular attention to cardiovascular and kidney health. For women, routine attention to mental health alongside physical complications is especially important.

The study is observational, so it cannot prove that being male or female directly causes a particular diabetes complication.

A visit to a petting zoo usually means excited children playing around with a few goats. But in North Carolina, an ordinary animal encounter has triggered a public health warning after four baby goats linked to a mobile petting zoo tested positive for rabies.

The goats belonged to Farm Adventures, a mobile petting zoo based in Harmony, North Carolina. Three goats tested positive for rabies at the North Carolina State Laboratory of Public Health on August 28, while a fourth was not tested but was presumed infected. All the four animals were euthanised.

Health officials are now urging anyone who touched or held the baby goats between July 28 and August 27 to contact their local health department and find out whether preventive treatment is needed. The animals had appeared at events across several North Carolina counties during that period.

A Skunk Could Have Been The Source

According to the North Carolina Department of Health and Human Services (NCDHHS), the goats were most likely exposed when a skunk entered their pen in late July.

The petting zoo said the goats were too young to receive rabies vaccinations at the time and staff did not know they had been bitten. The animals also showed no obvious signs of rabies, making the infection difficult to spot before testing.

That brings us to one of the most unsettling features of rabies. An infected animal does not necessarily look obviously sick at the time a person encounters it.

NCDHHS said the goats “may have been in direct contact with people at events while infectious” and is working with local health departments and event organisers to identify people who could have been exposed.

Also read: Bird Flu In US: Are Cats Spreading A Deadly Disease?

How Does Rabies Spread From Animals To Humans?

Rabies is caused by a virus that attacks the central nervous system. The most common route is an infected animal's bite, because the virus is present in saliva. Scratches contaminated with saliva can also pose a risk. Simply being near an infected animal does not mean you are exposed to rabies.

Once the virus enters the body, it can travel through peripheral nerves towards the brain and spinal cord. This helps explain why there can be a considerable gap between exposure and symptoms. It can last weeks to months, depending partly on where the exposure occurred and how far the virus has to travel to reach the brain.

Also read: Is There A Difference Between Zoonotic, Non-Zoonotic And Reverse Zoonotic Diseases

Why Is Rabies Almost Always Fatal Once Symptoms Begin?

This is where rabies becomes particularly dangerous. In the early stage, symptoms can resemble many ordinary illnesses, including fever, weakness and headache. There may also be pain, tingling or itching around the site of the bite.

But once the virus reaches the brain, the disease can progress to encephalitis, causing confusion, agitation, hallucinations, difficulty swallowing, excessive salivation, seizures and paralysis.

The CDC states that once clinical signs of rabies appear, the disease is nearly always fatal. There. By the time neurological symptoms appear, the virus has already established itself in the nervous system, where eliminating it becomes extremely difficult.

Window To Prevent Rabies Is Before Symptoms

Rabies is preventable even after an exposure, provided treatment is started promptly and before symptoms develop. Post-exposure prophylaxis, or PEP, generally includes thorough wound cleaning, rabies immune globulin for people who have never previously been vaccinated, and a course of rabies vaccine.

This is why North Carolina officials are not telling exposed visitors to wait for symptoms. Instead, NCDHHS says people who had contact with the goats should contact their local health department to determine whether medication is needed.

The US Food and Drug Administration (FDA) has approved Mimrylo (rusfertide) for adults with polycythemia vera (PV), a chronic disorder in which the body produces too many red blood cells.

The drug is the first approved treatment for PV that mimics hepcidin, a naturally occurring hormone that regulates iron in the body.

The approval, announced on August 28, is particularly significant for patients whose disease remains inadequately controlled despite existing treatment and who need frequent blood-removal procedures.

When The Blood Becomes Too Thick

Polycythemia vera belongs to a group of disorders in which the bone marrow produces blood cells excessively. In PV, the major problem is an overproduction of red blood cells.

More red blood cells mean a higher proportion of cells circulating in the blood. This can make blood thicker and increase the risk of blood clots, stroke and heart attack.

That is why doctors pay close attention to a patient's hematocrit, which represents the proportion of blood made up of red blood cells.

One of the major treatment goals is to keep hematocrit below 45%, which helps reduce cardiovascular risks.

Also read: Sweetener In Sugar-Free Gum Linked To 57% Higher Heart Attack And Stroke Risk: What Is Xylitol?

Why Do Patients Need Their Blood Removed?

One of the traditional ways of controlling PV is removing some blood. The procedure, called phlebotomy, involves taking blood from a vein, reducing the number of circulating red blood cells and bringing hematocrit down.

But for some patients, this can become a recurring routine. They may need repeated blood draws even while receiving standard treatment. That burden is one reason the new drug has attracted attention.

“People living with polycythemia vera have long faced the challenge of managing a chronic blood disorder with frequent blood draws,” said Tanya Wroblewski, M.D., Director of the Division of Nonmalignant Hematology at the FDA's Center for Drug Evaluation and Research.

She added, “Today's approval of Mimrylo offers a new, first-in-class option that has the potential to meaningfully reduce patient burden.”

Also read: Norway’s King Harald V Dies At 89: What Is Hemolytic Anemia?

How Does Mimrylo Work?

The FDA's approval was based on the VERIFY trial, a phase 3 study involving 293 adults with PV who continued to require frequent phlebotomies despite standard treatment. Participants received either Mimrylo or placebo for 32 weeks.

76.9% of patients receiving Mimrylo did not require a phlebotomy during weeks 20 to 32, compared with 32.9% of those receiving placebo, marking a substantial difference.

Mimrylo is administered once a week as an injection under the skin, with the dose adjusted to help maintain hematocrit below 45%.

The most common adverse reactions reported with Mimrylo were reactions at the injection site and anaemia, according to the FDA.

The drug was granted priority review and approved to Takeda Pharmaceuticals America.