Cigarettes with ultralow nicotine levels are now being called the game-changer in the fight against smoking. If you are having trouble in quitting smoking, then, it is for you, that soon the Biden White House is expected to formally propose a plan that will order cigarette nicotine levels to be reduced, reports The Washington Post. For now though, it has been a failure, as these cigarettes, also known as VLN cigarettes that stands for very low nicotine are only available in 5,100 stores in 26 states. This is a very small fraction of the overall market for cigarettes. The company that makes it, 22nd Century, is struggling not because of the low supply, but also from the advocates who have long believed slashing nicotine levels altogether.

The Advent and ideation

Nicotine is a chemical that is produced naturally from tobacco that makes the cigarette and also keeps people hooked. While it is believed that it makes people alert, and get the "hit" to keep them going, it exposes the users to harmful substances, carcinogens, and increases the risk of heart disease, lung cancer, and other illness.

Ultralow-nicotine cigarettes, like the VLN brand, contain about 95% less nicotine than the regular cigarettes. The idea is quite simple: without the addictive grip of nicotine, smokers will find it easier to quit. Research too has shown some promise. For instance, the studies funded by the National Institute on Drug Abuse revealed that very low nicotine cigarettes reduced addiction potential significantly without having users to increase their smoking frequency. However, the problem is, why would anyone choose for a low-nicotine that does not make them feel the same way, when the high-nicotine cigarette is right next to it, making them feel the same way, with the same alertness, sold at the same price.

“It’s very hard to imagine someone actively choosing to continue to use a low-nicotine product for the same price when a high-nicotine product is right next to it,” said Eric Donny, a Wake Forest University School of Medicine nicotine researcher.

No wonder, the experiment with low nicotine product by Philip Morris' Next cigarettes in the 1980s and Vector Tobacco's Quest brand in the early 2000s, flopped.

FDA's Role in the Push

The Food and Drug Administration (FDA) has supported the development of such products, even allowing VLN cigarettes to be marketed as lower-risk options. However, these products remain a niche market, available in only a fraction of U.S. stores.

Recently, the Biden administration has considered a bold step—mandating a dramatic reduction in nicotine levels for all cigarettes sold in the United States. Supporters believe this move could save millions of lives, while critics, including tobacco companies, warn of potential unintended consequences.

What Could Be The Challenges?

Resistance from Big Tobacco Companies: They could argue that slashing nicotine levels could backfire. Their claim is, smokers will turn to black markets or smoke more to satisfy their cravings, which may lead to greater exposure to harmful substances.

Consumer Reluctance: History is proof to the instances of smokers being hesitant to embrace the low-nicotine products.

Political Hurdle: It may face political roadblocks, as under the Trump administration, plans to cut nicotine were shelved.

Could Low-Nicotine Cigarettes Be The Solution?

Advocates believe that ultralow-nicotine cigarettes could be a game-changer, comparing them to decaf coffee or non-alcoholic beer—products that reduce harm while offering a similar experience.

Some experts warn that a black market for traditional cigarettes could undermine these efforts. They also stress the need for safer alternatives, such as vaping products, to support smokers transitioning away from traditional cigarettes.

India's food safety regulator has banned the sale of select whisky and rum products produced by some of the country's biggest liquor companies, including Diageo India's United Spirits.

FSSAI's move comes after they found artificial or "nature-identical" flavouring that allegedly violates Indian food standards.

Among the affected products are United Spirits' Antiquity Blue Whisky and Royal Challenge Whisky manufactured in Madhya Pradesh, Inbrew's Bagpiper Deluxe Whisky and Old Cask Deluxe XXX Rum, as well as three variants of Old Monk produced by Mohan Rocky Springwater in Maharashtra.

It is still unclear whether the restrictions apply only to products manufactured at these specific facilities or to the brands nationwide.

Why Did FSSAI Ban These Products?

The Food Safety and Standards Authority of India (FSSAI) said laboratory tests found that certain products manufactured by United Spirits, Inbrew Beverages and Mohan Rocky Springwater contained external artificial or nature-identical flavouring substances intended to recreate the taste and aroma of whisky or rum, instead of relying on traditional production methods.

According to the regulator, the use of natural flavouring substances in alcoholic beverages is permitted but manufacturers cannot add whisky flavour to whisky or rum flavour to rum.

"There is no internationally recognized manufacturing practice whereby rum flavour is added to rum or whisky flavour is added to whisky," FSSAI said in its statement.

The regulator added that these practices could bypass proper maturation and reduce reliance on ingredients traditionally used to develop flavour, including molasses, malt and grapes.

FSSAI classified the tested products as "sub-standard due to the presence of external artificial or nature-identical flavours in the product."

While Diageo India, Inbrew Beverages and Mohan Rocky Springwater did not immediately issue public responses to media queries, Reuters reported that some industry executives believe the use of flavouring does not violate existing Indian regulations.

Also read: You Can No Longer Buy Medicines Containing More Than 12% Alcohol Over the Counter: Health Ministry

What Are "Nature-Identical" Flavourings?

Nature-identical flavouring substances are chemically synthesised compounds created to replicate the flavours naturally found in foods or beverages.

Although they may be seem same like the naturally occurring compounds, regulators determine whether they can be used in specific products based on food standards.

In this case, FSSAI's objection is not to all flavourings, but specifically to the addition of whisky or rum flavouring to beverages marketed as whisky or rum.

They argue that the flavour should develop naturally through the approved manufacturing and ageing process.

India is among the world's largest alcohol markets, with annual sales estimated at around $40 billion, and United Spirits, owned by global drinks giant Diageo, is the country's largest liquor company by market share.

The affected products are widely consumed because they are significantly more affordable than the imported spirits.

The latest action also signals FSSAI's bigger effort to tighten regulations of the food and beverage industry. In recent weeks, the regulator has also intensified scrutiny of products marketed as energy drinks and other packaged foods over labelling and compliance issues.

Former England rugby captain and 2003 Rugby World Cup winner Phil Vickery has announced that he will donate his brain to science after his death. He said that he hopes it will help researchers understand the long-term effects of repeated head injuries in sport in a better way.

The decision comes after Vickery was diagnosed with chronic traumatic encephalopathy (CTE), a progressive brain disease caused due to repeated blows to the head.

Phil Vickery Pledges To Donate His Brain

Vickery's announcement has reignited conversations about the lasting neurological impact athletes face, particularly as hundreds of former rugby players continue to seek better support for concussion-related illnesses.

Speaking about his decision, Vickery questioned, "Is that gonna make someone stand up? I don't know. What a horrible thing to say. But what does it have to take?"

Describing what life with suspected brain injury feels like, he said, "Brain injuries are with you all the time, 24/7, 365 days a year... it weighs heavy, and it grinds at you all the time. It won't beat me. I keep going."

Also read: Impact Of Electronic Gadgets On Brain Health And The Role Of Ayurveda

Phil Vickery's Diagnosis And The Rugby Concussion Lawsuit

Vickery revealed that he received a diagnosis of probable CTE around two years ago. He is among more than 1,000 former rugby union and rugby league players involved in a legal case against governing bodies, including World Rugby, England's Rugby Football Union (RFU), the Welsh Rugby Union, and the Rugby Football League.

Several former players involved in the case have reported serious neurological conditions, including dementia, memory loss, depression, and suspected CTE.

The lawsuit alleges that the organisations failed to adequately protect players from repeated head injuries and concussion during their careers.

Also read: Alzheimer's Sleep Loss May Be Reversible; Study Sparks Hope For New Treatments

What Is Chronic Traumatic Encephalopathy (CTE)?

CTE is a progressive neurodegenerative disease believed to result from repeated head impacts over many years. It has been identified in athletes from contact sports such as rugby, American football, boxing, ice hockey, and soccer, as well as military veterans.

Researchers believe repeated trauma leads to abnormal accumulation of a protein called tau inside the brain. Over time, this damages brain cells and affects normal brain function.

One of the biggest challenges is that CTE cannot currently be diagnosed with certainty in living people. Doctors can only suspect the condition based on symptoms and clinical history. A definitive diagnosis requires examination of brain tissue after death.

Also read: Scientists Say Changes In Brain In Your 40s & 50s May Influence Dementia Risk

Symptoms Of CTE

Symptoms usually appear years after repeated head injuries and may worsen over time. They can include:

• Memory loss
• Difficulty concentrating
• Confusion
• Mood swings
• Depression
• Anxiety
• Impulsive behaviour
• Aggression
• Problems with judgement
• Balance and movement difficulties

Despite everything, Vickery says he still loves rugby. He said, "The sport's amazing... I would do it all again... I also sit here knowing there are lots of people out there... suffering because of the sport... Let's just help people."

India recorded 20,138 organ transplants in 2025, the highest ever in a single year, while deceased donor transplants increased to 3,526, Union Minister of State for Health and Family Welfare Anupriya Patel announced at the 16th Indian Organ Donation Day (IODD).

The Minister said India now ranks third globally in total organ transplants, after the United States and China.

Organ Transplants Hit Record High

Patel said the number of organ transplants increased from 4,990 in 2013 to 20,138 in 2025, marking the country's highest annual total.

She also highlighted the rise in deceased donor transplants, which increased from 837 in 2013 to 3,526 in 2025.

However, she noted that a significant gap remains between the demand for organs and their availability, adding that bridging this gap continues to be a national priority.

'Organ Donation Is the Highest Expression of Compassion'

Describing the 16th Indian Organ Donation Day as a celebration of service and humanity, Patel said organ donation offers a second chance at life for people with end-stage organ failure.

She expressed gratitude to the families of deceased organ donors, saying their selfless decisions have strengthened India's organ donation movement.

The Minister also announced that the country has crossed five lakh Aadhaar-verified organ donation pledges

since the launch of the national digital pledge portal in 2023.

Patel said misconceptions remain one of the biggest challenges to organ donation. She stressed that no major religion prohibits organ donation and that all faiths uphold the values of compassion, service and saving lives, making organ donation a noble humanitarian act.

New Campaign and Digital Initiatives Launched

The national event, organised by the National Organ and Tissue Transplant Organization (NOTTO) in New Delhi, witnessed the launch of 'Jug Jug Jiyo Abhiyaan', a year-long nationwide awareness campaign aimed at taking the message of organ donation to every community and reinforcing that organ donation is the greatest gift of life.

The Minister also launched 'e-Pratyaropan, a unified digital platform that integrates hospitals, doctors, donors, recipients and other stakeholders into a single system. The platform brings together registration, wait-list management, organ allocation, monitoring and public information services.

A new NOTTO Mobile Application was also launched to improve access to organ donation and transplantation-related services and information.

New National Guidelines Released

The National Brain Stem Death Certification Guidelines and the National Guidelines on Swap Transplantation were also released.

The guidelines provide a practical framework for transplant professionals and support States and Union Territories in implementing a robust, ethical and efficient organ donation and transplantation programme. They are expected to strengthen the national transplantation ecosystem and facilitate wider access to safe, equitable and high-quality transplantation services across the country.

Government Strengthening Organ Donation Network

Patel said the government has established a nationwide institutional network comprising:

• National Organ and Tissue Transplant Organization (NOTTO)
• Five Regional Organ and Tissue Transplant Organizations (ROTTOs)
• 26 State Organ and Tissue Transplant Organizations (SOTTOs)
• around 1,200 registered hospitals