Cigarettes with ultralow nicotine levels are now being called the game-changer in the fight against smoking. If you are having trouble in quitting smoking, then, it is for you, that soon the Biden White House is expected to formally propose a plan that will order cigarette nicotine levels to be reduced, reports The Washington Post. For now though, it has been a failure, as these cigarettes, also known as VLN cigarettes that stands for very low nicotine are only available in 5,100 stores in 26 states. This is a very small fraction of the overall market for cigarettes. The company that makes it, 22nd Century, is struggling not because of the low supply, but also from the advocates who have long believed slashing nicotine levels altogether.

The Advent and ideation

Nicotine is a chemical that is produced naturally from tobacco that makes the cigarette and also keeps people hooked. While it is believed that it makes people alert, and get the "hit" to keep them going, it exposes the users to harmful substances, carcinogens, and increases the risk of heart disease, lung cancer, and other illness.

Ultralow-nicotine cigarettes, like the VLN brand, contain about 95% less nicotine than the regular cigarettes. The idea is quite simple: without the addictive grip of nicotine, smokers will find it easier to quit. Research too has shown some promise. For instance, the studies funded by the National Institute on Drug Abuse revealed that very low nicotine cigarettes reduced addiction potential significantly without having users to increase their smoking frequency. However, the problem is, why would anyone choose for a low-nicotine that does not make them feel the same way, when the high-nicotine cigarette is right next to it, making them feel the same way, with the same alertness, sold at the same price.

“It’s very hard to imagine someone actively choosing to continue to use a low-nicotine product for the same price when a high-nicotine product is right next to it,” said Eric Donny, a Wake Forest University School of Medicine nicotine researcher.

No wonder, the experiment with low nicotine product by Philip Morris' Next cigarettes in the 1980s and Vector Tobacco's Quest brand in the early 2000s, flopped.

FDA's Role in the Push

The Food and Drug Administration (FDA) has supported the development of such products, even allowing VLN cigarettes to be marketed as lower-risk options. However, these products remain a niche market, available in only a fraction of U.S. stores.

Recently, the Biden administration has considered a bold step—mandating a dramatic reduction in nicotine levels for all cigarettes sold in the United States. Supporters believe this move could save millions of lives, while critics, including tobacco companies, warn of potential unintended consequences.

What Could Be The Challenges?

Resistance from Big Tobacco Companies: They could argue that slashing nicotine levels could backfire. Their claim is, smokers will turn to black markets or smoke more to satisfy their cravings, which may lead to greater exposure to harmful substances.

Consumer Reluctance: History is proof to the instances of smokers being hesitant to embrace the low-nicotine products.

Political Hurdle: It may face political roadblocks, as under the Trump administration, plans to cut nicotine were shelved.

Could Low-Nicotine Cigarettes Be The Solution?

Advocates believe that ultralow-nicotine cigarettes could be a game-changer, comparing them to decaf coffee or non-alcoholic beer—products that reduce harm while offering a similar experience.

Some experts warn that a black market for traditional cigarettes could undermine these efforts. They also stress the need for safer alternatives, such as vaping products, to support smokers transitioning away from traditional cigarettes.

Raw, unpasteurized milk has gained traction in the US over the past two years despite warnings about its health risks. The American Academy of Pediatrics (AAP) has renewed its call for a ban on the sale and distribution of raw milk and dairy products, including raw cheeses.

Recent cases have highlighted the risks associated with raw milk. Two California girls — 17-month-old Brooklyn and 6-year-old Victoria — were hospitalized with near-fatal E. coli infections after drinking raw goat milk. Hundreds of people have fallen ill across nine states in the past two years after consuming raw milk or products made from it.

“Claims that raw milk provides superior health benefits are not supported by scientific evidence,” the AAP said.

Raw Milk Riskier For Children, Pregnant People

Also read: Drinking Raw Milk Hospitalizes 2 Young Girls in US With Nearly Fatal E. Coli Infection: Health Risks Explained

In a policy statement published online ahead of print in the November 2026 issue of Pediatrics, the AAP said unpasteurized milk, cheese and other raw dairy products are unsafe, particularly for young children and people who are pregnant or breastfeeding.

“Nearly half of illnesses caused by raw dairy consumption occur in people under age 20 – and a significant share of those cases are in children under 5,” said Adam J. Ratner, MD, MPH, FAAP, lead author.

“These illnesses can be severe and lead to life-threatening complications. Pasteurization … dramatically reduces the risks without taking away the nutritional value families rely on.”

H5N1 Adds To Raw Milk Concerns

The updated guidance also highlights H5N1, or highly pathogenic avian influenza, as an emerging risk associated with raw milk. Sales and distribution of raw milk remain legal in at least 27 states.

The virus can be transmitted from infected dairy cattle into milk, where it can reach high concentrations and remain detectable in refrigerated raw milk for up to five weeks.

During the 2024 US dairy outbreak, infectious H5N1 was detected in nearly one-quarter of raw milk samples in affected areas. However, FDA and USDA testing of commercial pasteurized milk found no viable virus, showing that high-temperature, short-time (HTST) pasteurization neutralizes H5N1.

No human cases of H5N1 infection from consuming raw milk have been confirmed to date, but the AAP considers it a credible emerging threat.

Read More: Second Plague Death Reported As Russia Denies Outbreak

Raw Milk Can Carry Dangerous Pathogens

Unpasteurized milk can contain Listeria, E. coli, Salmonella, Campylobacter and Brucella. These infections can cause severe illness, hospitalization, miscarriage and death, particularly among young children, pregnant people and those with weakened immune systems.

Listeriosis is estimated to be 12 to 14 times more common during pregnancy than in the general population and can cause miscarriage, stillbirth, premature delivery or severe illness in newborns.

AAP Says Pasteurized Dairy Is Safest

“Parents may choose raw milk because they have heard it is healthier or more natural, but the scientific evidence tells a different story,” said Mark R. Corkins, MD, FAAP, co-author of the policy statement.

“Pasteurized dairy products provide the same essential nutrients without exposing children and families to preventable infections from dangerous bacteria and viruses. For infants, children and pregnant people, pasteurized dairy products are clearly the safest choice.”

Even as Bangladesh grapples with a significant measles burden, the country is now facing one of its worst dengue outbreaks.

According to health ministry data, more than 90,350 people have been hospitalised and 281 deaths reported since the beginning of the year.

In October alone, 10,736 people have been hospitalized and 36 have died, raising concerns that the outbreak could worsen.

Dengue Death Toll Among Highest Recorded

The death toll of 281 makes this the fourth-highest annual figure since Bangladesh’s first major dengue outbreak in 2000.

According to the Directorate General of Health Services, the highest number of dengue deaths was recorded in 2023, when 1,705 people died.

A death review by the Institute of Epidemiology Disease Control and Research (IEDCR), led by its Director Prof Quazi Ahmed Zaki, found that more than one-third of dengue patients who died did so within a day of hospital admission.

The review of 119 deaths also found that many patients had experienced delays of at least three days before being diagnosed, according to Prof Zaki, as reported by The Daily Star.

All 4 Dengue Serotypes Active

Also read: Dengue Is Spreading Beyond Monsoons And Into New Regions Across India, Says Expert

Medicine specialist Dr ABM Abdullah said repeated infections and delayed diagnosis were contributing to severe cases and deaths.

People previously infected with dengue could face a higher risk of severe illness during subsequent infections, he said.

“Dengue has four serotypes. When people are infected for the first time, they often do not realise that they have dengue. They may mistake the symptoms for influenza or another common illness and recover without serious complications,” he said.

However, subsequent infections can be more severe, particularly when a person contracts dengue for the second, third or fourth time, he added.

Prof Abdullah said dengue had also become harder to recognize early, with some patients developing mild or non-specific symptoms such as low-grade fever, body aches, a runny nose or cough.

“The problem is that patients often do not realize that they have dengue. By the time they are diagnosed, their condition may have become serious, leaving doctors with limited options,” he said.

He urged people to undergo dengue testing if they develop fever, body aches, headache, cold or other mild symptoms while dengue is circulating.

Bangladesh Considers Dengue Vaccine Trials

Read More: QDENGA: India’s First Approved Dengue Vaccine May Hit Shelves In 2027; How Effective Is It?

Amid the rising cases and deaths, Bangladesh is considering clinical trials of a dengue vaccine, Reuters reported.

Recent rainfall has created favorable conditions for mosquito breeding, raising concerns that the outbreak could worsen.

State Minister for Health M.A. Muhit said as all four dengue serotypes had been detected in Bangladesh, increasing the possibility of repeated infections because immunity to one serotype does not protect against the other three.

"With all four dengue serotypes now circulating in Bangladesh, we are considering conducting vaccine trials in the country," Muhit said.

Health experts have said dengue is no longer concentrated only in major cities and that spraying alone will not curb transmission unless mosquito breeding sites are eliminated.

The government is considering a dengue vaccine as a long-term measure to reduce infections and deaths, but there are no immediate plans to begin vaccination.

“We are discussing vaccines as a long-term measure. There are probably three dengue vaccine candidates in the world at present. We are also considering the issue in Bangladesh, but it is not happening at this moment,” Muhit said.

A second person may have died at a hospital in Russia’s Irkutsk region after reportedly contracting plague, local media have claimed, even as Moscow denies an outbreak.

The death has not been officially confirmed. The report comes as the World Health Organization (WHO) seeks more information from Russia about the death of a 28-year-old laboratory worker in Irkutsk and reports of a second employee with pneumonia of undetermined cause.

WHO Seeks Answers From Russia

The WHO said it has asked Russia for information on the cause of the severe pneumonia, the pathogen that prompted public health measures and reports of a second employee with pneumonia of undetermined cause.

Russia told the WHO on October 6 that no plague cases had been detected in Irkutsk, including among the laboratory worker or her contacts.

Second Death Reportedly Linked To Plague

Also read: Russia Plague Scare: What Black Death and Anthrax Outbreaks Teach Us About Lab Safety

Local media reported the second death after Baikalsk authorities issued a Telegram warning on October 3 about “unofficial information” of a confirmed plague case in Shelekhov, The Daily Mail reported.

“Due to unofficial information about a confirmed case of plague in a person in the city of Shelekhov, we ask you to limit visits to Shelekhov and nearby settlements until the circumstances surrounding this threat are clarified,” the administration said.

The post was deleted about two hours later, according to local media Lyudi Baikala. There is no official confirmation that the person had plague or died from Yersinia pestis.

Hospitals Under Quarantine In Irkutsk

The reports come amid increased health precautions in the region. People of Baikal reported doctors discussing plague and locals seeing people in protective suits and masks. Workers at aluminium factories and nursery staff have also reportedly been asked to wear masks.

The hospital where laboratory worker Darya Shipilova was treated has reportedly been quarantined.

Lyudi Baikala reported that five hospitals in the Irkutsk area had entered “epidemic” mode, including three city hospitals and Ivano-Matreninskaya Children’s Hospital.

Read More: Russia Plague Scare: Could It Trigger A New Pandemic? Experts Explain

Plague and Darya Shipilova’s Death

Shipilova, 28, worked at the Irkutsk Anti-Plague Research Institute. She fell ill on September 29, was placed on a ventilator and died on October 2.

Around 200 contacts were reportedly placed under medical observation after she allegedly told doctors she had accidentally broken a test tube containing live bacteria.

Russia maintains that she died from “unidentified pneumonia”. Authorities said tests of her contacts found no dangerous infectious-disease pathogens, although some reportedly tested positive for COVID-19 or rhinovirus.

Kremlin spokesperson Dmitry Peskov urged the public to rely on Russia’s health watchdog, Rospotrebnadzor, rather than “rumors and speculation”.

“One should rely on official statements from Rospotrebnadzor rather than listening to various rumors and speculation,” Peskov said.

Meanwhile, The Insider reported that REN TV deleted five reports about plague in Irkutsk. Reports from Channel 5 and Kommersant have also reportedly disappeared.

US Monitoring Situation

READ: Russia Plague Scare: Is Pneumonic Plague Deadlier Than Bubonic & Septicemic Plague?

US President Donald Trump said his administration was in “very deep discussions” about the incident and that he had a call with Russian President Vladimir Putin scheduled.

Secretary of State Marco Rubio said Washington was monitoring reports of possible plague but said they were not a “cause for alarm”. “There’s very limited travel between the US and Russia, obviously, but like anything else, something like that gets out, it could quickly spread,” Rubio said.

“So we're watching and monitoring it closely. I don't think it's cause for alarm – but it is cause for focus and a cause to just keep an eye on it. And we're doing that.”

Meanwhile, neighboring countries including Mongolia, Kyrgyzstan and Uzbekistan have reportedly tightened border health measures amid concerns about possible pneumonic plague.