Stomach cancer is a type of cancer that develops in the lining of the stomach. Also, known as Gastric cancer, it affects the elderly more than the adult. According to the American Cancer Society, about 6 of every 10 people diagnosed with stomach cancer each year are 65 or older. Also, the lifetime risk of developing stomach cancer is higher in men (about 1 in 101) than in women (about 1 in 155).

A health expert, speaking to a leading media house, emphasized five common symptoms of stomach cancer that should not be ignored:

1. Unexplained weight loss: Losing weight without trying or experiencing an unexplained drop in appetite, which may signal cancer progression.

2. Pain in the upper part of the abdomen: Persistent or occasional pain in the stomach area, often after eating, can become more severe as the condition progresses.

3. Frequent vomiting after meals: Nausea, sometimes accompanied by vomiting, may occur especially after meals and is linked to cancer blocking or irritating the stomach.

4. Vomiting blood, which may appear coffee-colored: This can indicate bleeding in the stomach, often caused by ulcers or tumors, and requires immediate medical attention.

5. Black, tarry stools: This occurs when blood from the stomach is digested and passed through the intestines, signaling potential internal bleeding

There are also other concerning signs that should not be overlooked such as jaundice, unexplained weight loss, early onset of diabetes, dark stools, and loss of appetite. Health experts strongly advise seeking immediate medical attention if you notice any of these symptoms. If you or a loved one experience these signs, it's crucial to visit a physician for a thorough evaluation to rule out serious underlying health conditions.

How Does Stomach Cancer Spread?

Oncologist Dr Pankaj Kumar Pande, Director–Surgical Oncology, Max Super Specialty Hospital, Shalimar Bagh, Delhi explained that this form of cancer spreads through three main pathways: Direct spread, lymphatic spread, and bloodstream.

1. Direct Spread: In its early stages, stomach cancer can invade nearby tissues and grow into the deeper layers of the stomach or spread to surrounding organs such as the oesophagus, liver, pancreas, or intestines.

2. Lymphatic Spread: Cancer cells can travel through the lymphatic system. The most common areas affected are the regional lymph nodes near the stomach, particularly those around the liver and diaphragm.

3. Bloodstream: "Cancer cells can enter the bloodstream and travel to distant parts of the body," which is a common route for stomach cancer to metastasize to distant organs.

He further explained that cancerous cells spread from the original tumour to other parts of the body through a process called Metastasis. The most common sites for the spread are the liver, lymph nodes, peritoneum, lungs, bones, and ovaries.

What if one blood sample could detect symptoms of multiple cancers at once, while also disclosing which organ may be affected? A new study from UCLA has brought that possibility a step closer to reality.

Researchers have at UCLA have developed a blood test called MethylScan that can detect molecular signals linked to multiple cancers and other diseases by analysing DNA fragments circulating in the bloodstream.

The findings, published in the Proceedings of the National Academy of Sciences, suggest the test could offer a simpler and potentially cheaper way to screen for serious diseases like cancer before their symptoms appear.

How Can One Blood Test Detect Different Cancers?

A blood test may be able to detect multiple cancers at once due to cell-free DNA (cfDNA). Every day, billions of cells die and release tiny fragments of DNA into the bloodstream. These fragments carry information about where they came from and what is happening in that tissue.

Instead of primarily searching for cancer-causing mutations, MethylScan looks at DNA methylation, a type of chemical tags that regulate how genes behave.

Different organs have distinct methylation patterns, and those patterns can change when cells become cancerous or diseased.

“DNA methylation reflects the health status of a tissue. It’s a very informative signal,” said Dr Wenyuan Li, professor of pathology and laboratory medicine at UCLA.

The researchers also developed a method to filter out the DNA released by normal blood cells, reducing the "background noise” that can make early cancer signals difficult to detect.

Also read: Studying Live Cancer Cells Could Transform Drug Discovery; Researchers Turn Cell Biology Into ‘Live Cinema’

What Are The Study's Findings?

The researchers tested MethylScan using blood samples from 1,061 people, including patients with liver, lung, ovarian and stomach cancers, people with liver diseases and healthy participants.

At 98% specificity, the test detected about 63% of cancers across all stages. For early-stage cancers, its sensitivity was around 55%.

The test also showed promise in identifying where an abnormal signal originated. This could help as a positive blood test would still need to be followed by imaging or other diagnostic tests.

“Being able to trace signals back to their source is important because a positive blood test needs to be followed by imaging or other diagnostic procedures directed at the right organ,” Li said.

Also read: Tudriqev: US FDA Approves Replimune's Skin Cancer Drug After Rejecting It Twice

Early Cancer Detection Is Key

“Early detection is crucial,” said Dr Jasmine Zhou, the study’s senior author. “Survival rates are far higher when cancers are caught before they spread.”

The findings are promising, but larger trials will be needed to establish whether such tests can reliably detect cancers in people who have no symptoms.

Also read: Following A Western Diet? Changes In Your Gut Bacteria Could Increase Colon Cancer Risk

More Developments In The Field

The findings come as another multi-cancer test, Galleri, is designed to detect signals from more than 50 cancers from a single blood sample.

Reuters reported this month that the US FDA plans to convene an advisory panel in September to review its application for approval.

But experts continue to stress that these tests are not replacements for established screening, such as mammograms or colonoscopies.

US President Donald Trump has signed an executive order aimed at changing childhood vaccine recommendations, including moving toward separating the measles, mumps and rubella (MMR) vaccine into individual shots.

The executive order, titled “Delivering Gold Standard Childhood Vaccine Recommendations for Americans,” has sparked debate over how childhood vaccines should be administered and whether combination vaccines should instead be given separately.

Amid criticism of the move, HealthandMe spoke to public health experts to understand whether splitting the MMR vaccine offers any proven health benefit and what it could mean for children and vaccination coverage.

What Does Splitting MMR Mean?

Dr. Sabine Kapasi, Global Health Strategist and a UN Advisor, told HealthandMe that combination vaccines are more than a matter of convenience.

“Combination vaccines are not simply a matter of convenience. They can reduce the number of injections and healthcare visits required, support timely vaccination and help health systems reach children who may otherwise be missed,” she said.

“The more fragmented the pathway becomes, the more important it is to understand its impact on uptake, completion and equity,” Dr. Sabine added.

Dr. Rajeev Jayadevan, former President of IMA Cochin and Convener of the Research Cell, Kerala, also highlighted the practical disadvantage of requiring parents to make additional clinic visits when vaccines that can be administered together are separated.

Is Splitting MMR Healthier?

There is currently no adequate scientific validation for the argument that giving the MMR components separately is inherently healthier, according to Dr. Rajeev.

“The argument that splitting the shots is a healthier option does not have adequate scientific validation, because the body’s immune system routinely encounters numerous antigens simultaneously and effectively in everyday life,” he told HealthandMe.

Dr. Sabine emphasized that any change to childhood immunization policy should be based on evidence rather than simply altering an established schedule.

“Any change to childhood immunization policy should therefore be grounded in transparent evidence, rigorous safety and effectiveness assessment, and real-world data on vaccination coverage and completion,” she added.

Could More Vaccine Visits Increase Hesitancy?

Separating combination vaccines could make vaccination more cumbersome for families by requiring additional visits.

Dr. Sabine said vaccination programs operate within different health systems, meaning even small changes in scheduling can have implications for access, logistics, costs and continuity of care.

“The priority should remain consistent: designing immunization systems that are evidence-led, accessible and resilient enough to protect children across populations—not simply changing the schedule for the sake of changing it,” she said.

In a post on X US Senator Bill Cassidy, a physician, also criticized the executive order and warned that breaking up combination vaccines could mean children need more shots to receive the same protection.

“It will increase hesitancy and make children less safe,” he said, urging parents to discuss vaccination decisions with their child’s pediatrician.

Former White House COVID-19 Response Coordinator Dr. Ashish Jha said European countries do not routinely split the MMR vaccine into three separate shots. “No European country splits the MMR vaccine as 3 separate shots,” he said in a post on X.

He added that Russia and Tajikistan were historical partial exceptions but have since moved to full MMR vaccination.

Are There Any Potential Advantages?

Dr. Rajeev said one potential advantage of the new approach is the separation of vaccines into essential and optional categories.

He said this could give parents greater clarity about which vaccines are considered the highest priority and potentially help address some forms of vaccine hesitancy. The expert also pointed to US policy around childhood COVID-19 and influenza vaccines, saying that making these vaccines a shared decision between doctors and parents could be viewed as a progressive step.

For years, people living with Long COVID have described a strange combination of symptoms: severe fatigue, brain fog, memory problems, slowed thinking and a loss of motivation. Researchers may have found an important clue behind at least some of these brain symptoms.

A new study published in eBioMedicine found that people with Long COVID had 16% to 20% lower markers of dopamine nerve endings in key regions of the brain, with the average reduction of around 18%.

The findings suggest that the brain's dopamine system may be affected long after the initial COVID-19 infection has passed.

What Are The Study's Findings?

Researchers from the Centre for Addiction and Mental Health (CAMH) and the University of Toronto used PET brain scans to examine 24 adults with Long COVID and 24 healthy, age-matched individuals.

They focused on VMAT2, a protein found in nerve terminals that release dopamine. VMAT2 stores and packages dopamine inside nerve cells. Lower VMAT2 on the scans indicated reduced dopamine nerve-terminal density. However, it does not prove that dopamine neurons have permanently died.

The reductions appeared across three important regions of the striatum, which is involved in motivation, movement and thinking. Lower dopamine markers in the ventral striatum were associated with reduced motivation. Changes in the putamen were linked with slower movement, while changes in the caudate were associated with memory difficulties.

Also read: Can Long COVID Be Prevented Before It Starts? Study Suggests Early Paxlovid May Help

The Dopamine Factor

When dopamine production is disrupted, people can experience problems that go far beyond mood swings or low motivation.

The changes were also detected in people who had been living with Long COVID for as long as 4.6 years. This could help explain why some Long COVID patients report that even simple tasks feel unusually difficult or that they struggle to find the motivation to do things they previously enjoyed.

Long COVID is already known to involve a wide range of neurological symptoms, including fatigue, headaches, cognitive problems, anxiety and depression.

A 2026 review in Nature Reviews Neurology noted that approximately 6% of people who have experienced acute COVID-19 may develop this post-COVID condition.

Also read: Are Women More Likely To Experience More Severe Neurological Symptoms Of Long COVID Than Men? New Study Finds

Scope Of Treatment

The study does not mean that people with Long COVID have Parkinson's disease, nor does it establish that dopamine loss causes all Long COVID symptoms. The researchers also acknowledge that the study was small and that the findings show an association rather than proving cause and effect.

Still researchers say that the findings suggest that medications which enhance dopamine function, including dopamine precursors and drugs that reduce dopamine breakdown, could be investigated as potential treatments. They plan to launch a clinical trial targeting dopamine function in people with Long COVID.

More About Long COVID

Long COVID is a debilitating condition that can persist for months or even years after a SARS-CoV-2 infection. Long COVID is an infection-associated chronic condition marked by fatigue, cognitive impairment, exercise intolerance, and multisystem dysfunction.

It has affected an estimated 400 million people worldwide and continues to have significant health, social, and economic consequences. Despite the ongoing risk, prevention strategies have received relatively little attention.