Stomach cancer is a type of cancer that develops in the lining of the stomach. Also, known as Gastric cancer, it affects the elderly more than the adult. According to the American Cancer Society, about 6 of every 10 people diagnosed with stomach cancer each year are 65 or older. Also, the lifetime risk of developing stomach cancer is higher in men (about 1 in 101) than in women (about 1 in 155).

A health expert, speaking to a leading media house, emphasized five common symptoms of stomach cancer that should not be ignored:

1. Unexplained weight loss: Losing weight without trying or experiencing an unexplained drop in appetite, which may signal cancer progression.

2. Pain in the upper part of the abdomen: Persistent or occasional pain in the stomach area, often after eating, can become more severe as the condition progresses.

3. Frequent vomiting after meals: Nausea, sometimes accompanied by vomiting, may occur especially after meals and is linked to cancer blocking or irritating the stomach.

4. Vomiting blood, which may appear coffee-colored: This can indicate bleeding in the stomach, often caused by ulcers or tumors, and requires immediate medical attention.

5. Black, tarry stools: This occurs when blood from the stomach is digested and passed through the intestines, signaling potential internal bleeding

There are also other concerning signs that should not be overlooked such as jaundice, unexplained weight loss, early onset of diabetes, dark stools, and loss of appetite. Health experts strongly advise seeking immediate medical attention if you notice any of these symptoms. If you or a loved one experience these signs, it's crucial to visit a physician for a thorough evaluation to rule out serious underlying health conditions.

How Does Stomach Cancer Spread?

Oncologist Dr Pankaj Kumar Pande, Director–Surgical Oncology, Max Super Specialty Hospital, Shalimar Bagh, Delhi explained that this form of cancer spreads through three main pathways: Direct spread, lymphatic spread, and bloodstream.

1. Direct Spread: In its early stages, stomach cancer can invade nearby tissues and grow into the deeper layers of the stomach or spread to surrounding organs such as the oesophagus, liver, pancreas, or intestines.

2. Lymphatic Spread: Cancer cells can travel through the lymphatic system. The most common areas affected are the regional lymph nodes near the stomach, particularly those around the liver and diaphragm.

3. Bloodstream: "Cancer cells can enter the bloodstream and travel to distant parts of the body," which is a common route for stomach cancer to metastasize to distant organs.

He further explained that cancerous cells spread from the original tumour to other parts of the body through a process called Metastasis. The most common sites for the spread are the liver, lymph nodes, peritoneum, lungs, bones, and ovaries.

UK’s National Institute for Health and Care Excellence (NICE) has advised healthcare professionals to look for signs of obsessive-compulsive disorder (OCD) and body dysmorphic disorder (BDD) in people seeking cosmetic procedures such as Botox and fillers.

The recommendation is part of a draft guideline aimed at earlier identification of the two conditions, which can remain undiagnosed for years because people may hide symptoms due to shame or embarrassment. In addition, the cosmetic industry is vastly unregulated, increasing potential health risk.

“People with obsessive-compulsive disorder (OCD) and body dysmorphic disorder (BDD) could be identified earlier and offered more appropriate treatment,” said the draft NICE guidance published today.

What Does The NICE Guidance Say?

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NICE’s new draft recommends considering assessment for OCD or BDD among people with depression, anxiety, autism or ADHD, as well as those seeking cosmetic procedures.

The committee said symptoms can be overlooked or attributed to other conditions, delaying diagnosis and treatment.

"People with obsessive-compulsive disorder and body dysmorphic disorder can experience symptoms for a long time before they receive the right diagnosis and support. These conditions are often misunderstood, and many people find them difficult to talk about because of embarrassment, shame or fear of being judged,” Eric Power, interim director of the Centre for Guidelines at NICE, said.

Mental Health Checks Before Botox And Fillers

Healthcare professionals providing cosmetic treatments, including surgeons, dentists and dermatologists, would be advised to ask structured questions about appearance-related concerns and document their findings.

If responses suggest possible BDD, NICE recommends specialist assessment rather than proceeding with the cosmetic procedure at that stage.

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The committee noted that cosmetic procedures rarely improve the underlying condition and may sometimes worsen symptoms.

A 2024 systematic review and meta-analysis estimated that 18.6% of people attending aesthetic and reconstructive plastic surgery services had clinically significant BDD symptoms, compared with around 2% of adults in the wider population.

"Our draft recommendations aim to help healthcare professionals recognize symptoms earlier, ask the right questions and support people to access appropriate treatment sooner," Power said.

"Earlier identification can help ensure people receive care that reflects their needs, preferences and circumstances, rather than waiting until symptoms become more severe or reach crisis point," he added.

New Approach To OCD Treatment

The draft guideline also proposes a personalized “matched care” approach to OCD treatment, with interventions based on a person’s clinical needs, treatment history and preferences rather than a fixed sequence.

For children and young people with OCD, the draft recommends family-based cognitive behavioral therapy for many patients.

What Are OCD And BDD?

OCD affects an estimated 1.2% of the population. It involves unwanted, distressing thoughts, images, urges or doubts, often followed by repetitive behaviors or mental rituals such as checking, washing, counting or seeking reassurance.

BDD involves excessive preoccupation with perceived flaws in appearance, which can cause significant distress and interfere with daily life. Research suggests it affects around 2% of adults.

The consultation on the draft NICE guideline is open until October 21, 2026.

Endometriosis does not usually present with typical symptoms. Due to this, getting a diagnosis can take years.

This may change soon as a team of Australian researchers recently developed an artificial intelligence tool that can identify two major imaging signs of advanced endometriosis in just 18 milliseconds.

Called EndoFusion, the tool was developed by researchers at Adelaide University as part of the IMAGENDO research programme. The findings were published in Artificial Intelligence in Medicine.

The 18-millisecond figure refers to how quickly the AI analyses a scan and produces its assessment. It does not mean that a woman can currently walk into a clinic and receive a confirmed diagnosis in 18 milliseconds.

The technology is still in development and requires further testing before it can become part of routine clinical diagnosis.

Endometriosis May Take Years To Diagnose

Endometriosis occurs when tissue similar to the lining of the uterus grows outside the uterus, commonly affecting areas such as the ovaries and fallopian tubes.

It can cause severe period pain, pelvic pain, heavy bleeding, fatigue, pain during sex and difficulty becoming pregnant.

Diagnosis is challenging as symptoms can vary, and some women have little or no visible symptoms on conventional imaging.

Research has consistently found substantial diagnostic delays. A systematic review found delays ranging from months to as long as 12 years.

In Australia, women reportedly wait an average of around six and a half years for a diagnosis, according to Endometriosis Australia.

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More About The AI Tool Work

EndoFusion was trained using four datasets containing more than 9,000 pelvic MRI scans and over 800 transvaginal ultrasound scans as they can identify different signs of endometriosis effectively.

A patient who receives only one type of scan may therefore have some symptoms of the disease missed.

Associate Professor Jodie Avery of Adelaide University's Robinson Research Institute said, “Current scanning methods each have their own strengths when it comes to detecting two common markers that indicate the likelihood of endometriosis and patients will often only have access to one of them.”

She added, “This means that some patients could be disadvantaged if they are scanned by the less optimal option for their particular signs. Some of the imaging tools also rely on operator experience and can be costly.”

In its early evaluation, EndoFusion correctly distinguished positive and negative cases 83% of the time, performing better than the other AI models researchers compared it with.

Lead author Dr Yuan Zhang said, “This is a positive step forward and moves us closer to a future where an AI tool can help clinicians to provide a faster, more accurate diagnosis without the need for surgery.” However, 83% accuracy is not enough to replace clinical diagnosis.

The researchers say the next step is to expand the dataset and incorporate additional markers of endometriosis to improve classification accuracy.

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Could It Reduce The Need For Surgery?

Endometriosis diagnosis has historically relied heavily on imaging and, in some cases, laparoscopy, in which a camera is inserted through a small abdominal incision to look for lesions.

A reliable non-invasive tool could help doctors identify women who need specialist assessment sooner and potentially reduce unnecessary invasive investigations.

As Avery said, “The development of accurate, non-invasive early diagnostic methods is critical to shorten the diagnostic timeline and reduce associated costs.”

Pancreatic cancer is one of the most difficult cancers to detect in its early stages. By the time it is diagnosed, the disease may have already spread, limiting treatment options and lowering survival.

Now, a novel blood test called Panxeon, developed by researchers at City of Hope, could offer a way to detect pancreatic cancer earlier.

Panxeon is an investigational liquid biopsy designed to detect pancreatic cancer, including stage 1 and 2 disease, using a blood sample.

The test also showed potential for identifying high-grade dysplasia, a precancerous condition sometimes considered “stage 0” pancreatic cancer.

In a study of nearly 1,800 patients across the US, Europe and Asia, published in Nature Medicine, the blood test correctly identified stage 1 and 2 pancreatic cancer in 87% of cases. Its false-positive rate was 3% among people in low-risk groups and 16% among those in high-risk groups.

Panxeon also detected high-grade dysplasia more than 64% of the time. This could help doctors identify which pancreatic cysts may require closer monitoring or further intervention before invasive cancer develops.

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How Does Panxeon Detect Pancreatic Cancer?

Pancreatic cancer has one of the lowest survival rates among cancers. Only 14% of patients survive five years after diagnosis, according to the US National Cancer Institute.

Panxeon assesses three biological signals associated with pancreatic cancer: circulating microRNAs, exosomal microRNAs and a protein called CA19-9.

The test then uses artificial intelligence to combine these measurements into a single score estimating a person's risk of pancreatic cancer.

“Pancreatic cancer remains so deadly largely because we find it after the window for cure has begun to close,” said senior author Ajay Goel, chair of the Department of Molecular Diagnostics and Experimental Therapeutics at City of Hope.

“For patients, these findings represent progress toward finding pancreatic cancer before symptoms appear and while more treatment options remain available,” he added.

According to the researchers, Panxeon is the first investigational test to combine these three biomarkers into a single blood test.

However, Panxeon is not intended to replace imaging or other diagnostic tests. Instead, it could potentially help identify people at higher risk who need further evaluation, said Goel.

Who Could Benefit From the Test?

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Early detection of pancreatic cancer has been a longstanding research challenge, with previous blood-based tests failing to provide sufficient accuracy.

The researchers said Panxeon's approach differs by combining multiple biomarkers and evaluating the test in people with risk factors such as inherited or familial risk, pancreatic cysts and chronic pancreatitis, rather than relying only on healthy controls.

“Most biomarkers tell you one part of the story. Combining multiple biological signals gives us a clearer picture of what may be happening in the pancreas,” Goel said.

People who may potentially benefit from such testing include those with an inherited risk or family history of pancreatic cancer, pancreatic cysts or chronic pancreatitis.

These groups are often monitored using imaging and other tests. A reliable blood test could eventually help identify who needs further evaluation.

“A stage shift is not just a statistic,” Goel said. “The earlier we find pancreatic cancer, the greater the chance that meaningful intervention is still possible.”

Pancreatic Cancer: Know The Warning Signs

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Pancreatic cancer can begin with few or nonspecific symptoms, making early diagnosis difficult. Symptoms may become more apparent as the disease progresses.

Symptoms that should not be ignored include:

• Abdominal or back pain
• Unexplained weight loss
• Jaundice
• Changes in urine or stool.