Stomach cancer (credit: canva)
Stomach cancer is a type of cancer that develops in the lining of the stomach. Also, known as Gastric cancer, it affects the elderly more than the adult. According to the American Cancer Society, about 6 of every 10 people diagnosed with stomach cancer each year are 65 or older. Also, the lifetime risk of developing stomach cancer is higher in men (about 1 in 101) than in women (about 1 in 155).
A health expert, speaking to a leading media house, emphasized five common symptoms of stomach cancer that should not be ignored:
1. Unexplained weight loss: Losing weight without trying or experiencing an unexplained drop in appetite, which may signal cancer progression.
2. Pain in the upper part of the abdomen: Persistent or occasional pain in the stomach area, often after eating, can become more severe as the condition progresses.
3. Frequent vomiting after meals: Nausea, sometimes accompanied by vomiting, may occur especially after meals and is linked to cancer blocking or irritating the stomach.
4. Vomiting blood, which may appear coffee-colored: This can indicate bleeding in the stomach, often caused by ulcers or tumors, and requires immediate medical attention.
5. Black, tarry stools: This occurs when blood from the stomach is digested and passed through the intestines, signaling potential internal bleeding
There are also other concerning signs that should not be overlooked such as jaundice, unexplained weight loss, early onset of diabetes, dark stools, and loss of appetite. Health experts strongly advise seeking immediate medical attention if you notice any of these symptoms. If you or a loved one experience these signs, it's crucial to visit a physician for a thorough evaluation to rule out serious underlying health conditions.
Oncologist Dr Pankaj Kumar Pande, Director–Surgical Oncology, Max Super Specialty Hospital, Shalimar Bagh, Delhi explained that this form of cancer spreads through three main pathways: Direct spread, lymphatic spread, and bloodstream.
1. Direct Spread: In its early stages, stomach cancer can invade nearby tissues and grow into the deeper layers of the stomach or spread to surrounding organs such as the oesophagus, liver, pancreas, or intestines.
2. Lymphatic Spread: Cancer cells can travel through the lymphatic system. The most common areas affected are the regional lymph nodes near the stomach, particularly those around the liver and diaphragm.
3. Bloodstream: "Cancer cells can enter the bloodstream and travel to distant parts of the body," which is a common route for stomach cancer to metastasize to distant organs.
He further explained that cancerous cells spread from the original tumour to other parts of the body through a process called Metastasis. The most common sites for the spread are the liver, lymph nodes, peritoneum, lungs, bones, and ovaries.
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The US Food and Drug Administration (FDA) is investigating a possible cancer risk linked to Novartis' gene therapy Zolgensma after the Swiss drugmaker reported several cases of tumours in patients who had received the treatment. It included two patients aged less than two years old with spinal muscular atrophy (SMA) in which investigators found evidence linking the tumour to the therapy.
Zolgensma is a one-time gene therapy used to treat children under two years of age with spinal muscular atrophy (SMA), a rare genetic disorder that causes progressive muscle weakness. More than 6,000 patients have received the treatment since its approval in 2019.
In a safety update issued on November 6, the FDA said it had received reports of neoplasia, or tumour formation including malignancy, known as insertional oncogenesis. This occurs when genetic material delivered by a gene therapy becomes integrated into a patient's DNA and contributes to abnormal cell growth.
In two cases, molecular analysis of tumour tissue showed that DNA from the therapy's viral vector had integrated into the patients' genomes within the GLI1 gene, which can promote cancer when activated. The FDA said it was also investigating a third tumour linked with GLI1.
The agency said tumours had been found in the central and peripheral nervous systems, spinal and paraspinal regions, and kidney.
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The FDA is assessing whether regulatory action is needed and is reviewing whether the long-term safety studies address the risk.
However, it stressed that the benefits of both Zolgensma and Novartis' other SMA gene therapy, Itvisma, continue to outweigh their potential risks for their approved uses.
The two therapies use the same viral vector and genetic material but are administered differently. Zolgensma is given through an intravenous infusion to children under two, while Itvisma is injected into the spinal canal and is approved for adults and children aged two and older. The FDA said no cases of tumour formation had been reported following Itvisma treatment so far.
The risk of tumour formation due to viral DNA integration is already mentioned in Zolgensma's information as a theoretical risk. The FDA said patients receiving either treatment should be monitored for tumour formation.
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Novartis said the two patients whose tumours showed evidence of vector DNA integration had undergone treatment and continued to be monitored.
In a statement, the company said, “Patient safety is our priority. In each case, we timely and appropriately notified health authorities and will continue to work with them on next steps.”
The company also said it had received nine tumour reports since Zolgensma's approval and that the risk was included in the drug's prescribing information.
The disclosures have raised questions among families and patients about when the information was shared. SMA Europe urged the company to explain what is known, what remains uncertain and what the findings could mean for children who have already received treatment. Novartis did not provide details on where the two new cases were in its statement.
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The United States is in the midst of one of the worst measles outbreak. It has reported more than 5,000 measles cases in 2026, marking the highest annual total cases since 1991.
This has raised concerns that the country could lose its measles elimination status after more than 25 years.
According to an update issued on November 6, the US Centers for Disease Control and Prevention (CDC) reported 5,182 confirmed cases as of November 5. This is the first time since 1991 that the annual number of infections has crossed the 5,000 mark.
The latest figure marks an increase of 330 cases from the previous week. The CDC also reported 562 hospitalisations due to measles this year, which accounts for 11% of confirmed cases.
The outbreak has spread across 47 jurisdictions and 43 outbreaks reported so far in 2026. Approximately around 96% of infections have been linked to outbreaks, while 96% of people infected were either unvaccinated or their vaccination status was unknown.
The expanding measles outbreak has sparked concerns about the country's ability to maintain the elimination status it achieved in 2000.
The US declared measles eliminated in 2000, meaning that the country had stopped continuous transmission of the virus for at least 12 months, but infections could still occur when people brought the virus into the country from abroad. However, recent outbreaks have raised concerns that measles could become endemic again.
According to the CDC, elimination status is determined by the absence of continuous measles transmission in a geographical area for 12 months or longer, supported by an effective disease surveillance system.
The United States is facing a review of its elimination status by the Pan American Health Organization (PAHO), which is expected to assess the country's progress in controlling transmission during its November 2026 meeting.
The review will examine whether the ongoing outbreaks represent sustained transmission of the virus and whether the country continues to meet the criteria for elimination. Losing elimination status would that the country had failed to interrupt sustained transmission of the virus.
The Americas region had already lost its measles elimination status in November 2025 after Canada experienced continuous transmission for at least 12 months.
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Losing measles elimination status would mark a major setback for public health efforts that successfully interrupted continuous measles transmission in the country in 2000.
It would also signal that the virus is circulating continuously within the population rather than appearing mainly through imported infections that cause outbreaks that get eventually contained.
However, elimination status can be regained if sustained transmission is interrupted and the required criteria are met. Public health experts continue to emphasise the importance of maintaining high vaccination coverage, identifying cases quickly and responding to outbreaks promptly.
The latest CDC data show that measles is affecting people across different age groups. Adults aged 20 and older accounted for 2,132 cases, followed by 2,104 infections among people aged five to 19. Children younger than five accounted for 908 cases.
The CDC reported four measles deaths in 2026, compared with three during the whole of 2025. However, the CDC's national death count differs from figures reported by individual state health departments because the agency uses National Center for Health Statistics mortality data for its official tally.
Pennsylvania has been among the hardest-hit states, reporting 1,487 cases, 287 hospitalisations and six associated deaths, according to Reuters. The outbreak has also spread to South Carolina and Utah, which reported 670 and 536 cases, respectively.
According to state health department reports, the country has recorded eight measles-related deaths this year: six in Pennsylvania, one in New York and one in Wisconsin. At least four involved children or infants.
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Life-threatening bleeding episodes among US infants have risen sharply as more parents refuse the routine vitamin K shot given at birth, two new studies have found.
Published in JAMA and JAMA Pediatrics, the studies found that the proportion of newborns who missed the vitamin K shot more than doubled between 2017 and 2025, reaching 6.8%. These infants were also more likely to experience bleeding, including bleeding in the brain.
Although the studies do not establish causation, the parallel rise in refusals and bleeding episodes is significant, said Dr Steven Woolf, an epidemiologist at Virginia Commonwealth University and lead author of the JAMA Pediatrics study, as reported by NBC News.
"Now we're stepping away from that, and we're seeing the consequences," Woolf said.
Vitamin K shots have been standard newborn care since 1961 and help prevent vitamin K deficiency bleeding (VKDB), a rare but potentially life-threatening condition.
Woolf and colleagues analysed medical records of more than 11 million infants aged six months and younger between 2017 and 2025.
During this period, the proportion of newborns receiving a vitamin K shot fell from 97.7% to 95%, while vitamin K deficiency bleeding nearly quadrupled.
The researchers identified 5,217 bleeding events during the study period. The rate in 2025 was approximately double that in 2024, Woolf said.
The researchers noted that the increase coincided with declining public trust following the COVID-19 pandemic, growing vaccine hesitancy and parental scepticism about routine newborn interventions.
A separate JAMA study by Dr Kristan Scott and colleagues analysed medical records of more than 5.2 million US infants born between 2017 and 2025.
The proportion of newborns who missed the vitamin K shot rose from 3.1% in 2017 to 6.8% in 2025. It had reached 5.1% by the end of 2024.
The study also found that infants who did not receive the shot had:
The authors estimated that one additional bleeding event would occur for every 114 newborns who missed the vitamin K shot.
Separately, an analysis of more than one million births by health data company Truveta for Reuters found that vitamin K refusals increased by more than 57% between January and June 2026.
Vitamin K is a fat-soluble nutrient essential for blood clotting and bone health. Newborns naturally have low levels, leaving them vulnerable to VKDB.
The American Academy of Pediatrics (AAP) has recommended a vitamin K injection for all newborns since 1961.
Without adequate vitamin K, babies can develop spontaneous bleeding, including severe internal bleeding and bleeding in the brain. These episodes can cause permanent brain damage or death.
Importantly, the vitamin K shot is not a vaccine. It is a one-time injection given shortly after birth to protect babies against VKDB.
Breast milk contains relatively little vitamin K. Exclusively breastfed babies who miss the birth injection therefore remain vulnerable to deficiency bleeding.
The researchers also found increased use of oral vitamin K. However, oral doses are less effective than intramuscular injections, particularly in preventing late-onset VKDB, which can occur weeks or months after birth.
Vitamin K refusals have risen since the COVID-19 pandemic amid growing parental concerns about vaccines and routine newborn interventions.
Health experts have also raised concerns about declining trust in health authorities and mixed messages surrounding preventive care.
Refusals have accelerated under US Health Secretary Robert F Kennedy Jr, who has questioned vaccine safety and overseen changes to federal childhood vaccination recommendations.
A US Department of Health and Human Services spokesperson said the Centers for Disease Control and Prevention (CDC) continues to recommend vitamin K shots for newborns. However, the department did not say whether the agency would begin tracking refusals or associated bleeding episodes.
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