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Headaches are a common symptom of a stressful lifestyle, your body not feeling well and other issues. While headaches can be dealt with easily, migraines are not so easy to handle. Migraines are a type of headache that feels like severe throbbing and pulsing sensation, almost like you are hearing your own heartbeat in your brain, usually on one side of the brain. Many people believe that migraines are not that big of a deal because you just have to deal with the pain, but that is not all migraine is, some people find it very difficult to do their daily tasks as they experience dizzying spells, nausea and extreme sensitivity to light and sound! These attacks can last hours and make it difficult for people to go about their daily lives as well. While there are medications available for migraine patients, these medications need time to take effect, so you may be in a lot of pain, but there are not many quick reliefs you can have in place other than learning the symptoms of a migraine attack and taking medication before it happens. But a new approval by the FDA may change this!
The U.S. Food and Drug Administration (FDA) has approved Symbravo, a new medicine to treat acute migraine attacks in adults. This means adults can now use Symbravo to get relief from their migraine symptoms. The FDA's decision was based on the results of three big studies, called Phase 3 trials. These trials involved over 21,000 migraine attacks, so the FDA has a lot of information about how well Symbravo works and how safe it is. The FDA only approves medicines that have been shown to be both safe and effective through a thorough testing process.
"Migraine attacks can happen suddenly and really mess up people's lives. It's estimated that over 39 million people in the U.S. alone get migraines," said Herriot Tabuteau, M.D., CEO of Axsome Therapeutics told US News. This shows how common migraines are and how important it is to have good treatments. "Symbravo gives patients and doctors a new option that can quickly stop a migraine attack, keep it away, and let people get back to their normal activities, all with just one dose." Having a medicine that can give fast and long-lasting relief from migraine pain is a big deal for millions of people. This new treatment is a real step forward in how we treat migraines.
The trials took place in 3 steps, the Momentum trial study focused on people whose migraines had moderate to severe pain. The results showed that a lot more people taking Symbravo felt pain-free two hours after taking the medicine compared to those who took a placebo which is a dummy pill. Even better, many people felt relief for up to 24 and even 48 hours after just one dose. This long-lasting relief is really important for people with migraines because it means they can get back to their normal lives without worrying about the pain coming back. The study also looked at how many people were free from their worst symptom, like sensitivity to light or sound, or nausea. Symbravo worked better than the placebo in this area too.
While the intercept trial looked at people who took Symbravo when their migraine pain was still mild. Even when the pain was just starting, Symbravo was effective. The results were similar to the MOMENTUM trial, with many people getting pain relief and relief from their worst symptoms. Treating migraines early is often better because it can stop the pain from getting really bad.
And lastly the Movement trial which was to see how safe the medication is when people take it regularly. This study followed 706 people who had at least two migraines a month. The most common side effects people experienced were sleepiness and dizziness. While these side effects are important to know about, the study showed that Symbravo is generally safe for people to use on a regular basis.
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The UK government has mandated that all schools across the country stock life-saving allergy pens from September under new statutory guidance known as Benedict's Law.
Published by the Department for Education (DfE), the guidance requires schools to keep adrenaline auto-injectors (AAIs), commonly known as allergy pens, on site. Teachers will also receive training to ensure they can respond quickly during emergencies, including administering the devices.
The nationwide rollout follows campaigning by the National Allergy Strategy Group and families, including Helen and Peter Blythe, parents of Benedict Blythe, who died after suffering an allergic reaction at school in 2021.
Under the new guidance, schools will also be expected to have clear allergy policies and healthcare plans, the DfE said.
"Today is a really important day for the thousands of families across the country who for too long have worried about keeping their children safe," said Education Minister Olivia Bailey.
"Benedict's Law means every single school will now have the training plans and the life-saving equipment in place to protect every child."
The statutory guidance, which sets out what schools must do to adhere to the law, will come into force in September.
From 2027, the same measures will become statutory duties and will apply to state schools, independent schools and fee-paying special schools. This means schools will be legally required to implement the changes.
Benedict Blythe died after accidental exposure to cow's milk protein while at Barnack Primary School, between Stamford and Peterborough, in December 2021.
Benedict was just 5 years old when he died following an allergic reaction at school.
On the morning of 1st December 2021, he opened his advent calendar and happily went off to class, a few hours later he collapsed and died from anaphylaxis. He was allergic to dairy, eggs, peanuts, sesame and chickpeas.
His mother, Helen Blythe, said she had worked with the school to put together an allergy action plan, but an inquest heard that process had not been followed.
"Had Benedict's Law and this guidance been in place when he'd been at school, he almost certainly would still be with us," Blythe said.
She noted that the Benedict's Law meant children would be "stepping into an education system far safer than the one that has come before," BBC reported.
She added there was a "significant gap" in schools' preparedness for children with allergies that would be addressed by Benedict's Law.
According to research by the Benedict Blythe Foundation, 50% of schools in England do not have any spare medication, one-third have no allergy policy, and 70% do not have all the measures now being introduced.
"The publication of this guidance is the beginning of a new era for allergy safety," Blythe said.
"It will improve the safety of hundreds of thousands of children and ensure around one and a half million adults working in schools have the knowledge and confidence to recognize an allergic reaction and respond quickly in an emergency."
The Mayo Clinic defines anaphylaxis as a sudden, severe, and potentially life-threatening allergic reaction. It can occur within seconds or minutes of exposure to something you're allergic to, such as peanuts or bee stings.
Anaphylaxis causes the immune system to release a flood of chemicals that can cause you to go into shock — blood pressure drops suddenly and the airways narrow, blocking breathing.
Signs and symptoms include:
The first-line treatment for anaphylaxis is epinephrine (adrenaline), which is available by prescription as an auto-injector or nasal spray. It works by reversing the life-threatening symptoms of a severe allergic reaction.
Delays in using epinephrine are common in fatal food allergy reactions. Other medications, such as antihistamines, are not adequate substitutes because they do not reverse airway swelling or raise dangerously low blood pressure.
Allergists advise that everyone with food allergies carry their epinephrine delivery device at all times, particularly those who have previously experienced anaphylaxis, have both food allergies and asthma, or are allergic to peanuts, tree nuts, fish or crustacean shellfish.
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While the devastating COVID-19 pandemic has significantly increased awareness about zoonotic diseases, the world remains inadequately prepared for another outbreak, which is "very likely," according to Dr Mario Raviglione, consultant to a HPV project at the International Agency for Research on Cancer (IARC), World Health Organization, on the occasion of World Zoonoses Day.
Observed every year on July 6, World Zoonoses Day aims to raise awareness about zoonotic diseases—infections that spread between animals and humans. This year's theme, "One World, One Health: Prevent Zoonoses," underscores the close link between human, animal and environmental health, according to the International Society for Infectious Diseases (ISID).
In an exclusive interview with HealthandMe, Dr Mario said the world has learned important lessons from COVID-19, but preparedness for the next zoonotic outbreak remains inadequate.
"The biggest lessons learned in my view are the understanding... that indeed we are in an era where pandemics could happen on a daily basis essentially," he said, noting that around three-quarters of emerging and re-emerging infections now originate in the animal world.
However, despite greater awareness among politicians, policymakers and health ministries, he said there is still no full understanding of the level of preparedness needed to confront future threats.
According to Dr Mario, the factors driving zoonotic spillovers are becoming more intense rather than diminishing. He pointed to:
"All of this put together tells us that the risk is high, that the risk is increasing, that the pandemic potential is definitely on an increase and, as a result, preparedness becomes really at this point an imperative," he said.
While acknowledging that many countries, particularly in Europe, now have pandemic preparedness plans, Dr Mario said these are often not backed by adequate financial commitments.
He said many countries continue to face shortages of trained human resources, laboratory capacity and disease surveillance systems. There are also insufficient links between human medicine, veterinary public health and environmental monitoring.
According to him, these shortcomings remain significant obstacles to effective preparedness and response during future epidemics, particularly in low- and middle-income countries.
Read More: COVID-19 Vaccination Reduced Risk of Heart Attacks and Strokes in Elderly by 40%: Study
Dr Mario, also a consultant for a tuberculosis project with the US National Institutes of Health (NIH), stressed that countries need stronger surveillance systems not only for human diseases but also for animals and the environment.
He also highlighted the need for improved laboratory capacity to identify emerging pathogens, stronger genomic surveillance, adequate facilities and trained personnel, and the ability to rapidly produce vaccines when needed.
"The environmental health is the one that is weaker... in terms of capacity to monitor," he said, describing it as the weakest component of the One Health triad.
READ: Australia Reports More H5 Bird Flu Cases: Does It Have Pandemic Potential?
Dr Mario said zoonotic diseases emerge from interactions between humans, animals and the environment, making the One Health approach fundamental to future pandemic preparedness.
He described One Health as "an approach that unites human health, animal health and environmental health," recognizing that all three are interconnected.
He said practical implementation should include:
Despite the increased awareness following COVID-19, Dr Mario said preparedness ultimately depends on governments translating commitments into action through sustained investment.
He said countries need solid preparedness plans, practical implementation and adequate financing to build resilient systems capable of responding to future threats.
"If you think prevention is expensive, try the disease then," he said, underscoring the importance of investing in prevention.
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Women who are conflicted while choosing between an injectable contraceptive, a copper intrauterine device (IUD) or a hormonal implant may not need to worry about its impact on human papillomavirus (HPV).
HPV is one of the most common sexually transmitted infections worldwide. While many HPV infections go away on their own without causing problems, some high-risk types can persist and increase the risk of cervical cancer in the long run.
Also Read: Vagus Nerve Implant Shows Promise for Lasting Relief in Treatment-Resistant Depression: Study
Before this study, scientists debated whether hormonal contraceptives could affect a woman's immune response, making it easier to contract HPV or harder for the body to clear the infection.
According to a new study published in The Lancet Regional Health – Africa, your choice of contraception may not have an impact on the risk of contracting HPV.
Researchers found that women using a commonly used injectable contraceptive known as depot medroxyprogesterone acetate (DMPA-IM), copper IUDs, and levonorgestrel implants had similar chances of contracting HPV and clearing existing infections.
Also read: You Can Still Get HPV If You're Not Sexually Active
The researchers examined data from women who participated in the large ECHO (Evidence for Contraceptive Options and HIV Outcomes) clinical trial. Participants were randomly assigned to one of three contraceptive methods:
They then compared how often women acquired HPV during the study and how often those who already had HPV were able to clear the infection naturally. The analysis found no meaningful differences between the three contraceptive methods.
Women using the injectable contraceptive were no more likely to acquire HPV than those using a copper IUD or a hormonal implant. Similarly, women across all three groups cleared HPV infections at comparable rates.
Also read: Teplizumab: UK NHS To Roll Out World-First Drug To Delay Onset Of Type 1 Diabetes
Earlier studies finding the link between hormonal contraceptives and HPV have reported mixed results. Some suggested that hormonal birth control might increase the risk of HPV infection or make infections last longer, while others found no clear outcomes.
This new research provides stronger evidence because it is based on a randomized clinical trial. The findings suggest that the type of contraceptive a woman chooses is unlikely to have an impact on her risk of getting HPV or her body's ability to clear the infection.
The study allows women to choose between these commonly used contraceptive methods based on factors such as effectiveness, convenience, side effects, and personal preference, rather than concerns about HPV risk.
However, experts stress that no contraceptive method protects against sexually transmitted infections, including HPV. Using condoms can help reduce the risk of HPV and other STIs.
The human papillomavirus causes more than 200 known infections. While some types lead to benign skin warts, others are responsible for severe health threats, such as cervical, throat, anal, and penile cancers. The HPV vaccine provides strong protection against the most lethal strains, avoiding long-term health complications.
The HPV vaccine helps the immune system recognize and fight off high-risk strains of the virus before they cause harm. It protects against:
Experts also stress that HPV vaccination and regular cervical cancer screening remain the most effective ways to prevent cervical cancer and detect abnormal changes early.
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