Headaches are a common symptom of a stressful lifestyle, your body not feeling well and other issues. While headaches can be dealt with easily, migraines are not so easy to handle. Migraines are a type of headache that feels like severe throbbing and pulsing sensation, almost like you are hearing your own heartbeat in your brain, usually on one side of the brain. Many people believe that migraines are not that big of a deal because you just have to deal with the pain, but that is not all migraine is, some people find it very difficult to do their daily tasks as they experience dizzying spells, nausea and extreme sensitivity to light and sound! These attacks can last hours and make it difficult for people to go about their daily lives as well. While there are medications available for migraine patients, these medications need time to take effect, so you may be in a lot of pain, but there are not many quick reliefs you can have in place other than learning the symptoms of a migraine attack and taking medication before it happens. But a new approval by the FDA may change this!

The U.S. Food and Drug Administration (FDA) has approved Symbravo, a new medicine to treat acute migraine attacks in adults. This means adults can now use Symbravo to get relief from their migraine symptoms. The FDA's decision was based on the results of three big studies, called Phase 3 trials. These trials involved over 21,000 migraine attacks, so the FDA has a lot of information about how well Symbravo works and how safe it is. The FDA only approves medicines that have been shown to be both safe and effective through a thorough testing process.

Importance of New Treatment Option

"Migraine attacks can happen suddenly and really mess up people's lives. It's estimated that over 39 million people in the U.S. alone get migraines," said Herriot Tabuteau, M.D., CEO of Axsome Therapeutics told US News. This shows how common migraines are and how important it is to have good treatments. "Symbravo gives patients and doctors a new option that can quickly stop a migraine attack, keep it away, and let people get back to their normal activities, all with just one dose." Having a medicine that can give fast and long-lasting relief from migraine pain is a big deal for millions of people. This new treatment is a real step forward in how we treat migraines.

Symbravo Trial Results, How Was It Approved

The trials took place in 3 steps, the Momentum trial study focused on people whose migraines had moderate to severe pain. The results showed that a lot more people taking Symbravo felt pain-free two hours after taking the medicine compared to those who took a placebo which is a dummy pill. Even better, many people felt relief for up to 24 and even 48 hours after just one dose. This long-lasting relief is really important for people with migraines because it means they can get back to their normal lives without worrying about the pain coming back. The study also looked at how many people were free from their worst symptom, like sensitivity to light or sound, or nausea. Symbravo worked better than the placebo in this area too.

While the intercept trial looked at people who took Symbravo when their migraine pain was still mild. Even when the pain was just starting, Symbravo was effective. The results were similar to the MOMENTUM trial, with many people getting pain relief and relief from their worst symptoms. Treating migraines early is often better because it can stop the pain from getting really bad.

And lastly the Movement trial which was to see how safe the medication is when people take it regularly. This study followed 706 people who had at least two migraines a month. The most common side effects people experienced were sleepiness and dizziness. While these side effects are important to know about, the study showed that Symbravo is generally safe for people to use on a regular basis.

Norovirus Outbreak: In a globe-hopping cruise ship, more than 100 guests and crew reported being sick with norovirus outbreak. As per the Centers for Disease Control and Prevention (CDC), the 21st outbreak of gastrointestinal disease on a cruise ship monitored by the agency this year.

AIDA Cruises alerted the CDC to the outbreak aboard the AIDAdiva on November 30, confirmed the agency. So far, the outbreak has impacted 95 passengers out of the 2,007 onboard, and 6 out of 640 staff members, noted CDC.

The passengers also suffered symptoms like diarrhea and vomiting on voyage, which had begun on November 10 and is slated to last through December 16. The cruise line responded by stepping up cleaning and disinfection efforts, separating sick passengers and crew from others, working closely with the CDC’s Vessel Sanitation Program, and collecting stool samples for testing, the agency said.

What Are The Cruise Officials Doing About The Ship Outbreak?

“Seasonal illness peaks between November and April, and the AIDAdiva report mirrors what we’re seeing on land,” AIDA told People. “We’ve increased hygiene measures onboard, and cases are already declining.”

The Independent reports that AIDAdiva is currently midway through its 133-day voyage from Hamburg, Germany, with planned stops across North America. According to CruiseMapper, the ship is now in Costa Rica.

This outbreak is the 21st recorded this year on a CDC-regulated cruise ship, most of them caused by norovirus. That’s higher than the recent yearly totals: 18 outbreaks in 2024 and 14 in 2023. While cruises are often linked with norovirus, only a small share of overall cases actually occur at sea. In most years, ship outbreaks simply mirror seasonal spikes happening on land.

Officials say it’s too soon to say why numbers are up.

“Although cruise ship outbreaks have been higher than in pre-pandemic years, we don’t yet know if this is a lasting trend,” the CDC told USA TODAY in April. They added that a newly dominant norovirus strain is driving many land-based outbreaks this season, and ships usually follow the same pattern.

Norovirus is the leading cause of vomiting, diarrhea, and foodborne illness in the U.S. It triggers acute gastroenteritis, an inflammation of the stomach or intestines. Most people recover within one to three days, but they can remain contagious even after symptoms improve.

The virus spreads easily through contaminated food, surfaces, or close contact. Regular handwashing, proper cooking and cleaning of produce and shellfish, and routine disinfection of surfaces are key steps to prevent infection.

What Is Norovirus?

Often called the “stomach flu” or “stomach bug,” norovirus is not related to influenza. It causes acute gastroenteritis, an inflammation of the stomach and intestines. Most people recover within 1 to 3 days, but the virus can still be contagious for several days afterward. In 2025 alone, the CDC has recorded 19 gastrointestinal outbreaks on cruise ships, 14 of which were caused by norovirus. The CDC notes that such illnesses spread quickly in enclosed environments like cruise ships.

Unique Symptoms Observed on This Cruise

Norovirus symptoms usually appear 12 to 48 hours after exposure. While diarrhea, vomiting, nausea, and stomach cramps remain common, this outbreak has shown some unusual signs:

• Dehydration
• Reduced urination
• Dry mouth and throat
• Feeling dizzy when standing
• Crying with few or no tears
• Unusual sleepiness or irritability

Eli Lily's CEO David Ricks announced a new US factory worth over $6 Billion as per several reports that will manufacture the awaited weight loss pill: Orforglipron. The company had earlier announced that the weight loss pill had successfully met the “primary and all key secondary endpoints” in a large clinical trial, paving the way for global regulatory submissions.

“With these positive data in hand, we are moving with urgency toward global regulatory submissions to potentially meet the needs of patients who are waiting,” said Kenneth Custer, Eli Lilly’s executive vice president and president of cardiometabolic health.

“If approved, we are ready to offer a convenient, once-daily pill that can be scaled globally, removing barriers and redefining how obesity is treated around the world.”

This comes after President Donald Trump on its website TrumpRx allowed Americans to purchase prescription medication from pharmaceutical companies at discounted rates, among them also include GLP-1 medications. The Trump administration also unveiled agreements with Eli Lily to make these drugs more affordable. Trump has taken a special interest in the 'fat drug'.

In an exclusive interview with CNN's Erin Burnett, CEO Ricks shared that this new weight loss pill will be coming out next year. Eli Lily is also the company that has made Zepbound. Talking about the side effects of weight loss drugs, which included weight loss drugs reducing age, or people reporting pancreas problems, or the drugs changing brain's make up to curb down cravings, the CEO said that these were just a selected few people reporting such results. He said that he has received emails, photos from before and after of people who have been on weight loss drugs and how they are with their transition. "There were people who were changing not just the way they look, but also their health status in this country and around the world. So most of the evidence is from the opposite side," he said.

In terms of life expectancy, he said that "most of the data that we have collected it [weight loss drugs] extends life". How? "They do it through preventing diabetes, preventing heart attacks, and preventing other serious anomalies that comes through obesity," said the CEO.

What Is Orforglipron?

Originally discovered by Japan’s Chugai Pharmaceutical and later licensed to Eli Lilly in 2018, orforglipron is now in Phase 3 trials. The company is testing it not just for weight management and type 2 diabetes but also for conditions linked to obesity, including obstructive sleep apnea and hypertension.

Why An Oral Option Matters

Injectable GLP-1 receptor agonists like semaglutide and tirzepatide have already transformed obesity and diabetes care, but accessibility remains a hurdle. For many patients, injections are intimidating, inconvenient, or simply not practical in daily life.

That’s where an oral pill could be a game-changer. A once-daily tablet could remove psychological and logistical barriers, making it easier for patients to stay on treatment. And given the rising global burden of obesity, which significantly raises the risk of cardiovascular disease, stroke, and some cancers, the demand for more convenient treatment options has never been greater.

Pills vs. Injections: Which Works Better?

The big question now is whether oral GLP-1 drugs are as effective as their injectable counterparts.

A 2021 research review published in Springer Nature, offers some clues. After examining multiple studies, researchers concluded that oral semaglutide, a similar class of drug, provided “similar or better efficacy and similar tolerability” compared to injectable GLP-1 receptor agonists.

Also Read: How To Identify A Counterfeit Ozempic? Look For These Signs

In some cases, oral versions were found to be just as effective for weight loss and lowering A1C levels in people with type 2 diabetes. However, the review focused on patients already using insulin, which may have influenced outcomes. Experts emphasize that while results are encouraging, more research is still needed to directly compare oral and injectable versions in broader populations.

An unknowing harboring of genetic mutation that raised the risk of cancer by a sperm donor who fathered at least 197 children across Europe. BBC reported on a major investigation that revealed that some children have already died and only "a minority who inherit the mutation will escape cancer in their lifetimes".

According to BBC, the sperm was not sold to UK clinics, in fact, a "very small" number of British family used the sperm while they had their fertility treatment in Denmark. It was the European Sperm Bank of Denmark that admitted that the sperm was used to make too many babies in some countries and that they had their "deepest sympathy" for the families affected.

What Was The Investigation All About?

The investigation was conducted by 14 public broadcasters, which included BBC, as part of the European Broadcasting Union's Investigative Journalism Network.

This is what the investigation revealed: This sperm donor, who was perfectly healthy on paper started donated sperm as a young student in 2005. He was paid for each donation. He passed all the routine screening tests and showed no signs of illness. For nearly 17 years, women across Europe used his sperm to have children.

But there was something inside his DNA that no one could have detected at the time.

Before the donor himself was born, a random change occurred in some of the cells that were forming his body. This mutation damaged a crucial gene called TP53. This gene acts like the body’s security guard. Its job is to spot dangerous changes in cells and stop them from turning cancerous.

Most of the donor’s body does not carry this mutation, which is why he has never become ill. However, his sperm cells are a different story. Up to 20% of them carry the faulty TP53 gene.

This created a devastating possibility. If a sperm carrying the mutation fertilizes an egg, the resulting child will have the mutation in every single cell of their body. That child is then born with Li Fraumeni syndrome, a condition that brings an up to 90 percent lifetime risk of cancer. These cancers often appear in childhood and include leukemia, bone cancers, brain tumors and breast cancer later in life.

The donor had no idea any of this was happening. Neither did the clinics using his sperm.

How Was This Mutation Discovered?

The alarm was first raised when doctors across Europe began seeing children with aggressive cancers whose genetic tests all pointed back to the same TP53 mutation. Eventually, they discovered that the children were conceived using sperm from the same donor.

By the time this was uncovered, the donor’s sperm had been used by 67 fertility clinics across 14 countries. At least 197 children are known to have been born using his donations, though the final number could be higher. It is not yet known how many of them inherited the dangerous gene.

Doctors say several of these children have already been diagnosed with cancer, some have developed more than one cancer, and some have died.

Dr Edwige Kasper, a cancer geneticist in France, has been helping families navigate the diagnosis.

“We have many children who have already developed cancer,” she said. “Some have had two cancers and some died very early.”

A Mother’s Discovery

One mother, whose name is changed to Céline (as per the BBC report), conceived her daughter with the donor’s sperm in Belgium. 14 years later, she received a call from the clinic urging her to get her child screened.

Her daughter tested positive for the mutation.

Céline says she does not blame the donor but is devastated that she was given sperm that “was not safe”. She knows cancer could strike at any point.

“We do not know when, we do not know which cancer, and we do not know how many times,” she said. “When it comes, we fight.”

How Regulation Failed

There is no global law limiting how many families a sperm donor can help. Each country sets its own rules.

In Belgium, for example, one donor should be used for no more than six families. This donor helped create 38 families in Belgium alone.

The UK limit is ten families, but the donor’s sperm was never sold directly to UK clinics. Instead, the Danish authorities informed the UK that a small number of British women travelled to Denmark for treatment using this donor’s sperm. Those women have since been contacted.

The European Sperm Bank admits national limits were breached in some countries and says the donor was immediately blocked once the mutation came to light. They say the donor and his relatives are healthy and that this type of mutation cannot be detected with standard screening.

Can Donor Screening Ever Catch Everything?

Experts say cases like this are extremely rare but nearly impossible to prevent entirely.

“You cannot screen for everything,” said Prof Allan Pacey from the University of Manchester. “If we make screening even tighter, we would not have any donors left.”

He added that countries have become too dependent on large international sperm banks, which supply multiple nations simultaneously.

Important Questions Parents Must Ask

Experts advise choosing licensed clinics and asking:

• Is the donor local or from another country?
• How many families has this donor helped?
• What screening has been done?