The US Food and Drug Administration has approved TNKase or Tenecteplase, which is a thrombolytic or clot-dissolving agent, for the treatment of acute ischemic stroke in adults.

Ischemic strokes happen when a blood clot blocks a blood vessel in your brain. It can cause permanent brain damage and death. If enough brain cells die, you can also lose the abilities or body functions those cells control. They are also the most common types of stroke, with 80% of all strokes being ischemic strokes.

How is TNKase administered?

It is delivered as a single five-second intravenous bolus, which is faster than the standard of care Activase or alteplase, which is administered as an intravenous bolus followed by a 60-minute infusion. The manufacturer of TNKase, Genetech said a new 25-mg vial configuration will also be available in the coming months.

How Was TNKase approved?

The approval came at the backdrop of a study that compared TNKase to Activase in patients with acute ischemic stroke. These patients also presented with a disabling neurological deficit. Results show that TNKase was comparable to Activase in terms of efficacy and safety.

How Common Are These Strokes?

In the United States it self, it affects more than 795,000 people each year and is the leading cause of long-term disability. It is also the fifth leading cause of death. Since brain damage can happen if this progresses rapidly, one needs an immediate, fast-acting medical care.

TNKase thus provide a faster and simpler administration which can be critical for anyone. The chief medical officer and head of global product development at Genetech, Levi Garraway, MD., PhD., said, "Today's approval is a significant step forward and underscores our commitment to advancing stroke treatment options for patients."

What Are The Symptoms Of Ischemic Strokes?

Some of the most common symptoms include weakness or paralysis on one side of your face and body. You may also feel trouble speaking or have loss of speech, also known as aphasia. You may faced slurred or garbled speaking, also known as dysarthria. Other symptoms include loss of muscle control on one side of your face, or sudden worsening or loss of your senses, including vision, hearing, smell, taste, and touch.

Other symptoms include:

• Loss of coordination or clumsiness
• Blurry vision or double vision
• Dizziness or vertigo
• Nausea and vomiting
• Neck stiffness
• Mood swings or sudden personality changes
• Confusion or agitation
• Seizures
• Memory loss (amnesia)
• Headaches which are sudden and severe
• Passing out or fainting
• Coma

Are There Any Warning Signs?

While these are symptoms one has who is prone to this condition. However, often, many may confuse it with other illnesses. It is best to keep an eye out for warning signs. These could be looking out for yourself or your loved one. Note if there is a sudden loss of balance. Look out for sudden vision loss or changes in one or both eyes. Look for a droop on one or both sides of your face, especially when you smile. Raise both arms and see if one arm sags or drops in a way it usually does not. Note for your speech. Are you as fluent? Are you have trouble speaking? If you see any of such signs, start tracking it and talk to your healthcare provider.

Rougeole/Measles: Christmas is not even 10 days away and other festivities are also lining up. With the holiday season coming in, more cases of measles are likely to be added to the five which had already been recorded in Montreal.

"It's certain that the holiday season worries us, because we gather, we meet our families, we have more contact, and therefore more opportunities for transmission of the virus," said Dr. Paul Le Guerrier on QUB radio and television, broadcast simultaneously on 99.5 FM Montreal, Tuesday.

As per the medical advisor at Montreal's Regional Public Health Department, a surge in cases during this time of the year is conducive as there will be more gathering. In fact, "almost 95% of population would need to be vaccinated to prevent community transmission."

"At the end of secondary school, we reach levels of 86-88%. But we are not yet at the desired threshold," the doctor specifies.

Can Measles Be Prevented?

The spread could be curbed and a significant outbreak during the holiday season could be avoided, if vaccination is done in full flow. Public health department has sent letters to all schools in Montreal province. "If children do not have two doses of measles vaccine, [they are encouraged] to make an appointment or go see their family doctor to increase their vaccination coverage," explained Dr. Le Guerrier.

The public is also urged to keep a check of common signs and measles symptoms like:

• Fever
• Nasal congestion with runny nose
• Cough
• Conjunctivitis
• Eyes sensitive to light
• Widespread unease

Measles In Canada

The Global News reported that so far, Quebec has confirmed three measles cases linked to pediatric medical center in an off-island suburb of Montreal.

The first case was identified in early December, marking the province’s first measles infection since April. Health officials say people who visited the UP pediatric emergency centre in St-Eustache, Que., on the afternoon or evening of Nov. 28 may have been exposed.

So far this year, Canada has reported more than 5,300 measles cases, largely in Ontario and Alberta. Quebec recorded 36 cases during an earlier outbreak. The provincial government warns additional cases are likely and stresses vaccination as the strongest protection against the highly contagious disease.

Unique Symptoms Of Measles To Look Out For

Measles has a high transmissibility, and high measles immunity levels are required to prevent sustained measles virus transmission. This is why herd immunity for measles could be easily breached.

It easily spreads from one infected person to another through breathes, coughs or sneezes and could cause severe disease, complications, and even death.

Read: Unique Symptoms Of Measles In 2025 And How Long Does The Infection Last?

The most unique symptom or the early sign of measles in the Koplik spots. These are tiny white dots that look like grains of salt on red gums inside the cheeks that appear before the red rash starts to appear on a person's face and then the body.

Furthermore, the symptoms of measles are also characterized by the three Cs:

• Cough
• Coryza or runny nose
• Conjunctivitis or red and water eyes

The progression of the symptom comes in two stages, first is the prodromal stage or Days 1 to 4, where one would notice high fever, cough, runny nose, red and watery eyes, sore throat, fatigue, and Koplik spots.

The second stage is called the rash stage or the days 5 to 10 or even more where rash start to appear on the hairline, and then it runs down the body. It lasts for several days and fades in the same order.

The first symptoms, notes the Centers for Disease Control and Prevention (CDC), appear 7 to 14 days after a measles infection. Often, it could also lead to ear infection, or even diarrhea. Though these complications happen in every 1 in 10 children or individual with measles.

Angelina Jolie, in an act of bravery, for what many women are often shamed, has revealed her mastectomy scars in a magazine photo shoot for Time France. Now 50, she said she chose to show the result of her preventative breast cancer operation because she was "moved" when other women shared their scars.

Jolie during the cover shoot of Time France said, "I share these scars with many women I love, and I am always moved when I see other women share theirs. I wanted to join them, knowing that Time France would be sharing information about breast health, prevention, and knowledge about breast cancer."

Angelia Jolie's Mastectomy Scars

The 50-year-old actress had a double mastectomy at the age of 37 in 2013. This was after she had discovered that she carried a faulty copy of BRCA1 gene, which had put her in the risk of cancer. The disease runs in her family, as her mother too died of ovarian cancer aged 56 in 2007. She had lost her grandmother and aunt to the same disease.

Now, the Oscar-winning actress has posed showing her double mastectomy scars for the first time so she could raise awareness. The cover photo could be seen with her wearing a low-cut sweater that reveals her scars on the cover photo. The magazine issue that will be published on December 18 will feature a full interview with more photos of her operation scars.

Back in 2015, she revealed in The New York Times article that she also had her ovaries and fallopian tubes removed as a preventative measure against developing cancer. She wrote that she had been planning this for "some time now" and that her "children will never have to say, 'Mom died of ovarian cancer'."

According to Cancer Research UK, around 7,600 women are diagnosed with ovarian cancer each year in the UK, and about 4,100 die from it. The disease often shows few or no symptoms until later stages. Jolie, a mother of six, has long advocated awareness due to her family history, urging women to seek medical advice, stressing that knowledge empowers.

Also Read: More Than A Diagnosis: Cancer Survivors Share The Small Wins That Helped Them Heal

What is the BRCA1 gene?

The BRCA1 gene is a tumor suppressor gene that provides instructions for making a protein that helps repair damaged DNA and maintain the stability of a cell's genetic information.

Mutations in this gene significantly increase the risk of developing certain cancers, most notably breast and ovarian cancers, and also contribute to a higher risk of pancreatic and prostate cancers.

Cancer preventive surgery, also called prophylactic surgery, removes tissues or organs before cancer develops in high-risk individuals to significantly lower their chances of getting cancer, often targeting genetic predispositions (like BRCA mutations) or precancerous conditions (like colon polyps). It's a proactive measure for healthy people at elevated risk, aiming to prevent cancer before it starts, unlike curative surgery that removes the existing cancer.

What is a mastectomy?

A mastectomy is a type of breast cancer surgery that removes all of your breast tissue. Healthcare providers can use it to treat most types of breast cancer. Your provider may also recommend it if you have a high risk of developing breast cancer.

If you have breast cancer, removing the cancer cells is the best way to stop it from spreading. A mastectomy removes all the breast tissue where cancer cells are located. After a mastectomy surgery, you may need other cancer treatments to kill any remaining cancer cells in the surrounding tissue.

US is facing a flu outbreak and as per the Centers for Disease Control and Prevention (CDC) data, an estimated 2.9 million people have gotten sick so far this season. Among them, 1,200 have also died. This is the 'worst' flu season, point out many experts. For US, the country is seeing a post-Thanksgiving spike in influenza, and saw an 8% increase in people testing positive for the flu.

Which Regions Are The Worst Affected By Flu In The US?

As of December 6, as per the latest national data, Colorado, New Jersey, New York, and Louisiana are currently experiencing "high" transmission of the virus.

An increase was also seen in Connecticut, Georgia, Idaho, Massachusetts, Michigan, Rhode Island, South Carolina, Texas, and Puerto Rico. These states are in the 'moderate' tier for flu cases.

New York City moved into the most severe category for 'very high' flu activity.

What Is Making This Flu Season The 'Worst'?

Much of this flu season is being driven by a new variant, a mutated subclade K, also known as the super flu. This is a subclade of H3N2 influenza, which is historically known for causing more hospitalization and deaths. The best line of defense is to get yourself vaccinated against the virus. “CDC recommends that every 6 months and older who has not yet been vaccinated this season get an annual influenza (flu) vaccine."

As of now, the CDC has distributed 127 million doses, however, things are expected to get worse before they get better.

Not Just US, UK Too Is Struggling With The K Strain Flu

Known as the superflu, this is H3N2 'subclade K'. It is a type of seasonal influenza A virus and people have not encountered much of it in the recent years. This is why there is less immunity against it. However, the National Health Service (NHS), UK, has already sent out a 'flu jab SOS' to vulnerable people.

NHS has confirmed that the super flu is circulating in England this year, and due to less immunity, it is making it easier to spread across people. The UK Health Security Agency (UKHSA) has urged people to get a flu jab. As per the early data, this year's vaccine has offered good protection despite the new strain.

Daniel Elkeles, chief executive of NHS Providers, said that the major concern is that H3N2 is associated with a more severe illness and superflu could be "a very nasty strain of flu". He said that UK could be experiencing a "tidal wave" of illness.

Should You Get The Flu Jab Even If You Are Healthy?

Even if you are healthy, you should get the shot, say doctors. Vaccines are still working against the drifted influenza A (H3N2) subclade, also known as the super flu. The vaccines in high street chemists are sold for £20.

Anyone can be vaccinated, except for those who have a serious allergy to any of its ingredients or to the vaccine it self. The best way to know is to speak to the pharmacist and your GP.

For the vaccine to work, it usually takes up to 14 days. However, what is more important to not is that during the 14-day-long period, you are still vulnerable to catching the virus.