The US Food and Drug Administration has approved TNKase or Tenecteplase, which is a thrombolytic or clot-dissolving agent, for the treatment of acute ischemic stroke in adults.

Ischemic strokes happen when a blood clot blocks a blood vessel in your brain. It can cause permanent brain damage and death. If enough brain cells die, you can also lose the abilities or body functions those cells control. They are also the most common types of stroke, with 80% of all strokes being ischemic strokes.

How is TNKase administered?

It is delivered as a single five-second intravenous bolus, which is faster than the standard of care Activase or alteplase, which is administered as an intravenous bolus followed by a 60-minute infusion. The manufacturer of TNKase, Genetech said a new 25-mg vial configuration will also be available in the coming months.

How Was TNKase approved?

The approval came at the backdrop of a study that compared TNKase to Activase in patients with acute ischemic stroke. These patients also presented with a disabling neurological deficit. Results show that TNKase was comparable to Activase in terms of efficacy and safety.

How Common Are These Strokes?

In the United States it self, it affects more than 795,000 people each year and is the leading cause of long-term disability. It is also the fifth leading cause of death. Since brain damage can happen if this progresses rapidly, one needs an immediate, fast-acting medical care.

TNKase thus provide a faster and simpler administration which can be critical for anyone. The chief medical officer and head of global product development at Genetech, Levi Garraway, MD., PhD., said, "Today's approval is a significant step forward and underscores our commitment to advancing stroke treatment options for patients."

What Are The Symptoms Of Ischemic Strokes?

Some of the most common symptoms include weakness or paralysis on one side of your face and body. You may also feel trouble speaking or have loss of speech, also known as aphasia. You may faced slurred or garbled speaking, also known as dysarthria. Other symptoms include loss of muscle control on one side of your face, or sudden worsening or loss of your senses, including vision, hearing, smell, taste, and touch.

Other symptoms include:

• Loss of coordination or clumsiness
• Blurry vision or double vision
• Dizziness or vertigo
• Nausea and vomiting
• Neck stiffness
• Mood swings or sudden personality changes
• Confusion or agitation
• Seizures
• Memory loss (amnesia)
• Headaches which are sudden and severe
• Passing out or fainting
• Coma

Are There Any Warning Signs?

While these are symptoms one has who is prone to this condition. However, often, many may confuse it with other illnesses. It is best to keep an eye out for warning signs. These could be looking out for yourself or your loved one. Note if there is a sudden loss of balance. Look out for sudden vision loss or changes in one or both eyes. Look for a droop on one or both sides of your face, especially when you smile. Raise both arms and see if one arm sags or drops in a way it usually does not. Note for your speech. Are you as fluent? Are you have trouble speaking? If you see any of such signs, start tracking it and talk to your healthcare provider.

While concern continues over the deadly hantavirus outbreak on the MV Hondius cruise ship, reports of more than 100 people falling ill on a Caribbean cruise with vomiting and diarrhea have also sparked alarm.

A cruise ship sailing from Florida with over 3,000 passengers reported a major outbreak around May 7. More than 100 passengers and crew were affected. Health officials confirmed the cause as norovirus.

According to Cruise operator Princess Cruises, enhanced cleaning protocols were introduced immediately after the outbreak was detected. Sick passengers and crew were isolated, and hygiene measures across dining and public areas were intensified.

What Is Norovirus?

Norovirus is a highly contagious virus that causes gastroenteritis, leading to inflammation of the stomach and intestines.

Speaking to HealthandMe, epidemiologist Dr. Amitav Banerjee, professor at DY Patil Vidyapeeth, Pune, described norovirus as “notorious because it spreads very fast.”

“It can spread through fomites like handles and knobs, and even a very low infectious dose—around 18 viral particles—can cause infection. So it spreads very fast,” he said.

He added that while many common disinfectants are ineffective against it, norovirus can be inactivated using bleach and chlorine-based cleaning agents.

Is The Norovirus Outbreak Of Concern?

Although outbreaks can look alarming, Dr. Banerjee emphasized that norovirus infections are generally self-limiting.

“In the ship, it can be managed with oral rehydration, and in severe cases, IV fluids can help prevent complications and mortality,” he said.

A recent report from the US also showed that norovirus can spread very rapidly from person to person on a cruise ship.

Dr. Banerjee also clarified that, unlike diseases with pandemic potential, norovirus outbreaks—while explosive in nature—do not typically pose a long-term global threat.

“So, this particular outbreak is not a cause for worry. It does not have pandemic potential, though it can spread very fast,” he added.

Read More: Hantavirus Alert on MV Hondius: One US Passenger Tests Positive, Two Others Show Symptoms

Who Is Most at Risk? What Are The Key Symptoms

Dr. Banerjee noted that extreme age groups, especially very young infants and the elderly, are at higher risk due to dehydration from diarrheal illness. However, deaths remain rare when proper care is provided.

Norovirus illnesses usually last between two and three days. Symptoms usually begin suddenly within 12 to 48 hours of exposure and may include:

• Nausea
• Vomiting
• Watery diarrhea
• Stomach cramps
• Low-grade fever
• Headache and body aches
• Fatigue

What You Can Do To Stop Its Spread

Because of how fast viruses spread, experts highly recommend preventive actions such as:

• Wash your hands frequently with soap and warm water, especially after using the toilet or before preparing food.
• Avoid visiting hospitals or care homes if experiencing symptoms.
• Stay home for at least 48 hours after symptoms subside to prevent spreading the virus.

Two of 17 American passengers evacuated from the hantavirus-hit MV Hondius have tested positive, the US Department of Health and Human Services (HHS) announced today.

A French national onboard the same cruise has also shown symptoms.

The Dutch-flagged vessel MV Hondius, carrying 94 people, including Filipinos, Britons, Americans, Indians, and Spaniards, arrived in Spain's Canary Islands on May 10. All have been evacuated and repatriated.

How Did Countries Evacuate?

US

The HHS in a post on social media platform X noted that all 17 American citizens have been repatriated from the MV Hondius cruise ship and are currently en route to the US.

The two passengers who tested positive for hantavirus are travelling in the plane's biocontainment units out of an abundance of caution.

“All 17 are currently en route via @StateDept airlift to the United States, with two of the passengers travelling in the plane's biocontainment units out of an abundance of caution. One passenger currently has mild symptoms, and another passenger tested mildly PCR positive for the Andes virus,” the HHS statement said.

The HHS added that the airlifted passengers will be transported “to the ASPR Regional Emerging Special Pathogen Treatment Center (RESPTC) at the University of Nebraska Medical Center/Nebraska Medicine in Omaha, Nebraska”.

The passenger with mild symptoms will be moved to a second RESPTC. Notably, everyone will undergo clinical assessment and receive appropriate care and support based on their condition.

Also read: Hantavirus: How Andes Strain Spreads Between Humans; Why It’s Not Another Pandemic

Spain

Prime Minister of France Sébastien Lecornu, informed that five Spaniards present on the MV Hondius have been repatriated to national territory.

Of these, one “exhibited symptoms on the repatriation flight”.

“As a result, all five passengers were immediately placed in strict isolation until further notice. They are receiving medical care and will undergo testing and a full health assessment,” he added.

Read More: Why The Norovirus Outbreak On A Caribbean Cruise Ship Is Not A Cause for Panic

Australia

Australia said it will charter a flight to evacuate its citizens. And the passengers returning are expected to be quarantined on arrival.

Environment Minister Murray ⁠Watt said the flight carries four Australians, one resident of Tenerife, and one resident of New Zealand.

"This is being done via an Australian government-supported flight, and we expect those people to return to Australia soon," Watt told reporters in Canberra.

"Quarantine arrangements are being finalized as we speak with the states and territories."

India

Two Indian nationals are healthy and unsymptomatic, the Embassy of India in Madrid said on May 10.

They have been medically evacuated to the Netherlands, where they will be quarantined as per relevant health safety protocol, the embassy said.

Planes to Canada, the Netherlands, Turkey, the UK, Ireland, and have also departed from Spain.

WHO Guidelines On Hantavirus

Dr. Maria Van Kerkhove, the WHO’s head of epidemic and pandemic preparedness, said that after being brought to shore, passengers will be kept cordoned off from the public and taken to repatriation flights.

In their home countries, many will be taken onward to isolation facilities. Van Kerkhove said that the WHO is recommending “active monitoring and follow-up” for all passengers and crew for 42 days from their “last point of exposure” to a confirmed case.

"Our recommendation is daily health checks, at home or in a specialized facility. It's up to countries to develop their policies, but our recommendations are very clear," Van Kerkhove said, highlighting that the incubation period for the virus was up to six weeks.

Maryland Governor Wes Moore has urged strengthening investment in maternal health initiatives in the US that will support mothers before and after they give birth.

Speaking to NBC News on the occasion of Mother’s Day on May 10, Moore, along with Arkansas Governor Sarah Huckabee Sanders, spoke about the need to improve access to care for mothers.

Moore, who has served as governor since January 2023, emphasized the need to leverage resources from the government, the private sector, and community organizations to address access gaps.

In light of this, the Maryland Governor highlighted a new partnership his administration entered with The Bridge Project to provide direct cash assistance to new mothers.

The Bridge Project, which has programs in 10 cities, counties, or regions across the country, offers mothers financial support and community resources to assist them during pregnancy and “for the first several years” with their baby.

“It’s going to happen for 150 families in the … areas of Maryland that you’ve had concentrated poverty being a long-term challenge,” said Moore, a father of two.

“And it’s now coming off the heels of additional initiatives that we pulled together, where we’ve reestablished the Governor’s Office for Children. We’ve started something called the ENOUGH Initiative, which is actually an acronym that stands for engaging neighborhoods, organizations, unions, governments, and households, which is the nation’s first place-based, state-led anti-poverty initiative,” he added.

Sanders Urges Bipartisan Action to Improve Maternal Health

Meanwhile, Sanders, who has three children, said she made maternal health a priority after becoming governor, citing Arkansas’ consistently poor ranking in maternal mortality rates.

“If we can see these women and help them and support them from the very beginning of their pregnancy all the way through, then we can help address some of these problems, and we can change maternal health,” Sanders. “Not just in our state, but across the country.”

Read More: Hantavirus: 2 Indian Crew Members On MV Hondius Asymptomatic; How Passengers Were Evacuated?

Sanders said she convened a strategic working group to identify ways to improve maternal health outcomes throughout the state and was “pleasantly shocked by how many people showed up.”

“People that I know actively campaigned against me were some of the most helpful people in developing our strategic plan on how we were going to address this problem in Arkansas,” the governor added. “It is something that breaks down a lot of walls. Everybody knows a mom. Everybody has a mom.”

The working group led Sanders to introduce the Healthy Moms, Healthy Babies Act and other initiatives, including the Proactive Postpartum Call Center run through the University of Arkansas for Medical Sciences, which calls women in their first six weeks postpartum to ask and answer questions about physical and mental health.

Maternal Mortality In The US

Also read: World Thalassemia Day 2026: Why Screening Before Marriage Or Pregnancy Is Important

As per March 2026 data from the Centers for Disease Control and Prevention (CDC), the 2024 figures raise concerns about maternal health in the country. The US has already had one of the highest maternal mortality rates among high-income countries.

The CDC's report stated that in 2024, 649 women died of maternal causes in the United States, compared with 669 in 2023

The maternal mortality rate for 2024, 17.9 deaths per 100,000 live births, shows no significant decline from 18.6 deaths in 2023.