The US Food and Drug Administration has approved TNKase or Tenecteplase, which is a thrombolytic or clot-dissolving agent, for the treatment of acute ischemic stroke in adults.

Ischemic strokes happen when a blood clot blocks a blood vessel in your brain. It can cause permanent brain damage and death. If enough brain cells die, you can also lose the abilities or body functions those cells control. They are also the most common types of stroke, with 80% of all strokes being ischemic strokes.

How is TNKase administered?

It is delivered as a single five-second intravenous bolus, which is faster than the standard of care Activase or alteplase, which is administered as an intravenous bolus followed by a 60-minute infusion. The manufacturer of TNKase, Genetech said a new 25-mg vial configuration will also be available in the coming months.

How Was TNKase approved?

The approval came at the backdrop of a study that compared TNKase to Activase in patients with acute ischemic stroke. These patients also presented with a disabling neurological deficit. Results show that TNKase was comparable to Activase in terms of efficacy and safety.

How Common Are These Strokes?

In the United States it self, it affects more than 795,000 people each year and is the leading cause of long-term disability. It is also the fifth leading cause of death. Since brain damage can happen if this progresses rapidly, one needs an immediate, fast-acting medical care.

TNKase thus provide a faster and simpler administration which can be critical for anyone. The chief medical officer and head of global product development at Genetech, Levi Garraway, MD., PhD., said, "Today's approval is a significant step forward and underscores our commitment to advancing stroke treatment options for patients."

What Are The Symptoms Of Ischemic Strokes?

Some of the most common symptoms include weakness or paralysis on one side of your face and body. You may also feel trouble speaking or have loss of speech, also known as aphasia. You may faced slurred or garbled speaking, also known as dysarthria. Other symptoms include loss of muscle control on one side of your face, or sudden worsening or loss of your senses, including vision, hearing, smell, taste, and touch.

Other symptoms include:

• Loss of coordination or clumsiness
• Blurry vision or double vision
• Dizziness or vertigo
• Nausea and vomiting
• Neck stiffness
• Mood swings or sudden personality changes
• Confusion or agitation
• Seizures
• Memory loss (amnesia)
• Headaches which are sudden and severe
• Passing out or fainting
• Coma

Are There Any Warning Signs?

While these are symptoms one has who is prone to this condition. However, often, many may confuse it with other illnesses. It is best to keep an eye out for warning signs. These could be looking out for yourself or your loved one. Note if there is a sudden loss of balance. Look out for sudden vision loss or changes in one or both eyes. Look for a droop on one or both sides of your face, especially when you smile. Raise both arms and see if one arm sags or drops in a way it usually does not. Note for your speech. Are you as fluent? Are you have trouble speaking? If you see any of such signs, start tracking it and talk to your healthcare provider.

In an ever-evolving world, people are always looking for something more convenient. Thanks to this never-ending search for an easier way out, even the ways of using medicine have changed. From popping pills to now using nasal sprays for decongestion, the way we deal with a cold or the flu has also changed. But just like all other aspects of life, one must know where to stop. Unsurprisingly, cases of nasal spray addiction have come to light, and the consequences are not pretty.

What happens when nasal sprays are used in excess?

In the UK, the Medicines and Healthcare products Regulatory Agency (MHRA) has stated that excessive use of nasal spray can lead to ‘rebound congestion’ and other major side effects. While people were mindlessly using nasal sprays for seven days in a row, a new advisory limits use to just five days. Brits are reportedly becoming addicted to nasal sprays because of excessive use to relieve blocked noses, thereby causing damage to the tissues inside.

What are the symptoms of overuse of nasal sprays?

Decongestant sprays constrict inflamed blood vessels in the nasal passages, thereby relieving congestion. In the short term, they work well. However, if used too much, the blood vessels in the nasal passages become sensitive to ingredients like xylometazoline and oxymetazoline. These passageways also start to swell when the medication wears off. In the long run, addiction or overuse of nasal sprays can lead to the following symptoms:

1. Damage to the sensitive lining of the nose
2. Dependence on the spray
3. Crusting
4. Dryness in the nose
5. Sleep problems
6. Palpitations
7. Anxiety
8. Irritation
9. Reduced effectiveness of the spray

Consequences of nasal spray addiction

In an interview with Health and Me, Dr Samir Garde, Director of the Department of Pulmonology and Lung Transplant at Gleneagles Hospital, Parel, said, “Many people have a habit of using nasal sprays mindlessly. So, even though they tend to provide that much-needed relief, they can take a toll on well-being. Using nasal sprays too often, particularly decongestant sprays, can do more harm than good. While they give quick relief from a blocked nose, overuse can lead to a problem called rebound congestion. This happens when the nose becomes even more blocked once the effect wears off. This can make people dependent on the spray and even cause addiction. Moreover, excessive use also dries out the nasal lining, causing irritation, burning, or even small nosebleeds.”

Some people may experience headaches or a constant feeling of stuffiness that can disturb peace of mind and interfere with daily routine. In the long run, it can damage the sensitive tissues inside the nose and reduce the spray’s effectiveness. So, use nasal sprays strictly as per a doctor’s advice. Do not overdo it. Anything done in excess can be harmful to health. Take charge of your wellbeing and follow medical advice carefully.

In a bid to ensure safe healthcare environments, India's Ministry of Health and Family Welfare (MoHFW) has launched a nationwide Fire Safety Week across healthcare facilities.

The Fire Safety Week will be observed from May 4 to May 10 across the country. The theme of this year’s Fire Safety Week is “Safe Schools, Safe Hospitals, and a Fire-Safety Aware Society: Together for Fire Prevention”.

Fire safety in healthcare facilities is a critical component of patient safety and health system resilience. Hospitals house vulnerable patients, high electrical loads, oxygen-rich environments, and complex medical equipment, making them particularly susceptible to fire hazards.

"Fire Safety Week provides an important opportunity to reassess existing infrastructure, evaluate whether facilities have been adequately audited, and identify gaps and discrepancies that need to be addressed," said Union Health Secretary, Punya Salila Srivastava, while launching the initiative.

Emphasizing capacity building, she stressed that healthcare professionals must be adequately trained and sensitized to effectively respond to fire emergencies.

How Will Fire Safety Week Be Conducted?

The nationwide campaign is designed to go beyond awareness and focus on actionable preparedness. States and healthcare institutions will:

• Conduct mock fire drills to test evacuation readiness
• Train staff in handling fire extinguishers and emergency protocols
• Review infrastructure such as alarms, sprinklers, and exits
• Promote compliance with fire safety norms
• Such drills have already shown impact in local initiatives. Additionally, capacity-building exercises will help administrators identify vulnerabilities and implement corrective measures.

Recognizing the increasing need to strengthen preparedness and ensure continuity of healthcare services during emergencies, the Health Ministry has also developed the National Guidelines on Fire and Life Safety in Healthcare Facilities (2026). This is a revised version of the Fire and Life Safety Guideline (2020).

What Do The Revised Guidelines Say

The primary objective of the guidelines is to provide a standardized and practical framework to strengthen fire prevention and response mechanisms in healthcare facilities. Key features of the revised guidelines include:

• Strengthened governance framework: The 2026 guidelines introduce clearly defined institutional roles, responsibilities, and committee structures, strengthening accountability beyond the action-oriented approach of the 2020 guidelines.
• Introduction of structured risk assessment approach: The guidelines incorporate systematic fire hazard assessment and risk categorization, enabling prioritization of safety measures based on vulnerability.
• Improved patient-centric evacuation planning: It expands evacuation planning with specialized protocols for vulnerable patient groups such as ICU, NICU, PICU, and operation theatre patients.
• Expanded coverage of fire safety infrastructure systems: It provides more comprehensive guidance on fire detection, suppression, electrical safety, medical gas systems, HVAC integration, and smoke management.
• Training and capacity building framework: It formalizes structured training programs, mock drills, and role-based preparedness mechanisms for healthcare personnel.
• Inclusion of detailed operational annexures: It introduced expanded annexures covering unit-specific (ICU, NICU, etc.) safety practices, evacuation methods, and fire safety equipment requirements.
• Strengthened institutional preparedness mechanisms: The guidelines integrate preparedness across governance, infrastructure, and response systems to enhance readiness during emergencies.
• Promotion of a safety-oriented organizational culture: It emphasizes continuous monitoring, periodic audits, and awareness activities to institutionalize long-term fire safety practices.

These guidelines are expected to:

• Strengthen fire safety preparedness across public and private healthcare facilities
• Reduce risk of fire-related incidents and associated loss of life
• Improve the safety of patients, healthcare workers, and visitors
• Enhance continuity of essential health services during emergencies
• Promote fire safety practices across states and union territories.

Amid rising obesity, early diabetes risk, and mental health issues among children, India has expanded its child health screening program to include behavioral disorders and non-communicable disease (NCD) risk factors.

The Ministry of Health and Family Welfare rolled out the screening measures under the revised Rashtriya Bal Swasthya Karyakram (RBSK) 2.0 guidelines.

The guidelines include steps to address mental health conditions and early risk factors for diseases such as diabetes and hypertension. These were released at the recently concluded National Summit on Good Practices and Innovations in Public Healthcare Service Delivery.

The screening services are free and will be delivered through mobile health teams at Anganwadi centers and schools, ensuring universal outreach and early identification.

What Does The RBSK 2.0 Guideline Include?

• The guidance document establishes, for the first time, a structured and standardized national framework for the screening, diagnosis, treatment, and long-term management of childhood diabetes. It calls for universal screening of all children from birth to 18 years.

• Suspected cases will undergo immediate blood glucose testing and timely referral to district-level health facilities for confirmatory diagnosis and treatment.

• A free-of-cost care package will be available at public health facilities. This includes screening, diagnostic services, lifelong insulin therapy, monitoring devices such as glucometers and test strips, and regular follow-up care. This will reduce the financial burden and ensure uninterrupted treatment for children diagnosed with diabetes.

• The initiative promotes the “4Ts” awareness framework—Toilet, Thirsty, Tired, and Thinner—enabling parents, teachers, and caregivers to recognize early warning signs of Type 1 diabetes.

• The document also emphasizes the need to provide structured training on insulin administration, blood glucose monitoring, emergency response, and daily disease management. It outlines evidence-based treatment guidelines, regular monitoring schedules, and protocols for preventing complications.

• RBSK 2.0 introduces digital health cards, real-time data systems, and integrated platforms for tracking, monitoring, and service delivery. These digital innovations are expected to enhance program efficiency, accountability, and evidence-based decision-making across all levels of implementation.

Signs Of Diabetes In Children

Children with Type 1 Diabetes Mellitus can develop diabetic ketoacidosis (DKA) if it is not diagnosed on time, since they are insulin-dependent.

Dr. Archana Arya, Senior Consultant Pediatric & Adolescent Endocrinologist at the Institute of Child Health, Sir Ganga Ram Hospital, New Delhi, told HealthandMe that DKA requires hospitalization for treatment, and if undiagnosed, it can lead to coma and death. Early diagnosis reduces morbidity and hospital admissions.

These children present with typical symptoms such as

• increased thirst,
• frequent urination,
• weight loss.

Type 2 Diabetes Mellitus may or may not present with typical symptoms, and children may develop long-term complications such as retinopathy and nephropathy if the condition goes undiagnosed for a prolonged period.

All overweight and obese children, especially those with a family history of Type 2 diabetes, those with acanthosis nigricans (thickened and dark skin behind the neck and underarms), and girls with PCOS are at high risk of developing Type 2 diabetes and should be screened annually to prevent complications.

The expert added that children with diabetes are at a higher risk of depression (2–3 times higher prevalence), anxiety, and suicidal ideation (in 8–27 percent of youth) due to dietary restrictions and the burden of multiple insulin injections in Type 1 diabetes. Diabetic youth are 1.7 times more likely to attempt suicide, often through insulin overdose.

Why Is The Initiative Important?

Dr. Seema Dhir, Unit Head & Senior Consultant, Internal Medicine, Artemis Hospitals, told HealthandMe that good health in early life is essential for preventing non-communicable diseases such as obesity, diabetes, and heart disease. Diabetes is often linked to poor lifestyle and health choices.

Early monitoring, detection, and effective management can reduce the growing burden of diabetes.

Dr. Munia Bhattacharya, Senior Consultant – Clinical Psychology, Mental Health and Behavioural Sciences, Marengo Asia Hospitals, Gurugram, emphasized that preventing non-communicable diseases like diabetes, heart disease, and obesity begins with maintaining both mental and physical well-being.

Providing mental support to children helps them cope better with stress and reduces the risk of anxiety, depression, and suicidal thoughts.

Children who are encouraged to express their feelings and seek help are less likely to experience anxiety, depression, and suicidal tendencies. Early awareness also builds coping skills, decision-making abilities, and healthier lifestyles—paving the way for long-term well-being and a more balanced, confident future.