The US Food and Drug Administration has approved TNKase or Tenecteplase, which is a thrombolytic or clot-dissolving agent, for the treatment of acute ischemic stroke in adults.

Ischemic strokes happen when a blood clot blocks a blood vessel in your brain. It can cause permanent brain damage and death. If enough brain cells die, you can also lose the abilities or body functions those cells control. They are also the most common types of stroke, with 80% of all strokes being ischemic strokes.

How is TNKase administered?

It is delivered as a single five-second intravenous bolus, which is faster than the standard of care Activase or alteplase, which is administered as an intravenous bolus followed by a 60-minute infusion. The manufacturer of TNKase, Genetech said a new 25-mg vial configuration will also be available in the coming months.

How Was TNKase approved?

The approval came at the backdrop of a study that compared TNKase to Activase in patients with acute ischemic stroke. These patients also presented with a disabling neurological deficit. Results show that TNKase was comparable to Activase in terms of efficacy and safety.

How Common Are These Strokes?

In the United States it self, it affects more than 795,000 people each year and is the leading cause of long-term disability. It is also the fifth leading cause of death. Since brain damage can happen if this progresses rapidly, one needs an immediate, fast-acting medical care.

TNKase thus provide a faster and simpler administration which can be critical for anyone. The chief medical officer and head of global product development at Genetech, Levi Garraway, MD., PhD., said, "Today's approval is a significant step forward and underscores our commitment to advancing stroke treatment options for patients."

What Are The Symptoms Of Ischemic Strokes?

Some of the most common symptoms include weakness or paralysis on one side of your face and body. You may also feel trouble speaking or have loss of speech, also known as aphasia. You may faced slurred or garbled speaking, also known as dysarthria. Other symptoms include loss of muscle control on one side of your face, or sudden worsening or loss of your senses, including vision, hearing, smell, taste, and touch.

Other symptoms include:

• Loss of coordination or clumsiness
• Blurry vision or double vision
• Dizziness or vertigo
• Nausea and vomiting
• Neck stiffness
• Mood swings or sudden personality changes
• Confusion or agitation
• Seizures
• Memory loss (amnesia)
• Headaches which are sudden and severe
• Passing out or fainting
• Coma

Are There Any Warning Signs?

While these are symptoms one has who is prone to this condition. However, often, many may confuse it with other illnesses. It is best to keep an eye out for warning signs. These could be looking out for yourself or your loved one. Note if there is a sudden loss of balance. Look out for sudden vision loss or changes in one or both eyes. Look for a droop on one or both sides of your face, especially when you smile. Raise both arms and see if one arm sags or drops in a way it usually does not. Note for your speech. Are you as fluent? Are you have trouble speaking? If you see any of such signs, start tracking it and talk to your healthcare provider.

The World Health Organization (WHO) has officially declared the hantavirus outbreak linked to the MV Hondius luxury cruise ship over after the last person being monitored completed quarantine without developing the disease.

Speaking at a media briefing on July 2, WHO Director-General Tedros Adhanom Ghebreyesus said the final person under observation tested negative after completing the recommended 42-day quarantine period for hantavirus exposure.

The individual has since returned home, and no additional infections have been detected since May 25.

"Today, the final contact of a person exposed to #hantavirus on the cruise ship MV Hondius completed their quarantine period, tested negative and returned home. No further cases have been reported since the 25th of May. Therefore, the WHO considers the hantavirus outbreak over," the WHO chief wrote on social media platform X.

The rat-borne virus outbreak infected 13 people and claimed three lives. It was caused by the Andes strain of hantavirus, which carries a risk of human-to-human transmission. There is currently no specific antiviral treatment or vaccine for the virus.

The Dutch-flagged ship departed from Ushuaia, Argentina, on April 1, visiting remote islands in the South Atlantic Ocean, including Tristan da Cunha, before heading to Tenerife in Spain's Canary Islands, where the remaining passengers were evacuated.

Also read: Can Hantavirus Spread Through Semen And Breast Milk? What Experts Say

Over 650 Contacts Traced Across 33 Countries

In an earlier post on X, Dr. Tedros said more than 650 contacts were identified and monitored by health authorities across 33 countries and territories.

"All but 54 contacts have completed their period of quarantine, and the remaining contacts are scheduled to complete their quarantine period by July 2," he told a press conference at WHO headquarters in Geneva.

"If no further cases are reported by then, WHO will consider the outbreak to be over," he added.

The WHO chief said the agency will continue efforts to better understand both the outbreak and the virus.

The UN health agency is working with partners who collected environmental samples from the ship and is coordinating a study among those exposed to better understand how the disease develops.

"We are also working on having a sample of the virus shared with the WHO BioHub in Switzerland," he said.

"This will be important for developing diagnostics, therapeutics, and vaccines for future outbreaks."

CDC Ends US Response

Meanwhile, the US Centers for Disease Control and Prevention (CDC) officially ended its hantavirus outbreak response on June 24.

The agency said none of the 18 Americans who were aboard the cruise ship became ill during the outbreak or the subsequent 42-day incubation period.

"The successful conclusion of this response demonstrates the strength of a coordinated response to infectious disease threats that occur outside of our borders," said CDC Acting Director Jay Bhattacharya in a statement.

"I am grateful for the world-class team at CDC, whose dedication and swift action helped identify potential exposures, provide clear guidance, and protect the American people. As a result, we prevented any new cases from arising in the US."

What Is Hantavirus?

According to the WHO, hantaviruses are zoonotic viruses that naturally infect rodents and are occasionally transmitted to humans.

Globally, an estimated 100,000 to 200,000 hantavirus infections occur each year, with the majority reported in Asia, particularly China. Most cases are sporadic or occur in small clusters linked to contact with infected rodents.

In humans, hantavirus infection can cause severe disease and may be fatal, although the clinical presentation varies depending on the virus strain and geographic region.

How Does Hantavirus Spread?

Hantavirus is primarily spread through contact with infected rodents, including exposure to:

• Urine
• Droppings
• Saliva
• Less commonly, scratches or bites from infected rodents.

Long COVID is a group of debilitating conditions that can persist for months or even years after infection with the SARS-CoV-2 virus, which causes COVID-19.

While scientists are still working to fully define the condition, one of the most common and disabling symptoms is brain fog—a cognitive impairment that can significantly affect people's personal and professional lives.

People with brain fog often report difficulty concentrating, multitasking, reading, remembering information, and speaking in full sentences. Fatigue frequently worsens these symptoms. Despite its widespread impact, there are currently no established diagnostic tests or approved treatments for long COVID-related cognitive impairment.

First Treatment For Brain Fog

A new clinical trial led by researchers at UCL now offers promising evidence that cognitive rehabilitation may provide lasting relief for these symptoms.

Published in JAMA Network Open, the study found that a 10-week cognitive rehabilitation program helped people with long COVID-related brain fog achieve meaningful improvements in returning to work, hobbies, and everyday activities.

The treatment consisted of weekly one-hour, one-to-one video sessions with a therapist who helped participants develop practical strategies to meet their personal rehabilitation goals. Most participants continued to benefit from the program for at least six months after treatment.

Also read: Natural Origin or Lab Leak? Gabbard Reignites COVID Origins Debate, Claims Fauci Funded Wuhan Lab Research

"As many as one in three people with COVID go on to develop long COVID, and cognitive difficulties are among the most common symptoms that can persist for months, disrupting day-to-day functioning and quality of life. People might find it hard to focus or hold on to their thoughts as they struggle with memory, attention and planning, often compounded by fatigue," said lead author Dr Martina Vanova, who completed the research at UCL before moving to Kingston University.

"In our study, we used well-established strategies of goal-oriented cognitive rehabilitation to help people develop ways to tackle the challenges that are most meaningful to them," Vanova added.

How Was The Study Conducted?

Read More: 1 in 6 Americans May Be Suffering From Long COVID, Study Finds

The study, funded by the National Institute for Health and Care Research (NIHR), included 78 participants in England who had experienced cognitive symptoms of long COVID for at least three months.

Half of the participants received the cognitive rehabilitation program, while the other half continued with standard NHS care, which varied by region.

Before treatment began, each participant completed an online goal-setting interview to identify three personal goals they wanted to achieve. Most goals focused on returning to work and improving job performance, while others involved everyday activities such as staying focused long enough to watch a full film or read a book.

Therapists then worked with participants to develop personalized strategies to help them achieve those goals.

What Did the Study Find?

Read: COVID-19 Vaccination Reduced Risk of Heart Attacks and Strokes in Elderly by 40%: Study

Three months after completing treatment, 84% of participants who received cognitive rehabilitation reported a significant improvement in goal attainment on a 10-point scale, compared with 53% of those receiving standard care.

The benefits were sustained over time. After six months, 53% of participants in the rehabilitation group reported a substantial improvement—defined as an increase of four or more points on the 10-point goal scale—compared with just 15% of those in the control group.

Researchers also observed measurable improvements in executive function, including better cognitive flexibility and faster processing speed.

Researchers also noted that early findings from a separate analysis suggest the program is cost-effective.

"We have found a treatment that provides clinically meaningful and sustained benefit for people with cognitive long COVID symptoms," said Joint senior author Dr Aida Suarez-Gonzalez of the UCL Queen Square Institute of Neurology.

"As this program is based on established cognitive rehabilitation techniques that have been used for other conditions, we hope that it can be easily rolled out as a treatment option for people currently living with long COVID."

For nearly eight decades, the U.S. Centers for Disease Control and Prevention (CDC) has been regarded as one of the world's leading public health institutions.

Established in 1946 to combat malaria, the public health agency has since evolved into a global authority and standard on infectious diseases, vaccinations, chronic illnesses, epidemics, emergency preparedness, health surveillance and much more.

However, the institute has undergone significant changes President Donald Trump returned to the White House in January 2025.

80 Years Of CDC

Since its inception in 1946, the CDC has led the response to numerous public health threats, including polio, HIV/AIDS, Ebola, Zika, H1N1 influenza, and the COVID-19 pandemic.

CDC scientists have spent decades shaping its long-standing vaccination programs and policies, disease tracking systems, and emergency responses during epidemics that have influenced public health policies and practices globally.

CDC Under Donald Trump’s Regime

As the institution completes eight decades, we take a look at how it has changed over time under Donald Trump’s administration. From changes in vaccination policies, reduction in workforce to a shuffle in leadership, CDC has undergone a tectonic shift.

While planning and preparedness for infectious disease has been a huge part of CDC's legacy, the current administration has increasingly focused on chronic diseases, nutrition, and environmental exposures.

Appointment of Robert F. Kennedy Jr. as HHS Secretary

One of the earliest and most controversial consequential decisions of the administration was the appointment of Robert F. Kennedy Jr. as Secretary of the U.S. Department of Health and Human Services (HHS).

Kennedy, who is a renowned anti-vaxxer, introduced different goals for federal public health, particularly on chronic disease prevention, environmental health, and greater scrutiny of long-standing vaccine policies.

Also read: Illinois Governor Claims Trump Continues To Suffer From Dementia

Soon after the administration took office, HHS was significantly restructured, with plans to consolidate many public health functions under a newly created Administration for a Healthy America.

Largest Staff Reduction In The History Of CDC

In February 2025, more than 1,300 employees of Centers for Disease Control and Prevention lost their jobs. Workforce restructuring was carried out in multiple departments in the following months.

Departments like outbreak surveillance, violence prevention, antibiotic resistance surveillance, Freedom of Information Act requests, and laboratory leadership programs were either downsized or eliminated.

Public health experts widely critcised the move, warning that the reductions could hamper the country’s ability to detect and respond quickly to future outbreaks.

Changes In Vaccine Policy

One of the healthcare sections that saw perhaps the biggest change under Trump’s administration was vaccination.

In June 2025, HHS dismissed all 17 members of the CDC's Advisory Committee on Immunization Practices (ACIP), the independent panel tasked for recommending how vaccines are used in the country.

Also read: New Book Examines Donald Trump's Health, Age Concerns; White House Responds

The committee was later recreated with new members. The move that drew criticism from several medical and scientific organisations. The administration revised several vaccine recommendations, particularly those relating to COVID-19, vaccination for healthy children and pregnant women.

The U.S. additionally withdrew its financial support for Gavi, the Vaccine Alliance. It also stopped hundreds of millions of dollars in federal funding for mRNA vaccine research, including projects involving COVID-19, influenza and RSV vaccines.

Changes In Gender-Related Healthcare Policies

Major changes were made in reproductive and gender-related healthcare policies. One of the most talked about was the Mexico City Policy, also known as the ‘global gag rule’. The move restricted U.S. funding for non-government organisations that provide abortion services.

Insurance coverage and funding for gender-affirming healthcare was withdrawn. Several LGBTQ+ references were removed from many federally supported health programs, which sparked widespread outrage.

Changes In Leadership

Susan Monarez was appointed as CDC Director in 2025. But her stint was short-lived after she was dismissed later that year. Reports stated that disagreements over vaccine recommendations led to the leadership dispute. Several senior CDC officials also resigned after Monarez’s exit.

Trump supporters support these changes as they believe they are a part of a long-overdue overhaul of an institution they believe had grown too bureaucratic and too reliant on established scientific principles.

However, many public health experts argue that the changes have affected scientific independence, disrupted long-standing public health programs, and altered the CDC's traditional role as a reliable evidence-driven body.