The US Food and Drug Administration has approved TNKase or Tenecteplase, which is a thrombolytic or clot-dissolving agent, for the treatment of acute ischemic stroke in adults.

Ischemic strokes happen when a blood clot blocks a blood vessel in your brain. It can cause permanent brain damage and death. If enough brain cells die, you can also lose the abilities or body functions those cells control. They are also the most common types of stroke, with 80% of all strokes being ischemic strokes.

How is TNKase administered?

It is delivered as a single five-second intravenous bolus, which is faster than the standard of care Activase or alteplase, which is administered as an intravenous bolus followed by a 60-minute infusion. The manufacturer of TNKase, Genetech said a new 25-mg vial configuration will also be available in the coming months.

How Was TNKase approved?

The approval came at the backdrop of a study that compared TNKase to Activase in patients with acute ischemic stroke. These patients also presented with a disabling neurological deficit. Results show that TNKase was comparable to Activase in terms of efficacy and safety.

How Common Are These Strokes?

In the United States it self, it affects more than 795,000 people each year and is the leading cause of long-term disability. It is also the fifth leading cause of death. Since brain damage can happen if this progresses rapidly, one needs an immediate, fast-acting medical care.

TNKase thus provide a faster and simpler administration which can be critical for anyone. The chief medical officer and head of global product development at Genetech, Levi Garraway, MD., PhD., said, "Today's approval is a significant step forward and underscores our commitment to advancing stroke treatment options for patients."

What Are The Symptoms Of Ischemic Strokes?

Some of the most common symptoms include weakness or paralysis on one side of your face and body. You may also feel trouble speaking or have loss of speech, also known as aphasia. You may faced slurred or garbled speaking, also known as dysarthria. Other symptoms include loss of muscle control on one side of your face, or sudden worsening or loss of your senses, including vision, hearing, smell, taste, and touch.

Other symptoms include:

• Loss of coordination or clumsiness
• Blurry vision or double vision
• Dizziness or vertigo
• Nausea and vomiting
• Neck stiffness
• Mood swings or sudden personality changes
• Confusion or agitation
• Seizures
• Memory loss (amnesia)
• Headaches which are sudden and severe
• Passing out or fainting
• Coma

Are There Any Warning Signs?

While these are symptoms one has who is prone to this condition. However, often, many may confuse it with other illnesses. It is best to keep an eye out for warning signs. These could be looking out for yourself or your loved one. Note if there is a sudden loss of balance. Look out for sudden vision loss or changes in one or both eyes. Look for a droop on one or both sides of your face, especially when you smile. Raise both arms and see if one arm sags or drops in a way it usually does not. Note for your speech. Are you as fluent? Are you have trouble speaking? If you see any of such signs, start tracking it and talk to your healthcare provider.

India's neighbor in the east, Bangladesh, is facing the worst of a crisis in the form of a massive measles outbreak. As per media reports, measles in Bangladesh has taken 545 lives. Facing this growing challenge, the authorities are in complete disarray.

The nation has been struggling with the disease almost from the beginning of the year, but as of now, the situation has worsened and appears as one of the worst outbreaks of measles since the inception of the country in 1971.

According to the local media, the country has a total of 458 suspected deaths and 87 confirmed deaths linked to measles since mid-March of this year. On the other hand, Bangladesh has seen 64,940 suspected measles cases and 8,719 confirmed infections in the same period.

The Directorate General of Health Services (DGHS) of Bangladesh has said that since the 15th of March, the number of admitted patients with measles was 51,585. This information was directly released by the Health Emergency Operations Center and Control Room, which is under the authority of DGHS.

Why The Measles Cases Are On The Rise In Bangladesh?

The United Nations Children’s Fund (UNICEF) said that gaps in immunization worsened during and after the 2024 student-led uprising that toppled the government, leaving large numbers of children unprotected. UNICEF emphasized the need to boost vaccination programmes and provide more funding for health facilities in the future.

Why The Situation Can Go South From Here?

Bakrid or Eid al-Adha is an occasion that is widely celebrated in Bangladesh. This Eid usually sees massive gatherings and festivities. As measles is a highly contagious disease, the chances of spreading the disease during the festivities are very likely. The public health experts and doctors are warning against attending mass gatherings. Other than that, usual long-distance travel and family visits during Eid holidays could spread the disease at an exorbitant pace.

What Is Measles?

Measles is a highly contagious virus that spreads through direct contact or through the air when an infected person coughs or sneezes. It is a vaccine-preventable disease that can cause devastating complications, including blindness, pneumonia, encephalitis, and long-term immune dysfunction.

Symptoms usually appear in 7 to 14 days after exposure and may include:

• high fever,
• cough,
• runny nose,
• red eyes,
• rashes across the body.

How To Stay Safe From Measles?

• Maintaining good hygiene, such as frequent handwashing and covering the mouth while coughing or sneezing, helps reduce transmission.

• Avoiding close contact with infected individuals and ensuring proper nutrition to boost immunity are also important.

• Public awareness and community health programs play a crucial role in prevention.

When it comes to weight loss, many try their own ways to drop the extra kilos. While portion control is advised, there are many who turn to starvation just to drop the extra kilos. In 2016, Japanese scientist Yoshinori Ohsumi won the Nobel Prize for his findings on autophagy. These findings facilitated a better understanding of conditions like dementia and Parkinson's disease. Autophagy refers to natural regeneration, which occurs at a cellular level. It reduces the chances of contracting diseases while also increasing lifespan.

Since then, drugmakers have been working towards coming up with a drug that can stimulate the process; wellness and diet experts have been willing to find a way to naturally induce the process by restricting carbs, fasting, and engaging in high-intensity exercise.

What do scientists have to say?

Experiments were also conducted on mice, and it was found that the ones who were put on genetic tools, fasting, or drugs had a tendency to live longer and remain in better overall shape. However, it is still unclear how the same effect can be replicated in humans. In mice, for instance, the effects of fasting on the brain are evident within 24 hours. In other body parts, such as the liver, the effects occur more quickly. Despite knowing that fasting is good for health, experts are unsure about the ideal duration of fasting for maximum health benefits. Researchers say that fasting does not induce autophagy, but it does have other health benefits.

What is autophagy?

Autophagy is derived from "self" and "phagein," which means "to eat." The process involves cells degrading and recycling their components. It provides fuel for energy and building blocks for cell renewal. Post-infection, it can destroy viruses and bacteria. Cells use the process to get rid of damaged organelles and proteins, and it helps counteract the adverse effects of ageing.

Autophagy was discovered in the 1960s, but its importance was recognised after Yoshinori Ohsumi's research. Researchers said that what they discovered protected against diseases like Huntington's, Parkinson's, and some forms of dementia. It also seemed beneficial in the context of infection control, along with protecting against excessive inflammation. New lifestyle books now suggest that the process can be switched on by making changes to diet and lifestyle or by observing a fast.

The impact on muscle mass

A book titled Glow 15 by Naomi Whittel shares a 15-day programme including 16-hour fasts three times a week. It shares a plan that reduces protein intake on some days, involves eating carbs later, and combines all this with high-intensity exercise. In the basic tests themselves, volunteers at Jacksonville University in Florida experienced several health benefits. Some of the participants lost about 3.5 kilos in 15 days. Others saw improvements in lean muscle mass, blood pressure, and a reduction in fine lines. Researchers said that none of these changes could cause harm to health.

Is fasting safe for all?

Researchers note that fasting too much is not a good idea for anyone. Before making drastic or major changes to lifestyle or diet, it is advised to check with a doctor first. Experts look at autophagy with optimism, and studies show that proteins together form clumps in the nerve cells of Alzheimer's and Parkinson's patients.

US President Donald Trump is expected to undergo his annual medical check-up today – his third in his second term as the oldest American President.

Trump, who turns 80 next month, will see his doctors at the Walter Reed National Military Medical Center on May 26, the White House had said in a brief statement.

The White House added that the visit will involve “routine annual dental and medical assessments as part of his regular preventive health care” but did not offer additional details on the medical exam.

His previous annual check-up was in April 2025. In October, he underwent another check-up.

“You have five doctors sitting there and … the questions are very easy at the beginning, then pretty easy, then pretty hard by the time you get to the end, there are not a lot of people in the room who can get them, believe me,” Trump informed the crowd at a rally in New York state last week, about the impending test, The Times reported.

“So the first question was, you have a bear, a snake, an elephant, and a horse. Name the horse. That’s the horse. The second question is a little tougher,” he said.

“Toward the end, they had a question like, pick a number, sir, any number. OK. 203. Multiply times nine, divided by two, add 1324, subtract 1292. Sir, multiply it out one more time by 19. What is the answer, sir? I got it right … and the one doctor said, I’ve been doing this test for 20 years, I’ve never seen anybody ace it. … So I’ve taken it, and I’ve aced it all three times, I’ll tell you, because it is a positive thing.”

Trump’s Health Checkups

Also read: ‘Sea Or See?’ Donald Trump's Remark Sparks Fresh Cognitive Health Speculation

The first visit was reported last April, when Trump had a check-up after noticing what the White House described as “mild swelling” in his lower legs. Tests by the White House medical unit found that Trump had chronic venous insufficiency, a condition common in older adults that causes blood to pool in the veins.

During the medical exam in October, which the White House called a “semiannual physical,” he also received his yearly flu shot and a COVID-19 booster vaccine. He later told The Wall Street Journal that he underwent advanced imaging on his heart and abdomen in October as preventive screening.

The upcoming evaluation follows two other recent visits to a local dentist near his estate in Florida, where Trump often spends his weekends.

Trump In 'Excellent Health'

The president’s health has been the subject of intense scrutiny — ranging from his mental state to visible bruising around his hands.

Trump — who has frequently criticized former President Joe Biden over age-related health and fitness issues — has recently remarked on how good he feels despite his age.

Read More: Vanessa Trump Reveals Breast Cancer Diagnosis

Trump said he feels the same as he did 50 years ago. “I feel literally the same,” he said at an Oval Office event. “I don’t know why. It’s not because I eat the best foods,” AP reported.

He also joked about his exercise regimen, saying that he works out “like about one minute a day, max.”

According to a White House summary of his previous annual medical examination in April last year, Trump was found to be in “excellent cognitive and physical health”.

“A comprehensive neurological examination revealed no abnormalities in his mental status, cranial nerves, motor and sensory functions, reflexes, gait, and balance. Cognitive function, assessed using the Montreal Cognitive Assessment (MoCA), was normal with a score of 30 out of 30,” his White House physician, Captain Sean Barbabella, wrote.

There were tests for depression and anxiety, and Trump recorded a score “within the normal range for both,” although numbers were not given.

Scans in October also demonstrated that Trump is in “excellent overall health”.