The US Food and Drug Administration has approved TNKase or Tenecteplase, which is a thrombolytic or clot-dissolving agent, for the treatment of acute ischemic stroke in adults.

Ischemic strokes happen when a blood clot blocks a blood vessel in your brain. It can cause permanent brain damage and death. If enough brain cells die, you can also lose the abilities or body functions those cells control. They are also the most common types of stroke, with 80% of all strokes being ischemic strokes.

How is TNKase administered?

It is delivered as a single five-second intravenous bolus, which is faster than the standard of care Activase or alteplase, which is administered as an intravenous bolus followed by a 60-minute infusion. The manufacturer of TNKase, Genetech said a new 25-mg vial configuration will also be available in the coming months.

How Was TNKase approved?

The approval came at the backdrop of a study that compared TNKase to Activase in patients with acute ischemic stroke. These patients also presented with a disabling neurological deficit. Results show that TNKase was comparable to Activase in terms of efficacy and safety.

How Common Are These Strokes?

In the United States it self, it affects more than 795,000 people each year and is the leading cause of long-term disability. It is also the fifth leading cause of death. Since brain damage can happen if this progresses rapidly, one needs an immediate, fast-acting medical care.

TNKase thus provide a faster and simpler administration which can be critical for anyone. The chief medical officer and head of global product development at Genetech, Levi Garraway, MD., PhD., said, "Today's approval is a significant step forward and underscores our commitment to advancing stroke treatment options for patients."

What Are The Symptoms Of Ischemic Strokes?

Some of the most common symptoms include weakness or paralysis on one side of your face and body. You may also feel trouble speaking or have loss of speech, also known as aphasia. You may faced slurred or garbled speaking, also known as dysarthria. Other symptoms include loss of muscle control on one side of your face, or sudden worsening or loss of your senses, including vision, hearing, smell, taste, and touch.

Other symptoms include:

• Loss of coordination or clumsiness
• Blurry vision or double vision
• Dizziness or vertigo
• Nausea and vomiting
• Neck stiffness
• Mood swings or sudden personality changes
• Confusion or agitation
• Seizures
• Memory loss (amnesia)
• Headaches which are sudden and severe
• Passing out or fainting
• Coma

Are There Any Warning Signs?

While these are symptoms one has who is prone to this condition. However, often, many may confuse it with other illnesses. It is best to keep an eye out for warning signs. These could be looking out for yourself or your loved one. Note if there is a sudden loss of balance. Look out for sudden vision loss or changes in one or both eyes. Look for a droop on one or both sides of your face, especially when you smile. Raise both arms and see if one arm sags or drops in a way it usually does not. Note for your speech. Are you as fluent? Are you have trouble speaking? If you see any of such signs, start tracking it and talk to your healthcare provider.

A biryani feast followed by a serving of watermelon proved deadly for a family of four in Mumbai on Sunday. The incident was reported from the Pydhonie area, where an entire family passed away after eating biryani for dinner and some watermelon before calling it a night. They had watermelon around 1.00 am or 1.30 am, and their condition started to deteriorate around 5.00 am. They all experienced diarrhoea and nausea and eventually passed away. The mystery now remains: was it a case of accidental watermelon poisoning or something else? Abdullah Dokadia (40), his wife Nasreen Dokadia (35), and their two daughters, Ayesha (16) and Zainab (13), lost their lives, and the police are currently suspecting it to be a case of food poisoning. But can eating watermelon really kill you? Let us find out.

What are the signs of watermelon poisoning?

Watermelon is a popular summer fruit that people enjoy eating during the hotter months. It is 70 per cent water, highly hydrating, and also beneficial for weight loss. However, going overboard is discouraged by doctors, as overeating or consuming adulterated watermelon can lead to abdominal discomfort and digestive distress. Watermelon-related food poisoning can occur because of E. coli or salmonella infections. It can cause rapid dehydration, diarrhoea, cramps, fever, weakness, and, in extreme cases, even death.

What happens when you eat too much watermelon?

Dr Aarti Ullal, Physician and Diabetologist at Gleneagles Hospital, Parel, in an interaction with Health and Me, said, “Eating too much watermelon may lead to bloating, stomach discomfort, or loose motions, mainly because of its high water and natural sugar content. In some individuals, especially those with sensitive digestion, it can also cause acidity or mild cramps and disturb their peace of mind.”

Dr Ullal also stated that watermelon poisoning can occur when the fruit is contaminated with pesticides, chemicals, or bacteria due to poor handling or improper storage. The symptoms may include nausea, vomiting, abdominal pain, diarrhoea, and weakness. These are typically short-term digestive issues but may require medical attention if severe or if they interfere with daily routine. However, questions also arise regarding watermelon allergies. Watermelon allergy is rare and may cause itching in the mouth, swelling, rashes, or stomach upset soon after consumption.

How to check if your watermelon is adulterated?

To check if a watermelon is adulterated, look for an unnaturally bright red colour, cracks, a chemical smell, or an overly soft texture. Always wash the outer surface, as it may contain pesticides or chemicals, before cutting. Make sure to buy from trusted sources to avoid any health issues. Watermelon is safe and healthy to consume, but moderation and proper hygiene are key.

Can eating a watermelon kill you?

Conclusively, it can be said that eating a watermelon specifically should not cause deaths. However, if you bring the fruit home, it is advised to check it for signs of adulteration before consuming. It helps eliminate the possibility of side effects, just in case. However, if you experience food poisoning-like symptoms, consult a doctor immediately.

Viral hepatitis B and C – responsible for 95 per cent of hepatitis-related deaths worldwide – caused 1.3 million deaths worldwide, according to the Global Hepatitis Report 2026, released today by the World Health Organization.

Of these, 1.1 million people died from hepatitis B and 240,000 from hepatitis C. Liver cirrhosis and hepatocellular carcinoma were the main causes of hepatitis related deaths, stated the report released at the World Hepatitis Summit.

Further, India emerged among the 10 countries that account for 69 per cent of global hepatitis B-related deaths. The country is also among the 10 countries contributing to 58 per cent of hepatitis C-related deaths worldwide.

The Global Hepatitis Burden And Treatment Gap

Despite being preventable and treatable, transmission of hepatitis continues, with more than 4,900 new infections every day, or 1.8 million each year.

As per the WHO report, a whopping 287 million people were living with chronic hepatitis B or C infection in 2024.

The same year, 0.9 million people were newly infected with hepatitis B.

The WHO African Region accounted for 68 per cent of new hepatitis B infections, yet only 17 per cent of newborns in the region received the hepatitis B birth-dose vaccination.

Another 0.9 million hepatitis C infections were recorded in 2024. People who inject drugs accounted for 44 per cent of new infections, highlighting the urgent need for stronger harm reduction services and safe injection practices.

Of the 240 million people with chronic hepatitis B in 2024, fewer than 5 per cent were receiving treatment. Similarly, only 20 per cent of people with hepatitis C have been treated since 2015.

Hepatitis: Measurable Gains

Notably, global efforts to combat viral hepatitis have also delivered measurable progress in reducing infections and deaths since 2015.

The annual number of new hepatitis B infections has dropped by 32 per cent, and hepatitis C-related deaths have fallen by 12 per cent globally.

Hepatitis B prevalence among children under five has also decreased to 0.6 per cent, with 85 countries achieving or surpassing the 2030 target of 0.1 per cent.

“Around the world, countries are showing that eliminating hepatitis is not a pipedream, it's possible with sustained political commitment, backed by reliable domestic financing,” said Dr Tedros Adhanom Ghebreyesus, WHO Director-General.

“At the same time, this report shows that progress is too slow and uneven. Many people remain undiagnosed and untreated due to stigma, weak health systems, and inequitable access to care. While we have the tools to eliminate hepatitis as a public health threat, urgent scale-up of prevention, diagnosis, and treatment is needed if the world is to meet the 2030 targets,” he added.

Hepatitis: How To Prevent

The report noted that highly effective tools to combat hepatitis infections are already available. These include the hepatitis B vaccine, which protects more than 95 per cent of vaccinated people against both acute and chronic infections.

Further, the long-term antiviral treatment for hepatitis B can also help effectively manage chronic infection and prevent severe liver disease. Another is the Hepatitis C short-course curative therapy which lasts 8-12 weeks and can cure more than 95 per cent of infections.

The report identifies priority actions to accelerate hepatitis elimination as a public health threat. These include:

• Scaling up treatment for chronic hepatitis B infection,
• Stronger political commitment and financing,
• Improved coverage of hepatitis B birth-dose vaccination
• Expanded antiviral prophylaxis to prevent mother-to-child transmission of HBV infection
• Improve injection safety in both health-care settings and community practices.

Weight-loss drugs like Ozempic have gained prominence in a short period of time. Now, Ozempic, Mounjaro, and Wegovy have become household names, especially for patients with diabetes and obesity. There is now a new name in the market that is gaining attention, even though it has not yet been approved. Retatrutide is a new injectable peptide that is being described as the next big thing in weight loss. Some are claiming that it might be more powerful than Wegovy or Ozempic, the most popular drugs so far. But what makes it stronger or sets it apart? It is the way Retatrutide works.

What is Retatrutide?

Retatrutide, also known as 'reta,' is a peptide that is currently being tested in clinical trials for weight-loss purposes. Despite not being approved for use anywhere in the world yet, it is making its way through online markets. The peptide is currently in clinical trials. Peptides are short chains of amino acids that can reduce inflammation and aid healing.

How does Retatrutide support weight loss?

For weight loss, retatrutide acts on three hormone pathways that affect metabolism, appetite, and blood sugar levels. GLP-1 is the first hormone, which reduces appetite and slows down the rate at which food leaves the stomach. The second is GIP, which regulates fat storage and blood sugar. The third is glucagon, which manages blood sugar. By working on these three hormones, Retatrutide reduces how much one eats and influences how much fat the body burns.

Read more: Shocking! Study Claims Weight Loss Drugs Cause More Muscle Loss Than Expected

The results from early trials were impressive—retatrutide performed much better for weight loss compared to its counterparts. In a 2023 trial, patients who were given a higher dose of the drug experienced 20 per cent more weight loss over 48 weeks. However, the trials were conducted in controlled clinical settings under medical supervision and on selected patients with regulated dosing. At present, people are buying the drug online and using it without medical supervision.

The effect of Retatrutide on gym-goers

A weekly dose of Retatrutide can support fat loss and suppress appetite. As a result, one can lose a significant amount of weight quickly and appear leaner and more defined, but rapid weight loss does not necessarily mean fat loss. It could also involve muscle mass, especially if one is not consuming enough protein or engaging in resistance training. As a result, gym-goers may lose weight faster. However, the psychological aspect is concerning. Appetite suppression can make it easier to eat clean, but it may take away the enjoyment of eating. Research suggests that retatrutide can affect mood, relationships, and motivation, although scientists are unsure why this happens.

What are the side effects of Retatrutide?

Current research shows that retatrutide can have several side effects, the most common being gastrointestinal—diarrhoea, nausea, vomiting, and constipation. The symptoms may be mild for some and severe for others. At present, at least one death has been reported due to drug use—the patient developed severe diarrhoea, and the case is currently being investigated.

How does retatrutide affect mental health?

Some media reports suggest that peptides like retatrutide affect more than just appetite—the medication acts on brain pathways involved in motivation and reward. This can influence one’s desire to eat food or drink alcohol. Research also indicates that it may affect libido and make individuals feel detached or emotionally flat in relationships.