The US Food and Drug Administration has approved TNKase or Tenecteplase, which is a thrombolytic or clot-dissolving agent, for the treatment of acute ischemic stroke in adults.

Ischemic strokes happen when a blood clot blocks a blood vessel in your brain. It can cause permanent brain damage and death. If enough brain cells die, you can also lose the abilities or body functions those cells control. They are also the most common types of stroke, with 80% of all strokes being ischemic strokes.

How is TNKase administered?

It is delivered as a single five-second intravenous bolus, which is faster than the standard of care Activase or alteplase, which is administered as an intravenous bolus followed by a 60-minute infusion. The manufacturer of TNKase, Genetech said a new 25-mg vial configuration will also be available in the coming months.

How Was TNKase approved?

The approval came at the backdrop of a study that compared TNKase to Activase in patients with acute ischemic stroke. These patients also presented with a disabling neurological deficit. Results show that TNKase was comparable to Activase in terms of efficacy and safety.

How Common Are These Strokes?

In the United States it self, it affects more than 795,000 people each year and is the leading cause of long-term disability. It is also the fifth leading cause of death. Since brain damage can happen if this progresses rapidly, one needs an immediate, fast-acting medical care.

TNKase thus provide a faster and simpler administration which can be critical for anyone. The chief medical officer and head of global product development at Genetech, Levi Garraway, MD., PhD., said, "Today's approval is a significant step forward and underscores our commitment to advancing stroke treatment options for patients."

What Are The Symptoms Of Ischemic Strokes?

Some of the most common symptoms include weakness or paralysis on one side of your face and body. You may also feel trouble speaking or have loss of speech, also known as aphasia. You may faced slurred or garbled speaking, also known as dysarthria. Other symptoms include loss of muscle control on one side of your face, or sudden worsening or loss of your senses, including vision, hearing, smell, taste, and touch.

Other symptoms include:

• Loss of coordination or clumsiness
• Blurry vision or double vision
• Dizziness or vertigo
• Nausea and vomiting
• Neck stiffness
• Mood swings or sudden personality changes
• Confusion or agitation
• Seizures
• Memory loss (amnesia)
• Headaches which are sudden and severe
• Passing out or fainting
• Coma

Are There Any Warning Signs?

While these are symptoms one has who is prone to this condition. However, often, many may confuse it with other illnesses. It is best to keep an eye out for warning signs. These could be looking out for yourself or your loved one. Note if there is a sudden loss of balance. Look out for sudden vision loss or changes in one or both eyes. Look for a droop on one or both sides of your face, especially when you smile. Raise both arms and see if one arm sags or drops in a way it usually does not. Note for your speech. Are you as fluent? Are you have trouble speaking? If you see any of such signs, start tracking it and talk to your healthcare provider.

Officials at the US Food and Drug Administration have blocked publication of several studies supporting the safety of widely used vaccines against COVID-19 and shingles in recent months, according to a spokesman for the Department of Health and Human Services (HHS).

While the studies found serious side effects to be very rare, the HHS said they were pulled over concerns about their conclusions. These withdrawals aim to limit access to vaccines, reflecting broader policy changes under US Health Secretary Robert F. Kennedy Jr., a staunch critic of vaccines.

"The studies were withdrawn because the authors drew broad conclusions that were not supported by the underlying data. The FDA acted to protect the integrity of its scientific process and ensure that any work associated with the agency meets its high standards," said Andrew Nixon, a spokesman for the HHS, which oversees the FDA, in an email to Reuters.

The last one year of Trump administration, along with Kennedy as the head of the HHS, saw significant cut in research funding for vaccine development. It also fueled doubt on vaccines, and blocked other information supporting their safety.

The list includes research on COVID vaccine effectiveness by scientists from the Centers for Disease Control and Prevention (CDC).

In October, the scientists were directed to withdraw two COVID vaccine studies that had been accepted for publication in medical journals. Further, in February, top FDA officials did not sign off on submitting abstracts about studies of Shingrix, a shingles vaccine, to a major drug safety conference.

“The design of that study fell outside the agency’s purview,” Nixon said on rejecting the shingles vaccine. He did not address a question about the Shingrix safety study, which found the vaccine to be safe.

Also read: Donald Trump’s 'Squirrel' Remark Fuels Debate Over Brain Health And Cognitive Tests

HHS Under Kennedy: Science And Vaccine Takes A Back Seat

In June 2025, his office asked CDC staff members to delete from the agency’s website a 17-page summary supporting the safety of thimerosal, an additive largely removed from vaccines 25 years ago.

Further, in August, Kennedy called the journal Annals of Internal Medicine to “immediately retract” a large Danish study concluding that the vaccine additive aluminum salts were safe. However, the study was not retracted.

Recently, Dr. Jay Bhattacharya, who was serving as interim leader of the CDC, canceled the publication of a report concluding that the Covid vaccine sharply cut the odds of hospitalizations and emergency room visits last winter, saying the study had limitations.

“At a moment when public trust in institutions like the CDC is fragile, we cannot afford to lower our standards,” Dr. Bhattacharya wrote in an editorial about news coverage of his decision.

Read More: Medical Miracle: World First Frozen Testicular Implant Gives ‘Infertile’ UK Man Hope of Fatherhood

Last June, a CDC panel backed by Kennedy voted to remove the mercury-based preservative thimerosal from flu shots, despite long-standing clinical evidence of its safety.

In August 2025, the HHS said it would wind down nearly $500 million in mRNA vaccine development, canceling 22 federal projects overseen by the Biomedical Advanced Research and Development Authority (BARDA), a government-backed funding body.

Other vaccines, including flu and hepatitis A, were also removed from routine recommendations. He also directed the CDC to stop recommending the vaccine for healthy pregnant women and children.

While President Donald Trump has boasted about his ability to correctly identify a squirrel on a cognitive screening test, his remarks have sparked debate about such tests. They also highlight misconceptions, raise awareness about brain health, and underscore the importance of screening.

Speaking on Monday at the White House Small Business Summit, Trump said he has taken the Montreal Cognitive Assessment three times and “aced each one,” claiming a doctor told him it was the first time they had seen a perfect score, The Daily Beast reported.

The US President said he answered the test questions easily, suggesting he is cognitively in good condition—a claim that critics have repeatedly questioned.

“The first question is very easy,” he said. “You have a lion, a bear, an alligator, and a—what’s another good…? A squirrel. Which is the squirrel?” He added that the difficulty increases as the test progresses. “By the time you get to the middle, they’re very tough.”

However, the test’s creator, Canadian neurologist Ziad Nasreddine, has challenged Trump’s claims. “It wasn’t designed to be a test of IQ,” he told nine.com.au. “It was designed to assess normal cognitive performance.”

The average score is 26 out of 30. Nasreddine said about 10 percent of people of Trump’s age achieve a perfect result. “I think he’s proud that he can demonstrate that his cognition is fine,” he added.

“President Trump is the sharpest and most accessible President in American history, working nonstop to solve problems and deliver on his promises, and he remains in excellent health,” White House spokesman Davis Ingle said, as quoted by The Daily Beast.

What Is The Montreal Cognitive Assessment?

The Montreal Cognitive Assessment is a short clinical screening tool used in roughly 200 countries to detect signs of cognitive impairment, including Alzheimer’s disease and dementia.

It includes tasks such as:

• Drawing a clock
• Recalling words
• Identifying the date and location

Does The test Signal Mental Ability?

Also read: Donald Trump’s Weekend Dental Appointment Triggers Fresh Health Concerns

The test is intentionally easy for healthy adults. It is designed to detect deficits—particularly in short-term memory, attention, and language—rather than measure intelligence.

A perfect score confirms the absence of obvious impairment. However, it does not indicate exceptional mental ability. Nasreddine also noted that the test is intended to be administered by professionals, not self-conducted.

As the oldest person elected president of the United States, Trump’s mental and physical health has been under public scrutiny.

While concerns about his mental health were raised during his first presidency (2017–2021), they have intensified in the past 15 months of his second presidency.

According to experts, Trump has displayed behaviors such as seeking “great adulation” and becoming “angry if reality does not meet his needs,” BMJ reported.

Trump’s Dipping Image Among Americans

Read More: Donald Trump’s Discolored Left Hand Triggers Health Speculation: Expert Explains

Nearly 60 percent of Americans are questioning whether Trump is healthy enough to serve in the Oval Office, according to a Washington Post–ABC News–Ipsos poll.

Alongside dissatisfaction with his leadership on the Iran war, the economy, and inflation, a growing share of Americans are also questioning his mental acuity.

Nearly 6 in 10 say he lacks the mental sharpness for the role, while 55 percent say he is not in good enough physical health to serve effectively.

Nathan Crawford from the UK was just 9-years-old when his testicular tissue was frozen, before undergoing chemotherapy for his brain tumor.

About 16 years later, the cryopreserved immature testicular tissue was reintroduced into his body, which triggered sperm cell production and restored his fertility, according to researchers from the Vrije Universiteit Brussel.

“This is an important step in further scientific research to preserve the fertility of children with cancer or other blood diseases for the future. While the procedure is specifically designed to restore fertility, we cannot at this time guarantee that it will be successful or that patients can go on to have children. This treatment offers lots of perspectives for these young adults. They now have options that they did not have until recently,” said Dr Veerle Vloeberghs, part of the novel trial and staff member at Brussels IVF.

What Had Happened To Nathan

Nathan, now 27-years-old, had a type of tumor called a glioma, which develops from the glial cells that support the nerve cells of the brain, The Guardian reported. The tumor was so close to vital brain tissue that surgeons were unable to remove it without causing serious damage to important brain functions.

He underwent radiotherapy and chemotherapy to shrink his tumor, before which surgeons at the John Radcliffe hospital in Oxford in a keyhole surgery removed and froze a wedge of testicular tissue, with the aim that it is one day re-implanted into Nathan.

How Is The Testicular Tissue Preserved?

While Chemotherapy and radiation therapy are lifesaving they can destroy testicular stem cells, the precursors of sperm cells in boys who undergo radical treatments before starting puberty. As it can affect their fertility, preventively removing and freezing testicular tissue is an option pioneered by UZ Brussel.

In 2002, UZ Brussel became the first hospital worldwide to initiate a clinical fertility preservation program for young boys suffering from cancer or diseases of the blood, bone marrow or lymph nodes.

Since then, the hospital has frozen testicular tissue fragments of 141 boys.

The tissue is preserved in liquid nitrogen at -196°C.

Prepubescent boys do not yet produce sperm cells. The removed tissue contains stem cells that would normally produce sperm after starting puberty.

"While the procedure is specifically designed to restore fertility, we cannot at this time guarantee that it will be successful or that patients can go on to have children,” Dr Vloeberghs said.

How Was The Testicular tissue Implanted

The Guardian reported that in 2025, four tissue fragments were grafted back into the remaining testicle and four under the skin of the scrotum.

After a year inside the body, the grafts were removed and analysed in the laboratory. The results are published in a preprint paper, which is yet to be peer reviewed.

Two of the grafts from inside the testicle had produced mature sperm, which was collected and frozen.

Because the tissue fragments are not directly connected to the sperm duct, the researchers do not expect sperm cells to naturally find their way into the semen.

“This is a huge finding,” Prof Ellen Goossens, of the Vrije Universiteit Brussel, who led the trial was quoted as saying. “Many more people will have hope that they can have biological children. It’s great to see for the patients for whom we already have tissue banked.”