The US Food and Drug Administration has approved TNKase or Tenecteplase, which is a thrombolytic or clot-dissolving agent, for the treatment of acute ischemic stroke in adults.

Ischemic strokes happen when a blood clot blocks a blood vessel in your brain. It can cause permanent brain damage and death. If enough brain cells die, you can also lose the abilities or body functions those cells control. They are also the most common types of stroke, with 80% of all strokes being ischemic strokes.

How is TNKase administered?

It is delivered as a single five-second intravenous bolus, which is faster than the standard of care Activase or alteplase, which is administered as an intravenous bolus followed by a 60-minute infusion. The manufacturer of TNKase, Genetech said a new 25-mg vial configuration will also be available in the coming months.

How Was TNKase approved?

The approval came at the backdrop of a study that compared TNKase to Activase in patients with acute ischemic stroke. These patients also presented with a disabling neurological deficit. Results show that TNKase was comparable to Activase in terms of efficacy and safety.

How Common Are These Strokes?

In the United States it self, it affects more than 795,000 people each year and is the leading cause of long-term disability. It is also the fifth leading cause of death. Since brain damage can happen if this progresses rapidly, one needs an immediate, fast-acting medical care.

TNKase thus provide a faster and simpler administration which can be critical for anyone. The chief medical officer and head of global product development at Genetech, Levi Garraway, MD., PhD., said, "Today's approval is a significant step forward and underscores our commitment to advancing stroke treatment options for patients."

What Are The Symptoms Of Ischemic Strokes?

Some of the most common symptoms include weakness or paralysis on one side of your face and body. You may also feel trouble speaking or have loss of speech, also known as aphasia. You may faced slurred or garbled speaking, also known as dysarthria. Other symptoms include loss of muscle control on one side of your face, or sudden worsening or loss of your senses, including vision, hearing, smell, taste, and touch.

Other symptoms include:

• Loss of coordination or clumsiness
• Blurry vision or double vision
• Dizziness or vertigo
• Nausea and vomiting
• Neck stiffness
• Mood swings or sudden personality changes
• Confusion or agitation
• Seizures
• Memory loss (amnesia)
• Headaches which are sudden and severe
• Passing out or fainting
• Coma

Are There Any Warning Signs?

While these are symptoms one has who is prone to this condition. However, often, many may confuse it with other illnesses. It is best to keep an eye out for warning signs. These could be looking out for yourself or your loved one. Note if there is a sudden loss of balance. Look out for sudden vision loss or changes in one or both eyes. Look for a droop on one or both sides of your face, especially when you smile. Raise both arms and see if one arm sags or drops in a way it usually does not. Note for your speech. Are you as fluent? Are you have trouble speaking? If you see any of such signs, start tracking it and talk to your healthcare provider.

Meghalaya's Health Minister Wailadmiki Shylla has raised alarm over the rising HIV cases in the state, noting that 10,293 infected residents were receiving antiretroviral treatment.

Along with this, Shylla noted that nearly 750 people have died due to the condition in the past decade with East Khasi Hills district reporting 435 of those cases. Coming in second is West Jaintia Hills with 123 cases, East Jaintia Hills with 90 cases, Ri Bhoi with 51 cases and Eastern West Khasi Hills reporting 16.

Nine deaths in West Garo Hills, eight in West Khasi Hills, seven in South West Khasi Hills, three in South Garo Hills, two in South West Garo Hills, and one in North Garo Hills have also been recorded.

During a question hour in an assembly session on February 25, the official said: "It is very unfortunate, but Meghalaya is having the highest cases in India".

He also highlighted the confidentiality clauses in the HIV and AIDS Prevention and Control Act, 2017 as well as existing social stigma as major challenges in addressing the rampant spread of the issue. “Early detection and intervention get complicated because testing requires consent and treatment cannot be forced,” he said.

“The State government has sanctioned a ₹25-crore intervention program for the next five years to address the alarming rise in HIV/AIDS cases,” Shylla declared as well as assured that the Department has been intensifying awareness campaigns to improve testing and treatment.

The global challenge of HIV/AIDS remains one of the most pressing public health issues today. According to the latest data from UNAIDS, around 38.4 million people worldwide are living with HIV/AIDS.

As of 2024–2025, India has approximately 2.5 million to 2.56 million people living with HIV (PLHIV), marking the third-largest HIV epidemic globally, underlining the need for not only medical intervention but also comprehensive awareness, education, and social change.

What Is HIV?

HIV is the virus responsible for attacking the body’s immune system, specifically targeting CD4 cells, which are crucial for the body’s defense against infections. As HIV progresses, it destroys these cells, weakening the immune system over time. If left untreated, this continuous damage can lead to AIDS.

HIV is highly contagious and can be transmitted through the exchange of bodily fluids such as blood, semen, vaginal fluids, and breast milk. It is primarily spread through unprotected sexual contact, sharing needles, from mother to child during childbirth or breastfeeding.

Without treatment, HIV progresses through three stages:

- Acute HIV Infection: This stage occurs shortly after transmission and may include symptoms like fever, fatigue, and swollen lymph nodes.

- Chronic HIV Infection: Often asymptomatic or mildly symptomatic, the virus continues to damage the immune system but at a slower rate.

- AIDS: This is the final stage, marked by severe immune damage and the presence of infections that take advantage of the compromised immune defenses.

The disease is diagnosed through blood tests or oral swabs that detect the presence of the virus or antibodies produced by the immune system in response to the virus. Early detection of HIV is crucial, as it allows for timely intervention and treatment, which can prevent the virus from progressing to AIDS.

For HIV, the primary treatment goal is to suppress the virus to undetectable levels, thus maintaining a strong immune system and preventing further transmission of the virus. People living with HIV can often live long, healthy lives if they adhere to antiretroviral therapy (ART).

What's Happening In Mizoram?

Mizoram Health Minister Lalrinpuii has expressed serious concern about rising HIV cases, as data shows that cases in the state are 13 times higher than the national average.

Calling it a "collective disgrace", Lalrinpuii said: “About 70 per cent of HIV transmissions in Mizoram occur through sexual contact. While the national prevalence rate stands at a mere 0.2 per cent, Mizoram’s rate has climbed to 2.74 per cent. This is a matter of shame for Mizo society.”

Speaking at an event organised for International Condom Day in Aizawl on February 13, she noted that a majority of that sexual contact remains the primary route of HIV infections in the state, accounting for 70 per cent of all cases.

The minister noted that the spread is largely driven by infidelity and a lack of preventive measures, which she argued contradicted the moral and religious values of the Mizo society.

She urged the people of the state to remain faithful to their partners. “To protect the future of Mizoram, our youth must remain vigilant,” Lalrinpuii added.

Kenyan-Mexican actress Lupita Nyong’o has revealed that her fibroids have returned after undergoing surgery in 2014 -- now doubling up to 50, raising awareness about the often-overlooked health condition in women.

Speaking at the Today show, the Oscar-winning star Nyong’o said that she was first diagnosed with fibroids, a noncancerous tumor -- about 30 in number -- in 2014.

The growths made of muscle and tissue were removed with myomectomy, the fibroid-removal surgery.

However, the fibroids came back after over a decade, with the largest being the size of an orange, Nyong’o said.

She noted that the doubled-up fibroids are causing her more pain, while her treatment options remain largely the same.

“The first time I got the fibroids taken out, they took out 23,” she said on the show. “And this time, I’ve been informed two years ago that I have over 50.”

“And I’m being faced with the same options,” she added. “Surgery or live with the pain.”

Even as she is contemplating her treatment options, the A Quiet Place: Day One star opened up about feeling left alone and scared for her reproductive health during the initial phase.

She is now speaking out and connecting with other women suffering like her. Nyong’o is also advocating and raising money for scientists to research less invasive and non-invasive treatment methods for fibroids.

I was told that fibroids were something women live with. In refuse to accept that. Millions of women are suffering in silence, and we deserve better answers, better care and better options," Nyong’o wrote in a post on Instagram.

What Are Fibroids

Uterine fibroids are noncancerous growths that form inside or on the uterus. They are very common, affecting an estimated 40 to 80 percent of people with a uterus between the ages of 30 and 50.

In some cases, fibroids do not cause any noticeable symptoms, which means many people may not realize they have them. However, when symptoms are present, they often include:

• Heavy menstrual bleeding or painful periods
• Longer or more frequent periods
• Pelvic pressure or pain
• Frequent urination or trouble urinating
• Growing stomach area
• Constipation
• Pain in the stomach area or lower back, or pain during sex

Obesity and a higher body mass index (BMI) are the most common risk factors that can increase the chances of developing fibroids. Others include family history, not having children, early onset of menstruation (getting your period at a young age), and late age of menopause.

How To Treat Fibroids? Can They Recur?

There are several tests that can be done to confirm fibroids and determine their size and location.

These tests can include ultrasonography, magnetic resonance imaging (MRI), computed tomography (CT) scan, hysteroscopy, and laparoscopy.

Myomectomy is a commonly used surgical procedure to remove fibroids. There are several types of myomectomy, and they are used depending on the location of the fibroids, their size, and number.

The types of myomectomy procedures include hysteroscopy, laparoscopy, laparotomy, hysterectomy, uterine fibroid embolization, and radiofrequency ablation (RFA).

Even after a successful myomectomy, new fibroids can still develop. The recurrence risk is more common among young adults (under age 40) with many fibroids. The risk is less among people near menopause or with few fibroids.

Visit your doctor if you have:

• Pelvic pain that doesn't go away
• Heavy or painful periods that limit what you can do
• Spotting or bleeding between periods
• Trouble emptying your bladder
• Ongoing tiredness and weakness, which can be symptoms of anemia, meaning a low level of red blood cells.

For the first time, a baby boy has been born to a mother with a womb transplanted from a deceased donor at Queen Charlotte’s and Chelsea hospital in London.

Weighing merely 3.09kg (6lb 13oz), Hugo Powell was born to Grace Bell and Steve Powell from Kent, right before Christmas 2025. "It's simply a miracle. I never, ever thought that this would be possible," Bell said. "I'm the happiest I've ever been in my life. When I was 16, I was told that this would never be possible," she said of her son's birth.

The father added: "When he came over the curtain, it was just sort of overwhelming emotions. I felt like I wanted to cry, but couldn't. From where we started - first meeting - to where we are today, with Hugo, is nothing short of a miracle after everything we've been through. It just felt quite unreal at the time, because this has been a long journey for us both."

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The couple also paid tribute to the "kindness and selflessness" of their transplant donor and her family for their "incredible gift", while also thanking medical teams in Oxford and London who supported their journey.

"There are no words to say thank you enough to my donor and her family. Their kindness and selflessness to a complete stranger is the reason I have been able to fulfil my lifelong dream of being a mum.

"I hope they know that my child will always know of their incredible gift, and the miracle that brought him into this world," Bell said.

What Is Mayer-Rokitansky-Kuster-Hauser Disorder?

Bell, an IT programme manager, was born with Mayer-Rokitansky-Kuster-Hauser (MRKH), a disorder that causes the vagina and uterus to be underdeveloped or absent. MRKH syndrome is also called:

• Müllerian agenesis
• Müllerian aplasia
• Congenital absence of the uterus and vagina
• Rokitansky syndrome

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While women with MRKH syndrome have normal external genitalia, functioning ovaries, breast and pubic hair development, they are unable to carry a pregnancy and rely on either surrogacy or a womb transplant, as in the case of Bell.

There are two versions of the disorder:

• Type 1: The patient has normally functioning ovaries and fallopian tubes but a blocked or missing upper vagina, cervix and uterus. No other organs are affected.
• Type 2: The patient has a blocked or missing upper vagina, cervix and uterus as well as issues with ovaries, fallopian tubes, spine, kidneys or other organs.

However, these genetic changes have been found in only a small number of affected people and subsequent studies have not identified a clear association between MRKH syndrome and any specific environmental factors. It remains unclears whether they actually cause MRKH syndrome.

Treatment for MRKH depends on the patient's goals and symptoms and some options include:

• Vaginal dilators: Dilators are made of plastic or silicone and vary in length and width. These tubelike devices help expand and stretch the inside of the vagina.
• Vaginoplasty: This is a surgical procedure to create a vagina. There are several ways surgeons perform vaginoplasty, but most involve creating a hole and lining it with tissue from another part of your body.
• Uterus transplant: This is a major surgery that involves placing a donor uterus inside someone without a uterus. Uterine transplants give people with MRKH an opportunity to carry and deliver a child. Uterus transplants are rare.

How Did Bell Conceive Her Child?

"I still can't believe that I'm here today and I've gone through this. It's just amazing."

At the age of 16, the new mother was told she wouldn't be able to carry her own child. However, in 2024 she received a phone call saying a womb had been donated and a transplant was possible, a moment she recalls left her "in complete shock" and "really excited".

Bell's womb transplant operation lasted 10 hours and took place at The Churchill Hospital in Oxford in June 2024 After her transplant surgery, she began fertility treatments several months after the transplant in 2024 and her son was born a year later.

According to The Guardian, Bell's transplanted womb will be removed when the couple have finished having children, to save her from a lifetime of taking immunosuppressant drugs.