The US Food and Drug Administration has approved TNKase or Tenecteplase, which is a thrombolytic or clot-dissolving agent, for the treatment of acute ischemic stroke in adults.

Ischemic strokes happen when a blood clot blocks a blood vessel in your brain. It can cause permanent brain damage and death. If enough brain cells die, you can also lose the abilities or body functions those cells control. They are also the most common types of stroke, with 80% of all strokes being ischemic strokes.

How is TNKase administered?

It is delivered as a single five-second intravenous bolus, which is faster than the standard of care Activase or alteplase, which is administered as an intravenous bolus followed by a 60-minute infusion. The manufacturer of TNKase, Genetech said a new 25-mg vial configuration will also be available in the coming months.

How Was TNKase approved?

The approval came at the backdrop of a study that compared TNKase to Activase in patients with acute ischemic stroke. These patients also presented with a disabling neurological deficit. Results show that TNKase was comparable to Activase in terms of efficacy and safety.

How Common Are These Strokes?

In the United States it self, it affects more than 795,000 people each year and is the leading cause of long-term disability. It is also the fifth leading cause of death. Since brain damage can happen if this progresses rapidly, one needs an immediate, fast-acting medical care.

TNKase thus provide a faster and simpler administration which can be critical for anyone. The chief medical officer and head of global product development at Genetech, Levi Garraway, MD., PhD., said, "Today's approval is a significant step forward and underscores our commitment to advancing stroke treatment options for patients."

What Are The Symptoms Of Ischemic Strokes?

Some of the most common symptoms include weakness or paralysis on one side of your face and body. You may also feel trouble speaking or have loss of speech, also known as aphasia. You may faced slurred or garbled speaking, also known as dysarthria. Other symptoms include loss of muscle control on one side of your face, or sudden worsening or loss of your senses, including vision, hearing, smell, taste, and touch.

Other symptoms include:

• Loss of coordination or clumsiness
• Blurry vision or double vision
• Dizziness or vertigo
• Nausea and vomiting
• Neck stiffness
• Mood swings or sudden personality changes
• Confusion or agitation
• Seizures
• Memory loss (amnesia)
• Headaches which are sudden and severe
• Passing out or fainting
• Coma

Are There Any Warning Signs?

While these are symptoms one has who is prone to this condition. However, often, many may confuse it with other illnesses. It is best to keep an eye out for warning signs. These could be looking out for yourself or your loved one. Note if there is a sudden loss of balance. Look out for sudden vision loss or changes in one or both eyes. Look for a droop on one or both sides of your face, especially when you smile. Raise both arms and see if one arm sags or drops in a way it usually does not. Note for your speech. Are you as fluent? Are you have trouble speaking? If you see any of such signs, start tracking it and talk to your healthcare provider.

zDelhi woke up again to a yet another thick smoggy morning, with visibility dropping low. On Monday morning, the city's average air quality index or AQI stood at 'severe' category for the third consecutive day. As of 6am, the data from the Air Quality Early Warning System for Delhi stood at 457. As per the Central Pollution Control Board (CPCB), at least four stations, including Ashok Vihar, Jahangirpuri, Rohini, Wazirpur, recorded AQI of 500 at 7am.

As of 10am on Monday morning, Delhi stood at 480, Noida at 551, Greater Noida at 568, Gurugram at 454, Faridabad at 546, and Ghaziabad at 569, all under 'severe' category.

As a result, the Commission for Air Quality Management has issued directives to Delhi and NCR state governments on Sunday, December 14. The directives suggest for an immediate halt on all outdoor physical sports activity. This move has come after concerns were raised around schools that are still continuing outdoor activities despite poor air quality.

Amid this, a Lancet study also revealed that 15 lakh annual deaths in India are due to long-term exposure to air pollution. The particulate matter or PM2.5 found in air pollution is linked to many health issues. Since the particles are so small in size, it could easily penetrate deep into the lungs and enter the bloodstream, and cause serious health impacts. However, despite the global studies highlighting the country's ever-growing pollution problem, the Centre stated that "there is no conclusive data available in the country to establish direct correlation if death/disease exclusively due to air pollution."

What Does The Lancet Study Say About Air Pollution And Health?

The comprehensive Lancet study conducted an analysis from 2009 to 2019, and measured the consequence of long-term exposure to fine particulate matter or PM2.5.

The study estimated: “1·5 million deaths occurred annually due to long-term exposure to PM2·5 in India every year in excess of the 5 μg/m3 that is recommended by the WHO ambient air quality guidelines.”

The study noted that every 10μg/m³ increase in annual PM2·5 concentration was associated with an 8.6 pc higher risk of all-cause mortality.

Using India’s National Ambient Air Quality Standards, researchers estimate that about 3.8 million deaths between 2009 and 2019 were linked to PM2.5 exposure. When WHO guidelines were applied, the number rose sharply to 16.6 million, nearly one-fourth of all deaths in the country. The analysis relied on advanced causal methods and high-resolution models that mapped district-level PM2.5 exposure across India, while accounting for factors such as socioeconomic status, age distribution, and indoor air pollution.

These findings are backed by a 2017 time-series study from Delhi that examined the short-term impact of air pollution on deaths from natural causes. The researchers pointed out that studies worldwide have consistently shown a clear link between common urban air pollutants and harmful health effects. Despite Delhi’s well-documented air quality crisis, they noted that limited local evidence on how specific pollutants affect health had long slowed meaningful policy action.

Different Pollutants Impact Different Age Groups

To bridge this gap, the study analyzed data from 2008 to 2010, focusing on key pollutants: particulate matter under 10 micrometres (PM10), sulphur dioxide (SO2), nitrogen dioxide (NO2), carbon monoxide (CO), and ozone (O3). Using a semi-parametric regression model that adjusted for non-linear factors such as time trends, temperature, and humidity, the researchers found strong links between short-term exposure to both particulate and gaseous pollutants and daily all-cause mortality.

They estimated that every 10 μg/m³ rise in PM10 levels was associated with a 0.14 per cent increase in all-cause deaths. Among gaseous pollutants, NO2 had the strongest impact, with a 1 per cent rise in mortality for every 10 μg/m³ increase in daily concentration. Ozone and carbon monoxide also showed significant effects, even after accounting for NO2 levels. The analysis that was done based on age also revealed that particulate matter affected older adults aged 65 and above. Whereas, gaseous pollutants had a greater impact on people aged 5 to 44.

Overall, the researchers concluded that the evidence clearly reinforces the link between poor ambient air quality and increased all-cause mortality.

The World Health Organization (WHO) notes that in 2022, there were nearly 20 million new cancer case in the world. These have included lung, breast, and colorectal cancers. This has led to death of 9.7 million in the year. This means about 1 in 5 people could develop cancer in their lifestyle, and the number is rising significantly by 2050.

While there are new studies, targeted cell therapies that are now opening more doors to cancer treatments, a new study by the University of California, San Diego, could be worrisome. This new study found that some cancer cells turn on their "cell death" mode during drug therapy. So, what happens is that the drug, instead of killing them, persist and regrow in some of the case. This is how drug resistance in cancer cells functions, and by targeting this cell-death programme in cancer cells, scientists could potentially stop the growth of cancer after therapy.

The findings have been found in a peer-reviewed journal Nature Cell Biology.

Why cancer often comes back

Cancer remains one of the biggest global health threats, causing nearly 10 million deaths every year. One of the hardest parts of treating cancer is that it can return, even after treatment seems successful. Doctors call this cancer relapse or recurrence. It happens when some cancer cells survive the first round of treatment and begin growing again after a period of dormancy.

Relapse rates vary by cancer type. Lung cancer, for instance, has a higher chance of returning, while breast cancer generally has lower relapse rates. Still, one problem cuts across many cancers: drug resistance. Over time, cancer cells can learn how to survive medicines designed to kill them.

A surprising discovery during treatment

In this study, researchers set out to look for early signs of drug resistance in cancer cells. They expected to find genetic changes or mutations. Instead, they found something unexpected. Some cancer cells respond to treatment by turning into what scientists call “persister cells.”

These persister cells stop growing during therapy and enter a dormant state. At first glance, this looks like success. But what happens next is more troubling. These cells activate a built-in cell death program, the same process the body uses to break down dying cells. However, the program does not finish the job.

How cancer cells escape death

Rather than dying, these persister cells release enzymes that help them restart growth. One key enzyme involved is DNA Fragmentation Factor B, or DFFB. Normally, DFFB helps fragment DNA in cells that are meant to die. In these cancer cells, it is activated at low levels. That is not enough to kill the cell, but enough to help it escape dormancy and start growing again.

“This flips our understanding of cancer cell death on its head,” said senior author Matthew J. Hangauer. He explained that signals meant to kill cancer cells can sometimes help them survive and regrow instead.

What this means for cancer treatment

The findings offer a new way to think about drug resistance. Instead of relying on genetic mutations, cancer cells may use internal survival mechanisms to outlast treatment. This insight opens the door to new treatment strategies.

The researchers tested this idea by disabling DFFB in melanoma, lung cancer, and breast cancer models. Without the enzyme, the cancer cells stayed dormant and could not restart growth. Importantly, DFFB does not appear to be essential in normal cells, suggesting that targeting it may not cause major side effects.

As first author August F. Williams noted, focusing on these early, non-genetic survival pathways could help patients stay in remission longer and lower the risk of cancer returning.

Winter vomiting disease cases are rising. This is highly contagious and is spreading rapidly across the United States. We are talking about norovirus. This contagious stomach flu has led to health officials raising warning for people to take extra precautions. In fact, experts say that the number of people affected could be higher, all thanks to holiday gathering season.

What makes Norovirus unique is that this virus is particularly hard to kill and many do not even realize that they are spreading it, unless it is too late.

The Centers for Disease Control and Prevention (CDC) has noted that the cases of norovirus has spiked ever since the Thanksgiving holiday. they have also noted that this particularly hard to kill virus is also known as the "winter vomiting disease".

For now cases of this winter vomiting disease have been reported from Illinois, the Midwest, and Southern California. The California Department of Public Health has also noted a rise in cases in Los Angeles and San Francisco Bay areas.

The contagious virus affects the gastrointestinal system, causes vomiting, stomach pain, and diarrhea that could last several days. The symptoms usually take 12 to 48 hours to appear after the exposure.

New Strain Of The Unique Norovirus In 2025

There has been an emergence of a new strain GII.17. This could lead to an increase of 50% more infections than this year, said the CDC. Medical experts have urged the public to stay alert and practice goof hygiene.

As per the DuPage Country Health Department's social medica awareness post, "cases of norovirus are continuing to increase". "Norovirus is very contagious, and anyone can get infected and sick," the health department wrote on Facebook.

How To Avoid Getting Sick From Winter Vomiting Disease?

Dr Suman Radhakrishna, Director of Infectious Disease at Dignity Health Medical Center, tells KTLA, "It [the virus] can stay on doorknobs and food and it’s pretty hearty. When someone ingests it or touches it and then places their hand on their mouth, they can get the virus. You don’t need a lot of the virus to get infected.”

“Whether you have the virus or not, sing the Happy Birthday [song] twice when you’re washing with soap and water, especially before you eat,” Radhakrishna advised. “Other times, the hand sanitizer works, but it doesn’t work very well for norovirus, unfortunately.”

Other practices to follow is to avoid touching your face with dirty hands, or avoid touching food or items that could have been handled or touched by other people. Disinfect any surface, which could have been contaminated.

If you already have it, the doctor suggests to seek care in the emergency room and keep drinking enough fluids. "Or let’s say, if you were lying down and when you try to sit up, you feel dizzy because you are so dehydrated, these are times when you should call your doctor, go to the emergency room or go to urgent care,” said Dr Radhakrishna.

Symptoms Of Norovirus

• Diarrhea
• Vomiting
• Nausea
• Stomach pain
• Fever
• Headache
• Body aches