The US Food and Drug Administration has approved TNKase or Tenecteplase, which is a thrombolytic or clot-dissolving agent, for the treatment of acute ischemic stroke in adults.

Ischemic strokes happen when a blood clot blocks a blood vessel in your brain. It can cause permanent brain damage and death. If enough brain cells die, you can also lose the abilities or body functions those cells control. They are also the most common types of stroke, with 80% of all strokes being ischemic strokes.

How is TNKase administered?

It is delivered as a single five-second intravenous bolus, which is faster than the standard of care Activase or alteplase, which is administered as an intravenous bolus followed by a 60-minute infusion. The manufacturer of TNKase, Genetech said a new 25-mg vial configuration will also be available in the coming months.

How Was TNKase approved?

The approval came at the backdrop of a study that compared TNKase to Activase in patients with acute ischemic stroke. These patients also presented with a disabling neurological deficit. Results show that TNKase was comparable to Activase in terms of efficacy and safety.

How Common Are These Strokes?

In the United States it self, it affects more than 795,000 people each year and is the leading cause of long-term disability. It is also the fifth leading cause of death. Since brain damage can happen if this progresses rapidly, one needs an immediate, fast-acting medical care.

TNKase thus provide a faster and simpler administration which can be critical for anyone. The chief medical officer and head of global product development at Genetech, Levi Garraway, MD., PhD., said, "Today's approval is a significant step forward and underscores our commitment to advancing stroke treatment options for patients."

What Are The Symptoms Of Ischemic Strokes?

Some of the most common symptoms include weakness or paralysis on one side of your face and body. You may also feel trouble speaking or have loss of speech, also known as aphasia. You may faced slurred or garbled speaking, also known as dysarthria. Other symptoms include loss of muscle control on one side of your face, or sudden worsening or loss of your senses, including vision, hearing, smell, taste, and touch.

Other symptoms include:

• Loss of coordination or clumsiness
• Blurry vision or double vision
• Dizziness or vertigo
• Nausea and vomiting
• Neck stiffness
• Mood swings or sudden personality changes
• Confusion or agitation
• Seizures
• Memory loss (amnesia)
• Headaches which are sudden and severe
• Passing out or fainting
• Coma

Are There Any Warning Signs?

While these are symptoms one has who is prone to this condition. However, often, many may confuse it with other illnesses. It is best to keep an eye out for warning signs. These could be looking out for yourself or your loved one. Note if there is a sudden loss of balance. Look out for sudden vision loss or changes in one or both eyes. Look for a droop on one or both sides of your face, especially when you smile. Raise both arms and see if one arm sags or drops in a way it usually does not. Note for your speech. Are you as fluent? Are you have trouble speaking? If you see any of such signs, start tracking it and talk to your healthcare provider.

Health officials in Kerala have reported two deaths caused by West Nile fever in Ernakulam district.

The deceased was identified as Muraleedharan, a 70-year-old man from Kadangalloor near Aluva. The elderly man died while undergoing treatment on Monday at Kalamassery Medical College, officials said.

Muraleedharan, who was suffering from cancer and had respiratory problems, was admitted to the Medical College Hospital a few days ago with symptoms of West Nile fever. This is the second death from West Nile fever in the Ernakulam district in a week.

Saraswathiyamma, a native of Paravur, died of West Nile fever the other day. Many people have reportedly sought treatment at various hospitals in Ernakulam district with West Nile fever and dengue fever symptoms.

Health Department Issues Advisory

Following the incident, the state health department urged people to remain cautious and also issued an advisory urging the public to take precautions against the mosquito-borne disease.

The West Nile Fever "is caused by a flavivirus commonly found in migratory birds and is transmitted to humans through the bite of infected mosquitoes," the department said, in a statement.

It clarified that "the disease does not spread from person to person and that preventing mosquito bites is the most effective way to avoid infection".

According to health authorities, symptoms may include fever, high body temperature, stiffness of the neck, behavioral changes, confusion, semi-consciousness, or loss of consciousness, PTI reported.

The statement warned that severe infection could affect the nervous system and lead to conditions such as encephalitis and meningitis.

"Elderly persons, those with low immunity, individuals with underlying illnesses, pregnant women, and children have been identified as high-risk groups requiring special attention. Culex mosquitoes, which breed in stagnant and polluted water bodies, drainage channels, septic tanks, marshy areas, paddy fields, and overgrown vegetation, are the primary carriers of the disease," the statement said.

What Is West Nile Fever?

The disease is spread through mosquito bites, and most who get infected do not have any symptoms. However, one in every five infected people has a fever, headache, body aches, and other flu-like symptoms.

The West Nile virus also infects the nervous system and is capable of causing serious brain or spinal cord inflammation.

According to the WHO, West Nile Virus is a member of the flavivirus genus and belongs to the Japanese encephalitis antigenic complex of the family Flaviviridae.

The mosquitoes become infected when they feed on birds that carry the virus in their blood, and then bite humans and infect them.

West Nile Fever: The Symptoms

The symptoms include fever, headache, muscle aches, nausea and vomiting, diarrhoea, rash around the chest and back, swollen lymph nodes, sore throats, and pain behind the eyes.

In severe cases, individuals may have an intense headache, high fever, stiff neck, making you unable to move your chin towards your chest, confusion, muscle weakness, loss of control over your muscle movements, seizures, paralysis, and coma.

West Nile Fever: How Does It Spread?

While the mosquitoes that feed on infected birds are the carriers, there is still a lack of evidence to determine whether it comes directly from the birds. The incubation period for symptoms to show up is two to six days, but it can extend to 14 days, too.

It can be transmitted from a pregnant person to their fetus, through human milk, blood transfusion, and organ transplant. People who are over the age of 60, have cancer, diabetes, or high blood pressure are more prone to the virus.

West Nile Fever: Treatment

There are no treatments or antiviral medications available for it. However, one can treat the mild symptoms at home with over-the-counter medications that you take for a cold or the flu. The best way to prevent is to protect yourself from mosquito bites.

Dr. Ravi Vij, an Indian-origin cancer specialist and an alumnus of Maulana Azad Medical College in New Delhi, has been given the prestigious honor of a professorship for his contributions to advancing treatments for blood cancers.

He has been appointed as the inaugural Jeffrey S. and Prue H. Gershman Distinguished Professor in the John T. Milliken Department of Medicine at Washington University School of Medicine.

Vij is currently a professor of medicine in the department’s Division of Oncology. The professorship has been funded by St. Louis philanthropists Jeffrey and Prue Gershman, who support local education, health, and arts organizations.

In a statement, Chancellor Andrew D. Martin stated that this professorship, "will accelerate progress against blood cancers by supporting Dr. Vij’s work to bring new, more effective treatments to patients".

Martin also lauded Dr. Vij’s leadership, noting that it has "helped grow WashU Medicine’s reputation as a national force in stem cell transplantation and immunotherapy".

Leading Blood Cancer Research

Dr Vij's work includes studying the genetic underpinnings and cellular microenvironment of multiple myeloma — a cancer of the plasma cells in bone marrow.

He also treats patients at Siteman Cancer Center, based at Barnes-Jewish Hospital and WashU Medicine, and is the principal investigator of the Multiple Myeloma Tissue Banking initiative at Siteman.

He has led several clinical trials of investigational therapies for blood cancers, including immunotherapy agents and novel stem cell transplant strategies, that later became standard treatments. He has authored more than 300 scientific publications in the field of blood cancers.

Also read:I’m Cancer-Free After 14 Years, Says Robin Quivers

Contributions Beyond Research

Beyond his research into blood cancer, Dr. Vij has served on the American Society of Clinical Oncology education and scientific committees and on the myeloma committees of the Clinical Trials Network and Alliance for Clinical Trials in Oncology.

He currently serves as senior editor of the journal Clinical Lymphoma, Myeloma and Leukemia and is a past chair of the American Society of Hematology scientific committee on plasma cell dyscrasias, a group of disorders linked to blood cancers.

His accolades include the Multiple Myeloma Research Foundation Innovator Award, the Center of Excellence Award, and the Leukemia & Lymphoma Society Visionary of the Year Award.

A respected educator, Vij has mentored 25 early-career researchers and received the Teacher of the Year Award from the Hematology and Oncology Fellowship Program at WashU Medicine in 2007.

Read More: Benjamin Netanyahu Undergoes Treatment For Early-stage Prostate Cancer: Symptoms You Should Not Ignore

Education and Career

Dr. Vij completed his medical education at Maulana Azad Medical College in New Delhi, India, followed by postgraduate training at Halifax General Hospital and Royal Infirmary in the United Kingdom.

He completed an internal medicine residency at Rush University in Chicago and fellowships in medical oncology, hematology, and bone marrow transplantation at WashU Medicine. He joined the WashU Medicine faculty in 2000.

What Is Blood Cancer?

Blood cancer is broadly classified into three main types: leukemia, lymphoma, and myeloma. Leukemia is a cancer of the blood and bone marrow, while lymphoma affects the lymphatic system, particularly the lymph nodes and immune cells. Myeloma is a cancer of plasma cells found in the bone marrow.

These cancers disrupt normal blood cell function and can cause symptoms such as fatigue, infections, and unexplained bleeding.

Symptoms And Treatment

Common symptoms of blood cancer include:

• Persistent fatigue
• Frequent infections
• Unexplained bruising or bleeding
• Weight loss
• Swollen lymph nodes

The causes and risk factors for blood cancer vary. Genetic mutations, exposure to radiation or harmful chemicals, certain infections, and a family history of blood cancer are known risk factors. The risk of developing blood cancer generally increases with age.

Advanced treatment options for blood cancers include immunotherapies such as CAR-T cell therapy and stem cell transplantation.

Health officials in Kerala have reported two deaths caused by West Nile fever in Ernakulam district.

The deceased was identified as Muraleedharan, a 70-year-old man from Kadangalloor near Aluva. The elderly man died while undergoing treatment on Monday at Kalamassery Medical College, officials said.

Muraleedharan, who was suffering from cancer and had respiratory problems, was admitted to the Medical College Hospital a few days ago with symptoms of West Nile fever. This is the second death from West Nile fever in the Ernakulam district in a week.

Saraswathiyamma, a native of Paravur, died of West Nile fever the other day. Many people have reportedly sought treatment at various hospitals in Ernakulam district with West Nile fever and dengue fever symptoms.

Health Department Issues Advisory

Following the incident, the state health department urged people to remain cautious and also issued an advisory urging the public to take precautions against the mosquito-borne disease.

In a statement, the department said the disease is caused by a flavivirus commonly found in migratory birds and is transmitted to humans through the bite of infected mosquitoes.

It clarified that the disease does not spread from person to person and that preventing mosquito bites is the most effective way to avoid infection.

According to health authorities, symptoms may include fever, high body temperature, stiffness of the neck, behavioral changes, confusion, semi-consciousness, or loss of consciousness, PTI reported.

Also read: Shigella: The Infection That Claimed A 4-Year-Old's Life In Kerala; Government On Alert

The statement warned that severe infection could affect the nervous system and lead to conditions such as encephalitis and meningitis.

"Elderly persons, those with low immunity, individuals with underlying illnesses, pregnant women, and children have been identified as high-risk groups requiring special attention. Culex mosquitoes, which breed in stagnant and polluted water bodies, drainage channels, septic tanks, marshy areas, paddy fields, and overgrown vegetation, are the primary carriers of the disease," the statement said.

What Is West Nile Fever?

The disease is spread through mosquito bites, and most who get infected do not have any symptoms. However, one in every five infected people has a fever, headache, body aches, and other flu-like symptoms.

The West Nile virus also infects the nervous system and is capable of causing serious brain or spinal cord inflammation.

According to the WHO, West Nile Virus is a member of the flavivirus genus and belongs to the Japanese encephalitis antigenic complex of the family Flaviviridae.

The mosquitoes become infected when they feed on birds that carry the virus in their blood, and then bite humans and infect them.

It is found in different parts of the world, including North America, Europe, Africa, Central Asia, Australia, and Asia. Cases in 49 states in the US have been reported, and the total number of symptomatic cases in the US is 51,000 since the first cases were detected in the country in 1999.

Read More: Salmonella Outbreak: Instant Noodles Sicken Over 80 In The UK, Europe

What Are The Symptoms?

The symptoms include fever, headache, muscle aches, nausea and vomiting, diarrhea, rash around the chest and back, swollen lymph nodes, sore throats, and pain behind the eyes.

In severe cases, individuals may have an intense headache, high fever, stiff neck, making you unable to move your chin towards your chest, confusion, muscle weakness, loss of control over your muscle movements, seizures, paralysis, and coma.

How Can It Spread?

While the mosquitoes that feed on infected birds are the carriers, there is still a lack of evidence to determine whether it comes directly from the birds. The incubation period for symptoms to show up is two to six days, but it can extend to 14 days, too.

It can be transmitted from a pregnant person to their fetus, through human milk, blood transfusion, and organ transplant. People who are over the age of 60, have cancer, diabetes, or high blood pressure are more prone to the virus.

Treatment

There are no treatments or antiviral medications available for it. However, you can treat the mild symptoms at home with over-the-counter medications that you take for a cold or the flu. The best way to prevent is to protect yourself from mosquito bites.