The US Food and Drug Administration has approved TNKase or Tenecteplase, which is a thrombolytic or clot-dissolving agent, for the treatment of acute ischemic stroke in adults.

Ischemic strokes happen when a blood clot blocks a blood vessel in your brain. It can cause permanent brain damage and death. If enough brain cells die, you can also lose the abilities or body functions those cells control. They are also the most common types of stroke, with 80% of all strokes being ischemic strokes.

How is TNKase administered?

It is delivered as a single five-second intravenous bolus, which is faster than the standard of care Activase or alteplase, which is administered as an intravenous bolus followed by a 60-minute infusion. The manufacturer of TNKase, Genetech said a new 25-mg vial configuration will also be available in the coming months.

How Was TNKase approved?

The approval came at the backdrop of a study that compared TNKase to Activase in patients with acute ischemic stroke. These patients also presented with a disabling neurological deficit. Results show that TNKase was comparable to Activase in terms of efficacy and safety.

How Common Are These Strokes?

In the United States it self, it affects more than 795,000 people each year and is the leading cause of long-term disability. It is also the fifth leading cause of death. Since brain damage can happen if this progresses rapidly, one needs an immediate, fast-acting medical care.

TNKase thus provide a faster and simpler administration which can be critical for anyone. The chief medical officer and head of global product development at Genetech, Levi Garraway, MD., PhD., said, "Today's approval is a significant step forward and underscores our commitment to advancing stroke treatment options for patients."

What Are The Symptoms Of Ischemic Strokes?

Some of the most common symptoms include weakness or paralysis on one side of your face and body. You may also feel trouble speaking or have loss of speech, also known as aphasia. You may faced slurred or garbled speaking, also known as dysarthria. Other symptoms include loss of muscle control on one side of your face, or sudden worsening or loss of your senses, including vision, hearing, smell, taste, and touch.

Other symptoms include:

• Loss of coordination or clumsiness
• Blurry vision or double vision
• Dizziness or vertigo
• Nausea and vomiting
• Neck stiffness
• Mood swings or sudden personality changes
• Confusion or agitation
• Seizures
• Memory loss (amnesia)
• Headaches which are sudden and severe
• Passing out or fainting
• Coma

Are There Any Warning Signs?

While these are symptoms one has who is prone to this condition. However, often, many may confuse it with other illnesses. It is best to keep an eye out for warning signs. These could be looking out for yourself or your loved one. Note if there is a sudden loss of balance. Look out for sudden vision loss or changes in one or both eyes. Look for a droop on one or both sides of your face, especially when you smile. Raise both arms and see if one arm sags or drops in a way it usually does not. Note for your speech. Are you as fluent? Are you have trouble speaking? If you see any of such signs, start tracking it and talk to your healthcare provider.

Health officials in the US are warning consumers about yet another multistate outbreak of Salmonella and E. coli infections. This time its linked to alfalfa sprouts, which have sickened more than 40 people.

The outbreak comes as the US is also witnessing a major rise in Cyclospora infections, which can cause severe diarrhea. Federal health officials have posted 20 foodborne illness investigations so far this year, with about 10,500 illnesses associated with outbreaks.

Which States Are Reporting Cases?

Minnesota and Wisconsin have reported more than 40 illnesses linked to alfalfa sprouts.

Officials said additional illnesses are being identified in other states, and the number of cases could increase as the investigation continues.

Minnesota

The Minnesota Department of Health and Minnesota Department of Agriculture said 23 Minnesotans became ill between July 8 and August 8 with Salmonella and/or Shiga toxin-producing E. coli (STEC) infections.

Two people have been hospitalized, and no deaths have been reported.

Of the cases, three people had Salmonella, including one who also had STEC O168:H8. Seven people were infected with STEC O103:H25, while 13 had STEC O26:H11.

According to officials, Minnesota reports approximately 1,000 Salmonella infections and 85 STEC infections with the serogroups associated with this outbreak each year.

Wisconsin

Officials in Wisconsin have identified 17 cases, with one person hospitalized.

The Wisconsin cases are connected to a multistate outbreak of STEC and Salmonella infections linked to alfalfa sprouts distributed to restaurants and grocery stores.

Approximately 1,000 Salmonella infections and 500 STEC infections are reported each year in Wisconsin.

Which Alfalfa Sprout Brands Are Linked To The Outbreak?

The illnesses have been linked to alfalfa sprouts produced by Everything Sprouts, a Minnesota grower, and sold under the Calco and Everything Sprouts brands to restaurants and grocery stores.

Health officials recommend checking homes for these products, not eating them and throwing them away.

What Are The Symptoms Of E. Coli Infection?

Shiga toxin-producing Escherichia coli (STEC) is a group of bacteria that make dangerous poisons called Shiga toxins. While most E. coli are harmless, STEC infections can cause:

• Stomach cramps
• Diarrhea, often with bloody stools
• Low-grade or no fever

People usually become sick two to five days after swallowing the bacteria.

Most people recover within five to seven days.

However, STEC infections can also cause hemolytic uremic syndrome (HUS), a severe complication that can lead to acute kidney failure and other serious health problems.

The officials warned that diarrhea caused by STEC infections generally should not be treated with antibiotics, as this can increase the risk of HUS. Anyone who believes they may have an STEC infection should contact a healthcare provider.

What Are The Symptoms Of Salmonella Infection?

Salmonella is a bacterial infection that commonly causes diarrhea and gastrointestinal illness.

Salmonella infection can cause:

• Diarrhea
• Abdominal pain
• Fever

Symptoms usually begin six hours to six days after swallowing the bacteria.

Most people recover from Salmonella infection without medical treatment. However, children, older adults and people with weakened immune systems may develop serious illness requiring medical care.

How To Stay Safe?

Officials advise people to:

• Check their homes for alfalfa sprouts from Everything Sprouts and Calco.
• Do not eat the sprouts.
• Throw them away.
• Anyone who has eaten the sprouts should monitor for symptoms of Salmonella or STEC infection.
• Contact a healthcare provider if symptoms become severe.

American Olympic bronze medallist Jenny Simpson has announced her diagnosis of Arrhythmogenic ‌Right Ventricular Cardiomyopathy (ARVC) -- a rare inherited heart condition that is forcing her to give up her career as it makes running dangerous.

The 39-year-old, former 1500 meters world champion, was diagnosed after collapsing in June ⁠at a community track event hosted by Sir Walter Running and required CPR.

What Happened To Jenny Simpson?

After receiving lifesaving care at the track event, Simpson was transferred to Duke University Hospital for more advanced heart failure support.

Her heart was not pumping strongly enough, causing fluid to build up in her lungs. She described the experience as beginning to “drown.”

“My body was dying, but my spirit wouldn’t give up,” her post read. “I fought for my life.”

Within days, however, her heart and lungs were strong enough to function on their own.

Simpson Forced To End Her Career

Simpson said her diagnosis means “it would be dangerous for me to return to running.” She retired from elite racing in 2024 and described the diagnosis as the end of that chapter of her life.

"I was diagnosed with a rare inherited heart condition, Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)... My future is an incredible gift. It is hopeful, and it will continue to have a ‌great ⁠purpose. But my diagnosis also means it would be dangerous for me to return to running," Simpson said in a post on Instagram.

“That chapter has ended,” the post read. “Thankfully, my story hasn’t.”

Why Can ARVC Be Dangerous?

Simpson was diagnosed with ARVC, a rare inherited condition in which scar tissue in the heart can disrupt its electrical system and trigger dangerous heart rhythms.

The condition can weaken the heart muscle and affect its ability to pump blood effectively. It can affect one or both ventricles; when it mainly affects the right ventricle, it is called ARVC. In Simpson’s case, the abnormal heart rhythms ultimately caused her heart to stop.

“As devastating as that diagnosis sounds, I truly feel profoundly fortunate. CPR, AED shocks, exceptional medical care, and a healthy body and fighting spirit that have spent a lifetime adapting to hard things all came together to give me another chance at life.”

Simpson is the only US woman to win a world 1500m title, which she achieved in 2011, and one of two US women to win an Olympic 1500m medal, taking bronze in 2016.

From 2007 through 2019, she finished among the top three in the 1500m, 5000m or 3000m steeplechase at all 13 USA Track and Field Outdoor Championships.

What Is ARVC?

In ARVC, heart muscle cells do not stick together properly, causing scar tissue and weakening the heart muscle. This can affect the heart’s ability to pump blood effectively.

The condition can affect one or both ventricles. When it primarily affects the right ventricle, it is called ARVC.

ARVC: Symptoms

• Heart palpitations
• Lightheadedness
• Fainting
• Shortness of breath
• Abnormal heart rhythms
• Swelling in the ankles, legs or abdomen
• Chest pain or discomfort

ARVC: Diagnosis

Doctors may use several tests to assess the heart, including:

• Cardiac MRI
• ECG
• Exercise test
• Echocardiogram

ARVC: Treatment

There is no cure for ARVC, but treatment can help manage abnormal heart rhythms and reduce complications. Options may include:

• Pacemaker
• ICD
• Cardioversion
• Catheter ablation.

Anchovies are tiny fish packed with major health benefits, including high amounts of heart-healthy omega-3 fatty acids (EPA and DHA), lean protein, selenium, niacin, iron and calcium. However, a new study by Andhra University researchers detected microplastics in the edible muscle tissue of anchovies, which form a significant part of the local seafood chain.

The finding, published in the International Journal of Environmental Sciences, raises concerns about potential exposure to microplastics and their possible impact on cognitive function.

While the detection of microplastics in muscle tissue suggests the particles may move beyond the digestive system and potentially expose humans through contaminated seafood, researchers led by Prof C Manjulatha from the Department of Zoology and Gondu Chandrika from the Department of Environmental Sciences stressed the need for further assessment.

Where Were Microplastics Found?

• Microplastic particles were found in the gastrointestinal tracts, gills and muscle tissue of fish collected from Visakhapatnam’s Vizag harbor.
• The gastrointestinal tract had the highest concentration, followed by the gills and muscle tissue, according to Times of India.
• Plastic fibers accounted for nearly 80% of the detected particles, followed by fragments and foam.
• Most particles measured between 0.5 mm and 4.5 mm.
• The researchers identified particles in different colors, with red and blue among the prominent ones.
• FTIR spectroscopy identified polymers including polyamide, PET, polyester, polyethylene, polyacrylate and polypropylene.

Polyamide and PET were among the dominant polymers, pointing to multiple possible sources of contamination, such as synthetic fibers, plastic waste and fishing-related materials.

“These findings emphasize the need for proper disposal and treatment of plastic waste,” the researchers said.

What Does This Mean For Brain Health?

Microplastics are small pieces of plastic, ranging from one nanometer to five millimeters — a fraction of the width of a human hair to about the size of a grain of rice. These have now been detected in human blood, placenta, liver, kidneys and the brain. The study also prompted questions about whether consuming microplastics could have implications for brain health.

In a post on X, Dr Sudhir Kumar, Neurologist at Apollo Hospitals, Hyderabad, explained that although the gastrointestinal tract had the highest load, muscle contamination is what reaches your plate.

“Microplastics tend to accumulate in fat-rich tissue like the brain's myelin sheath, the insulation around neurons. Animal studies show microplastic exposure can trigger oxidative stress and inflammation that disrupt neurotransmission and impair cognition. Human data is still emerging, but the biological plausibility is real,” Dr Sudhir said.

He stressed that it “is a concerning signal, not yet a confirmed verdict”.

Can Microplastics End Up On Our Plates?

“Plastic pollution entering the sea fragments into particles small enough for marine life to absorb; fish take it up through feeding, we take it up by eating the fish. The Vizag study flags exactly this: sewage discharge, urban runoff, and fishing waste feeding this cycle,” the expert said.

How To Stay Safe

The expert advised people to:

• Vary protein sources.
• Don't rely on one fish species or source daily.
• Reduce synthetic fibre shedding and use a laundry filter bag.
• Avoid heating food in plastic containers.
• Support better waste treatment, as it is fundamentally a pollution problem, not just a diet one.