The US Food and Drug Administration has approved TNKase or Tenecteplase, which is a thrombolytic or clot-dissolving agent, for the treatment of acute ischemic stroke in adults.

Ischemic strokes happen when a blood clot blocks a blood vessel in your brain. It can cause permanent brain damage and death. If enough brain cells die, you can also lose the abilities or body functions those cells control. They are also the most common types of stroke, with 80% of all strokes being ischemic strokes.

How is TNKase administered?

It is delivered as a single five-second intravenous bolus, which is faster than the standard of care Activase or alteplase, which is administered as an intravenous bolus followed by a 60-minute infusion. The manufacturer of TNKase, Genetech said a new 25-mg vial configuration will also be available in the coming months.

How Was TNKase approved?

The approval came at the backdrop of a study that compared TNKase to Activase in patients with acute ischemic stroke. These patients also presented with a disabling neurological deficit. Results show that TNKase was comparable to Activase in terms of efficacy and safety.

How Common Are These Strokes?

In the United States it self, it affects more than 795,000 people each year and is the leading cause of long-term disability. It is also the fifth leading cause of death. Since brain damage can happen if this progresses rapidly, one needs an immediate, fast-acting medical care.

TNKase thus provide a faster and simpler administration which can be critical for anyone. The chief medical officer and head of global product development at Genetech, Levi Garraway, MD., PhD., said, "Today's approval is a significant step forward and underscores our commitment to advancing stroke treatment options for patients."

What Are The Symptoms Of Ischemic Strokes?

Some of the most common symptoms include weakness or paralysis on one side of your face and body. You may also feel trouble speaking or have loss of speech, also known as aphasia. You may faced slurred or garbled speaking, also known as dysarthria. Other symptoms include loss of muscle control on one side of your face, or sudden worsening or loss of your senses, including vision, hearing, smell, taste, and touch.

Other symptoms include:

• Loss of coordination or clumsiness
• Blurry vision or double vision
• Dizziness or vertigo
• Nausea and vomiting
• Neck stiffness
• Mood swings or sudden personality changes
• Confusion or agitation
• Seizures
• Memory loss (amnesia)
• Headaches which are sudden and severe
• Passing out or fainting
• Coma

Are There Any Warning Signs?

While these are symptoms one has who is prone to this condition. However, often, many may confuse it with other illnesses. It is best to keep an eye out for warning signs. These could be looking out for yourself or your loved one. Note if there is a sudden loss of balance. Look out for sudden vision loss or changes in one or both eyes. Look for a droop on one or both sides of your face, especially when you smile. Raise both arms and see if one arm sags or drops in a way it usually does not. Note for your speech. Are you as fluent? Are you have trouble speaking? If you see any of such signs, start tracking it and talk to your healthcare provider.

Night shift workers often face the risks of poor sleep or sleep deprivation. They have long been advised to aim for one uninterrupted block of daytime sleep after work.

However, a new review suggests that splitting sleep into two separate periods, known as biphasic sleep, can help them avoid certain health risks.

Can Biphasic Sleep Help Night Shift Workers?

Night shifts have become an unavoidable part of our lives. Healthcare professionals, emergency responders, factory employees, and transportation workers often work overnight.

Night shifts can disrupt the body's internal clock, increasing the risk of obesity, diabetes, cardiovascular disease, depression, and cognitive decline.

Research also shows that night shift workers typically sleep one to four hours less than daytime workers, leading to chronic sleep debt over time.

The recent review, published in the journal Sleep Medicine Reviews, examined existing research on biphasic sleep among shift workers.

Researchers found that while evidence is still emerging, dividing sleep into two episodes can help workers get more sleep, improve alertness during night shifts, and potentially reduce a few long-term health risks associated with chronic sleep deprivation.

The researchers noted that although sleep recommendations traditionally focus on obtaining one long sleep period, many shift workers naturally divide their sleep into two episodes. They usually sleep for a few hours immediately after work and then take another longer sleep before returning for the next night shift.

Also read: Not Just Exhaustion, Sleep Disorders Can Alter Your Brain's Attention & Decision-Making Centres: Study

"Biphasic sleep may help mitigate sleep loss-related impairments," the authors wrote, while observing that its potential benefits have not been fully understood until now.

According to the review, this split-sleep pattern could help workers accumulate more total sleep over a 24-hour period while fitting better around their daytime commitments.

Evidence also suggests biphasic sleep may improve alertness, reduce fatigue, and enhance cognitive performance compared to one uninterrupted daytime sleep, which is often shortened and disrupted by noise, light, or social obligations.

The findings build on a growing body of research suggesting that sleep does not necessarily have to occur in one continuous block to provide health benefits.

A 2025 review also stated that biphasic sleep may be a natural and flexible sleep pattern for some people and could be particularly useful for shift workers, new parents, and others facing unavoidable sleep disruption.

Split Sleep Is Not A Permanent Fix

Experts do caution that split sleep is not a permanent solution. The latest review emphasizes that evidence is still limited as there are just a few reliable studies that directly compare biphasic and monophasic sleep among night workers.

Factors like shift schedules, chronotype, workplace demands, and individual health conditions can all influence whether the strategy is effective.

Sleep specialists also stress that the total amount of sleep remains the most important factor.

Adults should still aim for seven to nine hours of sleep within a 24-hour period whenever possible. Good sleep hygiene, including using blackout curtains, reducing noise, avoiding caffeine before bedtime, and maintaining a consistent sleep schedule, continues to play a key role in protecting long-term health.

A new study suggests that rising temperatures, floods and droughts could affect the predictability and frequency of waterborne disease outbreaks. Climate change can alter the traditional patterns of disease transmission in ways that are more complex than previously understood.

Researchers state that public health systems can no longer rely on existing weather-disease relationships, as global warming has significantly changed the environmental conditions and their influence how pathogens survive, spread and infect people.

Effect Of Climate Change On Waterborne Diseases

The review says that increasing temperatures, extreme rainfall, prolonged droughts and flooding do not simply increase disease risk. Instead, they can alter the timing, intensity and location of outbreaks, making them less predictable.

"Climate change is resetting many of the environmental conditions that determine when and where waterborne diseases emerge," the researchers noted, emphasizing that disease surveillance systems must evolve to keep pace with these changing dynamics.

According to the researchers, several climate-related factors work together to increase the likelihood of contaminated water and disease transmission.

Also read: Cholera Outbreak In Sudan: 117 Dead, 838 Suspected Cases, Says WHO

Higher Temperatures

Warmer water allows bacteria, viruses and parasites to multiply more rapidly. Pathogens such as Vibrio cholerae, which causes cholera, thrive in warmer aquatic environments.

Heavy Rainfall And Floods

Extreme rainfall can overwhelm sewage systems and contaminate drinking water with human and animal waste. Floodwaters also spread pathogens into rivers, lakes and groundwater supplies.

Drought

Although drought reduces water availability, it can also increase disease risk. Limited water supplies often become more concentrated with pathogens, while communities may be forced to use unsafe water sources.

Poor Sanitation After Climate Disasters

Storms, cyclones and floods frequently damage sanitation infrastructure, creating conditions where waterborne infections can spread rapidly.

These factors interact in different ways depending on geography, infrastructure and local climate, making future outbreaks increasingly difficult to forecast.

Also read: How To Spot Leptospirosis, Dengue, Malaria During Monsoons? Early Symptoms Not To Neglect

What Diseases Are Likely To Be Affected By Climate Change?

Researchers say climate-sensitive waterborne illnesses include:

• Cholera
• Acute diarrheal diseases
• Typhoid fever
• Hepatitis A
• Gastroenteritis
• Other bacterial and parasitic infections spread through contaminated water

Children, older adults and people living in regions with limited access to safe drinking water and sanitation are expected to face the greatest risks.

What Do Experts Recommend?

The researchers stress that instead of reacting to outbreaks the governments should strengthen climate-friendly public health systems. The key recommendations include:

• Expanding water quality monitoring
• Improving disease surveillance
• Investing in resilient water and sanitation infrastructure
• Developing climate-informed early warning systems
• Strengthening emergency preparedness for floods and droughts

Researchers say that understanding the evolving relationship between climate and infectious diseases will be essential to protecting communities across the world as global temperatures continue to rise.

Climate change is increasingly being recognized as a major public health threat, extending beyond heatwaves and air pollution to affecting patterns of infectious diseases.

The new review suggests that future waterborne disease outbreaks may not simply become more frequent but also less predictable, requiring health systems to adapt quickly to a changing climate.

As extreme weather events become more common worldwide, researchers warn that protecting safe water supplies and strengthening surveillance will be critical to reducing the growing burden of waterborne diseases.

Nearly nine out of every 10 Indian adults have at least one abnormal blood lipid level, according to a recent nationwide study by ICMR-INDIAB.

The findings highlighted a massive looming public health crisis that could increase the risk of heart attacks, strokes and other cardiovascular diseases across the country in the near future.

India’s Silent Cholesterol Crisis

The findings, which were reported between July 17 and July 19, 2026, reveal that dyslipidemia, an unhealthy imbalance of cholesterol and triglycerides in the blood, affects an alarming number of Indian adults.

Despite being preventable and treatable, the condition often remains undiagnosed because it presents with little to no symptoms until serious complications surface.

The study was conducted by the Indian Council of Medical Research’s India Diabetes (ICMR-INDIAB) in what is one of the country’s largest community-based metabolic health surveys, involving over 113,000 adults from different states and Union Territories.

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Women And Urban Residents At Greater Risk

According to the study, women, those living in urban areas, and residents of Central India carried a disproportionately higher burden of abnormal lipid levels.

Researchers also found that dyslipidemia was significantly more common among people with prediabetes or diabetes, obesity, and hypertension.

These metabolic conditions substantially increasing the risk of various cardiovascular diseases and complications.

What Is Dyslipidemia?

Dyslipidemia refers to unhealthy levels of fats circulating in the bloodstream. These include:

• High LDL (bad) cholesterol, which contributes to plaque buildup in the arteries.
• Low HDL (good) cholesterol, reducing the body’s ability to remove excess cholesterol.
• High triglycerides, another blood fat that contributes to cardiovascular disease and pancreatitis.
• Elevated total cholesterol

ICMR-INDIAB programme has already shown that lipid disorders remain one of the concerning health risks. However, the latest study highlights just how serious the problem has become, with nearly 90% of adults exhibiting at least one lipid abnormality.

Also read: US Senator & Trump's Close Ally Lindsey Graham Died Of Aortic Dissection: All About The Fatal Heart Emergency

Why Is India Facing A Cholesterol Crisis?

Factors like rapid urbanisation, sedentary lifestyles, unhealthy diets, obesity and rising diabetes rates are likely contributing to the worsening burden of cholesterol.

Unlike many chronic diseases, dyslipidemia can be managed through early detection and lifestyle change. Doctors recommend the following preventive measures:

• Regular lipid profile screening, especially after age 30 or earlier for high-risk individuals.
• Maintaining a healthy body weight.
• Exercising regularly.
• Eating a diet rich in fruits, vegetables, whole grains and healthy fats while limiting saturated and trans fats.
• Managing diabetes and blood pressure.
• Taking cholesterol-lowering medications such as statins when prescribed.

India has witnessed a steady rise in metabolic disorders over the past two decades, with cases of diabetes, obesity, hypertension and abnormal cholesterol increasingly surging.

Researchers warn that unless preventive measures are strengthened and strict lifestyle changes adopted, the country could face an even greater burden of heart disease and other related disorders in the future.