Ebola Outbreak: Uganda Set To Start Vaccine Trials

Updated Feb 3, 2025 | 08:58 AM IST

SummaryAfter a nurse died of the Ebola virus, the country has declared Ebola outbreak and is now deploying vaccine against the Sudan strain of the virus.
Ebola vaccines

On Thursday, Uganda confirmed an outbreak of the Ebola virus in its capital city Kampala, with the first confirmed patient dying from it a day before. As per the new developments, the officials are now preparing to deploy a trial vaccine to put an end to this outbreak.

Groups of scientists are working on the vaccine and deployment of more than 2,000 doses of a candidate vaccine against the Sudan strain of Ebola has been planned and confirmed by the Uganda Virus Research Institute. As per the World Health Organization (WHO), Uganda has access to 2,169 doses of trial vaccine. For now, however, there are no approved vaccines for the strain and officials are still investigating the source of the outbreak.

The WHO had also allocated $1 million from its contingency fund for emergencies to support quick action and contain the outbreak in the country.

Confirmed Case

On Wednesday, the Sudan strain of Ebola killed a nurse employed at Kampala's main referral hospital. It is after his death that Ebola was declared an outbreak in the country. Post-mortem samples too have confirmed the Sudan Ebola Virus Disease and at least 44 contacts of the deceased man have been listed for tracing. 30 of these are health workers.

Ebola is a highly infectious hemorrhagic fever, which is transmitted through contact with bodily fluids and tissue. Symptoms include headache, vomiting of blood, muscle pains and bleeding.

it was in the late 2022, when Uganda had last suffered an Ebola outbreak. It killed 55 of the 143 people who were infected and was declared over on January 11, 2023.

What Is Ebola Virus Disease?

As per the WHO, Ebola virus disease (EVD) is a rare but severe illness in humans and is often fatal. People can get infected with the virus if they touch an infected animal when preparing food, or touch body fluids of an infected person such as saliva, urine, faeces or semen, or things that have body fluids of an infected person like clothes or sheets.

How Does Transmission Work?

Ebola enters the body through cuts in the skin or when one is touching their eyes, nose or mouth. Early symptoms include fever, fatigue and headache.

It was first discovered in 1976 in two simultaneous outbreak, when in Nzara, South Sudan and other in Yambuku, Democratic Republic of Congo. The latter occurred near a village near the Ebola River, which is where it gets its name from.

It is highly infectious and transmissible disease, in fact, there have been cases of health-care workers who have frequently been infected while treating patients with suspected or confirmed Ebola. This occurs through close contact with patients when infection control precautions are not practiced strictly.

Cases of people conducted burial ceremonies, involving direct contact with the body of the deceased too can lead to the transmission of Ebola. Even after the long suffering and recovery, there is a possibility of sexual transmission. Pregnant women who get acute Ebola and recover may still carry the virus in their breastmilk, or in pregnancy related fluids and tissues.

Symptoms:

  • feeling tired
  • headache
  • muscle and joint pain
  • eye pain and vision problems
  • weight gain
  • belly pain and loss of appetite
  • hair loss and skin problems
  • trouble sleeping
  • memory loss
  • hearing loss
  • depression and anxiety

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Andhra Pradesh To Launch Rare Disease Policy, Expand Universal Newborn Screening

Updated Jun 26, 2026 | 04:00 PM IST

Summary​Health Minister Y. Satya Kumar Yadav said that the proposed policy will provide free diagnostic tests, specialized treatment, and financial assistance to affected families.
Andhra Pradesh To Launch Rare Disease Policy, Expand Universal Newborn Screening

Credit: iStock

Andhra Pradesh is set to launch a Rare Disease Policy, aligned with the National Policy for Rare Diseases (NPRD), 2021, to improve diagnosis, treatment, and financial support for patients living with rare diseases.

The proposed policy will provide free diagnostic tests, specialized treatment, and financial assistance to affected families, Health Minister Y. Satya Kumar Yadav announced while addressing the Rare Diseases Care and Draft Policy Consultation at Dr NTR University of Health Sciences.

What's Included in Andhra Pradesh's Rare Disease Policy?

As part of the proposed policy, the state government plans to:

  • Establish referral cents for rare diseases in Kurnool, Tirupati, and Visakhapatnam.
  • Explore designating a government hospital as a Centre of Excellence for rare disease treatment.
  • Create a state registry for diseases identified by the Indian Council of Medical Research (ICMR) to better understand the disease burden.
  • Introduce universal newborn (neonatal) screening to enable early detection of rare diseases.
  • Mobilize donor support to help patients meet the high cost of treatment.

The minister said the government is committed to ensuring access to quality healthcare for rare disease patients regardless of their financial status. He also stressed the importance of increasing public awareness to facilitate early diagnosis and timely intervention.

Also read: How AI Is Transforming Early Diagnosis of Rare Diseases

Further, to improve access to treatment, the state will hold a meeting with pharmaceutical companies in the first week of July to discuss the production, availability, and distribution of medicines for rare diseases.

The government also plans to encourage the pharmaceutical industry to provide financial and other support to patients.

Health Secretary S. Suresh Kumar said integrating rare disease patients with the Ayushman Bharat Digital Mission would improve treatment tracking and continuity of care. NGOs, caregivers, patients, and medical experts participating in the consultation welcomed the government's initiative and offered recommendations for the draft policy.

What Is the National Policy for Rare Diseases (NPRD)?

The National Policy for Rare Diseases (NPRD), 2021, was introduced to improve access to diagnosis, treatment, and financial assistance for patients with rare diseases.

The policy classifies rare diseases into three categories:

  • Diseases that can be treated with a one-time curative intervention.
  • Diseases requiring long-term or lifelong treatment.
  • Diseases for which effective treatment is still under research.

Under the Rashtriya Arogya Nidhi (RAN) scheme, eligible patients can receive financial assistance of up to Rs 50 lakh for specified rare diseases covered under the policy.

Read More: Ebola Outbreak: The Unique Symptoms Seen In Patients Infected With Bundibugyo

What Is a Rare Disease?

The World Health Organization (WHO) defines a rare disease as a chronic, often debilitating or life-threatening condition affecting one or fewer people per 1,000 population.

According to the WHO's International Classification of Diseases (ICD-11), more than 5,500 rare diseases have been identified, while globally there are an estimated over 7,000 distinct rare diseases affecting more than 300 million people.

In India, a disease is generally considered rare if it affects fewer than one in 2,500 people. Most rare diseases are genetic and are frequently misdiagnosed because of limited awareness, delayed diagnosis, and inadequate access to specialized care.

According to estimates by the Foundation for Research on Rare Diseases and Disorders, more than 70 million Indians are living with rare diseases. Common examples include Gaucher disease, Duchenne muscular dystrophy, and lysosomal storage disorders.

Despite affecting relatively small numbers individually, rare diseases collectively represent a significant public health challenge due to limited treatment options, delayed diagnosis, and the high financial burden on patients and their families.

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Europe Heatwave Shatters June Records: Paris Limits Alcohol Sales, F1 Declares Heat Hazard

Updated Jun 26, 2026 | 03:09 PM IST

SummaryAccording to the World Meteorological Organization (WMO), temperatures are forecast to remain between 3°C and 10°C above average, with daily highs exceeding 35°C across many areas and locally crossing 40°C.
Europe Heatwave Shatters June Records: Paris Limits Alcohol Sales, F1 Declares Heat Hazard

Credit: AI generated image

Europe is enduring an unprecedented June heatwave, with temperatures reaching as high as 43.8°C and several countries breaking national records. The extreme weather has forced authorities to issue red alerts, restrict public activities, deploy cooling centers, limit alcohol sales and warn of worsening health risks.

France, Spain and the UK Break Temperature Records

France has been among the worst-hit countries. On June 24, it recorded its hottest day on record, with an average national temperature of 30.0°C, surpassing previous records set in July 2019 and August 2003, according to Météo-France. Temperatures peaked at 43.8°C in the western town of Pulluau, while overnight temperatures also set a new national record.

A record 58 French departments were placed under the highest-level red alert as officials warned of an elevated risk of forest fires amid worsening drought conditions. Forty people reportedly died in drowning accidents during the intense heat, UN News reported.

Spain also recorded its hottest June days on record on June 23 and 24, with temperatures exceeding 40°C in several locations.

In the UK, the Met Office issued a red extreme heat warning and reported a provisional June record of 36.1°C at Gosport in southern England.

Germany issued widespread red alerts, including for Bonn, Frankfurt and Cologne, while Swiss cities such as Geneva, Basel and Zurich were also placed under red alert.

WMO Warns of More Extreme Heat

Also read: Heatwave Linked To 212 Deaths In Spain: How Does Heat Impact Health?

According to the World Meteorological Organization (WMO), the heatwave is expected to spread across Western, Central and Southern Europe over the next two weeks. The agency said temperatures are forecast to remain between 3°C and 10°C above average, with daily highs exceeding 35°C across many areas and locally crossing 40°C.

The WMO also warned of more frequent "tropical nights," when temperatures remain above 20°C overnight, preventing the body from recovering from daytime heat.

Hospitals Under Pressure, Paris Restricts Alcohol Sales

The worsening conditions have disrupted healthcare services, with media reports saying hospitals have had to postpone critical imaging scans after sensitive equipment overheated. Cities have also opened emergency cooling centers to protect vulnerable residents.

In Paris, authorities have announced temporary bans on public alcohol consumption and takeaway alcohol sales to ease pressure on hospitals. Public drinking will be prohibited from noon to 7 a.m. over the weekend, while takeaway alcohol sales will be banned between 6 p.m. and 7 a.m. Licensed bars and restaurants are exempt.

French Prime Minister Sébastien Lecornu said the country's highest health alert level had been activated to boost hospital staffing and protect vulnerable people.

"We are reaching a saturation point in hospital facilities," said Paris police chief Patrice Faure, while speaking to local media.

Faure has also asked organizers of the Pride march and the Solidays music festival to cancel their events because of the continuing heatwave.

Read More: UK Met Office Warns of 'Pollen Bomb': What Hay Fever Patients Need to Know

Formula 1 Declares Heat Hazard

The extreme temperatures have also reached the sporting world. Formula 1's governing body, the FIA, has declared another "heat hazard" ahead of the Austrian Grand Prix weekend at Spielberg's Red Bull Ring, triggering additional measures to protect drivers, teams and spectators.

"Europe's savage heatwave has the fingerprints of the climate crisis all over it", said United Nations climate chief Simon Stiell. He has called for "a faster shift to renewables, protecting forests and boosting climate resilience".

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Ebola Cases Reach 1,155, Deaths Top 300 in Congo; WHO Warns of 70% Risk of Spread to South Sudan

Updated Jun 26, 2026 | 10:36 AM IST

SummaryThe WHO report said that South Sudan must continue to reinforce infection prevention and control, rapid response capacity, and cross-border surveillance.
Ebola Cases Reach 1,155, Deaths Top 300 in Congo; WHO Warns of 70% Risk of Spread to South Sudan

Credit: iStock

The Ebola outbreak in the Democratic Republic of Congo continues to worsen, with cases rising to 1,155 and deaths climbing to 304, as per the latest government data.

The figures represent the total confirmed cases as of June 24, according to a situation report which documented 37 new cases and five new deaths in the previous 24 hours. Ituri, North Kivu and South Kivu remain the most affected provinces in Congo.

Experimental treatments

Also read: Ebola Outbreak: The Unique Symptoms Seen In Patients Infected With Bundibugyo

The US is now providing doses of an experimental Ebola treatment developed by Mapp Biopharmaceutical for clinical trials in Congo.

The experimental therapy, known as MBP134, was developed by San Diego-based Mapp Biopharmaceutical. While the US had previously kept its stockpile for potential use in exposed American citizens, it is now making doses available to support clinical research in Congo. This is the first time Washington has publicly committed stockpiled supplies of the treatment for a broader international trial.

According to the World Health Organization, researchers will test MBP134 both on its own and alongside the antiviral drug remdesivir, marketed as Veklury. Remdesivir became widely known during the COVID-19 pandemic and is being evaluated to see whether it can improve outcomes when combined with the antibody treatment.

Ebola: Scientists Lack Access To Virus Samples

The ongoing outbreak is being driven by the rare Bundibugyo strain, for which no approved vaccine or treatment exists. However, scientists racing to develop vaccines and therapies are hampered by the lack of a viable sample of the virus.

“There’s nothing like having the authentic isolate,” said Thomas Geisbert, Professor of microbiology and immunology at the University of Texas Medical Branch in Galveston, who helped develop previous Ebola vaccines, Bloomberg reported.

“Despite so many cases, the global scientific community has not obtained a clinical sample to isolate the virus for the needed animal challenge studies,” added Jennifer Serwanga, head of immunology at the Uganda Virus Research Institute, the report said.

Ebola: WHO Warns Spread to South Sudan

Further, as per a new WHO modelling study published in The Lancet, the growing Congo Ebola outbreak, which has already spread to Uganda, has a 70 per cent chance of reaching South Sudan soon.

The study combined epidemic modelling with spillover estimation to quantify regional risks associated with the 2026 Ituri outbreak using laboratory-confirmed case data from WHO Situation Reports (33 cases as of May 18, 2026, to 598 cases as of June 8, 2026), with projections extending 12 weeks from May 18 to Aug. 10, 2026. It also integrates operational preparedness considerations relevant for neighboring countries.

The report showed that even with the intensified response within DR Congo, uncertainty remains around reported case numbers due to the low rate of contact tracing.

“Sustained control nonetheless remains the primary determinant of regional risk: importation into Uganda is already established, and South Sudan must continue to reinforce infection prevention and control, rapid response capacity, and cross-border surveillance under International Health Regulations 2005,” said researchers from the WHO Regional Office for Africa, Nairobi, Kenya.

The report called for:

  1. Enhanced surveillance at formal and informal points of entry to detect suspected cases early and prevent silent transmission.
  2. Strengthen infection prevention and control (IPC) measures in front-line health facilities to reduce nosocomial transmission and protect health-care workers.
  3. Train, equip, and pre-position rapid response teams for immediate deployment.

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