Many of us believe that we are great drinkers and that alcohol does not affect us as much. People who are able to drink without showing any sign of inebriation are known as social drinkers. In short, they are not addicted to alcohol but will not turn down the opportunity to have a good time! While it may seem like it doesn’t affect you, new studies suggest that it is just an illusion, even if you have high tolerance, alcohol affects your cognitive and motor functions more than you think.

The study reveals the below implications and techniques:

• Researchers used a new MRI technique to precisely measure brain electrical activity.
• By comparing brain scans before and after drinking, scientists identified specific areas affected by alcohol and how much brain activity slowed down.
• Participants were chosen to be regular social drinkers without alcohol addiction, ensuring the study focused on the effects of alcohol alone.
• MRI technology provided reliable data on brain activity changes caused by alcohol consumption.

How does the brain react to alcohol?

Think of it as the foundation for your brain's performance. When brain conductivity is high, information flows smoothly, and that helps your brain in rapid processing and response. On the other hand, low conductivity can hinder cognitive function, leading to slower thinking, impaired memory, and difficulties with coordination.

A study conducted at the Neuroscience Research Australia (NeuRA) and UNSW Science unveiled a startling connection between alcohol consumption and brain conductivity.

What is the connection between alcohol consumption and brain activity?

While many people brush off the effects of alcohol as temporary changes in behaviour, the reality is much more complex. Beyond the obvious impacts on coordination and judgment, alcohol significantly alters brain function. Alcohol dramatically slowed down brain activity, especially in areas responsible for decision-making, planning, and physical coordination. This decline was so significant that it resembled the brain changes seen in normal ageing. This means even one drink could temporarily accelerate the ageing process of your brain.

Alcohol and Brain activity: What does the study Imply?

The implications of this research are far-reaching. It provides compelling evidence that alcohol consumption has a direct and measurable impact on brain function. The discovery that alcohol can significantly reduce brain conductivity opens new avenues for understanding the neurocognitive effects of alcohol abuse and dependence. While you may not feel like alcohol is affecting you and you have a high tolerance, it most definitely changes and affects your decision-making abilities and impulse control.

Furthermore, the MRI technique employed in the study could be a valuable tool for assessing the impact of other substances on the brain and for developing interventions to mitigate alcohol-related brain damage.

Amid continued escalations in the Middle East conflict, the Indian government is considering a temporary price hike between 10 and 15 percent for essential medicines, according to a media report.

The surge in prices for select medicines could lead to higher drug prices but potentially benefit Indian pharmaceutical manufacturers facing the brunt of the Iran war.

“The immediate net consumer impact could be 3-5 percent higher prices, or roughly similar to what consumers paid before the late-September cuts in GST rates,” said the report by Economic Times, citing top industry executives aware of the government’s discussions.

The proposal was reportedly floated after several top drugmakers raised concerns about the sharp increase in prices of solvents and active pharmaceutical ingredients (APIs) due to global supply disruptions.

The price hike is expected to remain for up to four months and will be rolled back once the input cost stabilizes, the report said.

Further, it cited a senior government official saying that they have received the industry proposal for a price hike, but the decision to implement depends "on how long the geopolitical tension in West Asia lasts".

Increasing Raw Material Costs Drive Up Medical Device Prices

HealthandMe had earlier reported that the ongoing conflict has already spiked prices for medical devices—specifically plastics for syringes and catheters—due to the rising cost of raw materials. If disruptions persist, it can also warn of potential shortages.

“A shortage of liquid helium could impact the installation of new MRI scanners, each of which requires around 1,500 liters for the initial magnet fill. Supply disruptions linked to the war may delay new installations and push up costs, as helium prices are likely to rise amid tighter availability,” Dr. Harsh Mahajan, Mentor FICCI & Founder Mahajan Imaging & Labs, told HealthandMe.

The expert noted that there is no immediate concern for existing MRI machines. It is because most currently installed scanners use K4 technology with zero boil-off systems, allowing them to operate efficiently without frequent helium refills.

“Typically, a top-up is needed only once every three years, when the magnet’s cold head is replaced. As a result, the existing installed base is expected to continue functioning without disruption in the near term,” Dr. Mahajan said.

Also read: Report Claims Mojtaba Khamenei ‘Incapacitated’: What Does This Mean Medically

Long-term Hormuz Blockade Can Affect Critical Medical Supplies

However, the rapidly deteriorating situations and a longer blockade of Hormuz can lead to “substantial price increases, longer lead times, and highly elevated freight costs, which are pressuring cost structures and planning cycles”.

According to Rajiv Nath, AiMeD, the evolving global supply chain dynamics require close monitoring to prevent impacts on production timelines and industry stability.

The Medical Technology Association of India (MTaI) also warned that the ongoing US/Israel-Iran conflict and disruption in the Strait of Hormuz directly threaten India’s access to critical and life-saving medical technologies.

"Modern healthcare systems operate on just-in-time inventory models with minimal buffer stock. When large consignments - like those shipped by sea - are delayed or stranded, there is simply not enough inventory in the system to compensate, even through costlier alternatives like air freight," Pavan Choudary, Chairman, MTaI, told HealthandMe.

He also noted that shipment delays beyond March 31 can lead to "budget lapse, forcing a fresh approval cycle - thereby compounding delays that often stretch to months". It is because many public institutions in India front-load procurement toward the financial year-end.

Tech giant Amazon’s cloud unit has launched a new AI-powered application, Amazon Bio Discovery, that will help scientists design and test novel drugs more quickly, bringing new medical treatments to patients faster.

Developed by Amazon Web Services, the new agentic AI application—a smart assistant that automates complex tasks—helps scientists select the right models for their research goals, optimize the inputs, and evaluate candidates for experimentation.

"AI agents make powerful scientific capabilities accessible to all drug researchers, not just those with computational expertise," said Rajiv Chopra, vice president of AWS Healthcare AI and Life Sciences.

"These AI systems can help scientists design drug molecules, coordinate testing, learn from results, and get smarter with each experiment. This combination of cutting-edge AI and the robust, secure infrastructure AWS has built for regulated industries allows scientists to accelerate antibody discovery in ways that weren't possible before," Chopra added.

How Amazon Bio Discovery Will Help Boost Drug Discovery

With the help of Amazon Bio Discovery, scientists can run complex computational workflows ‌without writing code.

Notably, the platform also gives scientists direct access to a broad catalog of specialized AI models called biological foundation models (bioFMs) that are trained on vast biological datasets. These models generate and evaluate potential drug molecules, known as candidates, helping scientists accelerate antibody therapies during the early stages of drug discovery.

Also read: India Must Integrate Technology To Build Preventive, Holistic Healthcare: Experts

Amazon Bio Discovery also enables scientists to securely feed prior experimental data from their organization's lab results into the application. They can use their own lab data to train custom models with just a few clicks—no need to build complex training pipelines or write custom code.

Amazon Bio Discovery also provides three key capabilities:

• a benchmarked library of AI models and analysis packages,
• an AI agent that helps researchers design experiments,
• integrated lab partners that test the most promising antibody candidates and route results back to the scientists.

Amazon Bio Discovery: Early adopters

Amazon Bio Discovery provides complete data isolation and gives customers ownership over all their proprietary data and intellectual property.

According to AWS, Bayer, the Broad Institute, Fred Hutch Cancer Center, and Voyager Therapeutics are among early adopters, and 19 of the top 20 ‌global pharmaceutical ⁠companies already use its cloud services.

In a collaboration with Memorial Sloan Kettering Cancer Center, AWS said the platform used multiple models to generate nearly 300,000 novel antibody molecules and narrow them to 100,000 candidates for lab testing by partner Twist Bioscience, compressing work that can take months ⁠into weeks.

Surging AI Adoption in Drug Development

Drugmakers and technology companies have stepped up efforts to use AI to accelerate drug development.

Recently, Danish pharmaceuticals group Novo Nordisk, maker of the popular Ozempic and Wegovy anti-obesity drugs, announced a "strategic partnership" with OpenAI to accelerate the development of new medications.

Read More: Telangana, Astrazeneca India To Launch AI-powered Lung Cancer Screening In Public Hospitals

Novo Nordisk is banking heavily on AI to test new treatments and vaccines and bring them to market faster for less money.

In 2024, Boston Consulting Group ⁠and Merck announced GenAI Collaboration with Merck. The collaboration will initially focus on disease networks and pathways for chronic and degenerative diseases.

Diabetes patients rely upon metformin for controlling their blood sugar and insulin levels. Now, a new study claims that this common diabetes drug has many other health benefits to offer, and these can mimic the benefits of 'intense workouts.' The diabetes drug metformin is used by millions around the world who are struggling with this lifestyle disorder—it releases weight-regulating compounds in the body, the same ones that are released during workouts in inactive people. American scientists found that the drug can have a positive impact on a sedentary lifestyle—find out how.

Also Read: The 'Cicada' COVID Variant: A New Name, A Familiar Landscape

What is metformin?

Are workouts necessary during cancer treatment?

How does metformin mimic the benefits of workouts?

Exercising benefits the body by releasing hormones such as oxytocin and dopamine. Researchers from the Sylvester Comprehensive Cancer Center explored whether these could be triggered without exercise and whether metformin could do that. They noted that while the drug cannot fully replace workouts as part of a healthy routine, there is a need to understand how a widely used drug can be beneficial for metabolic health during prostate cancer treatment.

N-lactoyl-phenylalanine, or Lac-Phe, is a molecule that spikes after an intense workout session, and it also regulates appetite and calorie burning. Scientists found that Lac-Phe levels were higher in metformin users even when they were not working out. The Sylvester team noted that prostate cancer patients often struggle with poor blood sugar control, heart disease risk, and weight gain due to hormone therapy. They then took blood samples from 29 people and found that the patients who took metformin had similar Lac-Phe levels to people who were engaged in strenuous workouts. This was noted even when the patients were not exercising. However, metformin did not have an impact on prostate tumours.

The study was published in the EMBO Molecular Medicine journal.