The Union Health Ministry implemented a ban on 156 "irrational" FDC medicines, effective immediately. These medicines, including widely used antibiotics, painkillers, and multivitamins, were commonly used to treat fever, cough, and infections. The ban was imposed due to the associated health risks and lack of therapeutic justification for the ingredients in these FDCs.

What are FDC medicines?

FDCs or fixed-dosed combinations, also known as "cocktail drugs," are medications that combine multiple drugs in a single pill. They are designed to treat multiple symptoms or conditions simultaneously. While they offer convenience, they can pose significant risks. These risks include the possibility of overdose, adverse interactions between the drugs, and the development of antibiotic resistance. Additionally, many FDC medicines lack sufficient scientific evidence to support their safety and efficacy.

Expert opinions on FDC medicines

Experts have raised concerns about the use of FDC medicines. They believe that many of these combinations lack sufficient scientific evidence to support their safety and effectiveness. Additionally, the combination of multiple drugs in a single pill can increase the risk of adverse side effects and interactions with other medications.

Experts have also found that FDC medicines may not be as effective as individual drugs in treating certain conditions. It is important to note that safer and more effective alternatives are available for most of the medical conditions that FDC medicines were used to treat. One particular concern is the inclusion of antibiotics in some FDCs. Overuse of antibiotics can contribute to the development of antibiotic resistance, a major public health threat.

The risks of FDC medicines

The use of FDC medicines can lead to adverse effects, including serious ones. Additionally, safer alternatives, tested in clinical trials, are available to treat the same medical conditions. Experts recommend prescribing drugs individually based on a patient's clinical symptoms rather than combining them in FDCs.

The ban on irrational FDC medicines by the Union Health Ministry can be seen as a positive step towards promoting rational drug use and protecting public health. The goal is to eliminate unnecessary and potentially harmful drug combinations. This is a step forward in reducing the risks associated with medication and ensure safer and more effective treatment options for patients.

A second person may have died at a hospital in Russia’s Irkutsk region after reportedly contracting plague, local media have claimed, even as Moscow denies an outbreak.

The death has not been officially confirmed. The report comes as the World Health Organization (WHO) seeks more information from Russia about the death of a 28-year-old laboratory worker in Irkutsk and reports of a second employee with pneumonia of undetermined cause.

WHO Seeks Answers From Russia

The WHO said it has asked Russia for information on the cause of the severe pneumonia, the pathogen that prompted public health measures and reports of a second employee with pneumonia of undetermined cause.

Russia told the WHO on October 6 that no plague cases had been detected in Irkutsk, including among the laboratory worker or her contacts.

Second Death Reportedly Linked To Plague

Also read: Russia Plague Scare: What Black Death and Anthrax Outbreaks Teach Us About Lab Safety

Local media reported the second death after Baikalsk authorities issued a Telegram warning on October 3 about “unofficial information” of a confirmed plague case in Shelekhov, The Daily Mail reported.

“Due to unofficial information about a confirmed case of plague in a person in the city of Shelekhov, we ask you to limit visits to Shelekhov and nearby settlements until the circumstances surrounding this threat are clarified,” the administration said.

The post was deleted about two hours later, according to local media Lyudi Baikala. There is no official confirmation that the person had plague or died from Yersinia pestis.

Hospitals Under Quarantine In Irkutsk

The reports come amid increased health precautions in the region. People of Baikal reported doctors discussing plague and locals seeing people in protective suits and masks. Workers at aluminium factories and nursery staff have also reportedly been asked to wear masks.

The hospital where laboratory worker Darya Shipilova was treated has reportedly been quarantined.

Lyudi Baikala reported that five hospitals in the Irkutsk area had entered “epidemic” mode, including three city hospitals and Ivano-Matreninskaya Children’s Hospital.

Read More: Russia Plague Scare: Could It Trigger A New Pandemic? Experts Explain

Plague and Darya Shipilova’s Death

Shipilova, 28, worked at the Irkutsk Anti-Plague Research Institute. She fell ill on September 29, was placed on a ventilator and died on October 2.

Around 200 contacts were reportedly placed under medical observation after she allegedly told doctors she had accidentally broken a test tube containing live bacteria.

Russia maintains that she died from “unidentified pneumonia”. Authorities said tests of her contacts found no dangerous infectious-disease pathogens, although some reportedly tested positive for COVID-19 or rhinovirus.

Kremlin spokesperson Dmitry Peskov urged the public to rely on Russia’s health watchdog, Rospotrebnadzor, rather than “rumors and speculation”.

“One should rely on official statements from Rospotrebnadzor rather than listening to various rumors and speculation,” Peskov said.

Meanwhile, The Insider reported that REN TV deleted five reports about plague in Irkutsk. Reports from Channel 5 and Kommersant have also reportedly disappeared.

US Monitoring Situation

READ: Russia Plague Scare: Is Pneumonic Plague Deadlier Than Bubonic & Septicemic Plague?

US President Donald Trump said his administration was in “very deep discussions” about the incident and that he had a call with Russian President Vladimir Putin scheduled.

Secretary of State Marco Rubio said Washington was monitoring reports of possible plague but said they were not a “cause for alarm”. “There’s very limited travel between the US and Russia, obviously, but like anything else, something like that gets out, it could quickly spread,” Rubio said.

“So we're watching and monitoring it closely. I don't think it's cause for alarm – but it is cause for focus and a cause to just keep an eye on it. And we're doing that.”

Meanwhile, neighboring countries including Mongolia, Kyrgyzstan and Uzbekistan have reportedly tightened border health measures amid concerns about possible pneumonic plague.

The US Food and Drug Administration has expanded the recall of frozen blueberries and berry blends after an outbreak of E. coli O145 linked to frozen organic blueberries sickened 17 people in two states.

The latest recall does not mean that the outbreak is growing. The CDC recently declared that the outbreak was over on September 21, with no new illnesses reported since then. But on October 2, the company at the centre of the investigation expanded its recall to include additional batches of frozen berry products after the FDA obtained new information during an onsite inspection.

The agency said the company had previously not provided all records requested by FDA investigators. After obtaining additional information, the FDA identified more products that could be contaminated and the company expanded its recall.

The FDA has also added the Chilean company, Frutas y Hortalizas del Sur S.A.. to Import Alert 99-35, which means that frozen blueberries from the company entering the US can be detained without physical examination.

Which Frozen Berries Are Now Recalled?

Also read: Drinking Raw Milk Hospitalizes 2 Young Girls in US With Nearly Fatal E. Coli Infection: Health Risks Explained

The expanded recall involves products sold under Great Value and Trader Joe’s brands. The affected products include:

• Great Value Organic Triple Berry Blend, 10-ounce packages, with lot codes 6 031 01 and 6 041 01
• Great Value Organic Blueberries, 10-ounce packages, with lot codes 6 019 01, 6 040 01 and 6 163 01
• Trader Joe’s Organic Mixed Berry Blend, 12-ounce packages, lot code 6 051 01

The recalled Great Value products were distributed to Walmart stores in 30 states and Puerto Rico, while the recalled Trader Joe’s berry blend was distributed more widely through the retailer. Consumers who have the affected products should not eat them and should discard them or return them for a refund.

Some of the recalled products have 'Best By' dates extending into 2028, meaning they could still be sitting in consumers' freezers despite the outbreak having ended.

E. coli Left 17 Sick

Also read: After 488 Sickened & 65 Hospitalised In Salmonella Outbreak, FDA Issues Highest-Risk Recall For Salad Dressing

According to the CDC and FDA, 17 people were infected due to E. coli outbreak across Florida and Georgia. There were six hospitalisations and zero fatalities.

Infections were reported between May 11 and August 2, 2026. Among 13 people interviewed during the investigation, 11 reported eating frozen blueberries, which strengthened the epidemiological link to the packaged produce.

Earlier in the investigation, one sample of GreenWise frozen organic blueberries collected by Publix tested positive for the same E. coli strain responsible for the illnesses. This led to recalls that were subsequently expanded to other products from the same supplier.

Why Is E. Coli O145 Dangerous?

E. coli O145 belongs to a group known as Shiga toxin-producing E. coli (STEC). These bacteria can cause severe stomach cramps, diarrhoea, vomiting and, in some cases, bloody diarrhoea.

Most people recover, but the infection can sometimes lead to haemolytic uremic syndrome (HUS), a serious complication that can cause kidney failure. Young children, older adults and people with weak and strained immunity are particularly vulnerable to severe illness.

People who develop symptoms after eating a recalled product should contact a healthcare provider, particularly if they develop bloody diarrhoea, severe abdominal pain or signs of dehydration.

Consumers should also check their freezers rather than assume recalled products have already been removed from stores. The FDA says recalled products should no longer be available for sale, but some have long shelf lives and may still be at home.

Anyone with one of the affected lot codes should not taste the product to determine whether it is safe. It should be discarded or returned for a refund.

Russia has told the World Health Organization (WHO) that no cases of plague have been recorded in Irkutsk, the Siberian city that has sparked international headlines after a laboratory worker from an anti-plague research institute died after suspected exposure to pneumonic plague infection.

The WHO said Russian authorities responded on October 6 to its request for information under the International Health Regulations (IHR), saying the woman’s illness had initially appeared to be a typical acute respiratory viral infection.

Russia also reported that no plague case had been recorded in Irkutsk, either in the woman or among her contacts.

However, the exact cause of the woman’s death still remains unclear.

Russia Says No Plague Cases In Irkutsk

The WHO recently said, “WHO is aware of media reports that a laboratory worker in Irkutsk oblast, in the Russian Federation, died of suspected pneumonic plague, and that nearly 200 of her contacts were under medical observation and being tested."

“On 3 October, WHO asked the Russian authorities under the International Health Regulations (IHR) for any further information they had, so we could assess the risk.”

The WHO said Russia reported that “no case of plague has been recorded in Irkutsk, either in her or in anyone else.”

Adding further, the health body said, "They informed WHO that an epidemiological investigation had been conducted, preventive and control measures implemented, and identified contacts placed under medical observation and tested. They reported that no high-threat pathogens had been detected among the contacts and that medical observation of all identified contacts had been completed."

But the agency is still seeking an answer on what caused the fatal pneumonia as the lab worker's death still remains a mystery.

It said, “WHO has remained in contact with the Russian health authorities and has offered technical support. WHO has requested further information to clarify the cause of the severe pneumonia, the pathogen that prompted the public health measures, and media reports of a second employee with pneumonia of undetermined cause.”

Also read: Russia Plague Scare: What Black Death and Anthrax Outbreaks Teach Us About Lab Safety

Lab Worker's Death Still Remains Unexplained

The 28-year-old woman, identified by Russian media as Darya Shipilova, worked at the Irkutsk Anti-Plague Research Institute of Siberia and the Far East. She died on October 2 after developing severe pneumonia of "unknown origin", according to Russian authorities.

Her death sparked precautionary measures including quarantine. According to reports, around 200 people who had contact with her placed under medical observation. Russian health authorities said testing of those contacts found no dangerous infectious-disease pathogens. Some contacts reportedly tested positive for COVID-19 or rhinovirus.

Reports circulating on social media claimed she may have been infected after a laboratory accident involving Yersinia pestis, the bacterium that causes plague. Russian authorities have rejected the laboratory-accident theory, and there is currently no independent evidence confirming that such an incident occurred.

Also read: Russia Plague Scare: Is Pneumonic Plague Deadlier Than Bubonic & Septicemic Plague?

What Could Confirm Plague?

Javier Pizarro-Cerda, head of the Yersinia Research Unit at the Institut Pasteur in Paris, told CNBC that he was “very surprised” by the reported death because laboratories handling plague generally use strict protective measures.

“You work with a full body suit. You work with masks. You work with gloves. So even if you break a tube, normally you should be protected,” he said.

Pizarro-Cerda also said Russia has a plague vaccine, although he described its protection as low and transient compared with standards elsewhere.

Pizarro-Cerda said plague testing can be performed rapidly and that an autopsy should provide evidence if the woman had pulmonary plague.

The laboratory worker reportedly died on October 2, giving authorities several days to conduct diagnostic tests. Still, there is no confirmation that pneumonic plague caused her death or that a laboratory accident occurred.

Key questions remain whether Yersinia pestis was detected, whether there was evidence of laboratory exposure, and whether genetic testing can establish the source of any infection.

The suspected plague is still being investigated. The concern stems partly from the nature of the institute where Shipilova worked. The facility studies dangerous pathogens, including plague, in a region where the disease occurs naturally among wild animals.

Pneumonic plague is the most severe form of plague because it affects the lungs and can spread between people through respiratory droplets. Plague is treatable with antibiotics when diagnosed and treated promptly.

The WHO has assessed the public-health risk as moderate-to-low for Irkutsk, low for Russia overall and very low for the WHO European region.