The Union Health Ministry implemented a ban on 156 "irrational" FDC medicines, effective immediately. These medicines, including widely used antibiotics, painkillers, and multivitamins, were commonly used to treat fever, cough, and infections. The ban was imposed due to the associated health risks and lack of therapeutic justification for the ingredients in these FDCs.

What are FDC medicines?

FDCs or fixed-dosed combinations, also known as "cocktail drugs," are medications that combine multiple drugs in a single pill. They are designed to treat multiple symptoms or conditions simultaneously. While they offer convenience, they can pose significant risks. These risks include the possibility of overdose, adverse interactions between the drugs, and the development of antibiotic resistance. Additionally, many FDC medicines lack sufficient scientific evidence to support their safety and efficacy.

Expert opinions on FDC medicines

Experts have raised concerns about the use of FDC medicines. They believe that many of these combinations lack sufficient scientific evidence to support their safety and effectiveness. Additionally, the combination of multiple drugs in a single pill can increase the risk of adverse side effects and interactions with other medications.

Experts have also found that FDC medicines may not be as effective as individual drugs in treating certain conditions. It is important to note that safer and more effective alternatives are available for most of the medical conditions that FDC medicines were used to treat. One particular concern is the inclusion of antibiotics in some FDCs. Overuse of antibiotics can contribute to the development of antibiotic resistance, a major public health threat.

The risks of FDC medicines

The use of FDC medicines can lead to adverse effects, including serious ones. Additionally, safer alternatives, tested in clinical trials, are available to treat the same medical conditions. Experts recommend prescribing drugs individually based on a patient's clinical symptoms rather than combining them in FDCs.

The ban on irrational FDC medicines by the Union Health Ministry can be seen as a positive step towards promoting rational drug use and protecting public health. The goal is to eliminate unnecessary and potentially harmful drug combinations. This is a step forward in reducing the risks associated with medication and ensure safer and more effective treatment options for patients.

Danish pharmaceutical giant Novo Nordisk has launched Awiqli (insulin icodec) in India, introducing the world's first once-weekly basal insulin for adults with diabetes.

Individuals with Type 2 diabetes require daily insulin to manage their blood glucose when diet, exercise, and oral medications are no longer sufficient.

The daily basal insulin injections are typically taken once every 24 hours. But Awiqli is designed to provide background insulin support throughout the week, reducing the ‌number ⁠of injections from 365 per year to 52, Novo said.

More than 101 million people in India are living with diabetes, ⁠while another 136 million have prediabetes, Novo said in a statement.

Insulin initiation in India is delayed by an average of 7-9 years, partly due to fear of injections, anticipated pain, and cost concerns, it said.

"We believe Awiqli will reduce the psychological and physical barriers to insulin initiation," Novo Nordisk India Managing Director Vikrant Shrotriya said.

Also read: Can Ozempic-Like GLP-1 Drugs Slow Aging, Boost Longevity?

What is Awiqli?

Awiqli (insulin icodec) is a long-acting basal insulin designed to help adults with diabetes maintain stable blood sugar levels with just one injection every week. It is administered using the Awiqli FlexTouch pen on the same day each week.

The treatment is intended to simplify insulin therapy, potentially improving treatment adherence among people who struggle with daily injections.

Global Approval

Earlier this year, the US Food and Drug Administration (FDA) approved Awiqli (insulin icodec-abae) 700 units/mL as the first and only once-weekly basal insulin for adults with type 2 diabetes. The therapy is indicated as an adjunct to diet and exercise to improve glycemic control.

The approval offers a new treatment option for patients seeking an alternative to daily basal insulin, allowing diabetes care to be tailored to different lifestyles and treatment preferences.

"Awiqli may address challenges associated with the frequency of daily basal injections by reducing them from seven to one per week. It is an important advancement for adults with type 2 diabetes who may benefit from an alternative treatment option," said Anna Windle, Group Vice President, Clinical Development, Medical & Regulatory Affairs at Novo Nordisk Inc.

Where Is It Available?

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The therapy has now been launched in India. Awiqli has also received regulatory approval in the US, the European Union, and 13 other countries, with indications varying according to local regulatory approvals.

Clinical Evidence

The approval is supported by Novo Nordisk's ONWARDS Phase 3a clinical program, which enrolled nearly 2,680 adults with uncontrolled type 2 diabetes across four randomized, active-controlled trials.

The studies compared once-weekly Awiqli with daily basal insulin and demonstrated effective reductions in HbA1c, a key measure of long-term blood sugar control. The overall safety profile was found to be consistent with existing daily basal insulin therapies.

Who Can Use It?

Awiqli is prescribed for adults with diabetes and should be used exactly as directed by a healthcare professional.

Patients should inject the medicine once every week on the same day. The dosage should not be adjusted without medical advice, the company said.

Are There Any Side Effects

Like other insulin therapies, Awiqli may cause side effects, including:

• Low blood sugar (hypoglycemia)
• Injection-site reactions
• Weight gain
• Skin thickening or pitting at injection sites (lipodystrophy)
• Allergic reactions
• Swelling of the hands or feet

Patients are advised to monitor their blood sugar regularly and seek immediate medical attention if they experience symptoms of severe allergic reactions or persistent hypoglycemia.

Who should not take Awiqli?

Do not take Awiqli if you:

• are having an episode of low blood sugar (hypoglycemia)
• have an allergy to Awiqli or any of the ingredients in Awiqli.

Global cancer cases could reach nearly 35 million a year by 2050, without urgent action to improve cancer prevention, early diagnosis and access to treatment, according to the World Health Organization (WHO) Global Status Report on Cancer 2026.

The report warns that cancer remains the world's second leading cause of death, claiming more than 26,000 lives every day and nearly 10 million annually.

The report, jointly released by the WHO and the International Agency for Research on Cancer (IARC), warned that major inequalities in cancer prevention, diagnosis, treatment and supportive care continue to leave millions of people without access to life-saving services.

It also noted that ageing populations, population growth and persistent health inequalities are driving the cancer cases.

"Cancer is a deeply personal disease that touches nearly all of us. But whether a person survives cancer should never depend on where they were born or what they earn," said WHO Director-General Dr Tedros Adhanom Ghebreyesus.

"The inequities documented in this report are not inevitable; they are the consequence of choices, and they can be reversed through stronger and unified action."

Global Status Report on Cancer 2026: Key Findings

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Cancer survival varies sharply across countries

The report highlights major disparities in cancer outcomes.

• 87% of women diagnosed with breast cancer survive at least five years in high-income countries.
• In low-income countries, the five-year survival rate falls to around 42%.
• Fewer than one in three countries include comprehensive cancer care under universal health coverage.

Cancer places a heavy financial burden on families

Beyond its health impact, cancer also creates significant economic and emotional challenges.

• At least 45% of people living with cancer experience financial hardship.
• More than half report mental health challenges.
• Nearly all caregivers experience strain, including unpaid caregiving responsibilities and social isolation.

Read More: US Cyclospora Parasite Outbreak Nears 900 Cases: Experts Say Handwashing Key to Prevention

Which Regions Have the Highest Cancer Burden?

The report shows that the burden of cancer varies significantly across regions.

Asia

• Accounts for 50.7% of global cancer cases.
• Records 56.5% of cancer deaths worldwide.

Europe

Although home to only about 9% of the world's population, Europe accounts for:

• 21% of global cancer cases.
• 20% of global cancer deaths.

Africa

Many African countries continue to experience comparatively lower cancer incidence but disproportionately higher mortality because of delayed diagnosis and limited access to treatment.

Most Common Types of Cancer Worldwide

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According to the WHO report:

• Lung cancer remains the leading cause of cancer deaths globally.
• Among men, the most common cancers are:
  • Lung
  • Prostate
  • Colorectal
• Among women, the leading cancers are:
  • Breast
  • Lung
  • Colorectal

Nearly Four in Ten Cancer Cases Are Preventable

The report estimates that almost 40% of cancer cases worldwide are linked to preventable risk factors, including:

• Tobacco use
• Alcohol consumption
• High body weight
• Physical inactivity
• Human papillomavirus (HPV)
• Hepatitis B and Hepatitis C infections
• Helicobacter pylori infection

WHO's Recommendations to Improve Global Cancer Care

The WHO has urged governments, health organizations, researchers and the private sector to work together to strengthen cancer care through three broad priorities:

Better capabilities

• Integrate cancer control into universal health coverage.
• Invest in cancer prevention, early detection and the healthcare workforce.

Better protections

• Put people living with cancer and caregivers at the centre of health systems.
• Expand financial and social protection for affected families.

Better value

• Align cancer research and innovation with public health priorities.
• Ensure equitable access to effective, evidence-based cancer treatments worldwide.

Novo Nordisk, the maker of GLP-1 medicines like Ozempic and Wegovy, is currently exploring a new way to deliver weight-loss treatment that could reduce the need for weekly injections.

The Danish pharma company has partnered with Vivani Medical to evaluate an experimental long-acting GLP-1 implant (semaglutide) that could release the medication continuously for up to a year.

If successful, it could mark a significant step toward making GLP-1 drug more convenient for people living with obesity.

What Is The Semaglutide Implant?

The implant, known as NPM-139, is a miniature device developed using Vivani's proprietary NanoPortal technology. Rather than requiring patients to inject semaglutide every week, the tiny implant is placed beneath the skin and slowly releases the medication over an extended period.

According to Vivani, the goal is to provide consistent drug delivery with once- or twice-yearly dosing, with the long-term ambition of supporting treatment that could last up to a year from a single implant. However, the technology is still in development.

Adam Mendelsohn, Ph.D., President and CEO of Vivani Medical said, “The new agreement announced today supporting our semaglutide implant program in chronic weight management demonstrates Novo Nordisk's interest in evaluating our technology and its lead semaglutide application. This agreement reinforces our confidence regarding the market opportunity for our GLP-1 implants under development. We believe that our NanoPortal implants under development, including NPM-139, could address a growing segment of patients who would prefer a convenient once- or twice-yearly treatment option and the peace of mind that treatment could be stopped at any time if that became necessary.”

Also read: Wegovy Weight Loss Pill Available in UK Pharmacies From Today: All You Should Know

Why GLP-1 Implant Could Be Groundbreaking?

GLP-1 medications like Ozempic and Wegovy have transformed obesity treatment by helping people lose significant amounts of weight while also improving blood sugar control. However, these medications require regular injections, which can affect long-term adherence.

Research has shown that many patients discontinue GLP-1 therapy within the first year because of factors like treatment fatigue, gastrointestinal side effects, cost, and the inconvenience of ongoing injections.

An implant capable of delivering semaglutide continuously for months together could help by reducing dosing frequency and maintaining more consistent drug levels.

The Rise Of GLP-1 Therapies In Obesity Treatment

The obesity drug market is rapidly evolving. With the advent of GLP-1 medications, the number of users who have tried this therapy is at an all-time high. According to Gallup's latest National Health and Well-Being Index, 11% of U.S. adults currently use a GLP-1 medication for weight loss. In 2024, this number was just 3%.

The survey also said that 15% of adults have tried a GLP-1 medication at some point, compared to the 6% from two years ago.

With the ever-increasing demand, researchers are investigating oral GLP-1 medicines, monthly injections, combination therapies, and now long-acting implants that could reduce the number of treatments patients need each year.

While the yearly semaglutide implant is still an experimental concept, Novo Nordisk's decision to evaluate the technology highlights growing industry interest in making obesity treatment simpler and easier for patients to maintain in the long run.