The Union Health Ministry implemented a ban on 156 "irrational" FDC medicines, effective immediately. These medicines, including widely used antibiotics, painkillers, and multivitamins, were commonly used to treat fever, cough, and infections. The ban was imposed due to the associated health risks and lack of therapeutic justification for the ingredients in these FDCs.

What are FDC medicines?

FDCs or fixed-dosed combinations, also known as "cocktail drugs," are medications that combine multiple drugs in a single pill. They are designed to treat multiple symptoms or conditions simultaneously. While they offer convenience, they can pose significant risks. These risks include the possibility of overdose, adverse interactions between the drugs, and the development of antibiotic resistance. Additionally, many FDC medicines lack sufficient scientific evidence to support their safety and efficacy.

Expert opinions on FDC medicines

Experts have raised concerns about the use of FDC medicines. They believe that many of these combinations lack sufficient scientific evidence to support their safety and effectiveness. Additionally, the combination of multiple drugs in a single pill can increase the risk of adverse side effects and interactions with other medications.

Experts have also found that FDC medicines may not be as effective as individual drugs in treating certain conditions. It is important to note that safer and more effective alternatives are available for most of the medical conditions that FDC medicines were used to treat. One particular concern is the inclusion of antibiotics in some FDCs. Overuse of antibiotics can contribute to the development of antibiotic resistance, a major public health threat.

The risks of FDC medicines

The use of FDC medicines can lead to adverse effects, including serious ones. Additionally, safer alternatives, tested in clinical trials, are available to treat the same medical conditions. Experts recommend prescribing drugs individually based on a patient's clinical symptoms rather than combining them in FDCs.

The ban on irrational FDC medicines by the Union Health Ministry can be seen as a positive step towards promoting rational drug use and protecting public health. The goal is to eliminate unnecessary and potentially harmful drug combinations. This is a step forward in reducing the risks associated with medication and ensure safer and more effective treatment options for patients.

A massive analysis involving more than 100 million people has found strong links between recreational drug use and stroke, including among younger adults.

Stroke remains one of the world's biggest health problems and ranks as the third leading cause of death and disability combined.

The researchers found that cannabis use disorders were associated with stroke overall and were particularly linked to large artery stroke.

The study "provides compelling evidence that drugs like cocaine, amphetamines, and cannabis are causal risk factors for stroke. These findings give us stronger evidence to guide future research and public health strategies," said Dr. Megan Ritson from the Stroke Research Group at the University of Cambridge.

What Did the Study Find?

The team conducted a meta-analysis covering studies with more than 100 million participants. Their results, published in the International Journal of Stroke, showed substantial differences in stroke risk associated with several drugs.

Cocaine and amphetamine use were each linked to roughly twice the risk of stroke.

• Cocaine increased stroke risk by 96%.
• Amphetamine use was associated with a 122% increase.
• Cannabis use was associated with an increase of about 37%.
• Opioid use showed no statistically significant association with stroke risk.

Stroke Risk Was Especially High in Younger Users

The researchers separately examined people under age 55. Within this younger group, amphetamine use was associated with nearly three times the risk of stroke, an increase of 174%.

Cocaine use was associated with a 97% increase in stroke risk, while cannabis was linked to a smaller 14% increase.

Cocaine Linked to Brain Hemorrhage and Cardioembolic Stroke

Further genetic analysis revealed that cocaine use disorders were especially associated with brain hemorrhage and cardioembolic stroke.

In cardioembolic stroke, a blood clot forms in the heart and travels to the brain, blocking blood flow and causing damage to brain tissue.

According to the researchers, these genetic findings support the possibility of a causal relationship rather than an association alone.

Problematic alcohol use was also associated with an increased risk of cardioembolic stroke and large artery stroke. Alcohol addiction, meanwhile, was linked to a greater overall risk of stroke.

How Could Recreational Drugs Increase Stroke Risk?

The researchers noted several biological mechanisms that could help explain why these substances are associated with stroke. These include:

• Sudden increases in blood pressure
• Spasms and narrowing of blood vessels
• Abnormal heart rhythms
• Greater blood clotting, especially with cannabis
• Inflammation or vasculitis, particularly with amphetamines

All of these processes are already known to contribute to stroke. They can play a role in ischemic strokes, which occur when blood clots interrupt blood flow, as well as hemorrhagic strokes.

"Our analysis suggests that it is these drugs themselves that increase the risk of stroke, not just other lifestyle factors among users. Taken together, our findings emphasize the importance of public health measures to reduce substance abuse as a way of helping also reduce stroke risk," said Dr. Eric Harshfield, Alzheimer's Society Research Fellow at the Department of Clinical Neurosciences.

We often believe that depression may just result in changes in mood and behaviour. But a new study has found that major depressive disorder could disrupt production of new brain cells in the hippocampus, a region involved in memory and processing of emotions.

The study, published in Nature Medicine, analysed almost 500,000 individual brain cells from people with depression and people without the mental health condition. Researchers found changes not only in the formation of new neurons but also across the wider hippocampal circuit.

Depression May Disturb Brain’s Ability To Produce New Neurons

In the human brain, most neurons are produced before birth, but the hippocampus is one of the few regions where new neurons continue to develop even during adulthood. The researchers found that this process, known as adult hippocampal neurogenesis, stops in people with major depressive disorder.

Depression is viewed largely as a problem involving neurotransmitters such as serotonin. The new findings suggest a much more complex picture involving the brain's ability to adapt to stress and changing environments.

Maura Dupont, professor of psychiatry at Columbia University and the study's lead researcher, said, “Without the ability to create new neurons, people with depression may not have the resilience to effectively adapt to the environment."

Also read: Sugar Rationing In First 1,000 Days Linked To Lower Depression, Cancer Risk In Adulthood

The Hippocampus Links Memory With Emotional Responses

The hippocampus plays an important role in episodic memory, helping people distinguish between different experiences and connect memories with their emotional context.

Researchers say impaired neurogenesis may affect a process called pattern separation, which helps the brain keep similar experiences distinct. For instance, a friend being quiet in your company does not necessarily mean they are upset with you.

When the brain has a healthy pattern-separation system, it recognises that as an individual event rather than automatically misconstruing it and linking it to previous experiences of rejection.

Dupont said that when this ability is impaired, memories and their emotional associations can become blurred, potentially building the tendency to interpret new experiences negatively.

Also read: Lindsay Clancy Trial: What Postpartum Psychosis Really Looks Like, From A Survivor

Other Changes In Brain Changes That Extend Beyond Neuron Formation

The researchers found molecular changes across the hippocampal circuit, including genes involved in forming connections between neurons, communication between brain cells, energy production and movement of material inside cells.

The hippocampus's circuit also showed signs of inflammation and cellular stress in people with depression. This indicates that depression may involve widespread changes in how brain cells communicate and function.

What The Findings Could Mean For Depression Treatment?

The researchers say the findings could eventually help recognise different physiological effects of depression, helping develop specific treatments according to patients with different molecular structures.

Dupont said the team hopes depression could eventually be classified according to its molecular characteristics, similar to how some cancers are classified. However, the findings do not mean that depression can currently be treated by simply increasing the production of new neurons. The complete mechanism of the mental health condition is still not completely understood.

The H1N1 virus continues to surge in India’s national capital, Delhi, with vulnerable groups more likely to develop severe illness. While the infection is self-limiting in most cases, it is leading to increased hospitalizations, with some patients requiring ventilator support.

Delhi has reported 2,308 cases of swine flu, with the number described as around eight times higher than the average in previous years. However, no deaths have been reported so far.

The government has asked people to follow precautions similar to those followed during COVID, including the use of masks, and hand hygiene. However, it advised people not to panic but remain alert to symptoms.

To understand more about H1N1, HealthandMe interviewed Dr GC Khilnani, Chairman, PSRI Institute of Pulmonary, Critical Care & Sleep Medicine, PSRI Hospital, New Delhi, who explained the current surge, symptoms, warning signs, treatment and preventive measures.

Q. H1N1 cases are rising sharply in Delhi. What is driving this surge, and how concerning is it?

A. There has been a clear rise in H1N1 cases, which is concerning because influenza can occasionally cause severe pneumonia, ICU admissions, and deaths. The virus is also known to mutate, raising concerns about severe disease and wider outbreaks.

However, the current H1N1 virus is the same as in 2025. In healthy people, it usually causes a self-limiting illness lasting three to five days, with sore throat, fever, body aches, headache and sometimes mild chest pain.

Severe illness is more likely in vulnerable groups, including those aged 70–80 years or older, people with diabetes or chronic lung disease, and those who are immunocompromised due to long-term steroids, cancer treatment or other conditions.

We currently have patients on ventilators at PSRI Hospital because of H1N1, though thankfully there have been no deaths so far. The actual number of cases may also be higher than reported because not everyone gets tested.

Q. Is the H1N1 strain currently circulating in India different from previous years? How contagious is it?

A. It is a highly contagious strain. The ICMR has already said that it is the PDM09 Missouri type of virus, the same as it was in 2025. It has a very short incubation period of one to four days, and that means that it spreads very fast.

The attack rate is very high. That means that if it occurs in a family, all the family members are affected, and the contacts are affected. The spread is by droplet infection and also by touching non-living things like tables, chairs, or hands, as was happening in COVID. It spreads very fast. It's a short-term illness; therefore, the numbers are very high at this moment.

Q. What are the early symptoms of H1N1, and which warning signs mean a person needs hospital care?

A. Usual symptoms start with body aches, sore throat, headache, and fever, sometimes a very high-grade fever. Sometimes there is nausea and vomiting, and sometimes a little bit of chest pain is also there. It is sort of short-lived, and doesn't last for more than three to five days.

But if a person becomes breathless on mild exertion or at rest, or if the elderly person becomes drowsy or less responsive, then it's a point of worry.

If the oxygen level is below 91-92%, or the body turns blue, that means cyanosis (marked by a bluish or purplish tint to the skin or mucous membranes); these are signs of worry. Sometimes, if the chest pain is very severe, that should also not be ignored, and one should immediately go to the hospital.

Q. How can H1N1 progress from a routine flu infection to severe disease or complications?

A. It is a usual viral infection of the respiratory tract, upper as well as lower respiratory tract. It does cause a cytokine storm. It also causes multi-organ failure, and secondary infections are very common.

It is important for people who are susceptible and get admitted to hospital to look for secondary bacterial infection as well.

Q. Do antibiotics have any role in treating H1N1? How should it be treated?

A. There is absolutely, no role for antibiotics. We have the antiviral drugs, the most common being oseltamivir, popularly known as Tamiflu.

An important thing is that antivirals should be started within 48 hours of the start of the symptoms. After that, the role is very limited.

So, it is important that if the symptoms are there, it should be tested. The reports are available in 2–3 hours, and Tamiflu, is to be taken for five days, in a dose of 75 milligrams, that is, one tablet twice a day for five days.

The family members who are exposed, especially those who are susceptible, should also take a prophylactic dose of a 75-milligram tablet once a day for 7-10 days to prevent getting influenza illness.

Q. Does the seasonal flu vaccine protect against H1N1? Who should get vaccinated?

A. The flu vaccinations that are available in India definitely protects against H1N1. Like in COVID, it reduces the chances of infection, but more importantly, the severity of infection and mortality are reduced, underscoring the importance of vaccination.

Q. What is the best time to get the flu vaccine, especially now that cases are already rising?

A. One should take the flu vaccine once a year. The best months to receive this vaccination are before the expected outbreak.

Now that the outbreak is already underway, vaccination may offer limited immediate benefit, as it takes at least two weeks for the vaccine to become effective.

The best time to take it is, July-August because the outbreak usually comes in the monsoon period, or you can take it in January-February because the next outbreak occurs in March.

Q. What precautions should people take at home, workplaces and schools to prevent H1N1 transmission?

A. It is a question of—you know, during COVID, everybody was scared because mortality was highest. Everybody was following COVID-appropriate behavior.

Even now, people who develop symptoms should wear masks, even without testing, and avoid social events and crowded places to prevent spreading the infection to others.

The other thing which is more important is that those people who are likely to get severe disease—I have already described those people—should refrain from going to crowded places, like crowded markets or social gatherings and marriage parties.

Because, at this point in time it is likely that one person or another will be infected. Importantly, that person starts transmitting the virus one day before even getting the first symptom. So, you actually do not know who will be spreading it.

The infection rate is so high at this time that it is important for everybody not to go to crowded places if you are susceptible, meaning if you are 70-80 years old or your immunity is low.

And it is important that if you have to go to crowded places, then you should wear a mask and protect yourself.