The Union Health Ministry implemented a ban on 156 "irrational" FDC medicines, effective immediately. These medicines, including widely used antibiotics, painkillers, and multivitamins, were commonly used to treat fever, cough, and infections. The ban was imposed due to the associated health risks and lack of therapeutic justification for the ingredients in these FDCs.

What are FDC medicines?

FDCs or fixed-dosed combinations, also known as "cocktail drugs," are medications that combine multiple drugs in a single pill. They are designed to treat multiple symptoms or conditions simultaneously. While they offer convenience, they can pose significant risks. These risks include the possibility of overdose, adverse interactions between the drugs, and the development of antibiotic resistance. Additionally, many FDC medicines lack sufficient scientific evidence to support their safety and efficacy.

Expert opinions on FDC medicines

Experts have raised concerns about the use of FDC medicines. They believe that many of these combinations lack sufficient scientific evidence to support their safety and effectiveness. Additionally, the combination of multiple drugs in a single pill can increase the risk of adverse side effects and interactions with other medications.

Experts have also found that FDC medicines may not be as effective as individual drugs in treating certain conditions. It is important to note that safer and more effective alternatives are available for most of the medical conditions that FDC medicines were used to treat. One particular concern is the inclusion of antibiotics in some FDCs. Overuse of antibiotics can contribute to the development of antibiotic resistance, a major public health threat.

The risks of FDC medicines

The use of FDC medicines can lead to adverse effects, including serious ones. Additionally, safer alternatives, tested in clinical trials, are available to treat the same medical conditions. Experts recommend prescribing drugs individually based on a patient's clinical symptoms rather than combining them in FDCs.

The ban on irrational FDC medicines by the Union Health Ministry can be seen as a positive step towards promoting rational drug use and protecting public health. The goal is to eliminate unnecessary and potentially harmful drug combinations. This is a step forward in reducing the risks associated with medication and ensure safer and more effective treatment options for patients.

‘Scromiting’ is back in the news as emergency department visits in the US involving cannabis hyperemesis syndrome (CHS) were 3.7 times as high, according to a CDC report.

CHS is associated with frequent cannabis use and is characterized by episodes of severe nausea, vomiting and abdominal pain. The term “scromiting” refers to a combination of screaming and vomiting that can occur during severe episodes.

The CDC’s Morbidity and Mortality Weekly Report (MMWR), which analyzed data from January 2023 through May 2026, found that the rate of emergency department visits involving CHS remained largely steady from January 2023 through September 2025.

CHS is likely under-recognized in both adolescents and adults. Clinicians may not routinely assess or document cannabis use, while CHS can also be misdiagnosed as other gastrointestinal conditions, including cyclic vomiting syndrome.

To improve clinical identification, a specific International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) discharge diagnosis code for CHS was introduced on October 1, 2025. The CDC report examined CHS-related emergency department visits before and after the code was introduced.

The change was immediate. From September 2025 to October 2025, CHS-involved emergency department visits jumped from 3.35 per 10,000 to 11.26 per 10,000. The rate rose further to 13.10 per 10,000 by May 2026.

From October 2025 through May 2026, CHS-involved emergency department visits were 3.7 times as high as the monthly average recorded before the new diagnostic code was introduced.

The CDC noted that the new code made the condition easier to identify and track, meaning the sharp increase may partly reflect greater recognition and documentation of CHS.

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What Is Cannabis Hyperemesis Syndrome?

CHS is a syndrome associated with prolonged, frequent cannabis use. It is characterized by sudden episodes of severe nausea, repeated vomiting and abdominal pain.

Reports of suspected CHS increased sharply between 2016 and 2022, with the largest increase occurring during the COVID-19 pandemic. The CDC noted that the rise also coincided with widespread state-level cannabis legalization in the US, although cannabis remains illegal under federal law.

People with CHS often seek medical care because symptoms can be severe and debilitating. Outcomes can range from resolution of symptoms after stopping cannabis use to, in rare cases, death.

When Was CHS First Identified?

CHS was first identified in Australia in 2004, yet nearly two decades later, the condition remains poorly understood. It typically affects people who use marijuana daily or near daily for more than a year. Symptoms can include severe nausea, repeated vomiting and abdominal pain, along with a compulsive desire to take extremely hot showers or baths.

Many patients report that heat temporarily eases their symptoms, although the relief is often short-lived.

Symptoms Can Last For Days

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CHS episodes can last for days, while recovery may take weeks or even months, depending on overall health, eating habits and whether the person stops using marijuana. Continuing to use cannabis can quickly trigger symptoms again.

A study from George Washington University found that nearly half of surveyed patients had been hospitalized at least once because of CHS. Many reported using marijuana more than five times a day before symptoms began. Starting cannabis at an early age was also linked to a higher likelihood of developing the condition.

Why Is CHS Still Poorly Understood?

Researchers emphasize that CHS is real, although many questions remain unanswered, including why hot showers provide temporary relief and how much cannabis use puts someone at risk.

Health experts say greater clinical awareness is needed. Better screening for cannabis use and recognition of symptom patterns could help reduce misdiagnosis and guide patients towards the only proven treatment: stopping marijuana use.

The Food Safety and Standards Authority of India (FSSAI) has to stop the sale of all variants of ghee manufactured by Daman-based SDP Industries, after laboratory tests found signs of adulteration and violation of food safety standards.

The move came after an inspection conducted on May 19. FSSAI said multiple samples were found adulterated, with laboratory analysis detecting β-sitosterol, a plant sterol that should not be present in genuine ghee. The samples also contained abnormalities in fatty-acid composition. 

The food regulator has prohibited the manufacture, storage and sale of the company’s ghee products from its authorised premises until further orders. The products include brands like SHRADDHA, SHREE SARAS and GOKUL. 

Adulterants In Ghee Samples

As pure ghee is made from milk fat, the presence of β-sitosterol is a red flag as it is a plant sterol. FSSAI said its detection, together with the abnormal fatty-acid profile, indicated the presence of vegetable fats in ghee touted to be "pure". 

The latest action is not based on a single sample. FSSAI said that surveillance samples collected in 2024 and January 2026 had also shown non-compliance with critical parameters, including β-sitosterol, fatty-acid profile, B.R. reading and R.M. value. 

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Adulterated Ghee Is A Huge Health Concern

The health impact of adulteration depends on what has been added to or substituted for the ghee. Vegetable oils and other fats used in adulterated products may negatively alter the nutritional composition of the food. Some counterfeit products may also contain poor-quality, repeatedly heated or improperly processed oils and other non-food-grade substances.

Regular consumption of unhealthy fats can contribute to an overall diet high in saturated or trans fats, which may adversely affect cholesterol levels and cardiovascular health.

However, it is important not to assume that every adulterated ghee product will cause immediate poisoning or disease. The exact health risk depends on the adulterant, its concentration in the product and the amount consumed.

At the recent action in Hyderabad, authorities there seized around 36 tonnes of adulterated ghee, raw materials and chemical additives after inspecting 130 establishments. Officials said the suspected adulterated ghee involved ingredients including palm oil, vanaspati, skimmed milk powder and starch. 

Also read: FSSAI Warns Influencers, Celebrities Of Legal Action Over Unverified Food Claims

How To Spot Fake Ghee At Home?

There is no reliable kitchen test that can establish whether packaged ghee is genuine. Colour, smell, texture and whether ghee melts quickly are not enough to confirm purity because manufacturers can easily manipulate these characteristics. Instead, consumers should look for:

• A valid FSSAI license number on packaged products

• Proper labelling, including manufacturer details and batch information

• An intact seal and packaging

• A realistic price rather than unusually cheap “pure ghee”

• Products purchased from established retailers or authorised sellers

• The FSSAI licence and product details being consistent with the manufacturer

For suspected adulteration, laboratory testing is always the reliable method.

A recent cluster of shigellosis cases in Kerala has raised concerns over antimicrobial resistance (AMR). This adds another challenge to the treatment and management of an infection that can already cause severe intestinal distress. The concern comes as Kerala reported fresh cases of Shigella infection, including a three-year-old child who was hospitalised after consuming a roadside drink.

Shigellosis is caused by Shigella bacteria and can spread through contaminated food, water, hands and surfaces. Unlike some other foodborne infections, only a very small number of bacteria may be enough to cause illness, making the infection highly transmissible. This has raised fresh concerns about food and water safety in the state.

Drug Resistance Can Make Shigellosis Harder To Treat

Most people with shigellosis recover with fluids and supportive care, but people with severe symptoms may need antibiotics. The problem at hand is that Shigella is becoming increasingly resistant to commonly used antibiotics.

Kerala's KARS-NET (Kerala Antimicrobial Resistance Surveillance Network), one of the strongest AMR surveillance systems in the country, has been tracking the AMR profile of Shigellosis since 2023. Its data says that the resistance profile of primary antibiotics used to treat the infection is growing.

According to KARS-NET, Ciprofloxacin, which is recommended by the national guidelines for Shigella dysentery treatment, has a resistance profile of 96%. Therefore, it can no longer be relied upon for Shigellosis treatment.

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R. Aravind, head of infectious diseases, Government Medical College, Thiruvananthapuram, who is also the convener of KARS-Net said, “Till now, community-acquired AMR had not been a problem in the State. If you, as a citizen, have never been worried about AMR, you should be now, because it is showing up right at your doorstep. Our arsenal of effective and affordable antibiotics for common infections in the community is shrinking."

Ceftriaxone is the next available drug that has developed pathogenic resistance. It is a third-generation Cephalosporin class antibiotic, which has gone up to 36%.

He added, “Clinicians have been using Ceftriaxone for treating Shigellosis in patients who get admitted to hospital. But the clinical implication of growing resistance of Shigella to this drug is immense."

Also read: H1N1 Flu Rising in India: Why Heart Patients Need to Watch

Complications Due To Shigellosis

Shigellosis could get severe in vulnerable populations like children below five years and the elderly. It can lead to severe dehydration, sepsis and neurological complications.

In some cases, the infection can spread beyond the intestine and enter the bloodstream, causing bacteraemia and sepsis, which can become life-threatening. These complications warrant urgent use of antibiotics.

R. Aravind also said, "For Shigellosis patients with severe dysentery going into septic shock and multiorgan failure, it is absolutely important that the correct antibiotic is administered within an hour and that it is 100% sensitive. This means that for such serious patients, we can no longer depend on Ceftriaxone and have to go for high-end drugs like Meropenem which belongs to the Carbapenem class, widely considered the last-resort antibiotics."

Shigellosis: Prevention Tips

Because Shigella can spread through very small amounts of faecal contamination, basic hygiene remains crucial. Health experts recommend:

• Drinking safe or boiled water
• Washing hands thoroughly with soap
• Avoiding food from unhygienic sources
• Eating freshly prepared food
• Avoiding contaminated or improperly stored drinks
• Preventing infected people from preparing food for others