The Union Health Ministry implemented a ban on 156 "irrational" FDC medicines, effective immediately. These medicines, including widely used antibiotics, painkillers, and multivitamins, were commonly used to treat fever, cough, and infections. The ban was imposed due to the associated health risks and lack of therapeutic justification for the ingredients in these FDCs.

What are FDC medicines?

FDCs or fixed-dosed combinations, also known as "cocktail drugs," are medications that combine multiple drugs in a single pill. They are designed to treat multiple symptoms or conditions simultaneously. While they offer convenience, they can pose significant risks. These risks include the possibility of overdose, adverse interactions between the drugs, and the development of antibiotic resistance. Additionally, many FDC medicines lack sufficient scientific evidence to support their safety and efficacy.

Expert opinions on FDC medicines

Experts have raised concerns about the use of FDC medicines. They believe that many of these combinations lack sufficient scientific evidence to support their safety and effectiveness. Additionally, the combination of multiple drugs in a single pill can increase the risk of adverse side effects and interactions with other medications.

Experts have also found that FDC medicines may not be as effective as individual drugs in treating certain conditions. It is important to note that safer and more effective alternatives are available for most of the medical conditions that FDC medicines were used to treat. One particular concern is the inclusion of antibiotics in some FDCs. Overuse of antibiotics can contribute to the development of antibiotic resistance, a major public health threat.

The risks of FDC medicines

The use of FDC medicines can lead to adverse effects, including serious ones. Additionally, safer alternatives, tested in clinical trials, are available to treat the same medical conditions. Experts recommend prescribing drugs individually based on a patient's clinical symptoms rather than combining them in FDCs.

The ban on irrational FDC medicines by the Union Health Ministry can be seen as a positive step towards promoting rational drug use and protecting public health. The goal is to eliminate unnecessary and potentially harmful drug combinations. This is a step forward in reducing the risks associated with medication and ensure safer and more effective treatment options for patients.

A whopping $600 million global vaccine aid meant for poorer nations has been put on hold by US Health Secretary Robert F. Kennedy Jr., according to a media report.

The delay in vaccines is putting pressure on the international humanitarian group Gavi, the Vaccine Alliance that distributes them, Politico reported.

Gavi noted that it has not received the funds due for the current and previous fiscal years, which account for about 15 percent of its budget.

The funds are set to expire on September 30 if the Trump administration does not release them.

The organization provides vaccines for 20 diseases, including measles, malaria and polio, to more than 50 low-income countries worldwide.

Sania Nishtar, Gavi CEO, told the newswire AFP, the funding gap, combined with reductions from other donors, has particularly impacted malaria vaccination efforts.

Gavi has delivered 39 million doses of a malaria vaccine to 25 African countries, where the disease predominantly affects children under five. Nishtar warned that tens of thousands of children could die as a result of the funding cuts.

Why Is Kennedy Holding Up Vaccines

Kennedy argues that the shots are obsolete with dangerous ingredients that the US has long since phased out.

“Gavi has refused to provide the United States with the specific data, studies, or detailed accounting of how US funds are used,” Emily Hilliard, senior press secretary at the Health and Human Services Department, said in a statement.

Advocates for Gavi, the Vaccine Alliance warn that withholding funds could cost children’s lives. They argue that the vaccines used are safe and better suited for developing regions, where refrigeration is limited and administering booster doses is more difficult.

Hilliard said Gavi has declined to create a plan to phase out thimerosal, a mercury-based vaccine preservative that Kennedy believes may be linked to autism. The administration has asked Gavi to stop using vaccines containing this preservative.

Thimerosal is used in several vaccines distributed by Gavi, including combination shots protecting against multiple diseases, according to former chief executive Seth Berkley. He explained that many developing countries rely on multi-dose vials, which require less refrigeration but may contain thimerosal to prevent contamination.

Without such vaccines, “kids would go without vaccines… and that would lead directly to deaths,” Berkley said.

During testimony before the Senate Appropriations Committee, Kennedy also raised concerns about a vaccine used to protect against diphtheria, tetanus and pertussis, claiming it had been discontinued in the US due to safety issues.

Gavi responded that the vaccine remains in use because it offers longer-lasting protection and requires fewer doses. The organization said the vaccine “is safe and effective and estimated to have saved 40 million lives in the past 50 years,” the report said.

A plant-based diet is highly recommended for a healthy heart — weight watchers can also benefit from it, as can diabetics. When one goes vegan, the biggest change comes when one moves from dairy milk to oat, almond, or soy milk. Parents, too, are now shifting their children to trendy vegan milk options — little do they realise that this could bring their worst fears to life. According to the British Society for Allergy & Clinical Immunology, drinks that are aimed at children and often marketed as healthy are usually loaded with sugar and offer little or no nutrition.

Why has plant milk become a preferred choice?

Experts found that children under five years of age are more prone to malnutrition, tooth decay, or even obesity. The study is the first of its kind, and its warning will be published in the coming week. It is backed by the British Dental Association and the British Dietetic Association. Doctors say that plant-based drinks are often compared to cow’s milk in terms of nutrition. However, these claims are not supported by current evidence.

Why is plant milk discouraged for children?

Plant milk has gained popularity in recent years because of the health benefits that many believe it offers. While adults may benefit from it in several ways, toddlers must not be given these packaged, sugary drinks. The added sugars can become nothing more than a frequent treat for children, who may lose their milk teeth sooner and suffer from decay. Researchers found that families are often convinced that plant milk is good for children, but these oat, almond, and soy versions of milk are processed and full of sucrose and fructose syrups.

According to a report, most of these drinks contain large amounts of sugar in the form of maltodextrin, glucose syrup, sucrose, and fructose. A 350 ml glass of such milk contains more than double a toddler’s daily sugar allowance. Ideally, toddlers should not be given more than 14 grams of sugar every day. Their young bodies can struggle to absorb vitamin B12 and calcium from plant drinks. The BSACI recommends that parents opt for unsweetened, fortified plant milk instead, as these can play a crucial role in supporting children’s health.

How do ultra-processed foods affect children’s health?

Ultra-processed foods (UPFs) are defined as food groups that undergo a great deal of processing — the most natural foods fall under Group 1, while heavily processed foods are placed under Group 4. While these do not definitively determine how healthy a food option is, they indicate the level of processing involved. Highly processed foods are associated with a range of health problems, which is why it is important to make informed dietary choices.

What are minimally processed foods?

In your kitchen, foods with a minimal level of processing include:

1. Fruits
2. Vegetables
3. Grains
4. Legumes
5. Meat and poultry
6. Eggs
7. Fish and seafood
8. Fresh milk
9. Spices and herbs
10. Coffee and tea
11. Nuts and seeds
12. Plain yoghurt

What are ultra-processed foods in your kitchen?

Some of the most processed foods in your kitchen include:

1. Sweetened yoghurt
2. Soft drinks
3. Biscuits
4. Breakfast cereals
5. Candies
6. Cake mixes
7. Breads and buns
8. Energy drinks
9. Energy bars
10. Frozen foods — pies, pizzas, snacks, sausages, pepperoni, ham, and salami
11. Instant foods — noodles, soups, and sauces

Breast cancer is the most common type of cancer reported among women living in metropolitan India. And while the causes have largely been genetic or linked to family history, a new study says that a woman's breast tissue undergoes dramatic changes with age, creating an environment where cancer cells are more likely to flourish. Researchers at the University of Cambridge in the UK and the University of British Columbia in Canada mapped how breast tissue changes over time. Comprising over three million cells, the map tracks how breast tissue undergoes changes in women as they age. It was found that the most striking shift occurs around menopause.

How does age influence breast changes in women?

Researchers found that as women age, their breast tissue undergoes changes. During the 20s, these changes can be attributed to pregnancy and childbirth. However, the major and most dramatic changes occur around menopause. With age, the number of cells in breast tissue declines. As a result, the structure of the tissue also changes. This creates favourable conditions in which cancer cells can thrive and survive more easily, thereby explaining why breast cancer risk increases with age.

Researchers also identified a cluster of cell types in the breast tissue. As per the American Cancer Society, 320,000 women in the US might be diagnosed with breast cancer this year, making it the most common type of tumour in women. Breast cancer rates are also rising in younger women for unclear reasons, but most cases are still diagnosed in women aged 50 years and above. Age is an important risk factor for nearly all types of cancer. Researchers say that this is partly because people accumulate genetic mutations in their cells with age. As a result, abnormal cells spread uncontrollably and develop into tumours.

Why is age a risk factor for breast cancer?

Experts say that despite the rising incidence of breast cancer, it is not well understood how breast tissue changes with age and contributes to cancer risk. To investigate this, experts analysed normal breast tissue samples from 527 women aged 15–86 years who were undergoing breast reduction surgery. Using advanced imaging, experts mapped individual cells in a two-dimensional representation of how breast tissue changes over time.

The map also found that breast tissue divides less often with age, and the number of immune cells declines. The number of epithelial cells that line the milk-producing structures and mammary ducts also declines with age. However, the scale of changes across the breast is surprising.

Why does breast structure change with age?

Researchers found that the structure of breast tissue also changes with age. The milk-producing lobules shrink, blood vessels decrease, and fat cells increase. Stromal and immune cells also move away from epithelial cells, thereby making it easier for cancer cells to spread and escape. Younger breasts also have relatively more immune cells, known as active T-cells and B-cells, that can identify and destroy tumour cells before they multiply.

Older breasts have fewer cancer-fighting cells and immune cells that other studies implicate in cancer development. These changes create an inflammatory environment in which the immune system is less able to hold back cancer cells and is more permissive of carcinogenesis. However, it is unclear why certain types of cells change.

The age when breast cancer risk peaks

Researchers found that ageing peaks in the late 40s, corresponding to menopause. After this, depending on how quickly the breast tissue ages, one could be more prone to breast cancer risk. The study, however, did not analyse genetics and other breast cancer-influencing risk factors. Previous studies suggest that normal breast tissue in women with genetic risk factors in place ages faster than in others.

The research was published in the Nature Aging journal.