Until law, GLP-1 drugs were used to treat diabetes, obesity and even the recent evidences suggest that it could as well be used to treat chronic kidney problems. There is yet another research, published in JAMA Psychiatry on February 25, titled Once-Weekly Semaglutide in Adults With Alcohol Use Disorder: A Randomized Clinical Trial that explores if GLP-1 receptor agonist semaglutide reduce alcohol consumption and cravings in adults with alcohol use disorder.

What Do Studies Say?

The research was conducted over a period of 9 weeks, where in the randomized clinical trial, the participants who were administered semaglutide, it led to reductions in some but not all measures of weekly consumptions. It also reduced weekly alcohol and craving related to placebo, and also led to a greater relative reduction in cigarettes per day.

The research also found that weekly injections of semaglutide, which is the active ingredient in weight loss drugs like Wegovy also helped reduce cravings in people with alcohol use disorder.

The lead author Christian Hendershot said that these findings will help in developing new approaches to treat alcoholism. "Two drugs currently approved to reduce alcohol consumption aren't widely used. The popularity of Ozempic and other GLP-1 receptor agonists increases the chances of broad adoption of these treatments for alcohol use disorder," said Hendershot in news release by the University of Southern California's Institute for Addiction Research, where he is the director.

The study is government-funded research and was funded by the National Institute on Alcohol Abuse and Alcoholism, part of the National Institutes of Health.

How Was The Study Conducted?

The study was small, and took in account for only 48 adults over two months, thus experts say that it is not yet clear how safe these drugs are for people who do not need to lose weight. Though the results do add up with the evidence form animal studies on drugs like Ozempic and Wegovy on how it helps manage cravings, not just for food, but also for tobacco and alcohol. Scientists are also studying these drugs on smokers, people with opioid addiction and cocaine users.

Co-author Dr Klara Klein of the University of North Carolina at Chapel Hill who treats people with obesity and diabetes said, "This is such promising data. And we need more of it. We frequently will hear that once people start these medications that their desire to drink is very reduced, if not completely abolished."

Why Does It Work So Well Against Alcoholism?

The GLP-1 receptor agonists work by mimicking hormones GLP-1 in the gut and brain that regulates appetite and feelings of fullness. This response is what helps one lose weight, and what helps one curb their craving for alcohol. These drugs that mimic the functioning of your brain, which is responsible to tell your body when to stop consuming, are the same hormones that tell your body about other kinds of consumptions, including alcohol. Therefore by consuming the weight loss drugs one can treat alcohol use disorder.

However, the researchers have pointed out on the limited data on the research and have suggested to continue using the three approved drugs by the National Institute on Alcohol Abuse and Alcoholism and Substance Abuse and Mental Health Services Administration, namely, Disulfiram, Naltrexone, and Acamprosate to treat alcohol use disorder until large studies confirm these findings.

After 13 years of wait, on March 24, at 4.10pm, Harish Rana took his last breath in AIIMS Delhi and became the very first case of passive euthanasia in India. Two days after the Supreme Court permitted euthanasia in his case, on March 14 he was shifted to AIIMS Delhi and his life support was withdrawn. He waited for ten days without any life support.

Harish Rana Donates Heart Valves and Cornea

News agency ANI also noted that his family donated his corneas and heart valves after his death. As per the Association for Advancing Tissue and Biologics, heart valves can be donated after death and used in life-saving and life-enhancing transplants. The National Institutes of Health notes that valves are typically removed within 24 hours of death.

NHS Organ Donation notes that since corneas do not contain blood vessels, it eliminates the risk of transmitting most types of diseases. The donated cornea could be used for patients experiencing corneal blindness or damage to restore sight. The cornea is usually removed in a 15-minute procedure after 6 to 8 hours of death.

Read: Harish Rana, India’s First Passive Euthanasia Case, Dies at AIIMS

Harish Rana - First Case of Passive Euthanasia In India

It was in 2013 when he suffered severe head injuries after he fell from the fourth floor from his PG accommodation while he was studying at Panjab University. He had been bedridden ever since, and survived on feeding tube. His father filed a petition seeking passive euthanasia under the guidelines Supreme Court had laid down in 2018 under Common Cause judgment. This is the second time the parents have approached the apex court.

In 2024, the court also suggested that Rana could receive home-based care with support from the Uttar Pradesh government. The home-based care includes periodic visits by doctors and physiotherapists. The court suggested that in case home care was not feasible, he could be moved to Noida's district hospital. However, his parents have noted that his condition continued to worsen. Family advocate Rashmi Nandakumar also informed the bench that "nothing seems to be working out".

"He is falling ill quite often and is repeatedly admitted to hospital," she said. The advocate further added that the family only sought passive euthanasia, which is withdrawal of treatment, and not any active intervention.

Justice Pardiwala also read medical reports and observed, "Just look at the condition of the boy. It's pathetic."

Recent court ruling on this case involved a bench comprising Justice JB Pardiwala and Justice KV Viswanathan that allowed the withdrawal of life support for Harish Rana.

European health agencies are flagging a rise in infections caused by Shigella infection among travellers returning from Cape Verde, prompting renewed focus on hygiene and food safety during international travel.

What is Shigella and why is it concerning?

Shigella is a highly infectious bacteria that causes gastrointestinal illness, commonly known as shigellosis. Symptoms typically include diarrhea, fever and stomach cramps, which can range from mild to severe. Globally, the burden is significant. Estimates suggest around 188 million cases occur each year, leading to over 1.6 lakh deaths.

The infection spreads easily through contact with contaminated food, water or surfaces, and even through person-to-person transmission. This makes it particularly concerning in travel settings such as hotels and resorts, where shared facilities are common.

Cases linked to Cape Verde travel

Health authorities in Europe have observed a noticeable uptick in travel-related infections. According to surveillance data, the UK Health Security Agency reported 158 cases since October 2025, with a majority linked to international travel. Among these, most travellers had recently visited Cape Verde, particularly popular tourist areas like Santa Maria and Boa Vista.

Similarly, the European Centre for Disease Prevention and Control has tracked hundreds of cases across multiple countries, including the UK, France, Sweden and the Netherlands. Investigations suggest that many infections are caused by a specific strain of Shigella sonnei, indicating a possible common source or ongoing transmission route.

However, authorities note that while the numbers are higher than expected, the situation does not necessarily meet the threshold of a large-scale outbreak.

Is it an outbreak or not?

There is a difference in how the situation is being interpreted. European agencies have described it as an outbreak due to the rise above typical background levels. In contrast, Cape Verde’s public health officials maintain that their surveillance systems have not detected an outbreak.

Local authorities point out that cases of diarrhea can increase in hotel settings worldwide and that not all rapid tests used in private clinics are specific to Shigella. More detailed investigations are currently underway to determine the exact source of infections.

Who is most at risk?

Certain groups are more vulnerable to infection. These include young children, people with weakened immunity, and those travelling abroad. Experts also note that exposure risk increases in environments where hygiene practices may vary.

Interestingly, many affected travellers were staying in high-end, all-inclusive resorts, suggesting that even premium accommodations are not immune to such risks.

Travel advice and precautions

Despite the concerns, Cape Verde’s tourism authorities continue to emphasize that the destination remains safe. With over 1.2 million visitors annually, including a large number from the UK, officials argue that the proportion of infections remains relatively small.

Health experts agree that the focus should be on prevention rather than avoidance. Simple measures can significantly reduce risk. These include frequent handwashing, using hand sanitizers, and consuming freshly cooked, well-heated food. Avoiding raw or undercooked items and being cautious with water sources is also recommended.

Travel medicine specialists highlight that gastrointestinal illness is relatively common during international travel, especially in warmer destinations. In fact, a significant proportion of travellers may experience some form of digestive issue during their trips.

New Delhi: Harish Rana, India's first person to receive legal approval for passive euthanasia, passed away at AIIMS, New Delhi, on Tuesday evening, PTI reported. This comes after the Supreme Court allowed the withdrawal of the life-support system, thereby putting an end to an emotional chapter for the family. He had been in a vegetative state for over 13 years, with almost no hope of recovery. Doctors, after the Supreme Court's approval, removed the life-support tubes, thereby allowing him to die naturally. Passive euthanasia refers to withholding or withdrawing life-support treatment for a patient with little or no hope of recovery, allowing him or her to die naturally.

Read more: 'Sabko Maaf Karte Hue...Tum Jao': Emotional Farewell to Harish Rana After Supreme Court Allows ‘Right to Die with Dignity’

The apex court had granted permission for this on March 11 this year, thereby allowing the withdrawal of medical intervention under Article 21 to keep him alive. The Article gives the right to live with dignity. After the verdict, Rana was moved to AIIMS Delhi, where doctors followed a legally approved procedure to discontinue artificial life support.

Who is Harish Rana?

Harish Rana was a BTech student at Panjab University. In 2013, he reportedly fell from the fourth floor of a paying guest accommodation and suffered a traumatic brain injury. This left him 100% disabled and in a vegetative state. He required round-the-clock medical attention for survival and was being fed through a PEG (percutaneous endoscopic gastrostomy) tube. Doctors had been treating him for the past few years while maintaining that there were almost no chances of recovery.

A decade of suffering

For Harish Rana, the suffering last over a decade - 13 years of suffering silently. Hailing from Ghaziabad, for him it all began after a catastrophic fall from the fourth floor. Since then, he was in a coma unable to communicate or move apart from involuntary gulps and raqre flickering of his eyes. His parents approached the judiciary to put an end to the endless cycle of pain that their son could not even express. On March 11, the Supreme Court granted Rana hte right to 'die with dignity', thereby marking a first-ever case of passive euthanasia. The verdict allows doctors to remove support tubes that keep a patient in a vegetative state. On March 16, at AIIMS, Rana received an emotional farewell and was removed from life support.