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Until law, GLP-1 drugs were used to treat diabetes, obesity and even the recent evidences suggest that it could as well be used to treat chronic kidney problems. There is yet another research, published in JAMA Psychiatry on February 25, titled Once-Weekly Semaglutide in Adults With Alcohol Use Disorder: A Randomized Clinical Trial that explores if GLP-1 receptor agonist semaglutide reduce alcohol consumption and cravings in adults with alcohol use disorder.
The research was conducted over a period of 9 weeks, where in the randomized clinical trial, the participants who were administered semaglutide, it led to reductions in some but not all measures of weekly consumptions. It also reduced weekly alcohol and craving related to placebo, and also led to a greater relative reduction in cigarettes per day.
The research also found that weekly injections of semaglutide, which is the active ingredient in weight loss drugs like Wegovy also helped reduce cravings in people with alcohol use disorder.
The lead author Christian Hendershot said that these findings will help in developing new approaches to treat alcoholism. "Two drugs currently approved to reduce alcohol consumption aren't widely used. The popularity of Ozempic and other GLP-1 receptor agonists increases the chances of broad adoption of these treatments for alcohol use disorder," said Hendershot in news release by the University of Southern California's Institute for Addiction Research, where he is the director.
The study is government-funded research and was funded by the National Institute on Alcohol Abuse and Alcoholism, part of the National Institutes of Health.
The study was small, and took in account for only 48 adults over two months, thus experts say that it is not yet clear how safe these drugs are for people who do not need to lose weight. Though the results do add up with the evidence form animal studies on drugs like Ozempic and Wegovy on how it helps manage cravings, not just for food, but also for tobacco and alcohol. Scientists are also studying these drugs on smokers, people with opioid addiction and cocaine users.
Co-author Dr Klara Klein of the University of North Carolina at Chapel Hill who treats people with obesity and diabetes said, "This is such promising data. And we need more of it. We frequently will hear that once people start these medications that their desire to drink is very reduced, if not completely abolished."
The GLP-1 receptor agonists work by mimicking hormones GLP-1 in the gut and brain that regulates appetite and feelings of fullness. This response is what helps one lose weight, and what helps one curb their craving for alcohol. These drugs that mimic the functioning of your brain, which is responsible to tell your body when to stop consuming, are the same hormones that tell your body about other kinds of consumptions, including alcohol. Therefore by consuming the weight loss drugs one can treat alcohol use disorder.
However, the researchers have pointed out on the limited data on the research and have suggested to continue using the three approved drugs by the National Institute on Alcohol Abuse and Alcoholism and Substance Abuse and Mental Health Services Administration, namely, Disulfiram, Naltrexone, and Acamprosate to treat alcohol use disorder until large studies confirm these findings.
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Illinois Governor JB Pritzker has once again claimed that US President Donald Trump is "suffering from dementia," an allegation the White House has strongly denied.
Speaking to CNN, Pritzker said Trump is "a different man" than he was a decade ago.
"Look, the man is continually suffering from dementia," Pritzker said. "I don't think he really understands what he's saying."
He added that Trump often makes statements without fully thinking them through.
"This is a man who has threatened to jail the mayor of Chicago, the governor of Illinois. He regularly threatens to go after people and, indeed, has used the Department of Justice to go after people," Pritzker said.
According to Pritzker, Trump has "concepts in his head" that he tends to blurt out without careful consideration.
He also urged people to compare Trump's public appearances from 2015 and 2016 with his recent speeches and press conferences.
"I really think that there's something genuinely wrong with him," Pritzker said.
However, Pritzker acknowledged that he is not medically qualified to diagnose the president.
'I'm Not a Doctor,' Pritzker, while criticizing what he described as Trump's increasingly disjointed speech patterns.
He said the way Trump "puts words and sentences together... they are almost divergent in the same sentences."
Read More: ‘Sea Or See?’ Donald Trump's Remark Sparks Fresh Cognitive Health Speculation
Trump, who became the oldest US president in history after turning 80 this year, has faced growing public scrutiny over his health.
Recent public appearances have prompted speculation after observers noted swollen ankles, bruising on his hands, verbal slips and occasional episodes in which he appeared drowsy during meetings and international summits.
Some physicians have also publicly expressed concerns about the president's physical and cognitive health, although none have diagnosed him with dementia.
Also read: Did Donald Trump Take Eli Lilly's Weight Loss Drug? What Did White House Say
A recently released book, Regime Change: Inside the Imperial Presidency of Donald Trump, claims the president's medical condition is among the administration's most closely guarded subjects.
Written by The New York Times White House correspondent Maggie Haberman and investigative reporter Jonathan Swan, the book is based on more than 1,000 interviews conducted over three years.
According to the authors, Trump now prefers shorter public appearances, seated events and staying close to the White House, unlike his extensive travel schedule during the 2024 presidential campaign.
The book also describes Trump as more of a "homebody" during his second term and claims staff members observed that he was sleeping less while spending early morning hours watching television, speaking on the phone and posting on Truth Social.
The White House dismissed the claims made in the book.
"President Trump's sharpness, unmatched energy, and historic accessibility stand in stark contrast to what we saw during the last administration when Democrats and the legacy media intentionally covered up Joe Biden's serious mental and physical decline from the American people," White House spokesperson Davis Ingle told the Daily Mail.
"President Trump is the sharpest and most accessible President in American history who is working nonstop to solve problems and deliver on his promises."
Meanwhile, Trump has also repeatedly rejected allegations of cognitive decline or other serious health issues.
His most recent annual physical examination concluded that he is "in excellent health."
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A 42-year-old woman in the UK recently shared the story of her decade-long battle with a parasitic brain infection called neurocysticercosis. Lowri Denman took a 3-month trip to India in 2007. Three years later, she passed a meter-long tapeworm that left her horrified. Years later, her health worsened in the worst way imaginable.
Despite avoiding meat on her trip, Denman picked up the infection after she ate pork that contained microscopic tapeworm eggs.
After the doctor gave her a clean bill of health, she began experiencing headaches and seizures. A doctor's consultation and several diagnostic tests revealed that she had 38 parasites in her brain. After confirming her neurocysticercosis diagnosis, her treatment ensued to which she responded well. She spent a few years in good health.
But after some time, she developed swellings on her brain around the parasites that caused various new symptoms in her body. She ended up quitting her job and moved with her parents for medical care.
Also read: Doctors Day: From Burnout To Work Anxiety, The Mental Health Struggle Doctors Rarely Talk About
Treatment, medication, and psychological stress affected her physical appearance and mental well-being. She experienced paranoia, psychosis, severe anxiety, and panic attacks. She also spent six weeks in a neuropsychiatric hospital.
After years of recovery, Lowri regained normalcy and returned to work in 2022. Her case turned out to be rare, went on to be discussed by many experts in the UK and the US.
Lowri did not have any surgery to remove the parasites from her brain. The parasites have now calcified in her brain. She will remain on epilepsy medication for the rest of her life.
Lowri is now determined to spread awareness about the disease using her experience.
Also read: Uganda On Alert Over Suspected Marburg Virus Outbreak
Neurocysticercosis is a parasitic brain infection that also affects the spinal cord. It is caused by the larval stage of the pork tapeworm, Taenia Solium. It is the leading cause of acquired epilepsy in several underdeveloped and developing nations.
Neurocysticercosis occurs when a person swallows tapeworm eggs, usually through food or water contaminated with feces from someone carrying the adult tapeworm. The eggs then hatch in the body, travel through the bloodstream, and form cysts in the brain.
The symptoms of neurocysticercosis depend on the basis of the size and number of the cysts. They include:
Its prevention includes maintaining good hand hygiene, ensuring proper sanitation and sewage disposal, consuming thoroughly cooked pork, and identifying and treating people who carry the adult tapeworm. Preventing pigs from accessing human feces is also a preventative measure.
Although neurocysticercosis is uncommon in many developed nations; it still occurs, especially in people who have lived or traveled to regions where the parasite is endemic.
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At least 17 US states have reported cases of watery diarrhea, nausea and fatigue caused by the parasite Cyclospora cayetanensis.
According to the US Centers for Disease Control and Prevention (CDC), 145 people aged between five and 86 contracted the parasite between May 1 and June 16.
Twenty of those infected have been hospitalized. The infections have been reported across 17 states, with the highest number of cases recorded in New York.
"Local, state and federal (CDC, FDA) public health authorities are investigating several clusters of cases in more than one state. Investigations to identify potential sources are ongoing," the CDC said in its update on the outbreak.
New York has reported the highest number of cases, with between 31 and 80 infections, according to The Independent. Illinois and Texas have each reported between 11 and 30 cases. Other affected states include:
Also read: Ebola Scare In UK: Suspected Patient At Glasgow Hospital Tests Negative
Cyclospora infections usually increase during the summer months, and the CDC considers May 1 through August 31 to be the peak cyclosporiasis season. No deaths have been reported in the current outbreak.
As of June 16, the CDC had also recorded 45 travel-related cases of cyclosporiasis among people who became ill after consuming contaminated food or water outside the United States.
Three of those patients were hospitalized, but no deaths have been reported.
Health officials believe the current outbreak is linked to contaminated food consumed within the United States. Most of the affected patients had not travelled outside the country before becoming ill.
The officials are still working to identify the specific food item responsible for the outbreak.
Cyclospora cayetanensis is a parasite that leads to the illness Cyclosporiasis -- a form of food poisoning.
One can get a Cyclospora infection from contaminated food or water. It causes watery diarrhea and other intestinal symptoms.
A Cyclospora infection can be mild or very serious, and may last weeks or months. It is typically treated with antibiotics.
People with weakened immune systems, such as those with HIV/AIDS or cancer, are more at risk of severe disease.
Symptoms of cyclosporiasis usually start within a week of exposure (eating or drinking contaminated food or water) and include:
While it is not yet fully understood how Cyclospora gets into food and water, individuals can prevent cyclosporiasis by not consuming food or water that may be contaminated with feces.
The US CDC advises people to take measures to prevent the foodborne illness such as:
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