Until law, GLP-1 drugs were used to treat diabetes, obesity and even the recent evidences suggest that it could as well be used to treat chronic kidney problems. There is yet another research, published in JAMA Psychiatry on February 25, titled Once-Weekly Semaglutide in Adults With Alcohol Use Disorder: A Randomized Clinical Trial that explores if GLP-1 receptor agonist semaglutide reduce alcohol consumption and cravings in adults with alcohol use disorder.

What Do Studies Say?

The research was conducted over a period of 9 weeks, where in the randomized clinical trial, the participants who were administered semaglutide, it led to reductions in some but not all measures of weekly consumptions. It also reduced weekly alcohol and craving related to placebo, and also led to a greater relative reduction in cigarettes per day.

The research also found that weekly injections of semaglutide, which is the active ingredient in weight loss drugs like Wegovy also helped reduce cravings in people with alcohol use disorder.

The lead author Christian Hendershot said that these findings will help in developing new approaches to treat alcoholism. "Two drugs currently approved to reduce alcohol consumption aren't widely used. The popularity of Ozempic and other GLP-1 receptor agonists increases the chances of broad adoption of these treatments for alcohol use disorder," said Hendershot in news release by the University of Southern California's Institute for Addiction Research, where he is the director.

The study is government-funded research and was funded by the National Institute on Alcohol Abuse and Alcoholism, part of the National Institutes of Health.

How Was The Study Conducted?

The study was small, and took in account for only 48 adults over two months, thus experts say that it is not yet clear how safe these drugs are for people who do not need to lose weight. Though the results do add up with the evidence form animal studies on drugs like Ozempic and Wegovy on how it helps manage cravings, not just for food, but also for tobacco and alcohol. Scientists are also studying these drugs on smokers, people with opioid addiction and cocaine users.

Co-author Dr Klara Klein of the University of North Carolina at Chapel Hill who treats people with obesity and diabetes said, "This is such promising data. And we need more of it. We frequently will hear that once people start these medications that their desire to drink is very reduced, if not completely abolished."

Why Does It Work So Well Against Alcoholism?

The GLP-1 receptor agonists work by mimicking hormones GLP-1 in the gut and brain that regulates appetite and feelings of fullness. This response is what helps one lose weight, and what helps one curb their craving for alcohol. These drugs that mimic the functioning of your brain, which is responsible to tell your body when to stop consuming, are the same hormones that tell your body about other kinds of consumptions, including alcohol. Therefore by consuming the weight loss drugs one can treat alcohol use disorder.

However, the researchers have pointed out on the limited data on the research and have suggested to continue using the three approved drugs by the National Institute on Alcohol Abuse and Alcoholism and Substance Abuse and Mental Health Services Administration, namely, Disulfiram, Naltrexone, and Acamprosate to treat alcohol use disorder until large studies confirm these findings.

A legal battle ensued over a surrogate pregnancy after a California couple sued their surrogate for more than $100,000, alleging she broke their agreement by refusing to terminate the pregnancy after their unborn baby was diagnosed with a serious heart defect.

The case involves McKenna West, a 28-year-old nurse from Alaska, and intended parents Nausheen Gilkar and Omar Ahmed of California. The dispute began after a 20-week scan showed that the fetus had hypoplastic left heart syndrome (HLHS), a rare congenital heart defect in which the left side of the heart is severely underdeveloped.

The baby, referred to as Gabriel by West and Rumi by the intended parents, was born in Texas on August 12 and is now receiving specialist medical care. The parents have custody of the newborn, while West's legal counsel has challenged the parental arrangement.

A Diagnosis That Changed The Surrogacy Agreement

According to the parents' lawsuit, their surrogacy agreement contained a provision allowing termination if the fetus developed a serious abnormality.

After doctors diagnosed HLHS at around 20 weeks, Gilkar and Ahmed asked West to terminate the pregnancy. According to court filings, West initially agreed to the process but later changed her mind and refused to undergo an abortion.

West travelled from Alaska to Texas while pregnant, saying she wanted the baby to be born close to specialists capable of treating HLHS. The disagreement has eventually turned into a legal dispute involving California, Alaska and Texas, with different arguments about the surrogacy contract, parental rights and decision-making.

Also read: Decoding The Fertility Markers

Parents Seek More Than $100,000

The latest lawsuit, filed by Gilkar and Ahmed, accuses West of breaching the surrogacy agreement by refusing to terminate the pregnancy.

They are seeking more than $100,000 in damages, according to the latest reports. Earlier proceedings also involved claims over financial penalties under the surrogacy agreement, with reports citing amounts as high as $250,000. West continues to dispute the allegations and has been fighting a separate legal battle over her rights concerning the baby.

Also read: Maternal Anemia: Why It’s A Major Pregnancy Risk For Indian Women And How to Prevent It

What Is HLHS?

HLHS is a complex congenital heart defect that affects the left side of the heart, including the left ventricle and major blood vessels.

As the left side cannot adequately pump oxygen-rich blood to the body, newborns with HLHS require immediate medical treatment after birth, which usually involves a series of surgeries.

While HLHS remains a serious lifelong condition, advances in surgery and intensive care can help children lead a normal life well into their adulthood.

Texas Court Ordered Life-Saving Treatment

Before the baby's birth, Texas Attorney General Ken Paxton asked the court to ensure that the newborn would receive medically necessary treatment. A Texas judge subsequently ordered that life-saving care be provided after birth and prevented the baby from being taken out the state while the case was being considered.

Paxton said, “Baby Gabriel deserves a chance at life.” The parents' lawyer, however, accused the Texas attorney general and West of turning a private family crisis into a political agenda. After the birth, attorney Lee Budner said the baby was in his parents' physical custody and receiving specialist care.

BBC presenter Emma Barnett has revealed that she underwent a hysterectomy after years of living with endometriosis and adenomyosis, saying she had the surgery she “never wanted to have” after her symptoms worsened with time.

Barnett, 41, was filming her BBC documentary Fighting Endometriosis when her health deteriorated. She eventually underwent a nearly five-hour operation involving endometriosis surgery, removal of her womb and gallbladder surgery. She was still recovering when the documentary aired in June.

She told listeners, "I made a programme on endometriosis on BBC Two and ended up being in hospital for endometriosis." She added, "Some 48 hours before the documentary aired - I had undergone a near-5 hour surgery and somehow found myself lying in bed recovering from extensive endometriosis surgery, a hysterectomy and a gallbladder removal," she wrote.

She has since returned to BBC Radio 4's Today programme and opened up about the physical and emotional toll of the procedure, including her recovery and adjustment to hormone replacement therapy.

"So yes, I've been recuperating, shall we say, from surgery for endometriosis and a hysterectomy to boot. So that's been less fun than the Today programme, but it is lovely to be back."

Barnett has lived with endometriosis for more than two decades. She also has adenomyosis, a condition she said she had come to suspect was responsible for much of her pain.

Adenomyosis Affects Muscle Of The Womb

Also read: Emma Barnett: It Took 21 Years To Diagnose My Endometriosis

Adenomyosis is a condition in which the tissue that normally lines the inside of the womb grows into the muscular wall of the uterus. The tissue continues to respond to hormonal changes during the menstrual cycle, which can cause the uterus to become enlarged and inflamed, leading to pain and heavy bleeding.

Adenomyosis does not present with symptoms. When it does, heavy menstrual bleeding and painful periods are among the most common complaints. Some women may also face pelvic pain, bloating or a feeling of heaviness in the abdomen, pain during sex and, in some cases, fertility issues.

Even though the condition is different from endometriosis, the two can occur together. The symptoms can overlap with endometriosis, which can make it difficult to identify which condition is responsible for symptoms.

Treatment Depends On Symptoms And Reproduction Plans

Also read: Alexandria Ocasio-Cortez Plans To Freeze Eggs As She Eyes 2028 US Presidential Run

Treatment for adenomyosis generally focuses on controlling pain and heavy bleeding. Depending on the severity of symptoms, doctors may recommend anti-inflammatory painkillers, hormonal treatments like the contraceptive pill or hormonal intrauterine systems, or other medicines that suppress menstrual symptoms.

For women who have completed their families and continue to experience severe symptoms despite other treatments, a hysterectomy may be considered.

A hysterectomy removes the uterus and, because adenomyosis exists within the uterine muscle, removing the uterus can cure adenomyosis. The NHS says it is generally considered when other treatments have failed and a woman does not want to have more children. However, a hysterectomy is major surgery and is not considered a first-line treatment.

While removing the uterus can cure adenomyosis, endometriosis occurs outside the uterus, meaning a hysterectomy does not necessarily eliminate all endometriosis.

Endometriosis lesions elsewhere in the body may remain and can continue to cause symptoms. Barnett therefore underwent endometriosis surgery alongside the hysterectomy.

Barnett said her recovery has been lengthy and physically demanding. Around 11 weeks after the operation, she was still dealing with fatigue and the process of adjusting her hormones with HRT.

A Documentary To Expose A Neglected Disease

Recognizing that many women experience similar struggles, Barnett made a new documentary film "Emma Barnett: Fighting Endometriosis" in which she speaks with women, including doctors, researchers and even politicians about their experiences with endometriosis, highlighting a neglected disease that has no known cure.

Through the documentary, Barnett hopes to raise awareness of the condition, improve public understanding, and draw attention to the long delays many women face in receiving a diagnosis.

“One of the reasons I have made a film about endometriosis is that I want people to understand it is not just ‘painful periods’. It’s a system-wide inflammatory condition where tissue similar to the lining of the uterus grows outside of it, causing agonizing pain. I am hoping to boost public understanding of that, and beyond merely being able to pronounce it,” she wrote in The Independent.

“It’s very hard to make something invisible visible, but what I am trying to do with this film is bring the invisible into light and show that this is a silent emergency.”

The US continues to see a significant rise in foodborne illnesses caused by the bacterium Salmonella and the parasite Cyclospora.

The infections have sickened thousands of people, led to hospitalizations and prompted several food product recalls across the country. The CDC estimates that Salmonella causes more than 1 million foodborne illnesses in the United States every year.

Salmonella

The Centers for Disease Control and Prevention (CDC) said a Salmonella outbreak linked to jalapeño peppers has infected 431 people across 32 states. This is up from 345 cases in 27 states reported earlier this month.

The CDC said the outbreak, which began between June 19 and August 2, has so far resulted in 57 hospitalizations and no deaths.

The infections have been linked to jalapeño peppers from Sinaloa, Mexico, distributed by Coast Citrus Distributors. More than 90% of people interviewed reported eating at a Mexican-style restaurant before becoming ill, including at Chipotle Mexican Grill and QDOBA, the CDC said.

Chipotle has reportedly switched its jalapeño supplier, while QDOBA restaurants have stopped using the ingredient.

Symptoms of Salmonella Infection

Salmonella illness usually develops 12 to 72 hours after consuming contaminated food and typically lasts four to seven days. Common symptoms include:

• Diarrhea
• Fever
• Abdominal cramps

How To Reduce Salmonella Risk

• If you have recalled jalapeño peppers at home, do not eat them.
• Wash your hands with soap after handling food and during food preparation.
• Clean chopping boards and utensils after preparing food.
• Check food hygiene ratings when choosing catering outlets.

Cyclospora

The CDC’s latest report showed 15,716 confirmed cases of cyclosporiasis in the US. The confirmed cases, reported across 47 states, have led to 828 hospitalisations and two deaths as of August 17. At least 11,841 additional cases of cyclosporiasis may require further investigation and analysis, the CDC said.

The CDC and FDA are also investigating at least six other clusters for which sources have not yet been confirmed.

Michigan, the hardest-hit state in the 17-state cyclosporiasis outbreak, reported 13,909 cases linked to the parasitic disease last week. However, state officials believe that the outbreak may be over.

The cyclosporiasis outbreak is one of the largest foodborne illness events in recent US history. The illness is caused by the Cyclospora parasite, which can lead to diarrhea, nausea and other gastrointestinal symptoms.

How To Reduce Your Risk of Cyclospora

• Check whether recently purchased iceberg lettuce was sourced from Taylor Farms de Mexico, Guanajuato.
• The recall includes:
  1. 12-ounce and 24-ounce Iceberg Salad with best-by dates July 18–August 3
  2. 8-ounce and 16-ounce Shredded Lettuce with best-by dates July 18–August 3
• Discard or return any recalled products. An additional 33 recalled products were supplied to restaurants and are unlikely to be in home refrigerators.
• Avoid eating recalled shredded iceberg lettuce.
• Wash all fresh fruits and vegetables thoroughly under running water, even if labelled pre-washed.
• Choose whole heads of lettuce over bagged greens when possible. Remove the outer leaves and wash the inner leaves thoroughly.
• Cook produce whenever possible, as heat is the most effective way to kill Cyclospora.
• Follow safe food-handling practices and stay updated on food recalls.