Until law, GLP-1 drugs were used to treat diabetes, obesity and even the recent evidences suggest that it could as well be used to treat chronic kidney problems. There is yet another research, published in JAMA Psychiatry on February 25, titled Once-Weekly Semaglutide in Adults With Alcohol Use Disorder: A Randomized Clinical Trial that explores if GLP-1 receptor agonist semaglutide reduce alcohol consumption and cravings in adults with alcohol use disorder.

What Do Studies Say?

The research was conducted over a period of 9 weeks, where in the randomized clinical trial, the participants who were administered semaglutide, it led to reductions in some but not all measures of weekly consumptions. It also reduced weekly alcohol and craving related to placebo, and also led to a greater relative reduction in cigarettes per day.

The research also found that weekly injections of semaglutide, which is the active ingredient in weight loss drugs like Wegovy also helped reduce cravings in people with alcohol use disorder.

The lead author Christian Hendershot said that these findings will help in developing new approaches to treat alcoholism. "Two drugs currently approved to reduce alcohol consumption aren't widely used. The popularity of Ozempic and other GLP-1 receptor agonists increases the chances of broad adoption of these treatments for alcohol use disorder," said Hendershot in news release by the University of Southern California's Institute for Addiction Research, where he is the director.

The study is government-funded research and was funded by the National Institute on Alcohol Abuse and Alcoholism, part of the National Institutes of Health.

How Was The Study Conducted?

The study was small, and took in account for only 48 adults over two months, thus experts say that it is not yet clear how safe these drugs are for people who do not need to lose weight. Though the results do add up with the evidence form animal studies on drugs like Ozempic and Wegovy on how it helps manage cravings, not just for food, but also for tobacco and alcohol. Scientists are also studying these drugs on smokers, people with opioid addiction and cocaine users.

Co-author Dr Klara Klein of the University of North Carolina at Chapel Hill who treats people with obesity and diabetes said, "This is such promising data. And we need more of it. We frequently will hear that once people start these medications that their desire to drink is very reduced, if not completely abolished."

Why Does It Work So Well Against Alcoholism?

The GLP-1 receptor agonists work by mimicking hormones GLP-1 in the gut and brain that regulates appetite and feelings of fullness. This response is what helps one lose weight, and what helps one curb their craving for alcohol. These drugs that mimic the functioning of your brain, which is responsible to tell your body when to stop consuming, are the same hormones that tell your body about other kinds of consumptions, including alcohol. Therefore by consuming the weight loss drugs one can treat alcohol use disorder.

However, the researchers have pointed out on the limited data on the research and have suggested to continue using the three approved drugs by the National Institute on Alcohol Abuse and Alcoholism and Substance Abuse and Mental Health Services Administration, namely, Disulfiram, Naltrexone, and Acamprosate to treat alcohol use disorder until large studies confirm these findings.

Research shows that there are an estimated 300 to 450 living supercentenarians—people aged 110 or older—around the world at any given time. Japan is particularly known for healthy ageing, with an average life expectancy of over 84 years and nearly 100,000 centenarians.

While maintaining a healthy and balanced lifestyle may partly explain their longevity, a new study by a A team of Japanese scientists suggests that it may also be linked to an abundance of cancer-fighting immune cells.

The human immune system has specialized cells called CD4 cytotoxic T lymphocytes (CD4 CTLs), which have been shown to kill tumor cells in some cancers.

When a person gets sick, these cells multiply through a process called clonal expansion to help fight infection.

The study, published in the journal Cell Reports, showed that these immune cells may also play a role in healthy ageing among supercentenarians.

“Immune aging is not simply a process of decline,” said first author Kosuke Hashimoto, an associate professor at the University of Osaka in Japan.

“The selective expansion of certain T cells suggests that, even in extreme old age, the immune system may continue to adapt to age-related challenges,” Hashimoto added.

How Do Immune Cells Work In Supercentenarians?

CD4 CTLs are a cellular signature of supercentenarians—people who live to age 110 and beyond. The researchers discovered that these cells expand and adapt within this older population.

“CD4 CTLs are an atypical and relatively rare T cell population,” Hashimoto said. “So, their marked increase in supercentenarians may provide important clues as to how the immune system is maintained in extreme old age.”

What Did the Study Find?

The small study analyzed blood samples from 28 adults divided into three age groups:

• 70–99
• 100–109
• 110 and older

The findings showed that the proportion of CD4 CTLs increased with age, with median percentages of 4%, 9.6% and 17.6%, respectively.

Researchers found that older adults may be responding to persistent immune threats. As a result, CD4 CTLs clone themselves when the immune system is under attack.

The most prominent clone accounted for an average of 33.3% of CD4 CTLs, indicating that older adults may be responding to persistent immune threats. In one centenarian’s blood sample, a single clone accounted for 53.8% of their CD4 CTLs.

Next, researchers matched the receptor sequences of each participant’s top CD4 CTL clone with those in a public database. Nearly three dozen matches belonged to people with cancer, namely lung, breast and liver cancers.

Because none of the centenarians or supercentenarians studied had been diagnosed with these cancers, researchers theorized that their CD4 CTL expansion may reflect early immune responses.

“Some CD4 CTLs may recognize cancer-related targets, although their exact targets remain unknown,” Hashimoto said.

Evidence Remains Preliminary

The study, which focused on T cells circulating in the blood, does not prove that having an abundance of CD4 CTLs prevents cancer or causes a person to live longer.

Hashimoto said the team’s next step is to research how these cells behave in human tissues.

“As we age, abnormal cells, including senescent and cancerous cells, become more common,” Hashimoto said. “Our findings suggest that immune adaptation to these changes may contribute to exceptional longevity.”

Health officials in the US are warning consumers about yet another multistate outbreak of Salmonella and E. coli infections. This time its linked to alfalfa sprouts, which have sickened more than 40 people.

The outbreak comes as the US is also witnessing a major rise in Cyclospora infections, which can cause severe diarrhea. Federal health officials have posted 20 foodborne illness investigations so far this year, with about 10,500 illnesses associated with outbreaks.

Which States Are Reporting Cases?

Minnesota and Wisconsin have reported more than 40 illnesses linked to alfalfa sprouts.

Officials said additional illnesses are being identified in other states, and the number of cases could increase as the investigation continues.

Minnesota

The Minnesota Department of Health and Minnesota Department of Agriculture said 23 Minnesotans became ill between July 8 and August 8 with Salmonella and/or Shiga toxin-producing E. coli (STEC) infections.

Two people have been hospitalized, and no deaths have been reported.

Of the cases, three people had Salmonella, including one who also had STEC O168:H8. Seven people were infected with STEC O103:H25, while 13 had STEC O26:H11.

According to officials, Minnesota reports approximately 1,000 Salmonella infections and 85 STEC infections with the serogroups associated with this outbreak each year.

Wisconsin

Officials in Wisconsin have identified 17 cases, with one person hospitalized.

The Wisconsin cases are connected to a multistate outbreak of STEC and Salmonella infections linked to alfalfa sprouts distributed to restaurants and grocery stores.

Approximately 1,000 Salmonella infections and 500 STEC infections are reported each year in Wisconsin.

Which Alfalfa Sprout Brands Are Linked To The Outbreak?

The illnesses have been linked to alfalfa sprouts produced by Everything Sprouts, a Minnesota grower, and sold under the Calco and Everything Sprouts brands to restaurants and grocery stores.

Health officials recommend checking homes for these products, not eating them and throwing them away.

What Are The Symptoms Of E. Coli Infection?

Shiga toxin-producing Escherichia coli (STEC) is a group of bacteria that make dangerous poisons called Shiga toxins. While most E. coli are harmless, STEC infections can cause:

• Stomach cramps
• Diarrhea, often with bloody stools
• Low-grade or no fever

People usually become sick two to five days after swallowing the bacteria.

Most people recover within five to seven days.

However, STEC infections can also cause hemolytic uremic syndrome (HUS), a severe complication that can lead to acute kidney failure and other serious health problems.

The officials warned that diarrhea caused by STEC infections generally should not be treated with antibiotics, as this can increase the risk of HUS. Anyone who believes they may have an STEC infection should contact a healthcare provider.

What Are The Symptoms Of Salmonella Infection?

Salmonella is a bacterial infection that commonly causes diarrhea and gastrointestinal illness.

Salmonella infection can cause:

• Diarrhea
• Abdominal pain
• Fever

Symptoms usually begin six hours to six days after swallowing the bacteria.

Most people recover from Salmonella infection without medical treatment. However, children, older adults and people with weakened immune systems may develop serious illness requiring medical care.

How To Stay Safe?

Officials advise people to:

• Check their homes for alfalfa sprouts from Everything Sprouts and Calco.
• Do not eat the sprouts.
• Throw them away.
• Anyone who has eaten the sprouts should monitor for symptoms of Salmonella or STEC infection.
• Contact a healthcare provider if symptoms become severe.

American Olympic bronze medallist Jenny Simpson has announced her diagnosis of Arrhythmogenic ‌Right Ventricular Cardiomyopathy (ARVC) -- a rare inherited heart condition that is forcing her to give up her career as it makes running dangerous.

The 39-year-old, former 1500 meters world champion, was diagnosed after collapsing in June ⁠at a community track event hosted by Sir Walter Running and required CPR.

What Happened To Jenny Simpson?

After receiving lifesaving care at the track event, Simpson was transferred to Duke University Hospital for more advanced heart failure support.

Her heart was not pumping strongly enough, causing fluid to build up in her lungs. She described the experience as beginning to “drown.”

“My body was dying, but my spirit wouldn’t give up,” her post read. “I fought for my life.”

Within days, however, her heart and lungs were strong enough to function on their own.

Simpson Forced To End Her Career

Simpson said her diagnosis means “it would be dangerous for me to return to running.” She retired from elite racing in 2024 and described the diagnosis as the end of that chapter of her life.

"I was diagnosed with a rare inherited heart condition, Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)... My future is an incredible gift. It is hopeful, and it will continue to have a ‌great ⁠purpose. But my diagnosis also means it would be dangerous for me to return to running," Simpson said in a post on Instagram.

“That chapter has ended,” the post read. “Thankfully, my story hasn’t.”

Why Can ARVC Be Dangerous?

Simpson was diagnosed with ARVC, a rare inherited condition in which scar tissue in the heart can disrupt its electrical system and trigger dangerous heart rhythms.

The condition can weaken the heart muscle and affect its ability to pump blood effectively. It can affect one or both ventricles; when it mainly affects the right ventricle, it is called ARVC. In Simpson’s case, the abnormal heart rhythms ultimately caused her heart to stop.

“As devastating as that diagnosis sounds, I truly feel profoundly fortunate. CPR, AED shocks, exceptional medical care, and a healthy body and fighting spirit that have spent a lifetime adapting to hard things all came together to give me another chance at life.”

Simpson is the only US woman to win a world 1500m title, which she achieved in 2011, and one of two US women to win an Olympic 1500m medal, taking bronze in 2016.

From 2007 through 2019, she finished among the top three in the 1500m, 5000m or 3000m steeplechase at all 13 USA Track and Field Outdoor Championships.

What Is ARVC?

In ARVC, heart muscle cells do not stick together properly, causing scar tissue and weakening the heart muscle. This can affect the heart’s ability to pump blood effectively.

The condition can affect one or both ventricles. When it primarily affects the right ventricle, it is called ARVC.

ARVC: Symptoms

• Heart palpitations
• Lightheadedness
• Fainting
• Shortness of breath
• Abnormal heart rhythms
• Swelling in the ankles, legs or abdomen
• Chest pain or discomfort

ARVC: Diagnosis

Doctors may use several tests to assess the heart, including:

• Cardiac MRI
• ECG
• Exercise test
• Echocardiogram

ARVC: Treatment

There is no cure for ARVC, but treatment can help manage abnormal heart rhythms and reduce complications. Options may include:

• Pacemaker
• ICD
• Cardioversion
• Catheter ablation.