Until law, GLP-1 drugs were used to treat diabetes, obesity and even the recent evidences suggest that it could as well be used to treat chronic kidney problems. There is yet another research, published in JAMA Psychiatry on February 25, titled Once-Weekly Semaglutide in Adults With Alcohol Use Disorder: A Randomized Clinical Trial that explores if GLP-1 receptor agonist semaglutide reduce alcohol consumption and cravings in adults with alcohol use disorder.

What Do Studies Say?

The research was conducted over a period of 9 weeks, where in the randomized clinical trial, the participants who were administered semaglutide, it led to reductions in some but not all measures of weekly consumptions. It also reduced weekly alcohol and craving related to placebo, and also led to a greater relative reduction in cigarettes per day.

The research also found that weekly injections of semaglutide, which is the active ingredient in weight loss drugs like Wegovy also helped reduce cravings in people with alcohol use disorder.

The lead author Christian Hendershot said that these findings will help in developing new approaches to treat alcoholism. "Two drugs currently approved to reduce alcohol consumption aren't widely used. The popularity of Ozempic and other GLP-1 receptor agonists increases the chances of broad adoption of these treatments for alcohol use disorder," said Hendershot in news release by the University of Southern California's Institute for Addiction Research, where he is the director.

The study is government-funded research and was funded by the National Institute on Alcohol Abuse and Alcoholism, part of the National Institutes of Health.

How Was The Study Conducted?

The study was small, and took in account for only 48 adults over two months, thus experts say that it is not yet clear how safe these drugs are for people who do not need to lose weight. Though the results do add up with the evidence form animal studies on drugs like Ozempic and Wegovy on how it helps manage cravings, not just for food, but also for tobacco and alcohol. Scientists are also studying these drugs on smokers, people with opioid addiction and cocaine users.

Co-author Dr Klara Klein of the University of North Carolina at Chapel Hill who treats people with obesity and diabetes said, "This is such promising data. And we need more of it. We frequently will hear that once people start these medications that their desire to drink is very reduced, if not completely abolished."

Why Does It Work So Well Against Alcoholism?

The GLP-1 receptor agonists work by mimicking hormones GLP-1 in the gut and brain that regulates appetite and feelings of fullness. This response is what helps one lose weight, and what helps one curb their craving for alcohol. These drugs that mimic the functioning of your brain, which is responsible to tell your body when to stop consuming, are the same hormones that tell your body about other kinds of consumptions, including alcohol. Therefore by consuming the weight loss drugs one can treat alcohol use disorder.

However, the researchers have pointed out on the limited data on the research and have suggested to continue using the three approved drugs by the National Institute on Alcohol Abuse and Alcoholism and Substance Abuse and Mental Health Services Administration, namely, Disulfiram, Naltrexone, and Acamprosate to treat alcohol use disorder until large studies confirm these findings.

Health officials in the Democratic Republic of the Congo (DRC) have stated that the Ebola outbreak has reached its peak, with the number of new cases slowing for the first time since May.

However, the UN has warned that the epidemic remains “massive” and is still growing in some areas, while the World Health Organization (WHO) said it is too early to confidently conclude that the outbreak has passed its peak.

The outbreak, caused by the rare Bundibugyo virus, was declared by the WHO on May 15. It is the DRC’s 17th Ebola outbreak since the virus was first identified in 1976.

It is also the second-deadliest Ebola outbreak on record, behind the West African outbreak that lasted from 2014 to 2016.

While clinical trials are ongoing for vaccines and treatments against Bundibugyo virus, the DRC received more than 70,000 doses of the Ervebo vaccine last month. Ervebo is approved for protection against the more common Zaire Ebola virus.

Are Ebola Cases Slowing?

Also read: Ebola Bundibugyo Virus: American Health Worker Had 10x Higher Viral Load In Throat Than Blood

According to the latest data from the Congolese health ministry, more than 7,200 confirmed cases and over 3,475 deaths had been reported as of September 14.

Congolese Health Minister Samuel Roger Kamba said transmission of the Bundibugyo virus had declined, with daily cases falling from about 120 at the peak in mid-August to around 80.

“We are fighting a very dangerous virus that is killing many of our people. Today, we can say that the outbreak is under control,” he said.

“At one point, we were recording about 120 cases per day; today, we’re seeing about 80 per day. So the number of new cases is decreasing every day.”

Kamba said 10 of the 62 affected health zones had reported no new cases for more than 22 days. Six health zones had gone more than 42 days without a new case, while four had gone more than 21 days without one.

He said the figures were “encouraging” but stressed that people must remain fully mobilized and not lower their guard.

Concerns Over Government Claim

Read More: Chile Eliminates Dog-Transmitted Rabies: What Other Countries Can Learn

Last week, Sud-Ubangi province, which borders Congo-Brazzaville and the Central African Republic, became the sixth province to report Ebola cases.

While welcoming the progress, Iracan Gratien de Saint-Nicolas, an MP for Bunia, warned against “triumphalism” and called for greater transparency over the outbreak data, The Guardian reported.

“Claims that an epidemic is under control must be supported by objective indicators. If the indicators show that the epidemic is indeed under control, let’s make them public. Transparency in the data will strengthen public confidence,” he said.

He also called for lessons to be learned from failures in epidemiological surveillance that contributed to the rapid spread of the disease.

What Is The UN Saying?

UN officials acknowledged that response efforts were showing results but warned that the epidemic remained “massive” and could take months to bring under control.

“It remains a deadly and a massive epidemic. There are some areas of progress, but nonetheless, in other areas, we continue to see growth in cases,” Julien Harneis, the UN special Ebola coordinator, told a Geneva press briefing.

Asked about reports that the epidemic had reached a turning point, WHO's Olivier le Polain said: “It's too early to confidently say we have passed a peak”, Reuters reported.

A team of US researchers has developed an unconventional surveillance tool: a 3D-printed “mosquito toilet” that collects mosquito waste for genetic analysis.

The approach detected a complete West Nile virus genome and the first known evidence of a Hedwig-like virus in the Americas, along with several viruses that may be new to science and parasites.

Researchers from the Rutgers University adapted an approach used to track genetic evidence in wastewater, including during the COVID-19 pandemic and for polio surveillance, to mosquitoes.

How Does The Mosquito ‘Toilet’ Work?

Also read: ICMR Study Shows Pune Dengue Mosquitoes Resistant To Insecticides: What It Means for Public Health

The team built what it called “a mosquito toilet” — a 3D-printed funnel coated with a superhydrophobic (water-repelling) material that causes liquid to bead up and slide into a collection tube, explained lead author and entomologist Dana Price from the School of Environmental and Biological Sciences.

The researchers collected two groups of 50 wild Culex mosquitoes from a yard in New Brunswick, New Jersey, in 2021 and 2022. They placed each group in a screened container over the funnel and fed them a sugar solution. The mosquitoes produced drops of waste, which slid into a tube.

The scientists used shotgun metagenomic sequencing, which sequences all genetic material present in a mixed sample. Computers then assembled the millions of fragments generated and compared them with known sequences in scientific databases.

What Did The Mosquito Waste Reveal?

The team captured tiny traces of mosquito waste and conducted genetic sequencing.

The findings, published in the journal Microbiology Spectrum, revealed:

• A complete West Nile virus genome
• The first known evidence of a Hedwig-like virus in the Americas
• Several viruses that may be new to science
• Parasites
• The mosquito species that deposited the waste droplets

The study suggests mosquito waste could become a surveillance tool, allowing scientists to search broadly for familiar pathogens as well as threats they don't yet know exist, Price said.

Mosquitoes excrete small amounts of liquid containing genetic traces of viruses and other organisms. Because the waste contains far less mosquito tissue, and therefore less mosquito DNA, than a crushed insect, the scientists reasoned that viral material might be easier to find.

A Full West Nile Virus Genome

The 2022 sample contained a complete, high-quality genome of West Nile virus, which can cause serious neurological illness in people.

The researchers identified the virus as belonging to the NY07 genetic variant previously found in the region. Such detail could help scientists track how genetic variants of a virus emerge, spread and change.

"What came out was an entire viral genome," Price said. "Rather than just positive or negative, we have genetic data."

An Unexpected Virus In The Americas

Read More: Cyborg Cockroaches: Australian Researchers Create Tiny ‘Paramedics’ For Medical Missions

The researchers were even more intrigued by evidence of a Hedwig-like virus, which hadn't previously been reported in the Americas.

Hedwig virus was first identified in Europe in snowy owl tissue, prompting scientists to name it after Harry Potter's famous white owl. Some of the infected birds also had West Nile virus.

Scientists don't know whether Hedwig-like viruses make birds sick, facilitate West Nile infections or simply coexist with other viruses.

The finding doesn't establish that the virus is a threat, Price said. It shows that it has been circulating where no one knew to search for it.

"We didn't even look for it specifically," Price said. "We just looked for everything, and we found Hedwig in there."

A virus found for the first time in a region may have recently arrived or may have gone unnoticed for years. Because few broad mosquito-virus studies have been conducted in North America, organisms that seem geographically restricted may prove widespread.

Price is currently working with health officials at the New Jersey Department of Environmental Protection to screen organ and tissue samples for the virus. The samples are collected from deceased birds during a postmortem examination.

Chile has become the first country in South America to eliminate dog-transmitted rabies as a public health problem, marking a major milestone in the fight against a disease that is almost always fatal once symptoms appear.

The achievement follows more than five decades without a human case of rabies transmitted by dogs, supported by sustained dog vaccination, disease surveillance and timely access to post-exposure treatment.

“I congratulate the government and people of Chile on this historic achievement,” said Dr Tedros Adhanom Ghebreyesus, WHO Director-General.

“This validation reflects decades of commitment to protecting communities from rabies and demonstrates the impact of sustained investment in public health. Chile’s success offers valuable lessons for countries working to end human deaths from this preventable disease,” he added.

How Chile Eliminated Dog-Transmitted Rabies

Also read: Bhutan Eliminates Rabies While India Battles Persistent Deaths: What Can India Learn From Its Neighbor?'

WHO recognizes elimination when transmission among dogs has stopped, no human deaths from dog-mediated rabies have occurred for at least two years, and the country can prevent the disease from returning.

Chile’s last reported case of human rabies transmitted by dogs occurred in 1972.

Since then, the country has sustained efforts including timely vaccination for people exposed to the virus through bites, scratches or contact with saliva from infected or suspected rabid dogs.

These efforts were supported by:

• Door-to-door dog vaccination campaigns
• Targeted dog population management
• Community awareness and education
• Free mass vaccination for dogs and cats
• Epidemiological surveillance
• Strengthened laboratory diagnosis
• Monitoring of rabies virus in animals
• Timely access to post-exposure prophylaxis.

More recently, Chile has expanded preventive vaccination and surveillance to border areas at higher risk of rabies reintroduction.

What Chile’s Success Teaches

Chile’s achievement builds on decades of coordinated action across the Americas, where human cases of dog-mediated rabies have fallen by more than 98% since 1983.

It also contributes to the Pan American Health Organization’s (PAHO) Disease Elimination Initiative, which aims to eliminate more than 30 communicable diseases and related conditions in the Americas by 2030.

While the Americas has made significant progress, dog-transmitted rabies still causes tens of thousands of deaths globally each year, primarily in Asia and Africa.

Chile’s success shows how sustained investment in prevention, surveillance and access to care can bring this deadly but preventable disease to the point of elimination.

It also highlights the value of the One Health approach, bringing together human, animal and environmental health sectors to prevent and control diseases that spread between animals and people.

Read More: US CDC Warns Of Rising Human Rabies Exposure Risk: How To Stay Safe

What Is Rabies?

Rabies is a vaccine-preventable zoonotic disease that is almost invariably fatal once symptoms appear. However, deaths can be prevented through timely post-exposure prophylaxis, including wound care and vaccination.

Dogs account for up to 99% of human rabies transmissions globally.

Public education on dog behavior, bite prevention, appropriate action after a bite or scratch, and responsible pet ownership is also essential to rabies prevention.

Rabies is also one of 21 neglected tropical diseases (NTDs), which affect one billion people globally. As of September 2026, 65 countries had eliminated at least one NTD, including seven in the Americas.

Chile’s validation for rabies marks its second NTD elimination achievement; earlier this year, it was verified by WHO for the elimination of leprosy, becoming the first country in the Americas to achieve this target.