Fitness has a different definition for people, while for someone it may mean being an ideal weight, for others it may be gaining muscle. And all of these have different types of exercises, diets and other lifestyle changes which will help them reach their goal in a reasonable amount of time. One thing that everyone must understand is that you cannot rush fitness, but you can maximize your ability to reach your goal quicker. Maximizing means making the most of the opportunity, for example, you have an hour to exercise every day and you wish to lose weight, to maximize your opportunity you must fit in cardio that allows you to burn calories easily like Stairmaster, running on an inclination, as well as weightlifting. And on the other hand, if you wish to gain muscle, you will focus more on weights and lifting the most you can. Muscle gain is said to be a difficult task as you are practically depending on the wear and tear of your muscles to build them bigger.

While there are many ways to gain muscle periodization has shown to have better results in the long run.

What Is Periodization?

Think of periodization as planning your workouts like a coach plans a game. Instead of just showing up and doing the same thing every time, you break your training into different stages, each with a specific goal. It's like building a house, you don't start by putting on the roof! You lay the foundation first. Periodization helps you do the same with your fitness. You might spend some time focusing on building a base level of fitness, then move on to building strength, and then maybe work on power or speed. By changing things up regularly, you keep your body guessing and avoid hitting plateaus. It's all about working smarter, not just harder.

Periodization isn't just some random idea, it's based on how our bodies work. When you exercise, your body experiences stress. It reacts to this stress in a predictable way, going through different stages. Periodization uses this knowledge to its advantage. It pushes your body just enough to make it adapt and get stronger, but not so much that it gets worn out and injured. Think of it in food terms, not too hot, not too cold, but just right. Some of the benefits of periodization include getting stronger or faster, avoiding overtraining which can actually make you weaker! preventing injuries, staying motivated because you have a plan, and seeing consistent progress over time.

Can Periodization Be Used For Other Sports?

Periodization is a discipline that can be applied in many places. Periodization isn't just for bodybuilders or athletes; it can help anyone who exercises.

It can be used for strength training, if your goal is to build muscle, periodization helps you cycle through different phases to maximize growth. It is also useful for people who are into endurance training like runners, swimmers, and cyclists use it to prepare for long events by focusing on different energy systems. For athletes in all sports use periodization to peak at the right time and avoid getting injured during training. Even in bodybuilding, where the focus is on aesthetics, periodization plays a key role in maximizing muscle growth and achieving that competition-ready physique.

Putting periodization into practice takes some planning. First, you need to know your goals. What do you want to achieve? Then, choose a periodization model that fits your goals and how much experience you have. Next, divide your training year into phases, each with a specific purpose. This might be a few weeks or a few months long. Then, adjust your training volume which depends on how much you do, intensity which is how hard you work), and exercises to match each phase.

Eli Lilly’s highly anticipated GLP-1 weight-loss drug retatrutide has delivered nearly 21% average weight loss in people with type 2 diabetes and obesity, according to results from a large Phase 3 trial published in The Lancet. In an ever-expanding weight loss medication market, retatrutide is already showing significant promise in obesity and diabetes management.

The drug, retatrutide, is being developed by Eli Lilly and is not approved by the FDA yet. In the TRIUMPH-2 trial, people receiving the highest 12 mg dose lost an average of 20.8% of their body weight over 80 weeks, equivalent to about 49.6 pounds or 22.5 kg.

The findings about retatrutide's trial were presented at the European Association for the Study of Diabetes (EASD) annual meeting in Milan and published simultaneously in The Lancet.

How Is Retatrutide Different From Other GLP-1 Drugs?

Retatrutide is a triple agonist because it activates three hormone receptors:

• GIP
• GLP-1
• Glucagon

GLP-1-based medicines are already widely used for diabetes and obesity. Retatrutide activates GIP and glucagon pathways as well, creating a three-way approach to manage appetite, blood sugar and metabolism. The drug is given once weekly by injection and remains experimental and investigational.

Also read: World Heart Day: You Feel Healthy. But Plaque May Already Be Building In Your Arteries In Your 20s

Retatrutide Weight Loss Results

TRIUMPH-2 included adults with obesity or overweight and type 2 diabetes. Participants receiving retatrutide were assigned to 4 mg, 9 mg or 12 mg doses and followed for 80 weeks. The average weight loss was:

• 4 mg: 12.7%
• 9 mg: 19.1%
• 12 mg: 20.8%
• Placebo: 4.0%

The response was even greater among participants who started the study with a BMI of at least 35. Those receiving 12 mg lost an average of 23.4% of their body weight, or about 60.8 pounds.

By week 80, 59.5% of people taking 12 mg no longer met the BMI criteria for obesity.

Also read: 100% Blockage At 18, 25% Patients Under 40: On World Heart Day, Cardiologists Reveal An Alarming Heart Attack Pattern

Retatrutide Blood Sugar Results

Retatrutide not only led to one of the biggest weight losses ever seen, it also improved HbA1c, a measure of average blood glucose over the previous two to three months. At 80 weeks, HbA1c fell by:

• 1.4 percentage points with 4 mg
• 1.6 percentage points with 9 mg
• 1.5 percentage points with 12 mg

Up to 40% of participants receiving retatrutide achieved an HbA1c below 5.7%, which is within the normal range.

The Next Big Weight-Loss Drug?

The results are certainly seem promising, particularly as people with type 2 diabetes can sometimes lose less weight with obesity medicines than people without diabetes.

Retatrutide's combination of substantial weight loss and improved blood sugar control makes it an important drug to watch in a competitive GLP-1 market.

Since it's not approved yet, more evidence will be needed on its long-term safety, cardiovascular effects and how its benefits compare with existing treatments. It is also worth remembering that the 20.8% figure represents an average, not the amount every participant lost.

Retatrutide's development is a sign that obesity and diabetes treatment is extending beyond just managing blood sugar. The next generation of drugs is all about targeting weight, glucose and metabolism together.

Exercise is good for the heart. That part is not in question. But on the occasion of World Heart Day, doctors say the way you exercise, and how suddenly you start, can matter just as much as whether you exercise at all.

The Weekend Warrior Problem

A lot of us live sedentary weekdays and then try to make up for it with one hard gym, swimming or sports session over the weekend. Dr Dhirendra Singhania, Director of Interventional Cardiology at Yashoda Medicity, says this pattern puts real strain on the body. "In an untrained person, a sudden switch to a much increased load in terms of time or intensity of training is a huge physiological stress on the heart," he told Health and Me.

Dr Ajeet Singh, Senior Consultant and Head of Cardiology at ShardaCare Healthcity, describes the same risk from the other direction. "Stepping into a sedentary lifestyle with a sudden burst of extreme activity, and vice versa, can strain the heart," he told Health and Me. Weekend sport, after a week of sitting, is one of the most common triggers.

Dr Udgeath Dhir, Principal Director, Cardio Thoracic and Vascular Surgery at Fortis Gurugram, points to a related trend: people jumping straight into long-distance running or marathon training without building up to it. "Suddenly pushing an untrained body into long-distance running, marathon training or extreme high-intensity workouts can place unnecessary acute stress on the cardiovascular system," he says.

What the Research Shows

Medical literature backs this up. New England Journal of Medicine study found that people who exercised regularly were far better protected against a heart attack being triggered by sudden exertion than those who rarely worked out. Research published in Circulation notes that the least fit individuals face the greatest risk during sudden physical effort. Doctors describe this as a fitness "buffer". A trained heart handles a sharp rise in oxygen demand and blood pressure far better than an untrained one.

This doesn't mean irregular exercise is pointless. A large 2023 study in JAMA, using activity-tracker data from close to 90,000 people, found that "weekend warriors" who packed their exercise into one or two days had a similarly lower cardiovascular risk to people who spread activity evenly through the week. The catch, researchers noted, is that this benefit shows up in people who are already getting regular activity in some form. Suddenly forcing an untrained body into a high-intensity session is a different scenario altogether.

Read More: 100% Blockage At 18, 25% Patients Under 40: On World Heart Day, Cardiologists Reveal An Alarming Heart Attack Pattern

Who Should Be Extra Careful

All three doctors agree that people with undiagnosed heart problems, high blood pressure, high cholesterol, diabetes or a family history of heart disease need to be more cautious. Dr Singh says this doesn't mean exercise should be avoided. It simply has to match "age, fitness level, and overall health and medical history." Dr Singhania advises anyone with existing heart disease or risk factors to consult their doctor before starting intense activity.

Warning Signs to Watch For

All three point to the same red flags. Chest pain or pressure, unusual breathlessness, dizziness, a racing heart, or simply feeling off during exercise. Dr Singhania lists "angina, unusual breathlessness, pre-syncope, syncope and palpitations" as symptoms that should never be ignored.

The advice from all three doctors is simple. Warm up. Build intensity gradually. Cool down. Stay hydrated. And if something feels wrong mid-workout, stop and consult a doctor rather than trying to push through the discomfort. As Dr Dhir puts it, "Fitness is not about pushing the body to its maximum every day; it is about building a level of fitness that your individual heart can safely sustain."

Weight-loss drugs like Zepbound and Mounjaro work by suppressing appetite and making the user feel less hungry, reducing how much they eat. But a new study suggests tirzepatide, the active ingredient in both drugs, it could help the body use more energy by activating brown fat.

The finding primarily comes from mice, not humans, so it is too early to say that tirzepatide can directly increase the number of calories burned in users.

The study, led by researchers at the University of Barcelona and published in Biomedicine, looked at how tirzepatide affects different types of fat tissue.

How Does Tirzepatide Usually Help With Weight Loss?

Tirzepatide works by mimicking two hormones, GIP and GLP-1, which are involved in appetite, food intake and blood sugar regulation.

One of its major effects is reducing appetite, which can help people consume fewer calories. Research has already shown that tirzepatide can substantially reduce energy intake compared to placebo.

But researchers wanted to know whether there was something else happening inside the body that could not simply be explained by eating less, which led them to brown fat.

Also read: Stopping Ozempic, Wegovy, Mounjaro Linked To 22% Higher Heart Attack, Stroke Risk: Study

What Is Brown Fat?

Most of us are familiar with white fat, which stores excess energy. Brown fat is brown adipose tissue. It is known for using energy and producing heat. It contains mitochondria that allow it to burn fuel.

The researchers gave obese mice tirzepatide and compared them to mice that were not given the drug but consumed the same amount of food. This development allowed the scientists to separate the effects of the drug from the effects of simply eating fewer calories. They identified that tirzepatide activated brown adipose tissue.

According to the researchers, this was linked with a greater capacity to use metabolic energy and with the production of signalling molecules called batokines, which may have beneficial effects on metabolism.

Also read: CagriSema Beats Lilly’s Mounjaro & Zepbound In New Trial: All About Novo’s Next-Gen Obesity Drug

Could Mounjaro And Zepbound Also Burn Calories?

It’s a possibility but it has not yet been proven in humans. The study suggests that tirzepatide can activate a biological pathway involved in energy burning. That is different from proving that Mounjaro or Zepbound can burn calories as well.

This distinction is important because headlines about “boosting metabolism” can make the effect sound much larger or more established than the evidence currently allows.

For years, scientists have been exploring whether activating brown fat could help find another way of tackling obesity. Most weight-loss strategies focus heavily on reducing how much energy enters the body. Activating brown fat offers another way of increasing how much energy the body uses.

Previous attempts to stimulate brown fat pharmacologically have run into problems, particularly due to unforeseen cardiovascular effects.

The University of Barcelona researchers say tirzepatide’s known cardiovascular benefits make its brown-fat activation particularly interesting, although this finding itself still needs to be confirmed in huma Tirzepatide ns.

Tirzepatide already has several effects on the body through its GIP and GLP-1 activity. Reduced appetite and food intake remain important mechanisms behind its weight-loss effects. The new study suggests that changes in fat tissue and energy metabolism could add scope layer to the drug’s effects.

But it would be premature to conclude that brown-fat activation is responsible for a the weight loss seen with tirzepatide in people.