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Nearly three decades ago, Viagra (sildenafil) was invented in a Pfizer laboratory as a groundbreaking treatment for erectile dysfunction (ED). Since then, the drug used has been highly marketed for its ability to enhance blood flow to the penis by inhibiting an enzyme called Phosphodiesterase type 5 (PDE5). Interestingly, Viagra was not initially developed for ED.
Researchers originally studied sildenafil as a potential treatment for high blood pressure. However, during clinical trials, participants experienced erections as a side effect, leading to the drug's repurposing as an ED medication.
Given its origins, it is not surprising that Viagra can temporarily lower blood pressure. A 2002 study published in Urology examined the effects of sildenafil on blood pressure among men with and without hypertension. The findings revealed that a 100-milligram dose reduced systolic blood pressure by an average of 6 mmHg and diastolic blood pressure by 4.5 mmHg. Older participants experienced slightly greater reductions, though not to a dangerous extent.
Despite these effects, Viagra is not a reliable treatment for hypertension. More importantly, individuals taking certain medications must be cautious, as Viagra can interact with other drugs and cause a significant drop in blood pressure.
One of the more serious risks associated with Viagra is hypotension or dangerously low blood pressure. This can lead to dizziness, lightheadedness, or, in severe cases, a heart attack or stroke. The risk is particularly high for individuals taking nitrates for chest pain, high blood pressure medications, or heart failure drugs such as riociguat (Adempas). Recreational drugs known as "poppers"—which contain amyl or butyl nitrites—can also trigger dangerous interactions.
Additionally, sildenafil is used in another medication, Revatio, which is prescribed for pulmonary hypertension—a condition that affects blood flow between the heart and lungs. Revatio is taken in smaller doses multiple times a day, and individuals using it should avoid Viagra or other PDE5 inhibitors to prevent complications.
Even if you do not have high blood pressure, discussing ED with a healthcare professional is essential before starting Viagra. ED can sometimes signal underlying health issues such as high cholesterol, obesity, type 2 diabetes, sleep disorders, or substance use problems.
Moreover, ED is increasingly recognized as an early warning sign of cardiovascular disease. A 2021 study published in the Journal of Clinical Medicine found that ED could precede serious cardiovascular events—such as a heart attack or stroke—by about three years. This is because the smaller blood vessels in the penis often show signs of damage before larger vessels near the heart, brain, and lungs.
Before seeking ED treatment, individuals should undergo a comprehensive evaluation of their cardiovascular health, including risk factors like family history, metabolic conditions, and lifestyle habits.
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