The global obesity epidemic, affecting over one billion people worldwide, is largely driven by eating behaviors. Appetite, influenced by both intrinsic and environmental factors, plays a crucial role in weight management. A recent study how exercise affects appetite perception in obese males, shedding light on the physiological mechanisms behind hunger suppression post-exercise.

While exercise is well-known for its benefits in weight management, its direct impact on appetite control has remained a subject of debate. Appetite is regulated by a complex network of gastrointestinal and neurohormonal signals, including hormones like ghrelin, leptin, interleukin 6 (IL-6), and neuropeptide Y (NPY). These hormones influence hunger levels, satiety, and energy balance.

The study published in Physiological Reports examines investigated how moderate continuous aerobic exercise (MICE) alters these hormone levels in obese men, ultimately affecting their hunger perception. The findings reveal that certain myokines and cytokines shift dynamically post-exercise, potentially reducing appetite and offering a promising strategy for weight management.

Hormonal Responses to Exercise

The study found that after exercise, there was a significant increase in IL-6 and irisin levels in the exercise group compared to those who remained sedentary. These elevated concentrations persisted for an hour after working out. IL-6 has been associated with regulating metabolism and enhancing fat oxidation, while irisin plays a role in converting white fat into more metabolically active brown fat.

Conversely, the study reported a decrease in neuropeptide Y (NPY) levels, a key neurotransmitter responsible for stimulating appetite. The decline in NPY levels post-exercise suggests a temporary suppression of hunger, supporting the idea that exercise can curb cravings. However, the study did not observe significant changes in IL-7 or leptin levels, two other hormones involved in appetite regulation.

Why Some People Struggle to Lose Weight

Ghrelin, often called the “hunger hormone,” stimulates appetite by increasing activity in specific areas of the brain. Individuals with higher ghrelin levels generally find it harder to lose weight because their bodies signal hunger more frequently.

Research suggests that dieting can lead to an increase in ghrelin levels, making weight loss challenging. Certain medical conditions, such as Hashimoto’s thyroiditis, Prader-Willi syndrome, anorexia nervosa, and bulimia nervosa, are also linked to elevated ghrelin levels, complicating appetite regulation further.

Challenges in Implementing Exercise for Appetite Control

While exercise has clear benefits, the findings should be interpreted with caution. He pointed out that the study had a small sample size, making it difficult to draw definitive conclusions.

Moreover, he highlighted the challenges faced by obese individuals in maintaining an intensive exercise routine. While exercise-induced appetite suppression is promising, consistently engaging in high-intensity workouts may be unrealistic for those who struggle with mobility or fitness levels. More extensive studies are needed to determine the optimal exercise duration and intensity for effective appetite suppression.

Tips to Naturally And Safely Suppressing Appetite

Besides exercise, there are several strategies individuals can use to naturally suppress their appetite and improve satiety:

Increase Protein Intake: Protein-rich foods, such as lean meats, legumes, and dairy, promote feelings of fullness and reduce hunger.

Stay Hydrated: Drinking water before meals can help control portion sizes and prevent overeating.

Opt for Fiber-Rich Foods: Whole grains, vegetables, and fruits high in fiber take longer to digest, keeping you full for longer.

Reduce Simple Carbohydrates and Sugars: Simple carbs and sugars cause rapid spikes and crashes in blood sugar levels, leading to increased hunger.

Prioritize Sleep: Poor sleep disrupts hunger-regulating hormones, making it harder to control cravings.

Manage Stress: Chronic stress increases cortisol levels, which can lead to overeating and weight gain.

The study’s findings indicate that moderate exercise can temporarily suppress appetite by altering key hormones. While more research is needed to refine the details—such as optimal workout duration and intensity—this insight adds to the growing body of evidence supporting exercise as a tool for appetite regulation and weight management.

For individuals looking to curb cravings and maintain a healthy weight, incorporating a well-balanced diet alongside regular exercise remains the most sustainable approach. Future studies focusing on larger populations and long-term effects could provide deeper insights into how exercise can be optimized for appetite control, making it an effective strategy in combating obesity.

Exercise alone is not a magic solution for weight loss, but its impact on appetite hormones presents a promising avenue for managing hunger and energy balance. As research continues to evolve, it becomes increasingly clear that integrating physical activity with mindful eating habits can play a vital role in achieving and maintaining a healthy lifestyle.

Novak Djokovic, the 24-time Grand Slam champion, suffered his earliest Grand Slam exit in 20 years after crashing out in the first round of the US Open with a five-set defeat to Argentina’s Mariano Navone.

Djokovic was left in tears after bouts of vomiting, cramping and pain. He also relied on multiple medical timeouts, an inhaler and pills to stay on the court.

“I despised every moment I was on the court,” Djokovic told the media after the match, adding that he had been dealing with similar issues throughout the season.

“I think it was obvious that it was an awful feeling on the court for me. It’s something that I’ve been carrying, unfortunately, pretty much every match this year,” he said.

Djokovic described how his body broke down during the match.

“Vomiting, throwing up, a serious issue there. Then my whole body starts to collapse, basically cramping and pain. The back just gave up in the end and my shoulder, and I couldn’t close it out,” he added.

The defeat ended Djokovic’s hopes of winning a 25th Grand Slam title at this year’s US Open.

Also read: 47-Year-Old Assam Doctor Dies After Collapsing In The Gym: When Can Exercise Trigger A Cardiac Emergency?

Similar Struggles In Cincinnati

Earlier this month at the Cincinnati Open, Djokovic, who holds the all-time men’s record of 428 weeks as world No. 1 in singles, also struggled physically throughout his second-round match.

The 39-year-old was seen crouching on all fours between points, required a medical timeout and appeared to vomit into towels as extreme heat and humidity took a toll.

He then suffered a surprising second-round defeat, losing to Argentina’s Thiago Agustín Tirante 2-6, 6-4, 6-4.

Following the defeat, Djokovic revealed that he had been dealing with a longstanding health condition that becomes particularly difficult to manage in hot and humid conditions.

“It’s because of a health issue I have,” Djokovic told reporters after the match. “I’ve been dealing with it for many years now. It causes me a lot of problems, especially when there’s a lot of humidity and heat.”

Is Elite Tennis Becoming Too Demanding?

Read More: What Keeps Messi and Ronaldo Biologically Younger Than Their Age? Experts Explain

Djokovic is not alone in facing physical challenges. His exit comes after world No. 1 Jannik Sinner withdrew from the tournament due to injury, while defending champion Carlos Alcaraz entered the event after a long break.

Other names include Italy’s Lorenzo Musetti and France’s Arthur Fils who missed earlier Grand Slams in 2026 with injuries, and No. 2 seed Elena Rybakina managing a heel injury ahead of her opener.

Together, these developments raise a broader question: Are the demands of elite tennis becoming too much for even the world’s best players?

While Djokovic has not revealed the nature of his illness, he told reporters that he is “trying” to address the ailment.

Age, Recovery And The Demands Of Tennis

In 2023, Djokovic acknowledged that his body was beginning to feel the effects of a long career, although he still felt he had fuel left in the tank.

“The desire is still there, but things can change quickly – I am 36, I’ve been a pro for 20 years.”

He said he did not view age as a decisive factor, instead focusing on his overall physical condition and whether he continued to enjoy playing.

Age can affect tennis performance through changes such as reduced muscle mass, slower recovery and lower aerobic capacity, which can also increase injury risk.

Year-round Tours, Extreme Heat

In addition to performance pressures, the grueling schedules of the ATP and WTA Tours that span nearly 11 months of the year, give athletes limited time to rest and recover from injuries.

At the same time, rising global temperatures and intense matches lasting up to five hours have added further physical challenges.

“We’re losing the battle overall despite the advances in sports medicine,” Neeru Jayanthi, who leads the tennis medicine programme at Emory Healthcare in Atlanta, told The Straits Times.

Along with creating new avenues for managing type 2 diabetes and metabolic health, GLP-1 drugs like Ozempic, Wegovy, Mounjaro, and Zepbound are also transforming the weight loss game.

Despite its striking benefits in tackling obesity, it poses the risk of significant muscle loss as it works by reducing appetite rather than burning energy.

To address this issue, researchers at the University of California, Berkeley have identified an experimental compound. It could offer a very different approach to weight loss that may not result in excessive muscle loss.

How Was The Study Conducted?

The compound, called 5-tetradecyloxy-2-furoic acid, or TOFA, is not approved as a weight-loss treatment and has so far only been tested in animals. Weight loss is the result of mainly two bodily mechanisms: Taking in fewer calories than the amount burned during a specific period.

Since GLP-1 drugs only focus on the first part, the resultant weight loss also includes loss of lean muscle mass. TOFA is developed to increase the amount of energy burned rather than just supressing appetite.

Anders Näär, professor of metabolic biology and nutrition at UC Berkeley and senior author of the study, explained, "Body weight responds to two levers: taking in fewer calories or spending more energy. GLP-1s work almost entirely on the first, so we went after the second."

When tested on mice, it increased energy use by as much as 18% without making the animals more physically active or raising their body temperature. The mice lost body fat without a significant reduction in lean muscle mass.

Also read: US FDA Approves Eli Lilly’s Mounjaro To Reduce Cardiovascular Risk In Diabetics

How Does TOFA Compound Work?

TOFA belongs to a group of compounds known as ACC inhibitors. It interferes with the production of lipids like cholesterol and triglycerides while also activating cells involved in utilising fat as fuel.

Researchers found that TOFA activated PPARα and PPARδ, receptors that switch on genes involved in fat uptake and energy expenditure. Justin Y. Lee, the study's first author, said, “TOFA appears to engage a coordinated metabolic response.”

He added, “It is not simply blocking lipid synthesis. It is also activating energy expenditure pathways that may help the body handle excess lipid and glucose more effectively.”

The mice also showed improvements in insulin sensitivity, blood glucose, triglycerides, and signs of fatty liver disease.

Also read: Unapproved Weight-Loss Drug Caused Hospitalisations In Ireland: What Is Retatrutide & Why Is It Risky?

Could TOFA Be Combined With Ozempic Or Mounjaro?

The researchers tested TOFA alongside GLP-1 drugs including semaglutide and tirzepatide. In mice, the combinations produced greater improvements in body weight, glucose control, insulin levels, and triglycerides than either treatment alone.

Näär said, “TOFA worked additively or synergistically with the GLP-1 appetite-suppressing drugs, so we view it as complementary rather than as a replacement.”

In other words, researchers are looking to maximise the benefits of the two-pronged approach: One drug could dial your appetite down while another could turn up energy expenditure.

Despite promising results, we have to take a pause as TOFA is not yet an approved human weight-loss drug, meaning researchers do not yet know whether the compound will produce the same effects, or whether it will be safe, in humans.

Working out is usually associated with a healthier heart, stronger muscles, and better overall fitness. But in rare cases, intense physical exertion can expose an underlying heart problem, devastatingly resulting into an unforeseen casualty.

That's what happened in the case of a 47-year-old doctor in Assam after he reportedly collapsed while working out and passed away. The incident has once again raised questions about sudden cardiac emergencies during intense workouts.

What Happened?

According to multiple reports, Dr Sahin Rahman, an associate professor at Nagaon Medical College and Hospital, collapsed at a gym in Nagaon.

He was taken to hospital but could not be revived. Reports have described the incident as a suspected cardiac arrest, although the exact cause is yet to be established.

The tragedy is particularly striking because being physically active does not completely eliminate the possibility of an underlying heart condition.

Also read: How Fit You Really Are? Your Grip Strength & Walking Speed Could Reveal Your Biological Age

Looking Fit Does Not Always Mean Heart Is Healthy

Regular exercise is one of the most effective ways to reduce cardiovascular risk. It can improve blood pressure, cholesterol, blood sugar, body composition, and overall cardiovascular fitness. So why have there been so many cases of deaths due to cardiac emergencies in the gym?

In an X post, Dr Sudhir Kumar, Neurologist, Apollo Hospitals, Hyderabad, explained why intense workouts can trigger a heart attack and how to prevent the next cardiac emergency in the gym:

He wrote that India reportedly recorded 35,715 heart-attack deaths in 2023. Around 40% of victims were under 45.

During intense exercise, the body sees an increase in heart rate, blood pressure, and the body's demand for oxygen. If someone has an undiagnosed structural or electrical heart problem, that sudden increase in demand can, in rare circumstances, trigger a dangerous rhythm or other serious cardiac event.

Dr Kumar wrote, "Exercise does not “cause” the arrest. It unmasks a silent problem. Under 35–40: Cardiac arrest is usually caused by inherited conditions such as hypertrophic cardiomyopathy, anomalous coronaries, Long QT, ARVC, and myocarditis. Over 35–40 (his age), atherosclerotic coronary disease becomes the leading cause."

One of the worst risks of sudden cardiac events is that they can happen in people who appear healthy. Someone who has a healthy lifestyle can still have conditions like high blood pressure, cholesterol, inherited heart disorder, or an electrical rhythm problem.

Risk can also build silently over years through factors like smoking, diabetes, high cholesterol, chronic stress, inadequate sleep, and a family history of cardiovascular disease.

He added, "The heart can look and feel fine until the extra demand of heavy lifting or HIIT hits an abnormal muscle, a blocked artery, or an electrical fault. Then it fibrillates and stops pumping."

Doctors and other healthcare workers, who work stressful long shifts and have an uneven sleep pattern, face additional risk.

Also read: Sweetener In Sugar-Free Gum Linked To 57% Higher Heart Attack And Stroke Risk: What Is Xylitol?

Warning Signs You Should Not Ignore

During a workout, you are likely to experience a racing heart. But you must not simply push through events like:

• Chest pressure, pain or tightness
• Unexplained severe breathlessness
• Fainting or nearly fainting
• Sudden dizziness
• A new or unusual irregular heartbeat
• Extreme weakness that feels disproportionate to the workout
• Pain spreading to the arm, jaw, back or shoulder

If any of these symptoms occur, stop exercising and seek medical attention immediately.

How To Prevent A Cardiac Emergency In The Gym?

Dr Kumar suggests that getting tested regularly can help you understand how healthy your heart is. He suggests a list of tests that can catch underlying heart conditions.

He recommends, "Family history of sudden death under 50 + personal history of unexplained fainting or chest pain, resting ECG, 2D echo, lipids and blood sugar, stress test or CT coronary scan if you are 35+ and going intense."

The expert also explained what to do in case you witness a cardiac emergency unfolding in front of you.

He explains, "If it happens, immediate CPR doubles or triples survival. An automated external defibrillator (AED) used in the first few minutes can push neurologically intact survival above 80–90% in gyms that have one. Every minute without compression or shock drops the chance of survival by ~10%. Hands-only CPR is enough: hard, fast, centre of the chest, 100–120/min. Call ambulance first."

He concludes, "Do the tests if you have risk factors or are starting heavy training after being sedentary. Learn hands-only CPR this week. Ask your gym where the AED is. Regular exercise still saves far more lives than it takes. The goal is to stop preventable ones."